BR0111764A - Indole derivatives useful for the treatment of central nervous system (snc) disorders; compound; pharmaceutical composition; compound use and treatment method - Google Patents
Indole derivatives useful for the treatment of central nervous system (snc) disorders; compound; pharmaceutical composition; compound use and treatment methodInfo
- Publication number
- BR0111764A BR0111764A BR0111764-5A BR0111764A BR0111764A BR 0111764 A BR0111764 A BR 0111764A BR 0111764 A BR0111764 A BR 0111764A BR 0111764 A BR0111764 A BR 0111764A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- treatment
- disorders
- pharmaceutical composition
- nervous system
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE INDOL úTEIS PARA O TRATAMENTO DE DISTúRBIOS DO SISTEMA NERVOSO CENTRAL (SNC); COMPOSTO; COMPOSIçãO FARMACêUTICA; UTILIZAçãO DE COMPOSTO E MéTODO DE TRATAMENTO". A presente invenção refere-se a ligandos de receptor de serotonina e dopamina possuindo a fórmula geral (I), onde um entre Y^ 1^ e Y^ 2^ é N, o qual é unido a Y^ 4^, Y^ 3^ é Z-CH~ 2~, CH~ 2~-Z ou CH~ 2~CH~ 2~ e os outros significados de Y^ 1^, Y^ 2^, Y^ 3^, Y^ 4^, Z, W, n, m, X, R^ 1^ a R^ 9^ e R^ 10^ são como o definido nas reivindicações e na descrição. Os compostos da invenção são úteis no tratamento de certos distúrbios psiquiátricos e neurológicos, ou seja, esquizofrenia, outras psicoses, distúrbios de ansiedade, depressão, enxaqueca, distúrbios cognitivos, ADHD e na melhora de sono."INDOLATED DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) DISORDERS; COMPOUND; PHARMACEUTICAL COMPOSITION; USE OF COMPOUND AND METHOD OF TREATMENT". The present invention relates to serotonin and dopamine receptor ligands having the general formula (I), wherein one between Y4 1 ^ and Y ^ 2 ^ is N, which is attached to Y ^ 4 ^, Y ^ 3 ^ is Z-CH ~ 2 ~, CH ~ 2 ~ -Z or CH ~ 2 ~ CH ~ 2 ~ and the other meanings of Y ^ 1 ^, Y ^ 2 ^, Y ^ 3 ^, Y ^ 4 ^, Z , W, n, m, X, R 4 R 1 to R 9 9 and R 10 10 are as defined in the claims and the description. The compounds of the invention are useful in the treatment of certain psychiatric and neurological disorders, namely, schizophrenia, other psychoses, anxiety disorders, depression, migraine, cognitive disorders, ADHD, and sleep improvement.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200000919 | 2000-06-14 | ||
| PCT/DK2001/000406 WO2001096328A1 (en) | 2000-06-14 | 2001-06-13 | Indole derivatives useful for the treatment of cns disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0111764A true BR0111764A (en) | 2003-07-08 |
Family
ID=8159557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0111764-5A BR0111764A (en) | 2000-06-14 | 2001-06-13 | Indole derivatives useful for the treatment of central nervous system (snc) disorders; compound; pharmaceutical composition; compound use and treatment method |
Country Status (10)
| Country | Link |
|---|---|
| CN (1) | CN100415737C (en) |
| BR (1) | BR0111764A (en) |
| EA (1) | EA006315B1 (en) |
| HK (1) | HK1059086A1 (en) |
| IL (2) | IL153234A0 (en) |
| IS (1) | IS6643A (en) |
| PL (1) | PL358967A1 (en) |
| SK (1) | SK402003A3 (en) |
| UA (1) | UA74830C2 (en) |
| ZA (1) | ZA200209958B (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA9711376B (en) * | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
| GB9825413D0 (en) * | 1998-11-19 | 1999-01-13 | Lilly Co Eli | Pharmaceutical compounds |
-
2001
- 2001-06-13 UA UA2002129625A patent/UA74830C2/en unknown
- 2001-06-13 PL PL01358967A patent/PL358967A1/en not_active Application Discontinuation
- 2001-06-13 EA EA200300019A patent/EA006315B1/en not_active IP Right Cessation
- 2001-06-13 IL IL15323401A patent/IL153234A0/en active IP Right Grant
- 2001-06-13 SK SK40-2003A patent/SK402003A3/en unknown
- 2001-06-13 CN CNB018138101A patent/CN100415737C/en not_active Expired - Fee Related
- 2001-06-13 BR BR0111764-5A patent/BR0111764A/en not_active IP Right Cessation
-
2002
- 2002-11-29 IS IS6643A patent/IS6643A/en unknown
- 2002-12-03 IL IL153234A patent/IL153234A/en not_active IP Right Cessation
- 2002-12-09 ZA ZA200209958A patent/ZA200209958B/en unknown
-
2004
- 2004-03-22 HK HK04102087.6A patent/HK1059086A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200209958B (en) | 2004-06-23 |
| UA74830C2 (en) | 2006-02-15 |
| SK402003A3 (en) | 2003-07-01 |
| IS6643A (en) | 2002-11-29 |
| IL153234A (en) | 2007-12-03 |
| HK1059086A1 (en) | 2004-06-18 |
| IL153234A0 (en) | 2003-07-06 |
| CN1446211A (en) | 2003-10-01 |
| EA006315B1 (en) | 2005-10-27 |
| EA200300019A1 (en) | 2003-04-24 |
| PL358967A1 (en) | 2004-08-23 |
| CN100415737C (en) | 2008-09-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2007013021A (en) | Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists. | |
| BRPI0415657A (en) | dihydrobenzofuranyl alkanamine derivatives as 5ht2c agonists | |
| MX2007012883A (en) | Dihydrobenzofuran derivatives and uses thereof. | |
| BRPI0410711A (en) | new compounds | |
| PE20020720A1 (en) | BENZIMIDAZOLE AND PYRIDYLIMIDAZOLE DERIVATIVES AS LINKS FOR GABAA RECEPTORS | |
| PE20020911A1 (en) | INDOLE DERIVATIVES AS 5HT2 AGONISTS | |
| EA199700156A1 (en) | INDOL DERIVATIVES AS ANTAGONISTS OF 5-HT RECEPTOR | |
| BRPI0517955A (en) | substituted indolizines and derivatives as snc agents | |
| BR0114552A (en) | N1- (benzenesulfonyl) indoles 2-, 3-, 4-, 5- substituted and their use in therapy | |
| ATE449082T1 (en) | (3,4-DIHYDRO-QUINAZOLINE-2-YL)-(2-ARYLOXY-ETHYL) AMINE WITH ACTIVITY ON THE 5-HT RECEPTOR | |
| BRPI0415769A (en) | dihydrobenzofuranyl alkanamines and pharmaceutical compositions containing them | |
| ES2154605B1 (en) | NEW MIXED DERIVATIVES OF BENCIMIDAZOL-ARILPIPERAZINA AFFINED BY SEROTONINERGIC RECEPTORS 5-HT1A AND 5-HT3 | |
| DK1636239T3 (en) | Indole derivatives with an improved antipsychotic activity | |
| BR0112998A (en) | Indole derivatives useful for the treatment of central nervous system (snc) disorders; compound; its use; pharmaceutical composition and treatment method | |
| HRP20010969B1 (en) | Novel piperazinylalkylthiopyrimidine derivatives, | |
| BR0211140A (en) | Compounds and compositions of hexahydroazepine (4,5-g) indoles and indolines as 5-ht receptor binders | |
| CA2411412A1 (en) | Indole derivatives useful for the treatment of cns disorders | |
| BR0112286A (en) | Indole derivatives useful for the treatment of central nervous system (cns) disorders; compound; its pharmaceutical composition; use and method for treatment | |
| BR0111764A (en) | Indole derivatives useful for the treatment of central nervous system (snc) disorders; compound; pharmaceutical composition; compound use and treatment method | |
| BR0012575A (en) | Indole Derivatives | |
| NO176097C (en) | Analogous process for the preparation of therapeutically active substituted cyclohexenes | |
| RS20060619A (en) | Pyridine derivatives of alkyl oxindoles as 5-ht7 receptor active agents | |
| BR0111763A (en) | Indole derivatives useful for the treatment of central nervous system (cns) disorders; compound; pharmaceutical composition; compound use and treatment method | |
| PE44199A1 (en) | BENZO [E] ISOINDOLES AND BENZO [H] ISOQUINOLINES TRICICLICOS | |
| BR0308347A (en) | Process for the manufacture of chiral 1,4-disubstituted piperazines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 9A E 10A ANUIDADES. |
|
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |