BR0011884A - Method of treating obesity and comorbid conditions in a human in need of such treatment, compound of formula i, product containing compound of formula i, use of compound of formula i, and pharmaceutical composition - Google Patents
Method of treating obesity and comorbid conditions in a human in need of such treatment, compound of formula i, product containing compound of formula i, use of compound of formula i, and pharmaceutical compositionInfo
- Publication number
- BR0011884A BR0011884A BR0011884-2A BR0011884A BR0011884A BR 0011884 A BR0011884 A BR 0011884A BR 0011884 A BR0011884 A BR 0011884A BR 0011884 A BR0011884 A BR 0011884A
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- compound
- human
- treatment
- need
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"MéTODO DE TRATAMENTO DA OBESIDADE E CONDIçõES COMóRBIDAS EM UM SER HUMANO NECESSITANDO DE TAL TRATAMENTO, COMPOSTO DA FóRMULA I, PRODUTO CONTENDO O COMPOSTO DA FóRMULA I, USO DO COMPOSTO DA FóRMULA I, E, COMPOSIçãO FARMAMCêUTICA". Um método para o tratamento da obesidade e condições comórbidas associadas em um ser humano necessitando de tal tratamento, que compreende a administração ao ser humano de uma quantidade terapêuticamente efetiva de um composto da fórmula (I) incluindo enanciómeros e sais farmacêuticamente aceitáveis dos mesmos, no qual R~ 1~ e R~ 2~ são independentemente H ou metila, e uma quantidade terapêuticamente efetiva de um inibidor de lipase com exceção de orlistat; onde o composto da fórmula (I) e o inibidor de lipase são administrados simultaneamente, separadamente ou em sequência."METHOD OF TREATMENT OF OBESITY AND COMMON CONDITIONS IN A HUMAN BEING NEEDING SUCH TREATMENT, COMPOSITE OF FORMULA I, PRODUCT CONTAINING COMPOUND FORMULA I, USE OF COMPOUND FORMULA I, AND, COMPOSITION." A method for treating obesity and associated comorbid conditions in a human in need of such treatment comprising administering to the human a therapeutically effective amount of a compound of formula (I) including pharmaceutically acceptable salts and enanciomers thereof. which R1 and R2 are independently H or methyl, and a therapeutically effective amount of a lipase inhibitor other than orlistat; wherein the compound of formula (I) and the lipase inhibitor are administered simultaneously, separately or in sequence.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9914742.3A GB9914742D0 (en) | 1999-06-24 | 1999-06-24 | Therapeutic agents |
| PCT/EP2000/005544 WO2001000187A2 (en) | 1999-06-24 | 2000-06-16 | Pharmaceutical composition containing sibutramine and a lipase inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0011884A true BR0011884A (en) | 2003-08-12 |
Family
ID=10855953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0011884-2A BR0011884A (en) | 1999-06-24 | 2000-06-16 | Method of treating obesity and comorbid conditions in a human in need of such treatment, compound of formula i, product containing compound of formula i, use of compound of formula i, and pharmaceutical composition |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1189638A2 (en) |
| JP (1) | JP2003503344A (en) |
| KR (1) | KR20020012293A (en) |
| CN (1) | CN1365287A (en) |
| AU (1) | AU5815100A (en) |
| BG (1) | BG106209A (en) |
| BR (1) | BR0011884A (en) |
| CA (1) | CA2376213A1 (en) |
| CZ (1) | CZ20014614A3 (en) |
| GB (1) | GB9914742D0 (en) |
| HK (1) | HK1050476A1 (en) |
| HU (1) | HUP0201880A3 (en) |
| IL (1) | IL147078A0 (en) |
| MX (1) | MXPA01013023A (en) |
| NO (1) | NO20016301D0 (en) |
| PL (1) | PL352387A1 (en) |
| SK (1) | SK18822001A3 (en) |
| TR (1) | TR200103704T2 (en) |
| WO (1) | WO2001000187A2 (en) |
| ZA (1) | ZA200110046B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399826B1 (en) * | 1999-08-11 | 2002-06-04 | Sepracor Inc. | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain |
| US7089666B2 (en) * | 2003-06-06 | 2006-08-15 | The Regents Of The University Of California | Microfabricated vertical comb actuator using plastic deformation |
| MX2009002781A (en) | 2006-09-15 | 2009-03-30 | Reviva Pharmaceuticals Inc | Synthesis, methods of using, and compositions of cycloalkylmethylamines. |
| CN101890017A (en) * | 2009-05-22 | 2010-11-24 | 北京奥萨医药研究中心有限公司 | Medicament composition containing sibutramine and stanin fat-reducing medicament and application thereof |
| WO2012003501A2 (en) | 2010-07-02 | 2012-01-05 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives |
| ES2726807T3 (en) | 2011-12-30 | 2019-10-09 | Reviva Pharmaceuticals Inc | Compositions, synthesis and methods of use of 1- [1-phenyl-cyclobutyl] isobutylamine derivatives |
-
1999
- 1999-06-24 GB GBGB9914742.3A patent/GB9914742D0/en not_active Ceased
-
2000
- 2000-06-16 SK SK1882-2001A patent/SK18822001A3/en unknown
- 2000-06-16 EP EP00943819A patent/EP1189638A2/en not_active Withdrawn
- 2000-06-16 PL PL00352387A patent/PL352387A1/en unknown
- 2000-06-16 JP JP2001505897A patent/JP2003503344A/en active Pending
- 2000-06-16 HU HU0201880A patent/HUP0201880A3/en unknown
- 2000-06-16 WO PCT/EP2000/005544 patent/WO2001000187A2/en not_active Application Discontinuation
- 2000-06-16 MX MXPA01013023A patent/MXPA01013023A/en unknown
- 2000-06-16 BR BR0011884-2A patent/BR0011884A/en not_active IP Right Cessation
- 2000-06-16 AU AU58151/00A patent/AU5815100A/en not_active Abandoned
- 2000-06-16 CA CA002376213A patent/CA2376213A1/en not_active Abandoned
- 2000-06-16 KR KR1020017016577A patent/KR20020012293A/en not_active Application Discontinuation
- 2000-06-16 CN CN00810544A patent/CN1365287A/en active Pending
- 2000-06-16 TR TR2001/03704T patent/TR200103704T2/en unknown
- 2000-06-16 CZ CZ20014614A patent/CZ20014614A3/en unknown
- 2000-06-16 IL IL14707800A patent/IL147078A0/en unknown
-
2001
- 2001-12-06 ZA ZA200110046A patent/ZA200110046B/en unknown
- 2001-12-11 BG BG06209A patent/BG106209A/en unknown
- 2001-12-21 NO NO20016301A patent/NO20016301D0/en not_active Application Discontinuation
-
2003
- 2003-02-20 HK HK03101311.7A patent/HK1050476A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5815100A (en) | 2001-01-31 |
| SK18822001A3 (en) | 2003-04-01 |
| ZA200110046B (en) | 2003-03-06 |
| CN1365287A (en) | 2002-08-21 |
| NO20016301L (en) | 2001-12-21 |
| WO2001000187A2 (en) | 2001-01-04 |
| MXPA01013023A (en) | 2003-08-01 |
| BG106209A (en) | 2002-09-30 |
| CA2376213A1 (en) | 2001-01-04 |
| HUP0201880A3 (en) | 2003-03-28 |
| JP2003503344A (en) | 2003-01-28 |
| CZ20014614A3 (en) | 2004-02-18 |
| HUP0201880A2 (en) | 2002-12-28 |
| WO2001000187A3 (en) | 2001-11-15 |
| NO20016301D0 (en) | 2001-12-21 |
| HK1050476A1 (en) | 2003-06-27 |
| GB9914742D0 (en) | 1999-08-25 |
| TR200103704T2 (en) | 2002-05-21 |
| EP1189638A2 (en) | 2002-03-27 |
| PL352387A1 (en) | 2003-08-25 |
| KR20020012293A (en) | 2002-02-15 |
| IL147078A0 (en) | 2002-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1927 DE 11/12/2007. |