BR0211210A - Uso dos ácidos sulfonil aril ou heteroaril hidroxâmicos e de seus derivados como inibidores da agrecanase - Google Patents

Uso dos ácidos sulfonil aril ou heteroaril hidroxâmicos e de seus derivados como inibidores da agrecanase

Info

Publication number
BR0211210A
BR0211210A BR0211210-8A BR0211210A BR0211210A BR 0211210 A BR0211210 A BR 0211210A BR 0211210 A BR0211210 A BR 0211210A BR 0211210 A BR0211210 A BR 0211210A
Authority
BR
Brazil
Prior art keywords
agrecanase
inhibitors
derivatives
hydroxamic
acids
Prior art date
Application number
BR0211210-8A
Other languages
English (en)
Inventor
Joseph J Mcdonald
Thomas A Barta
Elizabeth Arner
Terri L Boehm
Daniel P Becker
Gary A Decrescenzo
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BR0211210A publication Critical patent/BR0211210A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract

"USO DOS áCIDOS SULFONIL ARIL OU HETEROARIL HIDROXâMICOS E DE SEUS DERIVADOS COMO INIBIDORES DA AGRECANASE". Esta invenção refere-se a um processo para inibir a atividade da agrecanase. O processo compreende administrar uma quantidade terapeuticamente eficaz de um ácido sulfonil aromático ou heteroaromático hidroxâmico, um derivado do mesmo, ou um sal farmaceuticamente aceitável do ácido hidroxâmico ou derivado a um animal hospedeiro. O composto, em geral, corresponde, na estrutura, à fórmula que se segue: em que W e os grupos R são descritos em mais detalhe no relatório descritivo das Requerentes.
BR0211210-8A 2001-07-19 2002-07-19 Uso dos ácidos sulfonil aril ou heteroaril hidroxâmicos e de seus derivados como inibidores da agrecanase BR0211210A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30662901P 2001-07-19 2001-07-19
PCT/US2002/022867 WO2003007930A2 (en) 2001-07-19 2002-07-19 Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors

Publications (1)

Publication Number Publication Date
BR0211210A true BR0211210A (pt) 2004-07-13

Family

ID=23186149

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211210-8A BR0211210A (pt) 2001-07-19 2002-07-19 Uso dos ácidos sulfonil aril ou heteroaril hidroxâmicos e de seus derivados como inibidores da agrecanase

Country Status (8)

Country Link
US (1) US6683078B2 (pt)
EP (1) EP1406602A2 (pt)
JP (1) JP2005504026A (pt)
AU (1) AU2002327264A1 (pt)
BR (1) BR0211210A (pt)
CA (1) CA2453602A1 (pt)
MX (1) MXPA04000485A (pt)
WO (1) WO2003007930A2 (pt)

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WO2000059285A2 (en) * 1999-04-02 2000-10-12 Du Pont Pharmaceuticals Company NOVEL LACTAM INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE
BR0011291A (pt) 1999-05-12 2002-05-14 Searle & Co Derivados de ácido hidroxâmico como inibidores de metaloprotease de matriz
EP1081137A1 (en) 1999-08-12 2001-03-07 Pfizer Products Inc. Selective inhibitors of aggrecanase in osteoarthritis treatment

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AU2002327264A1 (en) 2003-03-03
US6683078B2 (en) 2004-01-27
WO2003007930A2 (en) 2003-01-30
MXPA04000485A (es) 2004-05-04
EP1406602A2 (en) 2004-04-14
CA2453602A1 (en) 2003-01-30
US20030171404A1 (en) 2003-09-11
WO2003007930A3 (en) 2003-08-21

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