BR0307379A - Substituted amines as ig inhibitors - Google Patents

Substituted amines as ig inhibitors

Info

Publication number
BR0307379A
BR0307379A BR0307379-3A BR0307379A BR0307379A BR 0307379 A BR0307379 A BR 0307379A BR 0307379 A BR0307379 A BR 0307379A BR 0307379 A BR0307379 A BR 0307379A
Authority
BR
Brazil
Prior art keywords
inhibitors
substituted amines
substituted
phenyl
amines
Prior art date
Application number
BR0307379-3A
Other languages
Portuguese (pt)
Inventor
Murty Bulusu
Peter Ettmayer
Klaus Weigand
Max Woisetschlager
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0202381A external-priority patent/GB0202381D0/en
Priority claimed from GB0221953A external-priority patent/GB0221953D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR0307379A publication Critical patent/BR0307379A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"AMINAS SUBSTITUìDAS COMO INIBIDORES DE IgE". Uma amina, que é substituída por pirimidina substituída por fenila; e fenila; e um terceiro substituinte e seu uso como um produto farmacêutico."AMines REPLACED AS IgE INHIBITORS". An amine which is substituted by phenyl substituted pyrimidine; and phenyl; and a third substituent and its use as a pharmaceutical product.

BR0307379-3A 2002-02-01 2003-01-31 Substituted amines as ig inhibitors BR0307379A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0202381A GB0202381D0 (en) 2002-02-01 2002-02-01 Organic compounds
GB0221953A GB0221953D0 (en) 2002-09-20 2002-09-20 Organic compounds
PCT/EP2003/000973 WO2003063871A1 (en) 2002-02-01 2003-01-31 Phenylpyrimidine amines as ige inhibitors

Publications (1)

Publication Number Publication Date
BR0307379A true BR0307379A (en) 2004-12-28

Family

ID=27665364

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0307379-3A BR0307379A (en) 2002-02-01 2003-01-31 Substituted amines as ig inhibitors

Country Status (23)

Country Link
US (2) US20050119255A1 (en)
EP (1) EP1474146B1 (en)
JP (1) JP4393198B2 (en)
KR (1) KR20040081159A (en)
CN (2) CN1622807A (en)
AR (1) AR038368A1 (en)
AT (1) ATE406165T1 (en)
AU (1) AU2003206810B2 (en)
BR (1) BR0307379A (en)
CA (1) CA2471883C (en)
DE (1) DE60323205D1 (en)
EC (1) ECSP045213A (en)
ES (1) ES2312749T3 (en)
IL (1) IL162766A0 (en)
MX (1) MXPA04007395A (en)
NO (1) NO20043610L (en)
NZ (1) NZ534229A (en)
PE (1) PE20030983A1 (en)
PL (1) PL370666A1 (en)
PT (1) PT1474146E (en)
RU (1) RU2004126614A (en)
TW (1) TW200302728A (en)
WO (1) WO2003063871A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050014753A1 (en) * 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
CA2533474A1 (en) * 2003-07-30 2005-02-10 Shudong Wang 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
EP1679309A4 (en) * 2003-10-24 2007-03-28 Ono Pharmaceutical Co Antistress drug and medical use thereof
EP1933839A1 (en) 2005-09-29 2008-06-25 Novartis AG Phenyl-(4-phenyl-pyrimidin-2-yl)-amines for enhancing immunotolerance
KR20100044251A (en) 2007-08-15 2010-04-29 싸이토키네틱스, 인코포레이티드 Certain chemical entities, compositions, and methods
EP4077290A1 (en) 2019-12-20 2022-10-26 Ikena Oncology, Inc. 4-phenyl-n-(phenyl)thiazol-2-amine derivatives and related compounds as aryl hydrocarbon receptor (ahr) agonists for the treatment of e.g. angiogenesis implicated or inflammatory disorders

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1185039A (en) 1966-03-31 1970-03-18 Ici Ltd Pyrimidine Derivatives and Compositions containing them
GB2001069B (en) 1977-07-12 1982-01-20 Scras Pyrimidine derivatives
AU5319479A (en) 1978-12-22 1980-06-26 Ici Australia Limited Pyrimidinyl amino phenoxy carboxylate derivatives
US4351939A (en) 1980-10-16 1982-09-28 Mead Johnson & Company Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process
EP0084194B1 (en) 1982-01-14 1986-04-30 MERCK PATENT GmbH Liquid crystal mixtures
FR2536071B1 (en) 1982-11-12 1986-07-11 Sanofi Sa 2-PIPERAZINOPYRIMIDINE ACID SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2547821B1 (en) 1983-06-24 1985-12-06 Sanofi Sa 2-PIPERAZINOPYRIMIDINE SALT, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
US4659363A (en) 1983-07-25 1987-04-21 Ciba-Geigy Corporation N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof
EP0164204A1 (en) 1984-05-12 1985-12-11 FISONS plc Novel pharmaceutically useful pyrimidines
ATE60591T1 (en) 1984-06-25 1991-02-15 Ciba Geigy Ag PYRIMIDI DERIVATIVES EFFECTIVE AS PEST CONTROL AGENT.
EP0233461B2 (en) 1986-01-13 2002-05-29 American Cyanamid Company 4,5,6-Substituted-2-pyrimidinamines
DE3614060A1 (en) 1986-04-23 1987-10-29 Schering Ag PYRIMIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS FUNGICIDES
EP0254259A3 (en) 1986-07-21 1989-11-23 Otsuka Pharmaceutical Factory, Inc. P-aminophenol derivatives
EP0264348B1 (en) 1986-10-13 1993-12-15 Ciba-Geigy Ag Ureas
US4826990A (en) 1987-09-30 1989-05-02 American Home Products Corporation 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents
US4966622A (en) 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
EP0337946B1 (en) 1988-04-12 1993-07-28 Ciba-Geigy Ag Ureas
US4973690A (en) 1988-04-12 1990-11-27 Ciba-Geigy Corporation Novel ureas
JPH02308248A (en) 1989-05-24 1990-12-21 Fuji Photo Film Co Ltd Aminopyrimidine dye forming coupler and silver halide color photographic sensitive material containing this coupler
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
US5516775A (en) 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
DK0672041T3 (en) 1993-10-01 2002-02-25 Novartis Ag Pharmacologically active pyridine derivatives and processes for their preparation
ES2262137T3 (en) 1993-10-01 2006-11-16 Novartis Ag PHARMACOLOGICALLY ACTIVE PIRIMIDINAMINE DERIVATIVES AND PROCEDURES FOR THEIR PREPARATION.
US5612340A (en) 1993-10-01 1997-03-18 Ciba-Geigy Corporation Pyrimidineamine derivatives and processes for the preparation thereof
AU692484B2 (en) * 1993-10-12 1998-06-11 Du Pont Pharmaceuticals Company 1N-alkyl-N-arylpyrimidinamines and derivatives thereof
US5750531A (en) 1994-08-13 1998-05-12 Yuhan Corporation Pyrimidine derivatives and processes for the preparation thereof
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
JP2002514195A (en) 1996-12-05 2002-05-14 アムジエン・インコーポレーテツド Substituted pyrimidine compounds and uses thereof
CN1142931C (en) * 1997-03-26 2004-03-24 大正制药株式会社 4-tetrahydropyridylpyrimidine derivatives
IN188411B (en) 1997-03-27 2002-09-21 Yuhan Corp
US6440965B1 (en) 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
AU2516199A (en) * 1998-01-12 1999-07-26 Novartis Ag Pyridinylpyrimidine amines as immunoglobuline e (ige) synthesis inhibitors
HUP0103304A3 (en) * 1998-01-28 2002-10-28 Shionogi & Co Novel tricyclic compounds and pharmaceutical compositions thereof
EA002973B1 (en) 1998-03-27 2002-12-26 Янссен Фармацевтика Н.В. Hiv inhibiting pyrimidine derivatives
AR023052A1 (en) 1998-09-25 2002-09-04 Mitsuharu Yoshimura Milton DERIVATIVES OF PIRIMIDONA
CZ20011466A3 (en) * 1998-11-17 2001-09-12 Kumiai Chemical Industry Co., Ltd. Derivatives of pyrimidinyl benzimidazole, triazinyl benzimidazole, aniline pyrimidine or aniline triazine and agricultural and horticultural fungicidal agents containing thereof
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
DE60035271D1 (en) 1999-04-28 2007-08-02 Inst Med Molecular Design Inc Pyrimidincarbonsäurederivate
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
GB0003224D0 (en) 2000-02-11 2000-04-05 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
EP1474146A1 (en) 2004-11-10
MXPA04007395A (en) 2005-06-17
ECSP045213A (en) 2004-09-28
CN1622807A (en) 2005-06-01
ATE406165T1 (en) 2008-09-15
US20050119255A1 (en) 2005-06-02
PT1474146E (en) 2008-12-05
US20070281956A1 (en) 2007-12-06
RU2004126614A (en) 2005-05-27
PL370666A1 (en) 2005-05-30
TW200302728A (en) 2003-08-16
JP2005516051A (en) 2005-06-02
JP4393198B2 (en) 2010-01-06
CN101684097A (en) 2010-03-31
CA2471883A1 (en) 2003-08-07
PE20030983A1 (en) 2004-01-26
IL162766A0 (en) 2005-11-20
WO2003063871A1 (en) 2003-08-07
KR20040081159A (en) 2004-09-20
DE60323205D1 (en) 2008-10-09
AR038368A1 (en) 2005-01-12
NZ534229A (en) 2005-04-29
EP1474146B1 (en) 2008-08-27
CA2471883C (en) 2010-12-07
US7759357B2 (en) 2010-07-20
AU2003206810B2 (en) 2006-06-29
NO20043610L (en) 2004-10-05
ES2312749T3 (en) 2009-03-01

Similar Documents

Publication Publication Date Title
ECSP20027480A (en) INDOLIL ALKYL AMINO DERIVATIVES SUBSTITUTED AS NEW INHIBITORS OF HISTONE DESACETILASE
BRPI0408347B8 (en) pyrimidine derivatives, their use, and pharmaceutical composition and combination
DK1483265T3 (en) Purine derivatives as kinase inhibitors
BRPI0608886B8 (en) n-sulfonylpyrroles derivatives and their uses
ECSP055676A (en) HETEROCYCLIC PIPERAZINAS REPLACED FOR THE TREATMENT OF CHICHOPHRENIA
BRPI0409063A (en) pro pi-3 kinase inhibitor medications
ECSP077271A (en) PIRIMIDINE DERIVATIVES
ECSP077259A (en) PIRIMIDINE DERIVATIVES
CR11483A (en) PEPTIDE INHIBITORS DESFORMILASA
CR11518A (en) CARBAMOIL COMPOUNDS AS DGAT1 190 INHIBITORS
CR8254A (en) [1,8] NAFTIDRIN-2-ONAS AND RELATED COMPOUNDS FOR THE TREATMENT OF CHICHOPHRENIA
UY31468A1 (en) BIS- (SULFONYLAMINE) DERIVATIVES IN THERAPY 065
ECSP055853A (en) NEW DERIVATIVES OF HETEROCICLIC FLUOROGLYCOSIDS, PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS, AND THE USE OF THE SAME
UY29267A1 (en) PIPERIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS
ECSP099413A (en) BASED COMPOUNDS OF 4 - Phenyl - 6 - (2,2,2 - Trifluoro - 1 - Phenylethoxy) pyrimidine AND METHODS FOR USE
EA200700142A1 (en) HYDROCYCLO-SUBSTITUTED CYCLIC UREA DERIVATIVES, THEIR RECEIVING AND THEIR PHARMACEUTICAL APPLICATION AS KINASE INHIBITORS
AR047917A1 (en) DERIVATIVES OF 4-BENZIMIDAZOL-2-IL-PIRIDAZIN-3-ONA, PREPARATION OF THE SAME, AND ITS EMPLOYMENT IN MEDICATIONS
CR11106A (en) KINASE INHIBITORS P710 S6
BRPI0514372A (en) fructose 1,6-bisphosphatase thiazole inhibitors
CL2003002762A1 (en) COMPOUNDS DERIVED FROM PIRROLOPIRIMIDINA OR PIRROLOPIRIDINA REPLACED BY A CYCLIC AMINE, ITS SALTS; PHARMACEUTICAL COMPOSITION; AND ITS USE TO PREPARE AN ANTAGONIST OF CRF RECEIVERS, TO TREAT DISEASES AS DEPRESSION, ANXIETY, ALZ
MX2009009541A (en) Metalloprotease inhibitors containing a heterocyclic moiety.
UY30087A1 (en) PIPERAZINAS AND PIPERIDINAS AS POTENTIALS OF MGLUR5
BR0012697A (en) Th2 differentiation inhibitors
CR10963A (en) 2-AMINO PYRIMIDINE COMPOUNDS
NI200900052A (en) HETEROCYCLIC DERIVED FROM METALOPROTEASE INHIBITORS

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010.