BR0104747A - Use of cationic supravital mitochondrial marking agent in the detection and extinction of cancerous epithelial cells - Google Patents

Use of cationic supravital mitochondrial marking agent in the detection and extinction of cancerous epithelial cells

Info

Publication number
BR0104747A
BR0104747A BR0104747-7A BR0104747A BR0104747A BR 0104747 A BR0104747 A BR 0104747A BR 0104747 A BR0104747 A BR 0104747A BR 0104747 A BR0104747 A BR 0104747A
Authority
BR
Brazil
Prior art keywords
epithelial cells
extinction
marking agent
cancerous epithelial
detection
Prior art date
Application number
BR0104747-7A
Other languages
Portuguese (pt)
Inventor
Samuel D Bernal
Douglas D Burkett
Ralph E Green
Seth D Rose
Original Assignee
Zila Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zila Inc filed Critical Zila Inc
Publication of BR0104747A publication Critical patent/BR0104747A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"USO DE AGENTE DE MARCAçãO MITOCONDRIAL SUPRAVITAL CATIÈNICO NA DETECçãO E EXTINçãO DE CéLULAS EPITELIAIS CANCEROSAS". Um método de diagnóstico para detectar células epiteliais cancerosas por marcação seletiva da mitocóndria das células cancerosas, mediante fornecimento ao epitélio de um agente de marcação mitocondrial supravital catiónico. A destruição seletiva de células epiteliais cancerosas na presença de células normais é realizada pelo fornecimento de um agente de marcação mitocondrial supravital catiónico às células epiteliais cancerosas. O agente de destruição pode também compreender o produto de reação do agente de marcação e de um medicamento quimioterapêutico contra o câncer ou em mistura com o medicamento."USE OF CATHYNICAL SUPRAVITAL MITOCHONDRIAL MARKING AGENT IN THE DETECTION AND EXTINCTION OF CANCER EPITHELIAL CELLS". A diagnostic method for detecting cancerous epithelial cells by selectively marking the cancer cell's mitochondria by supplying the epithelium with a cationic supravital mitochondrial marking agent. The selective destruction of cancerous epithelial cells in the presence of normal cells is accomplished by supplying a cationic supravital mitochondrial marking agent to the cancerous epithelial cells. The destructive agent may also comprise the reaction product of the labeling agent and a chemotherapeutic drug against cancer or in admixture with the drug.

BR0104747-7A 2000-02-28 2001-02-27 Use of cationic supravital mitochondrial marking agent in the detection and extinction of cancerous epithelial cells BR0104747A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2000/005387 WO2001064110A1 (en) 2000-02-28 2000-02-28 Method for detecting and killing epithelial cancer cells
PCT/US2001/006318 WO2001064255A1 (en) 2000-02-28 2001-02-27 Method for detecting and killing epithelial cancer cells

Publications (1)

Publication Number Publication Date
BR0104747A true BR0104747A (en) 2002-09-17

Family

ID=21741108

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0104747-7A BR0104747A (en) 2000-02-28 2001-02-27 Use of cationic supravital mitochondrial marking agent in the detection and extinction of cancerous epithelial cells

Country Status (14)

Country Link
EP (1) EP1214101A4 (en)
JP (1) JP2003525044A (en)
KR (2) KR20080080681A (en)
CN (1) CN100544770C (en)
AU (2) AU2000237154A1 (en)
BR (1) BR0104747A (en)
CA (1) CA2370741A1 (en)
CZ (1) CZ20013861A3 (en)
IL (1) IL146141A0 (en)
MX (1) MXPA01010886A (en)
NO (1) NO20015242L (en)
NZ (1) NZ515202A (en)
RU (1) RU2226404C2 (en)
WO (2) WO2001064110A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2000237154A1 (en) * 2000-02-28 2001-09-12 Zila, Inc. Method for detecting and killing epithelial cancer cells
WO2002002149A1 (en) * 2000-06-30 2002-01-10 Zila, Inc. Rhodamine diagnostic agent and diagnostic methods for detection of epithelial cancer
EP1322339A4 (en) * 2000-09-26 2004-05-26 Zila Inc Method for early prediction of the onset of invasive cancer
IL159975A0 (en) * 2001-12-14 2004-06-20 Zila Inc Stain-directed molecular analysis for cancer prognosis and diagnosis
US6890571B2 (en) 2002-05-14 2005-05-10 National Starch And Chemical Investment Holding Corporation Slowly digestible starch product
US6929817B2 (en) 2002-05-14 2005-08-16 National Starch & Chemical Investment Holding Corporation Slowly digestible starch product
US7081261B2 (en) * 2002-05-14 2006-07-25 National Starch And Chemical Investment Holding Corporation Resistant starch prepared by isoamylase debranching of low amylose starch
BRPI0215775A2 (en) * 2002-06-04 2016-07-05 Zila Inc toluidine blue o substance (toluidine blue o) and its application for in vivo dyeing and chemotherapeutic treatment of dysplastic tissues.
AU2004324049A1 (en) * 2004-09-30 2006-04-20 Zila Biotechnology, Inc. Light-directed method for detecting and aiding further evaluation of abnormal mucosal tissue
EP3072522B1 (en) 2005-01-06 2019-04-24 Novo Nordisk A/S Anti-kir combination treatments and methods
WO2011008086A1 (en) 2009-07-15 2011-01-20 N.V. Nutricia Mixture of non-digestible oligosaccharides for stimulating the immune system
CN105510321A (en) * 2011-12-29 2016-04-20 闫文广 Detection agent composition for epithelial tissue tumor cells and preparing method thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321251A (en) * 1979-12-19 1982-03-23 The United States Of America As Represented By The Department Of Health And Human Services Detection of malignant lesions of the oral cavity utilizing toluidine blue rinse
US5194373A (en) * 1985-06-06 1993-03-16 Thomas Jefferson University Method of determining endothelial cell coverage of a prosthetic surface
US4816395A (en) * 1985-12-19 1989-03-28 Peralta Cancer Research Institute Method for predicting chemosensitivity of anti-cancer drugs
KR100242727B1 (en) * 1991-10-31 2000-03-02 에드윈 포머란츠 Biological stain composition, method of preparation and method of use for delineation of epithelial cancer
EP0814847B1 (en) * 1996-01-16 2003-11-05 Zila, Inc. Methods and compositions for in-vivo detection of oral cancers and precancerous conditions
US6086852A (en) * 1997-11-13 2000-07-11 Zila, Inc. In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
JP2002533416A (en) * 1998-12-23 2002-10-08 ジー．ディー．サール ＆ カンパニー Methods of using cyclooxygenase-2 inhibitors and one or more antineoplastic agents as combination therapy in the treatment of neoplasia
AU2000237154A1 (en) * 2000-02-28 2001-09-12 Zila, Inc. Method for detecting and killing epithelial cancer cells
WO2002007693A1 (en) * 2000-07-20 2002-01-31 Zila, Inc. Improved diagnostic method for detecting dysplastic epithelial tissue
EP1322339A4 (en) * 2000-09-26 2004-05-26 Zila Inc Method for early prediction of the onset of invasive cancer

Also Published As

Publication number Publication date
NO20015242D0 (en) 2001-10-26
KR20020000222A (en) 2002-01-05
AU785489B2 (en) 2007-11-15
NZ515202A (en) 2003-05-30
IL146141A0 (en) 2002-07-25
NO20015242L (en) 2001-11-29
EP1214101A1 (en) 2002-06-19
KR20080080681A (en) 2008-09-04
AU4331601A (en) 2001-09-12
EP1214101A4 (en) 2005-04-13
AU2000237154A1 (en) 2001-09-12
RU2226404C2 (en) 2004-04-10
WO2001064255A1 (en) 2001-09-07
JP2003525044A (en) 2003-08-26
CN1365288A (en) 2002-08-21
WO2001064110A1 (en) 2001-09-07
CA2370741A1 (en) 2001-09-07
MXPA01010886A (en) 2002-05-06
CZ20013861A3 (en) 2002-08-14
KR100907122B1 (en) 2009-07-09
CN100544770C (en) 2009-09-30

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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