BR0104841A - Method for preparing citalopram, a compound of formula iv, citalopram and their pharmaceutical composition - Google Patents

Method for preparing citalopram, a compound of formula iv, citalopram and their pharmaceutical composition

Info

Publication number
BR0104841A
BR0104841A BR0104841-4A BR0104841A BR0104841A BR 0104841 A BR0104841 A BR 0104841A BR 0104841 A BR0104841 A BR 0104841A BR 0104841 A BR0104841 A BR 0104841A
Authority
BR
Brazil
Prior art keywords
citalopram
formula
compound
pharmaceutical composition
preparing
Prior art date
Application number
BR0104841-4A
Other languages
Portuguese (pt)
Inventor
Hans Petersen
Robert Dancer
Haleh Ahmadian
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of BR0104841A publication Critical patent/BR0104841A/en

Links

Abstract

"MéTODO PARA PREPARAçãO DE CITALOPRAM; DE UM COMPOSTO DE FóRMULA IV, CITALOPRAM E SUA COMPOSIçãO FARMACêUTICA". Revela-se um método para a preparação de citalopram compreendendo reagir 5-carboxiftalida sucessivamente com um reagente de Grignard de 4-halo-fluorofenil e um reagente de Grignard de 3-halo-N,N-dimetil-propilamino e então efetuar o fechamento em anel do composto resultante de Fórmula XI seguido de conversão do composto de Fórmula IV em citalopram. Também são revelados métodos para a fabricação e conversão do composto de Fórmula IV."METHOD FOR PREPARING CITALOPRAM; OF A COMPOUND OF FORMULA IV, CITALOPRAM AND ITS PHARMACEUTICAL COMPOSITION". A method for the preparation of citalopram is disclosed comprising reacting 5-carboxyphthalide successively with a 4-halo-fluorophenyl Grignard reagent and a 3-halo-N, N-dimethyl-propylamino Grignard reagent and then closing in ring of the resulting Formula XI compound followed by conversion of the Formula IV compound to citalopram. Also disclosed are methods for making and converting the Formula IV compound.

BR0104841-4A 2000-08-18 2001-08-17 Method for preparing citalopram, a compound of formula iv, citalopram and their pharmaceutical composition BR0104841A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200000123 2000-08-18

Publications (1)

Publication Number Publication Date
BR0104841A true BR0104841A (en) 2002-06-04

Family

ID=8159010

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0104841-4A BR0104841A (en) 2000-08-18 2001-08-17 Method for preparing citalopram, a compound of formula iv, citalopram and their pharmaceutical composition
BR0105022-2A BR0105022A (en) 2000-08-18 2001-08-24 Method for preparing citalopram, methods for preparing compounds used in the preparation of it, citalopram and its pharmaceutical composition

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR0105022-2A BR0105022A (en) 2000-08-18 2001-08-24 Method for preparing citalopram, methods for preparing compounds used in the preparation of it, citalopram and its pharmaceutical composition

Country Status (3)

Country Link
BR (2) BR0104841A (en)
IT (2) ITMI20011786A1 (en)
ZA (1) ZA200106687B (en)

Also Published As

Publication number Publication date
ITMI20011785A0 (en) 2001-08-13
ITMI20011786A0 (en) 2001-08-13
ZA200106687B (en) 2002-02-14
ITMI20011785A1 (en) 2003-02-13
BR0105022A (en) 2002-06-04
ITMI20011786A1 (en) 2003-02-13

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Legal Events

Date Code Title Description
B07A Technical examination (opinion): publication of technical examination (opinion)
B09B Decision: refusal
B09B Decision: refusal

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