BR0011894A - Oral dosage form, process for making the dosage form, use of oral pharmaceutical dosage form, and methods to increase inhibition of gastric acid secretion and to increase the therapeutic effect in the treatment of gastrointestinal disorders associated with excess acid secretion - Google Patents
Oral dosage form, process for making the dosage form, use of oral pharmaceutical dosage form, and methods to increase inhibition of gastric acid secretion and to increase the therapeutic effect in the treatment of gastrointestinal disorders associated with excess acid secretionInfo
- Publication number
- BR0011894A BR0011894A BR0011894-0A BR0011894A BR0011894A BR 0011894 A BR0011894 A BR 0011894A BR 0011894 A BR0011894 A BR 0011894A BR 0011894 A BR0011894 A BR 0011894A
- Authority
- BR
- Brazil
- Prior art keywords
- dosage form
- increase
- acid secretion
- oral
- treatment
- Prior art date
Links
- 239000002552 dosage form Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 239000006186 oral dosage form Substances 0.000 title abstract 3
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 208000018522 Gastrointestinal disease Diseases 0.000 title 1
- 230000009858 acid secretion Effects 0.000 title 1
- 230000027119 gastric acid secretion Effects 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- 239000011162 core material Substances 0.000 abstract 2
- 159000000011 group IA salts Chemical class 0.000 abstract 2
- 229960000381 omeprazole Drugs 0.000 abstract 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002702 enteric coating Substances 0.000 abstract 1
- 238000009505 enteric coating Methods 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
"FORMA DE DOSAGEM ORAL, PROCESSO PARA A FABRICAçãO DE FORMA DE DOSAGEM, USO DE FORMA DE DOSAGEM FARMACêUTICA ORAL, E, MéTODOS PARA AUMENTAR INIBIçãO DE SECREçãO DO áCIDO GáSTRICO E PARA AUMENTAR O EFEITO TERAPêUTICO NO TRATAMENTO DE DISTúRBIOS GASTROINTESTINAIS ASSOCIADOS COM EXCESSO DE SECREçãO áCIDA". Forma de dosagem oral que compreende material núcleo revestido com membrana semipermeável em que o material núcleo compreende ingrediente ativo selecionado do grupo de omeprazol, sal alcalino do mesmo, S-omeprazol e sal alcalino do mesmo, em mistura com um ou mais aditivos alcalinos, um ou mais agentes de intumescimento, e opcionalmente excipientes farmaceuticamente aceitáveis, e a forma de dosagem não tem revestimento entérico."ORAL DOSAGE FORM, PROCESS FOR THE MANUFACTURE OF DOSAGE FORM, USE OF ORAL PHARMACEUTICAL DOSAGE FORM, AND, METHODS TO INCREASE GASTIC ACID SECRETATION INHIBITION AND TO INCREASE THE THERAPEUTIC EFFECT IN THE TREATMENT OF DISTORIATED GASTRIC TESTATION. ACID ". Oral dosage form comprising core material coated with semipermeable membrane in which the core material comprises active ingredient selected from the group of omeprazole, alkaline salt thereof, S-omeprazole and alkaline salt thereof, in mixture with one or more alkaline additives, one or more swelling agents, and optionally pharmaceutically acceptable excipients, and the dosage form has no enteric coating.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9902386A SE9902386D0 (en) | 1999-06-22 | 1999-06-22 | New formulation |
| PCT/SE2000/001310 WO2000078293A1 (en) | 1999-06-22 | 2000-06-20 | New formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0011894A true BR0011894A (en) | 2002-04-02 |
Family
ID=20416209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0011894-0A BR0011894A (en) | 1999-06-22 | 2000-06-20 | Oral dosage form, process for making the dosage form, use of oral pharmaceutical dosage form, and methods to increase inhibition of gastric acid secretion and to increase the therapeutic effect in the treatment of gastrointestinal disorders associated with excess acid secretion |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP1191926B1 (en) |
| JP (1) | JP2003502359A (en) |
| KR (1) | KR100717661B1 (en) |
| CN (1) | CN1243547C (en) |
