BR0211723A - Corineform bacteria that produce chemical compounds i - Google Patents

Corineform bacteria that produce chemical compounds i

Info

Publication number
BR0211723A
BR0211723A BR0211723-1A BR0211723A BR0211723A BR 0211723 A BR0211723 A BR 0211723A BR 0211723 A BR0211723 A BR 0211723A BR 0211723 A BR0211723 A BR 0211723A
Authority
BR
Brazil
Prior art keywords
chemical compounds
bacteria
produce chemical
corineform bacteria
orf
Prior art date
Application number
BR0211723-1A
Other languages
Portuguese (pt)
Inventor
Brigitte Bathe
Caroline Reynen
Bettina Moeckel
Georg Thierbach
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of BR0211723A publication Critical patent/BR0211723A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"BACTéRIAS CORINEFORMES QUE PRODUZEM COMPOSTOS QUìMICOS I". A presente invenção refere-se a bactérias corineformes que têm, além de pelo menos uma cópia, presente no sítio natural (local), de um quadro de leitura aberta (ORF), gene ou alelo que codifica para a síntese de uma proteína ou um RNA, em cada caso uma segunda, opcionalmente terceira ou quarta cópia deste quadro de leitura aberta (ORF), gene ou alelo, em cada caso em um segundo, opcionalmente terceiro ou quarto sítio em uma forma integrada no cromossoma, e a processos para a preparação de compostos químicos por fermentação destas bactérias."CORINEFORM BACTERIA PRODUCING CHEMICAL COMPOUNDS I". The present invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural (local) site, an open reading frame (ORF), gene or allele coding for the synthesis of a protein or protein. RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele, in each case in a second, optionally third or fourth site in an integrated form on the chromosome, and processes for preparation of chemical compounds by fermentation of these bacteria.

BR0211723-1A 2001-08-06 2002-07-30 Corineform bacteria that produce chemical compounds i BR0211723A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30987801P 2001-08-06 2001-08-06
PCT/EP2002/008464 WO2003040373A2 (en) 2001-08-06 2002-07-30 Production of l-lysine by genetically modified corynebacterium glutamicum strains

Publications (1)

Publication Number Publication Date
BR0211723A true BR0211723A (en) 2004-09-21

Family

ID=23200067

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211723-1A BR0211723A (en) 2001-08-06 2002-07-30 Corineform bacteria that produce chemical compounds i

Country Status (6)

