BR0213429A - Métodos para regenerar a função do pâncreas em um indivìduo, para tratar o diabete em um paciente humano e para produzir célula pancreática funcional de animal, célula pancreática funcional de animal, uso da mesma, e, método para roduzir célula pancreática de animal em diferentes estágios de desenvolvimento - Google Patents
Métodos para regenerar a função do pâncreas em um indivìduo, para tratar o diabete em um paciente humano e para produzir célula pancreática funcional de animal, célula pancreática funcional de animal, uso da mesma, e, método para roduzir célula pancreática de animal em diferentes estágios de desenvolvimentoInfo
- Publication number
- BR0213429A BR0213429A BR0213429-2A BR0213429A BR0213429A BR 0213429 A BR0213429 A BR 0213429A BR 0213429 A BR0213429 A BR 0213429A BR 0213429 A BR0213429 A BR 0213429A
- Authority
- BR
- Brazil
- Prior art keywords
- pancreatic cell
- animal
- individual
- development
- pancreatic
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 230000004203 pancreatic function Effects 0.000 title abstract 2
- 230000001172 regenerating effect Effects 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 5
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 abstract 1
- 101001033280 Homo sapiens Cytokine receptor common subunit beta Proteins 0.000 abstract 1
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000006870 function Effects 0.000 abstract 1
- 102000055647 human CSF2RB Human genes 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"MéTODOS PARA REGENERAR A FUNçãO DO PâNCREAS EM UM INDIVìDUO, PARA TRATAR O DIABETE EM UM PACIENTE HUMANO E PARA PRODUZIR CéLULA PANCREáTICA FUNCIONAL DE ANIMAL, CéLULA PANCREáTICA FUNCIONAL DE ANIMAL, USO DA MESMA, E, MéTODO PARA PRODUZIR CéLULA PANCREáTICA DE ANIMAL EM DIFERENTES ESTáGIOS DE DESENVOLVIMENTO". A invenção fornece um método para regenerar a função do pâncreas em um indivíduo, mediante o transplante de uma quantidade eficaz de células pancreáticas funcionais derivadas de células pancreáticas embriónicas não mais velhas do que 10 semanas de desenvolvimento. é igualmente fornecido o método para produzir célula pancreática animal funcional, mais precisamente uma linhagem de células beta humanas imortalizadas. A invenção também fornece um método de tratamento de diabéticos. Igualmente são fornecidas células beta pancreáticas como um medicamento para tratar de diabéticos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/981,750 US20030077256A1 (en) | 2001-10-19 | 2001-10-19 | Pancreas regeneration using embryonic pancreatic cells |
| PCT/IB2002/004599 WO2003033685A2 (en) | 2001-10-19 | 2002-10-18 | Method of producing human beta cell lines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0213429A true BR0213429A (pt) | 2004-11-09 |
Family
ID=25528625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0213429-2A BR0213429A (pt) | 2001-10-19 | 2002-10-18 | Métodos para regenerar a função do pâncreas em um indivìduo, para tratar o diabete em um paciente humano e para produzir célula pancreática funcional de animal, célula pancreática funcional de animal, uso da mesma, e, método para roduzir célula pancreática de animal em diferentes estágios de desenvolvimento |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20030077256A1 (pt) |
| EP (1) | EP1456356B1 (pt) |
| JP (1) | JP2005505635A (pt) |
| KR (1) | KR20040080430A (pt) |
| CN (1) | CN1662644A (pt) |
| AT (1) | ATE452967T1 (pt) |
| BR (1) | BR0213429A (pt) |
| CA (1) | CA2463979A1 (pt) |
| DE (1) | DE60234862D1 (pt) |
| GB (1) | GB2397825B (pt) |
| HR (1) | HRP20040446A2 (pt) |
| HU (1) | HUP0600102A2 (pt) |
| IL (1) | IL161468A0 (pt) |
| NZ (1) | NZ532965A (pt) |
| PL (1) | PL370167A1 (pt) |
| RU (1) | RU2004115108A (pt) |
| WO (1) | WO2003033685A2 (pt) |
| ZA (1) | ZA200403646B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1924690A4 (en) * | 2005-09-15 | 2009-07-29 | Burnham Inst Medical Research | METHODS FOR SCREENING COMPOUNDS MODULATING THE ACTIVITY OF THE INSULIN PROMOTER |
| JP5636192B2 (ja) * | 2007-02-21 | 2014-12-03 | エス・ア・エール・エル アンドセルＳａｒｌ Ｅｎｄｏｃｅｌｌｓ | 糖尿病の診断のためのヒト膵臓β細胞株 |
| US8859286B2 (en) * | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
| CN105579577A (zh) | 2013-06-11 | 2016-05-11 | 哈佛学院校长同事会 | SC-β细胞以及用于产生其的组合物和方法 |
| WO2016100930A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived b cells and methods of use thereof |
| US10443042B2 (en) | 2014-12-18 | 2019-10-15 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof |
| EP3234110B1 (en) | 2014-12-18 | 2024-02-28 | President and Fellows of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED ß CELLS AND USES THEREOF |
| IL312134A (en) | 2017-11-15 | 2024-06-01 | Vertex Pharma | Preparations for the production of islet cells and methods of use |
| AU2019320072A1 (en) | 2018-08-10 | 2021-02-25 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| CN110029130A (zh) * | 2019-04-24 | 2019-07-19 | 皖南医学院第一附属医院（皖南医学院弋矶山医院） | 基于CRISPR/Cas9系统在Beta-TC-6细胞株中剔除Sidt2基因方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5723333A (en) * | 1995-02-10 | 1998-03-03 | Regents Of The University Of California | Human pancreatic cell lines: developments and uses |
-
2001
- 2001-10-19 US US09/981,750 patent/US20030077256A1/en not_active Abandoned
-
2002
- 2002-10-18 HU HU0600102A patent/HUP0600102A2/hu unknown
- 2002-10-18 IL IL16146802A patent/IL161468A0/xx unknown
- 2002-10-18 RU RU2004115108/14A patent/RU2004115108A/ru not_active Application Discontinuation
- 2002-10-18 JP JP2003536414A patent/JP2005505635A/ja active Pending
- 2002-10-18 AT AT02785716T patent/ATE452967T1/de not_active IP Right Cessation
- 2002-10-18 CA CA002463979A patent/CA2463979A1/en not_active Abandoned
- 2002-10-18 KR KR10-2004-7005812A patent/KR20040080430A/ko not_active Application Discontinuation
- 2002-10-18 DE DE60234862T patent/DE60234862D1/de not_active Expired - Lifetime
- 2002-10-18 WO PCT/IB2002/004599 patent/WO2003033685A2/en active Search and Examination
- 2002-10-18 BR BR0213429-2A patent/BR0213429A/pt not_active IP Right Cessation
- 2002-10-18 US US10/273,152 patent/US20030219418A1/en active Pending
- 2002-10-18 NZ NZ532965A patent/NZ532965A/en not_active IP Right Cessation
- 2002-10-18 GB GB0411052A patent/GB2397825B/en not_active Expired - Lifetime
- 2002-10-18 PL PL02370167A patent/PL370167A1/xx unknown
- 2002-10-18 EP EP02785716A patent/EP1456356B1/en not_active Expired - Lifetime
- 2002-10-18 CN CN028247876A patent/CN1662644A/zh active Pending
-
2004
- 2004-05-13 ZA ZA2004/03646A patent/ZA200403646B/en unknown
- 2004-05-19 HR HR20040446A patent/HRP20040446A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2463979A1 (en) | 2003-04-24 |
| ATE452967T1 (de) | 2010-01-15 |
| US20030077256A1 (en) | 2003-04-24 |
| WO2003033685A3 (en) | 2004-05-27 |
| ZA200403646B (en) | 2005-01-26 |
| EP1456356B1 (en) | 2009-12-23 |
| GB2397825B (en) | 2006-02-22 |
| IL161468A0 (en) | 2004-09-27 |
| GB0411052D0 (en) | 2004-06-23 |
| JP2005505635A (ja) | 2005-02-24 |
| KR20040080430A (ko) | 2004-09-18 |
| GB2397825A (en) | 2004-08-04 |
| PL370167A1 (en) | 2005-05-16 |
| HUP0600102A2 (en) | 2006-05-29 |
| RU2004115108A (ru) | 2005-02-10 |
| NZ532965A (en) | 2006-04-28 |
| US20030219418A1 (en) | 2003-11-27 |
| HRP20040446A2 (en) | 2005-04-30 |
| CN1662644A (zh) | 2005-08-31 |
| DE60234862D1 (de) | 2010-02-04 |
| EP1456356A2 (en) | 2004-09-15 |
| WO2003033685A2 (en) | 2003-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010. |
|
| B15K | Others concerning applications: alteration of classification |
Ipc: C12N 5/071 (2010.01) |