| AT (1) | ATE291901T1 (en) |
| AU (1) | AU778158B2 (en) |
| BR (1) | BR0011894A (en) |
| CA (1) | CA2376226C (en) |
| CZ (1) | CZ20014579A3 (en) |
| DE (1) | DE60019116T2 (en) |
| DK (1) | DK1191926T3 (en) |
| EE (1) | EE200100693A (en) |
| ES (1) | ES2235912T3 (en) |
| HK (1) | HK1044480B (en) |
| HU (1) | HUP0201489A3 (en) |
| IL (2) | IL146818A0 (en) |
| IS (1) | IS6209A (en) |
| MX (1) | MXPA01012636A (en) |
| NO (1) | NO20016346L (en) |
| NZ (1) | NZ516186A (en) |
| PL (1) | PL352873A1 (en) |
| PT (1) | PT1191926E (en) |
| RU (1) | RU2240110C2 (en) |
| SE (1) | SE9902386D0 (en) |
| SK (1) | SK285326B6 (en) |
| TR (1) | TR200103693T2 (en) |
| UA (1) | UA73302C2 (en) |
| WO (1) | WO2000078293A1 (en) |
| ZA (1) | ZA200109803B (en) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
| CA2480826C (en) | 2002-04-09 | 2012-02-07 | Flamel Technologies | Oral pharmaceutical formulation in the form of microcapsule aqueous suspension allowing modified release of active ingredient(s) |
| SI21402A (en) | 2003-02-12 | 2004-08-31 | LEK farmacevtska dru�ba d.d. | Lined particles and pharmaceutical forms |
| WO2004075881A1 (en) * | 2003-02-28 | 2004-09-10 | Ranbaxy Laboratories Limited | Stable pharmaceutical composition of rabeprazole and processes for their preparation |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| EP1696889A1 (en) * | 2003-08-28 | 2006-09-06 | Ranbaxy Laboratories, Ltd. | Pharmaceutical compositions of benzimidazole and processes for their preparation |
| MXPA06002443A (en) * | 2003-09-03 | 2006-08-31 | Agi Therapeutics Ltd | Proton pump inhibitor formulations, and methods of preparing and using such formulations. |
| US7699964B2 (en) | 2004-02-09 | 2010-04-20 | Abbott Diabetes Care Inc. | Membrane suitable for use in an analyte sensor, analyte sensor, and associated method |
| US8165651B2 (en) | 2004-02-09 | 2012-04-24 | Abbott Diabetes Care Inc. | Analyte sensor, and associated system and method employing a catalytic agent |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| CA2578404A1 (en) * | 2004-08-23 | 2006-03-02 | Auckland Uniservices Limited | Gastric therapies and compositions therefor |
| US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
| US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
| FR2885526B1 (en) * | 2005-05-13 | 2007-07-27 | Flamel Technologies Sa | ORAL MEDICINE BASED ON PROTON PUMP INHIBITOR |
| EP1896002A4 (en) | 2005-06-27 | 2009-11-25 | Biovail Lab Int Srl | Modified-release formulations of a bupropion salt |
| CN101389316A (en) * | 2005-12-28 | 2009-03-18 | 武田药品工业株式会社 | Controlled release solid preparation |
| US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
| RU2467747C2 (en) | 2006-07-25 | 2012-11-27 | Векта Лтд. | Compositions and methods for gastric acid secretion inhibition with using small dicarboxylic acid derivatives in combination with ppi |
| EP2079448A2 (en) * | 2006-10-10 | 2009-07-22 | Dexcel Pharma Technologies Ltd. | Improved release of statins in the intestine |
| CA2736547C (en) | 2008-09-09 | 2016-11-01 | Pozen Inc. | Method for delivering a pharmaceutical composition to patient in need thereof |
| AU2010263304A1 (en) | 2009-06-25 | 2012-02-02 | Astrazeneca Ab | Method for treating a patient at risk for developing an NSAID-associated ulcer |
| BR112013029199B1 (en) * | 2011-05-13 | 2022-02-08 | Eb Ip Hybritabs B.V. | TWO-DRUG DISTRIBUTION DEVICE |
| EP2586429A1 (en) * | 2011-10-26 | 2013-05-01 | Freund Pharmatec Ltd. | Multi-unit drug delivery device for pulsatile or sustained release |
| MX2014007935A (en) | 2011-12-28 | 2014-11-14 | Pozen Inc | Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid. |
| WO2013122554A1 (en) | 2012-02-14 | 2013-08-22 | Mahmut Bilgic | Pellet formulations comprising esomeprazole |
| CN103127026B (en) * | 2013-02-05 | 2017-02-15 | 悦康药业集团有限公司 | Omeprazole enteric capsule and prepared method thereof |
| WO2015102745A1 (en) | 2013-12-31 | 2015-07-09 | Abbott Diabetes Care Inc. | Self-powered analyte sensor and devices using the same |
| EP3288556A4 (en) | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| RU2614730C1 (en) * | 2016-02-05 | 2017-03-28 | Игорь Юрьевич Чичерин | Antibacterial agents and method for treating intestinal yersiniosis or pseudotuberculosis, or colibacillosis |
| US10736855B2 (en) * | 2016-02-25 | 2020-08-11 | Dexcel Pharma Technologies Ltd. | Compositions comprising proton pump inhibitors |
| JP6462625B2 (en) * | 2016-04-06 | 2019-01-30 | ニプロ株式会社 | Tablets containing calcium blockers |
| JP6426115B2 (en) * | 2016-04-06 | 2018-11-21 | ニプロ株式会社 | Solid pharmaceutical composition containing a calcium blocker |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| CN109125282B (en) * | 2018-09-05 | 2020-07-14 | 珠海润都制药股份有限公司 | Omeprazole enteric capsule and preparation method thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1327010C (en) * | 1986-02-13 | 1994-02-15 | Tadashi Makino | Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production |
| SE9302395D0 (en) * | 1993-07-09 | 1993-07-09 | Ab Astra | NEW PHARMACEUTICAL FORMULATION |
| US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
| AU5179898A (en) * | 1996-11-06 | 1998-05-29 | Sharmatek, Inc. | Delayed delivery system for acid-sensitive drugs |
| SE9702000D0 (en) * | 1997-05-28 | 1997-05-28 | Astra Ab | New pharmaceutical formulation |
| JP4546643B2 (en) * | 1997-12-08 | 2010-09-15 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Novel suppository form containing an acid labile active compound |
| SI1105105T1 (en) * | 1998-08-12 | 2006-08-31 | Altana Pharma Ag | Oral administration form for pyridin-2-ylmethylsulfinyl-1h-benzimidazoles |
-
1999
- 1999-06-22 SE SE9902386A patent/SE9902386D0/en unknown
-
2000
- 2000-06-20 AT AT00946614T patent/ATE291901T1/en not_active IP Right Cessation
- 2000-06-20 PT PT00946614T patent/PT1191926E/en unknown
- 2000-06-20 DE DE60019116T patent/DE60019116T2/en not_active Expired - Lifetime
- 2000-06-20 PL PL00352873A patent/PL352873A1/en unknown
- 2000-06-20 EP EP00946614A patent/EP1191926B1/en not_active Expired - Lifetime
- 2000-06-20 SK SK1825-2001A patent/SK285326B6/en not_active IP Right Cessation
- 2000-06-20 NZ NZ516186A patent/NZ516186A/en unknown
- 2000-06-20 MX MXPA01012636A patent/MXPA01012636A/en active IP Right Grant
- 2000-06-20 JP JP2001504358A patent/JP2003502359A/en active Pending
- 2000-06-20 DK DK00946614T patent/DK1191926T3/en active
- 2000-06-20 RU RU2001132861/15A patent/RU2240110C2/en not_active IP Right Cessation
- 2000-06-20 TR TR2001/03693T patent/TR200103693T2/en unknown
- 2000-06-20 ES ES00946614T patent/ES2235912T3/en not_active Expired - Lifetime
- 2000-06-20 CN CNB008093369A patent/CN1243547C/en not_active Expired - Fee Related
- 2000-06-20 HU HU0201489A patent/HUP0201489A3/en unknown
- 2000-06-20 IL IL14681800A patent/IL146818A0/en active IP Right Grant
- 2000-06-20 CA CA002376226A patent/CA2376226C/en not_active Expired - Fee Related
- 2000-06-20 KR KR1020017016442A patent/KR100717661B1/en not_active IP Right Cessation
- 2000-06-20 WO PCT/SE2000/001310 patent/WO2000078293A1/en active IP Right Grant
- 2000-06-20 EE EEP200100693A patent/EE200100693A/en unknown
- 2000-06-20 UA UA2001128420A patent/UA73302C2/en unknown
- 2000-06-20 AU AU60344/00A patent/AU778158B2/en not_active Ceased
- 2000-06-20 BR BR0011894-0A patent/BR0011894A/en not_active Application Discontinuation
- 2000-06-20 CZ CZ20014579A patent/CZ20014579A3/en unknown
-
2001
- 2001-11-28 ZA ZA200109803A patent/ZA200109803B/en unknown
- 2001-11-29 IL IL146818A patent/IL146818A/en not_active IP Right Cessation
- 2001-12-21 NO NO20016346A patent/NO20016346L/en not_active Application Discontinuation
- 2001-12-21 IS IS6209A patent/IS6209A/en unknown
-
2002
- 2002-08-22 HK HK02106171.6A patent/HK1044480B/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8, 10(VIII), 11, 13 E 25 DA LPI |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |