BR0110735A - platelet function assay and reagent for the same - Google Patents

platelet function assay and reagent for the same

Info

Publication number
BR0110735A
BR0110735A BRPI0110735-6A BR0110735A BR0110735A BR 0110735 A BR0110735 A BR 0110735A BR 0110735 A BR0110735 A BR 0110735A BR 0110735 A BR0110735 A BR 0110735A
Authority
BR
Brazil
Prior art keywords
reagent
platelet function
same
assay
function assay
Prior art date
Application number
BRPI0110735-6A
Other languages
Portuguese (pt)
Inventor
Donald E Mahan
Michael W Stewart
Original Assignee
Pharmanetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmanetics Inc filed Critical Pharmanetics Inc
Publication of BR0110735A publication Critical patent/BR0110735A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

ENSAIO DE FUNçãO DE PLAQUETAS E REAGENTE PARA O MESMO. Um reagente de ensaio de função de plaquetas é fornecido para executar um ensaio de função de plaquetas em que o reagente contém uma mistura de particulas magnéticas e não-magneticas, em que as partículas magnéticas têm aderidas a uma superfície externa uma quantidade de um primeiro ligante que tem uma afinidade para interação direta com os receptores de GP-ib nas plaquetas de sangue e um que as partículas não-magnéticas têm aderidas a uma sua superfície externa uma quantidade de um segundo ligante que tem uma afunidade para interação direta com os receptores de GP-ib nas plaquetas de sangue,de tal modo que a interação de qualquer um do primeiro ou do segundo ligantes com o receptor de plaquetas de GP-ib ativará as plaquetas de sangue da direção da agregação em que o primeiro ligante e o segundo ligante podem ser o mesmo ou diferente, e o ensaio utilizando tal reagente, para fornecer uma avaliação de ponto de atentimento rápido, confíavel.Platelet function test and reagent for the same. A platelet function assay reagent is provided to perform a platelet function assay wherein the reagent contains a mixture of magnetic and nonmagnetic particles, wherein the magnetic particles have adhered to an outer surface an amount of a first binder. which has an affinity for direct interaction with GP-ib receptors on blood platelets and one that non-magnetic particles have adhered to their outer surface an amount of a second binder that has an affinity for direct interaction with blood receptors. GP-ib in blood platelets such that the interaction of either the first or second ligands with the GP-ib platelet receptor will activate the blood platelets in the direction of aggregation where the first ligand and the second ligand they may be the same or different, and the assay using such a reagent to provide a reliable, rapid watchpoint assessment.

BRPI0110735-6A 2000-05-09 2001-05-09 platelet function assay and reagent for the same BR0110735A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20263800P 2000-05-09 2000-05-09
PCT/US2001/011760 WO2001086248A2 (en) 2000-05-09 2001-05-09 Platelet function assay and reagent therefor

Publications (1)

Publication Number Publication Date
BR0110735A true BR0110735A (en) 2007-05-08

Family

ID=22750704

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0110735-6A BR0110735A (en) 2000-05-09 2001-05-09 platelet function assay and reagent for the same

Country Status (9)

Country Link
EP (1) EP1280931A4 (en)
JP (1) JP2003532891A (en)
KR (1) KR20030014219A (en)
AU (1) AU2001261020A1 (en)
BR (1) BR0110735A (en)
CA (1) CA2408850A1 (en)
MX (1) MXPA02011017A (en)
NO (1) NO20025300L (en)
WO (1) WO2001086248A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6680177B2 (en) * 2001-12-07 2004-01-20 Cardiovascular Diagnostics, Inc. Low molecular weight heparin assay, system and reagent therefor
JP4078247B2 (en) * 2003-05-02 2008-04-23 キヤノン株式会社 Magnetic substance-biological substance complex type structure, peptide fragment having amino acid sequence capable of binding to magnetic substance and gene thereof, and method for producing magnetic substance-biological substance complex type structure
WO2011135397A1 (en) * 2010-04-29 2011-11-03 University Of Calcutta Antiplatelet agent and methods of using the same
KR101276179B1 (en) * 2011-08-08 2013-06-18 고려대학교 산학협력단 Apparatus and method of platelet multi-function analysis, and micro stirring chip
US8772040B2 (en) 2012-08-31 2014-07-08 Korea University Research And Business Foundation Apparatus and method of platelet multi-function analysis, and micro stirring chip