Country Link
EP (1) EP1414970A2 (en)
CN (1) CN100554426C (en)
AU (1) AU2002325923A1 (en)
BR (1) BR0211723A (en)
CA (1) CA2455878A1 (en)
WO (1) WO2003040373A2 (en)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7160711B2 (en) 2001-08-06 2007-01-09 Degussa Ag Coryneform bacteria which produce chemical compounds I
US6844176B1 (en) 2001-10-16 2005-01-18 Degussa Ag Alleles of the lysC gene from corynebacteria
DE10359594A1 (en) 2003-12-18 2005-07-28 Basf Ag PEF TU-expression units
DE102004035067A1 (en) * 2004-07-20 2006-02-16 Basf Ag P1-35 expression units
DE102005013676A1 (en) 2005-03-24 2006-09-28 Degussa Ag Alleles of the zwf gene from coryneform bacteria
DE102005023829A1 (en) 2005-05-24 2006-11-30 Degussa Ag Alleles of the opcA gene from coryneform bacteria
DE102005047596A1 (en) 2005-10-05 2007-04-12 Degussa Ag Process for the fermentative production of L-amino acids using coryneform bacteria
DE102006026328A1 (en) * 2006-06-02 2008-01-03 Evonik Degussa Gmbh Process for the preparation of a feed additive containing L-lysine
KR100830289B1 (en) * 2007-01-18 2008-05-16 씨제이제일제당 (주) Corynebacterium glutamicum variety producing l-arginine and method for fabricating the same
DE102007005072A1 (en) 2007-02-01 2008-08-07 Evonik Degussa Gmbh Process for the fermentative production of cadaverine
JP2011067095A (en) 2008-01-10 2011-04-07 Ajinomoto Co Inc Method for producing target substance by fermentation process
KR100987281B1 (en) * 2008-01-31 2010-10-12 씨제이제일제당 (주) Enhanced promoter and method for producing L-lysine using the same
DE102008001874A1 (en) 2008-05-20 2009-11-26 Evonik Degussa Gmbh Process for the preparation of L-amino acids
DE102009030342A1 (en) 2009-06-25 2010-12-30 Evonik Degussa Gmbh Process for the fermentative production of organic chemical compounds
DE102010003419B4 (en) 2010-03-30 2019-09-12 Evonik Degussa Gmbh Process for the fermentative production of L-ornithine
DE102010025124A1 (en) 2010-06-25 2011-12-29 Forschungszentrum Jülich GmbH Process for the preparation of D-amino acids, microorganism, and vector
EP2479279A1 (en) 2011-01-20 2012-07-25 Evonik Degussa GmbH Method for producing sulphuric amino acids by means of fermentation
US9745608B2 (en) 2011-02-22 2017-08-29 Basf Se Processes and recombinant microorganisms for the production of cadaverine
DE102011006716A1 (en) 2011-04-04 2012-10-04 Evonik Degussa Gmbh Microorganism and process for the fermentative production of an organic chemical compound
JP2014131487A (en) 2011-04-18 2014-07-17 Ajinomoto Co Inc Method for producing l-cysteine
DE102011118019A1 (en) 2011-06-28 2013-01-03 Evonik Degussa Gmbh Variants of the promoter of the glyceraldehyde-3-phosphate dehydrogenase-encoding gap gene
EP2774982B1 (en) 2011-11-02 2017-06-21 Ajinomoto Co., Inc. Method for secreting and producing proteins
BR112013016373B1 (en) 2011-11-11 2021-05-18 Ajinomoto Co., Inc method for producing a target substance
EP2628792A1 (en) 2012-02-17 2013-08-21 Evonik Industries AG Cell with reduced ppGppase activity
EP2631298A1 (en) 2012-02-22 2013-08-28 Evonik Industries AG Biotechnological method for producing butanol and butyric acid
JP6341907B2 (en) 2012-04-27 2018-06-13 エボニック テクノヘミー ゲゼルシャフト ミット ベシュレンクテル ハフツングＥｖｏｎｉｋ Ｔｅｃｈｎｏｃｈｅｍｉｅ ＧｍｂＨ Feedback resistant alpha-isopropylmalate synthase
EP2674489A1 (en) 2012-06-15 2013-12-18 Evonik Industries AG Biotechnological 2-hydroxyisobutyric acid production
EP2700715B1 (en) 2012-08-20 2018-07-25 Evonik Degussa GmbH Method for manufacturing L-amino acids using improved strains of the enterobacteriaceae family by means of fermentation
DE102012016716A1 (en) 2012-08-22 2014-02-27 Forschungszentrum Jülich GmbH A process for the preparation of vectors comprising a gene coding for an enzyme which has been reduced or eliminated in its feedback inhibition and the use thereof for the production of amino acids and nucleotides
EP2762571A1 (en) 2013-01-30 2014-08-06 Evonik Industries AG Microorganism and method for the production of amino acids by fermentation
ES2623161T3 (en) 2013-06-03 2017-07-10 Evonik Degussa Gmbh Procedure for the preparation of L-valine using recombinant corinebacteria containing the propionate inducible ilvBN operon
CN103374540B (en) * 2013-08-13 2015-04-22 廊坊梅花生物技术开发有限公司 Corynebacterium glutamicum and application thereof
EP2940143B1 (en) 2014-04-30 2020-02-05 Evonik Operations GmbH Method for the production of l-amino acids using an alkaliphilic bacterium
DE102014208199A1 (en) 2014-04-30 2015-11-05 Evonik Degussa Gmbh Process for the production of L-amino acids using an alkaliphilic bacterium
EP2940144A1 (en) 2014-04-30 2015-11-04 Evonik Degussa GmbH Method for the production of l-lysine using an alkaliphilic bacterium
EP2940039A1 (en) 2014-04-30 2015-11-04 Evonik Degussa GmbH Method for the production of l-amino acids in coryne bacteria using a glycine splitting system
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
CA3007635A1 (en) 2015-12-07 2017-06-15 Zymergen Inc. Promoters from corynebacterium glutamicum
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
KR101756338B1 (en) * 2016-01-15 2017-07-10 고려대학교 산학협력단 Variant Microorganism for Producing L-Cystein and Method for Preparing L-Cystein Using thereof
CN105838740B (en) * 2016-05-03 2020-11-06 湖北大学 Method for preparing nano red element selenium by using tea tree endophytic asplenium
US10544390B2 (en) 2016-06-30 2020-01-28 Zymergen Inc. Methods for generating a bacterial hemoglobin library and uses thereof
EP3478845A4 (en) 2016-06-30 2019-07-31 Zymergen, Inc. Methods for generating a glucose permease library and uses thereof
WO2018007560A1 (en) * 2016-07-08 2018-01-11 Metabolic Explorer Method for the fermentative production of molecules of interest by microorganisms comprising genes coding sugar phosphotransferase system (pts)
CN106635944A (en) * 2016-12-29 2017-05-10 廊坊梅花生物技术开发有限公司 Glutamic acid corynebacterium and construction method and application thereof
JP2020524492A (en) 2017-06-07 2020-08-20 ザイマージェン インコーポレイテッド Promoters from Corynebacterium glutamicum and their use in controlling accessory gene expression
EP3415622A1 (en) 2017-06-14 2018-12-19 Evonik Degussa GmbH Method for production of fine chemicals using a corynebacterium secreting modified alpha-1,6-glucosidases
KR102011994B1 (en) 2017-06-30 2019-08-20 씨제이제일제당 주식회사 Novel aspartokinase variant and method of producing L-amino acid using thereof
CN109536428B (en) * 2018-12-07 2022-08-30 武汉远大弘元股份有限公司 Genetically engineered bacterium for producing L-isoleucine and construction method and application thereof
CN111471638B (en) * 2020-05-22 2021-11-23 江南大学 Construction and application of corynebacterium glutamicum mutant strain capable of producing L-homoserine
CN113994002B (en) * 2021-05-07 2022-06-03 Cj第一制糖株式会社 Novel promoter and use thereof
CN114181288B (en) * 2022-02-17 2022-05-03 北京中科伊品生物科技有限公司 Process for producing L-valine, gene used therefor and protein encoded by the gene

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19931317A1 (en) * 1999-07-07 2001-01-11 Degussa L-lysine-producing coryneform bacteria and method for producing L-lysine
US6893848B1 (en) * 1999-04-19 2005-05-17 Kyowa Hakko Kogyo Co., Ltd. Desensitized aspartokinase
DE19950409A1 (en) * 1999-10-20 2001-04-26 Degussa New nucleotide sequences coding for the pck gene
JP4623825B2 (en) * 1999-12-16 2011-02-02 協和発酵バイオ株式会社 Novel polynucleotide

Also Published As

Publication number Publication date
CN100554426C (en) 2009-10-28
EP1414970A2 (en) 2004-05-06
AU2002325923A1 (en) 2003-05-19
WO2003040373A2 (en) 2003-05-15
CA2455878A1 (en) 2003-05-15
WO2003040373A3 (en) 2003-12-18
CN1539015A (en) 2004-10-20

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: DEGUSSA GMBH (DE)

Free format text: NOME ALTERADO DE: DEGUSSA AG

B25D Requested change of name of applicant approved

Owner name: EVONIK DEGUSSA GMBH (DE)

Free format text: NOME ALTERADO DE: DEGUSSA GMBH

B25G Requested change of headquarter approved

Owner name: EVONIK DEGUSSA GMBH (DE)

Free format text: ENDERECO ALTERADO CONFORME SOLICITADO NA PETICAO NO 020100037415/RJ DE 29/04/2010.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09B Decision: refusal

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 24, 8O C/C 13 E 25 DA LPI.

B09B Decision: refusal

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.