BR0116686A - Silenced anti-cd28 Antibodies and usage - Google Patents
Silenced anti-cd28 Antibodies and usageInfo
- Publication number
- BR0116686A BR0116686A BR0116686-7A BR0116686A BR0116686A BR 0116686 A BR0116686 A BR 0116686A BR 0116686 A BR0116686 A BR 0116686A BR 0116686 A BR0116686 A BR 0116686A
- Authority
- BR
- Brazil
- Prior art keywords
- antibodies
- usage
- silenced
- silenced anti
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
"ANTICORPOS ANTI-CD28 SILENCIADOS E USO DOS MESMOS". A presente invenção provê anticorpos anti-CD28 deficientes em atividade mitogênica (anticorpos anti-CD28 silenciados), métodos para sua produção, composições contendo o anticorpo e métodos de imunossupressão, para induzir tolerância à célula T e para tratar rejeições de transplante de órgão e/ou tecido."Silenced Anti-CD28 Antibodies and USE". The present invention provides mitogenic activity-deficient anti-CD28 antibodies (silenced anti-CD28 antibodies), methods for their production, antibody-containing compositions and immunosuppression methods, to induce T cell tolerance and to treat organ transplant rejections and / or fabric.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25515500P | 2000-12-14 | 2000-12-14 | |
PCT/US2001/047955 WO2002047721A1 (en) | 2000-12-14 | 2001-12-14 | Silensed anti-cd28 antibodies and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0116686A true BR0116686A (en) | 2003-12-30 |
Family
ID=22967074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0116686-7A BR0116686A (en) | 2000-12-14 | 2001-12-14 | Silenced anti-cd28 Antibodies and usage |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1341553A4 (en) |
JP (1) | JP2004515243A (en) |
KR (1) | KR20040020866A (en) |
CN (1) | CN1272345C (en) |
AR (1) | AR031924A1 (en) |
AU (2) | AU2002226086C1 (en) |
BR (1) | BR0116686A (en) |
CA (1) | CA2432736A1 (en) |
CZ (1) | CZ20031909A3 (en) |
HU (1) | HUP0400697A3 (en) |
IL (1) | IL156262A0 (en) |
MX (1) | MXPA03005327A (en) |
NO (1) | NO20032542L (en) |
NZ (1) | NZ526569A (en) |
PL (1) | PL363239A1 (en) |
RU (1) | RU2261723C2 (en) |
WO (1) | WO2002047721A1 (en) |
ZA (1) | ZA200305384B (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080095774A1 (en) * | 2001-02-16 | 2008-04-24 | Wyeth | Agents and Methods for Specifically Blocking CD28-Mediated Signaling |
US7531168B2 (en) | 2001-02-16 | 2009-05-12 | Genetics Institute Llc | Method for downmodulating immune response in type I diabetes |
EP3673919A1 (en) | 2005-06-14 | 2020-07-01 | Amgen Inc. | Self-buffering protein formulations |
FR2951176A1 (en) | 2009-10-09 | 2011-04-15 | Tcl Pharma | MONOVALENT LIGANDS OF THE HUMAN CD28 RECEPTOR |
EP2536764B1 (en) * | 2010-02-18 | 2018-07-04 | OSE Immunotherapeutics | Anti-cd28 humanized antibodies |
JP6884858B2 (en) | 2016-10-21 | 2021-06-09 | アムジエン・インコーポレーテツド | Pharmaceutical product and its manufacturing method |
US20210251994A1 (en) | 2018-06-15 | 2021-08-19 | Flagship Pioneering Innovations V, Inc. | Increasing immune activity through modulation of postcellular signaling factors |
CN113692286A (en) * | 2019-03-14 | 2021-11-23 | 比昂生物制剂公司 | A method for immunosuppression |
EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
US20230114107A1 (en) | 2019-12-17 | 2023-04-13 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
EP4172323A1 (en) | 2020-06-29 | 2023-05-03 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
IL300666A (en) | 2020-08-19 | 2023-04-01 | Xencor Inc | Anti-cd28 compositions |
US20220325287A1 (en) | 2021-03-31 | 2022-10-13 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
AU2022303363A1 (en) | 2021-06-29 | 2024-01-18 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
US20240174732A1 (en) | 2022-10-05 | 2024-05-30 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5521288A (en) * | 1990-03-26 | 1996-05-28 | Bristol-Myers Squibb Company | CD28IG fusion protein |
-
2001
- 2001-12-14 EP EP01995504A patent/EP1341553A4/en not_active Withdrawn
- 2001-12-14 WO PCT/US2001/047955 patent/WO2002047721A1/en not_active Application Discontinuation
- 2001-12-14 AR ARP010105828A patent/AR031924A1/en unknown
- 2001-12-14 AU AU2002226086A patent/AU2002226086C1/en not_active Ceased
- 2001-12-14 NZ NZ526569A patent/NZ526569A/en unknown
- 2001-12-14 IL IL15626201A patent/IL156262A0/en unknown
- 2001-12-14 RU RU2003121231/15A patent/RU2261723C2/en not_active IP Right Cessation
- 2001-12-14 JP JP2002549291A patent/JP2004515243A/en not_active Withdrawn
- 2001-12-14 CZ CZ20031909A patent/CZ20031909A3/en unknown
- 2001-12-14 PL PL01363239A patent/PL363239A1/en not_active Application Discontinuation
- 2001-12-14 HU HU0400697A patent/HUP0400697A3/en unknown
- 2001-12-14 BR BR0116686-7A patent/BR0116686A/en not_active IP Right Cessation
- 2001-12-14 MX MXPA03005327A patent/MXPA03005327A/en unknown
- 2001-12-14 AU AU2608602A patent/AU2608602A/en active Pending
- 2001-12-14 KR KR10-2003-7007798A patent/KR20040020866A/en not_active Application Discontinuation
- 2001-12-14 CN CNB018226361A patent/CN1272345C/en not_active Expired - Fee Related
- 2001-12-14 CA CA002432736A patent/CA2432736A1/en not_active Abandoned
-
2003
- 2003-06-05 NO NO20032542A patent/NO20032542L/en not_active Application Discontinuation
- 2003-07-11 ZA ZA200305384A patent/ZA200305384B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP1341553A4 (en) | 2004-07-28 |
JP2004515243A (en) | 2004-05-27 |
AU2002226086C1 (en) | 2006-03-09 |
RU2261723C2 (en) | 2005-10-10 |
AU2002226086B2 (en) | 2005-08-25 |
AR031924A1 (en) | 2003-10-08 |
RU2003121231A (en) | 2005-02-10 |
CZ20031909A3 (en) | 2003-11-12 |
NZ526569A (en) | 2005-07-29 |
NO20032542L (en) | 2003-08-07 |
KR20040020866A (en) | 2004-03-09 |
PL363239A1 (en) | 2004-11-15 |
CA2432736A1 (en) | 2002-06-20 |
WO2002047721A1 (en) | 2002-06-20 |
HUP0400697A2 (en) | 2004-06-28 |
ZA200305384B (en) | 2004-10-11 |
MXPA03005327A (en) | 2004-12-03 |
IL156262A0 (en) | 2004-01-04 |
HUP0400697A3 (en) | 2007-05-02 |
CN1489473A (en) | 2004-04-14 |
AU2608602A (en) | 2002-06-24 |
NO20032542D0 (en) | 2003-06-05 |
EP1341553A1 (en) | 2003-09-10 |
CN1272345C (en) | 2006-08-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0116686A (en) | Silenced anti-cd28 Antibodies and usage | |
ATE412432T1 (en) | INTERNALIZING ERBB2 ANTIBODIES | |
DE69129302D1 (en) | TUMOR GROWTH INHIBITORS FROM FABRICS, METHODS OF THEIR PRODUCTION AND USE | |
ES2293973T3 (en) | ANTIBODIES ANTI-CCR2 HUMANIZED AND METHODS OF USE OF THE SAME. | |
CR10878A (en) | ANTIBODIES FOR CD40 (EXP. 7343 DIVISIONAL) | |
RS80704A (en) | ANTI- av?6.ANTIBODIES | |
PT1315520E (en) | USE OF BIASPECIFIC AND TRIESPECIFIC TRIFUNCTIONAL ANTIBODIES FOR THE TREATMENT OF MALIGNANT ASCITES | |
BRPI0410031A (en) | optimized fc variants and methods for their generation | |
BR9606706A (en) | Bispecific or bivalent antibody fragment analog use process to produce the same | |
DE60226797D1 (en) | Instrument for introducing fasteners for transplants | |
DE69619493T2 (en) | POLYPEPTIDE-DENDRIMER COMPLEXES | |
IL195338A (en) | Antibody comprising an fc variant comprising d or e amino acid substitution at position 239 and pharmaceutical composition and use thereof | |
ATE248605T1 (en) | CROSS-REACTIVE MONOCLONAL ANTIBODIES SPECIFIC FOR E-SELECTIN AND P-SELECTIN | |
DE69433406D1 (en) | ANTIBODIES AGAINST CD40 | |
RS53984B1 (en) | Ip-10 antibodies and their uses | |
DK0973550T3 (en) | Antagonistic anti-AVB3 integrin antibodies | |
WO2000002917A3 (en) | Compounds and methods for modulating cadherin-mediated functions | |
BR0210965A (en) | Chelator conjugate, radiometal complex, radiopharmaceutical, kit for preparing same, compound, and process for preparing same | |
ATE395364T1 (en) | ANTIBODIES DIRECTED AGAINST PROCALCITONIN, THEIR PRODUCTION AND USE | |
DE69837387D1 (en) | (d) METHADONE, A NON-OPIOID PAIN | |
DK1068328T3 (en) | Treatment and diagnosis of staphylococcal infections | |
BR0314716A (en) | Lfa-1 alpha subunit antibodies and methods of use | |
BR0109164A (en) | Monoclonal antibodies to the human LDL receptor, production and use thereof | |
DE69814007D1 (en) | Magnetic fastener, especially for clothing | |
ATE202117T1 (en) | ANGIOTENSIN II RECEPTOR TYPE I SPECIFIC MONOCLONAL ANTIBODIES AND HYBRIDOMA |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) Free format text: TRANSFERIDO POR FUSAO DE: FUJISAWA PHARMACEUTICAL CO. LTD. |
|
B25D | Requested change of name of applicant approved |
Owner name: ASTELLAS PHARMA INC. (JP) Free format text: ALTERADO DE: YAMANOUCHI PHARMACEUTICAL CO., LTD. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 6A., 7A. E 8A. ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2021 DE 29/09/2009. |