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110727A (en) * 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
TW221493B (en) * 1990-07-10 1994-03-01 Cardiovascular Diagnostics Inc
US5616311A (en) * 1991-01-15 1997-04-01 Hemosphere, Inc. Non-crosslinked protein particles for therapeutic and diagnostic use
US5446132A (en) * 1992-10-01 1995-08-29 The General Hospital Corporation Thrombin-activated platelet protein-2 (TAPP-2)
US5427913A (en) * 1992-12-03 1995-06-27 Alberta Cancer Board Methods for determining platelet function
CA2156174A1 (en) * 1993-02-17 1994-09-01 Bruce Oberhardt Dry chemistry cascade immunoassay and affinity assay
US5686597A (en) * 1995-06-06 1997-11-11 Incyte Pharmaceuticals, Inc. Thrombin receptor homolog
US5922551A (en) * 1997-03-20 1999-07-13 Accumetrics, Inc. Agglutrimetric platelet binding assays in blood
US6046051A (en) * 1997-06-27 2000-04-04 Hemosense, Inc. Method and device for measuring blood coagulation or lysis by viscosity changes
US5932445A (en) * 1997-11-07 1999-08-03 Incyte Pharmaceuticals, Inc. Signal peptide-containing proteins

Also Published As

Publication number Publication date
MXPA02011017A (en) 2004-08-19
AU2001261020A1 (en) 2001-11-20
EP1280931A4 (en) 2005-02-09
JP2003532891A (en) 2003-11-05
WO2001086248A2 (en) 2001-11-15
EP1280931A2 (en) 2003-02-05
NO20025300D0 (en) 2002-11-05
CA2408850A1 (en) 2001-11-15
KR20030014219A (en) 2003-02-15
WO2001086248A3 (en) 2002-02-28
NO20025300L (en) 2003-01-07

Similar Documents

Publication Publication Date Title
BR0115396A (en) Platelet and leukocyte interaction assay and reagents for platelet
ATE174122T1 (en) PLATELE BLOCKADE TEST
EP0227173A3 (en) New method for the detection of specific binding agents and their corresponding bindable substances
Connor et al. Detection of the procoagulant activity of microparticle-associated phosphatidylserine using XACT
IL57722A0 (en) Dispersed metal particle labelled assay method and kit and reagents for use therein
DE69816474D1 (en) Stabilized particles of their preparation and use
KR870003388A (en) Detection method of ligand
DE69230105T2 (en) DIFFERENTIAL BINDING SFFINITIES AND BASED DISSOCIATION TEST PROCEDURES
JP2005503534A5 (en)
KR890012165A (en) Ion-Capture Analysis Method and Apparatus
BRPI0720361A8 (en) METHOD FOR MEASURING AGGLUTINATION OF ONE OR MORE PARTICLES IN A TARGET-INDUCED AGGLUTINATION ASSAY PERFORMED IN A REACTION CHAMBER, AND, KIT AND DEVICE FOR MEASURING ONE OR MORE PARTICLES AGGLUTINATION ASSAY IN A TARGET-INDUCED AGGLUTINATION ASSAY
WO2006051548A3 (en) Blood type method system and device
Preis et al. Laboratory tests for paroxysmal nocturnal hemoglobinuria
BR9915406A (en) Device and method for the analysis of a biological sample
BR0110735A (en) platelet function assay and reagent for the same
DE60128794D1 (en) MULTIANALYT DIAGNOSTIC PROCEDURE FOR THYROID DISORDER
KR890702039A (en) How to Analyze 1,25-Dihydroxy Vitamin D
Houslay et al. Lysophosphatidylcholines can modulate the activity of the glucagon-stimulated adenylate cyclase from rat liver plasma membranes
ES2161011T3 (en) REAGENTS FOR ION DIAZONIAL TESTING AND METHODS FOR USE.
Dong et al. Flow cytometric immunphenotyping of epithelial cancer cells in effusions—Technical considerations and pitfalls
DE69229960D1 (en) AGGLUTATION ASSAYS AND COLLOID DYES TESTS USING
BR9913770A (en) Test procedure for determining cobalamin bound to transcobalamin ii (tcii) in a body sample, kit for use in a diagnostic assay, and use of holo-tc ii
BR9911677A (en) Immunoassay test kit and containers
CN205539002U (en) Detect test paper strip of gosling pestivirus antibody
Zhan A method for quick measurement of protein binding to unilamellar vesicles