BR0104841A - Method for preparing citalopram, a compound of formula iv, citalopram and their pharmaceutical composition - Google Patents
Method for preparing citalopram, a compound of formula iv, citalopram and their pharmaceutical compositionInfo
- Publication number
- BR0104841A BR0104841A BR0104841-4A BR0104841A BR0104841A BR 0104841 A BR0104841 A BR 0104841A BR 0104841 A BR0104841 A BR 0104841A BR 0104841 A BR0104841 A BR 0104841A
- Authority
- BR
- Brazil
- Prior art keywords
- citalopram
- formula
- compound
- pharmaceutical composition
- preparing
- Prior art date
Links
Abstract
"MéTODO PARA PREPARAçãO DE CITALOPRAM; DE UM COMPOSTO DE FóRMULA IV, CITALOPRAM E SUA COMPOSIçãO FARMACêUTICA". Revela-se um método para a preparação de citalopram compreendendo reagir 5-carboxiftalida sucessivamente com um reagente de Grignard de 4-halo-fluorofenil e um reagente de Grignard de 3-halo-N,N-dimetil-propilamino e então efetuar o fechamento em anel do composto resultante de Fórmula XI seguido de conversão do composto de Fórmula IV em citalopram. Também são revelados métodos para a fabricação e conversão do composto de Fórmula IV."METHOD FOR PREPARING CITALOPRAM; OF A COMPOUND OF FORMULA IV, CITALOPRAM AND ITS PHARMACEUTICAL COMPOSITION". A method for the preparation of citalopram is disclosed comprising reacting 5-carboxyphthalide successively with a 4-halo-fluorophenyl Grignard reagent and a 3-halo-N, N-dimethyl-propylamino Grignard reagent and then closing in ring of the resulting Formula XI compound followed by conversion of the Formula IV compound to citalopram. Also disclosed are methods for making and converting the Formula IV compound.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200000123 | 2000-08-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0104841A true BR0104841A (en) | 2002-06-04 |
Family
ID=8159010
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0104841-4A BR0104841A (en) | 2000-08-18 | 2001-08-17 | Method for preparing citalopram, a compound of formula iv, citalopram and their pharmaceutical composition |
BR0105022-2A BR0105022A (en) | 2000-08-18 | 2001-08-24 | Method for preparing citalopram, methods for preparing compounds used in the preparation of it, citalopram and its pharmaceutical composition |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0105022-2A BR0105022A (en) | 2000-08-18 | 2001-08-24 | Method for preparing citalopram, methods for preparing compounds used in the preparation of it, citalopram and its pharmaceutical composition |
Country Status (3)
Country | Link |
---|---|
BR (2) | BR0104841A (en) |
IT (2) | ITMI20011786A1 (en) |
ZA (1) | ZA200106687B (en) |
-
2001
- 2001-08-13 IT IT2001MI001786A patent/ITMI20011786A1/en unknown
- 2001-08-13 IT IT2001MI001785A patent/ITMI20011785A1/en unknown
- 2001-08-14 ZA ZA200106687A patent/ZA200106687B/en unknown
- 2001-08-17 BR BR0104841-4A patent/BR0104841A/en not_active Application Discontinuation
- 2001-08-24 BR BR0105022-2A patent/BR0105022A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ITMI20011785A0 (en) | 2001-08-13 |
ITMI20011786A0 (en) | 2001-08-13 |
ZA200106687B (en) | 2002-02-14 |
ITMI20011785A1 (en) | 2003-02-13 |
BR0105022A (en) | 2002-06-04 |
ITMI20011786A1 (en) | 2003-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Technical examination (opinion): publication of technical examination (opinion) | ||
B09B | Decision: refusal | ||
B09B | Decision: refusal |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |