BR0113732A - Polymorphic form of 17-beta- (n-tert.butyl carbamoyl) -4-aza-5-alpha-androst-1-en-3-one and process for its preparation - Google Patents

Polymorphic form of 17-beta- (n-tert.butyl carbamoyl) -4-aza-5-alpha-androst-1-en-3-one and process for its preparation

Info

Publication number
BR0113732A
BR0113732A BR0113732-8A BR0113732A BR0113732A BR 0113732 A BR0113732 A BR 0113732A BR 0113732 A BR0113732 A BR 0113732A BR 0113732 A BR0113732 A BR 0113732A
Authority
BR
Brazil
Prior art keywords
androst
aza
preparation
polymorphic form
tert
Prior art date
Application number
BR0113732-8A
Other languages
Portuguese (pt)
Inventor
M Satyanarayana Reddy
S T Rajan
M V N Brahmashwara Rao
K Vyas
S Vishnuvardhana Reddy
K Shashi Rekha
Original Assignee
Reddys Lab Ltd Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddys Lab Ltd Dr filed Critical Reddys Lab Ltd Dr
Publication of BR0113732A publication Critical patent/BR0113732A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"FORMA POLIMóRFICA DA 17-BETA-(N-TER. BUTIL CARBAMOIL)-4-AZA-5-ALFA-ANDROST-1-EN-3-ONA E PROCESSO PARA SUA PREPARAçãO". A presente invenção refere-se a uma forma polimórfica da 17-<225>-(N-terc.butil carbamoil)-4-aza-5-<244>-androst-1-en-3-ona (Finasterida) da fórmula (I) e processos para a sua preparação."17-BETA- (N-TER. BUTIL CARBAMOIL) -4-AZA-5-ALPHA-ANDROST-1-EN-3-ONA POLYMORPHIC FORM AND PROCESS FOR PREPARATION". The present invention relates to a polymorphic form of 17- Î ± - (N-tert.butyl carbamoyl) -4-aza-5- <244-androst-1-en-3-one (Finasteride) of the formula (I) and processes for their preparation.

BR0113732-8A 2000-09-07 2001-06-19 Polymorphic form of 17-beta- (n-tert.butyl carbamoyl) -4-aza-5-alpha-androst-1-en-3-one and process for its preparation BR0113732A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN737DE2000 2000-09-07
PCT/US2001/019546 WO2002020553A1 (en) 2000-09-07 2001-06-19 NOVEL POLYMORPHIC FORM OF 17-β-(N-TER.BUTYL CARBAMOYL)-4-AZA-5-α-ANDROST-1-EN-3-ONE AND A PROCESS FOR PREPARING IT

Publications (1)

Publication Number Publication Date
BR0113732A true BR0113732A (en) 2003-07-29

Family

ID=11097081

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113732-8A BR0113732A (en) 2000-09-07 2001-06-19 Polymorphic form of 17-beta- (n-tert.butyl carbamoyl) -4-aza-5-alpha-androst-1-en-3-one and process for its preparation

Country Status (12)

Country Link
EP (1) EP1322663A1 (en)
JP (1) JP2004508380A (en)
AU (1) AU6991101A (en)
BR (1) BR0113732A (en)
CA (1) CA2422159A1 (en)
HU (1) HUP0300937A3 (en)
IL (1) IL154785A0 (en)
NO (1) NO20031045L (en)
NZ (1) NZ525116A (en)
PL (1) PL361014A1 (en)
WO (1) WO2002020553A1 (en)
ZA (1) ZA200302554B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2206065B1 (en) * 2002-10-31 2005-08-16 Ragactives, S.L. PROCEDURE FOR OBTAINING THE POLYMORPHIC FORM I OF FINASTERIDA.
EP1651661B1 (en) * 2003-07-03 2008-08-27 Cipla Ltd. Process for the preparation of finasteride form i
CN1294913C (en) * 2004-12-23 2007-01-17 鲁南制药集团股份有限公司 Medication combination of containing finasteride and cyclodextrin or ramification

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ225100A (en) * 1987-06-29 1991-09-25 Merck & Co Inc Reaction of steroids (including 4-azasteroids) with a silylating agent in the presence of a quinone to introduce a delta' double bond and silylated intermediates
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US5021575A (en) * 1989-11-13 1991-06-04 Merck & Co., Inc. Method for introducing a 1,2 double bond into azasteroids
US5091534A (en) * 1990-08-27 1992-02-25 Merck & Co., Inc. Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids
US5468860A (en) * 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes

Also Published As

Publication number Publication date
HUP0300937A2 (en) 2007-02-28
ZA200302554B (en) 2004-02-19
NZ525116A (en) 2004-11-26
CA2422159A1 (en) 2002-03-14
WO2002020553A1 (en) 2002-03-14
HUP0300937A3 (en) 2007-10-29
NO20031045D0 (en) 2003-03-06
JP2004508380A (en) 2004-03-18
PL361014A1 (en) 2004-09-20
EP1322663A1 (en) 2003-07-02
NO20031045L (en) 2003-04-29
AU6991101A (en) 2002-03-22
IL154785A0 (en) 2003-10-31

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]