BR0015425A - N-aryl- (homopiperazinyl) -cyclohexylamines as 5-ht carriers - Google Patents
N-aryl- (homopiperazinyl) -cyclohexylamines as 5-ht carriersInfo
- Publication number
- BR0015425A BR0015425A BR0015425-3A BR0015425A BR0015425A BR 0015425 A BR0015425 A BR 0015425A BR 0015425 A BR0015425 A BR 0015425A BR 0015425 A BR0015425 A BR 0015425A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- aryl
- carriers
- carbon atoms
- substitutable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"N-ARIL-(HOMOPIPERAZINIL)-CICLOHEXILAMINAS COMO TRANSPORTADORAS DE 5-HT" A presente invenção refere-se a novos compostos e métodos e composições usando os mesmos no tratamento de distúrbios do sistema nervoso central, incluindo depressão e ansiedade, os compostos tendo a fórmula (I), em que Ar representa um grupo arila, arilalquila ou heteroarila; R~ 1~ e R~ 2~ são independentemente selecionados de hidrogênio, alquila de 1 a 12 átomos de carbono que pode ser substituído por cicloalquila de 3 a 10 átomos de carbono, que pode ser substituído; R~ 3~ é H, alquila que pode ser substituído, alquila cíclica que pode ser substituído, halogênio, alcóxi, haloalquila, OH, nitro, amino, CN, carbóxi, alcoxicarbonila, alquilcarbonila, aminocarbonila e alquilaminocarbonila, ou um sal farmaceuticamente aceitável dos mesmos."N-ARIL- (HOMOPIPERAZINIL) -CYCLEHEXYLAMINES AS 5-HT CARRIERS" The present invention relates to new compounds and methods and compositions using them in the treatment of central nervous system disorders, including depression and anxiety, compounds having formula (I), where Ar represents an aryl, arylalkyl or heteroaryl group; R ~ 1 ~ and R ~ 2 ~ are independently selected from hydrogen, alkyl of 1 to 12 carbon atoms which can be replaced by cycloalkyl of 3 to 10 carbon atoms, which can be substituted; R ~ 3 ~ is H, substitutable alkyl, substitutable cyclic alkyl, halogen, alkoxy, haloalkyl, OH, nitro, amino, CN, carboxy, alkoxycarbonyl, alkylcarbonyl, aminocarbonyl and alkylaminocarbonyl, or a pharmaceutically acceptable salt of themselves.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43612999A | 1999-11-08 | 1999-11-08 | |
PCT/US2000/014020 WO2001034597A1 (en) | 1999-11-08 | 2000-05-19 | N-aryl-(homopiperazinyl)-cyclohexyl amines as 5-ht transporters |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0015425A true BR0015425A (en) | 2002-07-16 |
Family
ID=23731225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0015425-3A BR0015425A (en) | 1999-11-08 | 2000-05-19 | N-aryl- (homopiperazinyl) -cyclohexylamines as 5-ht carriers |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1228064A1 (en) |
JP (1) | JP2003513969A (en) |
CN (1) | CN1420883A (en) |
AU (1) | AU5152300A (en) |
BR (1) | BR0015425A (en) |
CA (1) | CA2390530A1 (en) |
MX (1) | MXPA02004554A (en) |
WO (1) | WO2001034597A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0103648D0 (en) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic quinolone compounds |
SE0103649D0 (en) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic quinoline compounds |
JP2007106746A (en) * | 2005-09-13 | 2007-04-26 | Tosoh Corp | New aryl homopiperazine compounds, or their salt and production method |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4954502A (en) * | 1988-06-10 | 1990-09-04 | Bristol-Myers Squibb Company | 1-indolyalkyl-4-(substituted-pyridinyl)piperazines |
CA2275299C (en) * | 1996-12-20 | 2003-12-16 | H. Lundbeck A/S | Indane or dihydroindole derivatives |
-
2000
- 2000-05-19 BR BR0015425-3A patent/BR0015425A/en not_active Application Discontinuation
- 2000-05-19 EP EP00936166A patent/EP1228064A1/en not_active Withdrawn
- 2000-05-19 CA CA002390530A patent/CA2390530A1/en not_active Abandoned
- 2000-05-19 WO PCT/US2000/014020 patent/WO2001034597A1/en not_active Application Discontinuation
- 2000-05-19 JP JP2001536544A patent/JP2003513969A/en active Pending
- 2000-05-19 CN CN00818247A patent/CN1420883A/en active Pending
- 2000-05-19 MX MXPA02004554A patent/MXPA02004554A/en unknown
- 2000-05-19 AU AU51523/00A patent/AU5152300A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2001034597A1 (en) | 2001-05-17 |
AU5152300A (en) | 2001-06-06 |
CN1420883A (en) | 2003-05-28 |
JP2003513969A (en) | 2003-04-15 |
CA2390530A1 (en) | 2001-05-17 |
EP1228064A1 (en) | 2002-08-07 |
MXPA02004554A (en) | 2004-09-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |