BG97542A - Therapeutically active mixture of glutathione and anthocyan compounds - Google Patents

Abstract

A mixture of substances for therapeutically treating the human or animal body contains reduced glutathion and at least an anthocyan compound from the group composed of pelargonidine, peonidine, cyanidine, melvidine, petunidine and delphinidine. The reduced glutathion can be entirely or partially substituted by at least a thiol-derivate of glutathion from the group composed of methyl-glutathionyl-(thio)-ether, ethylglutathionyl-(thio)-ether, mono-acetyl-glutathionyl-(thio)-ester and mono-phosphoric acid glutationyl-(thio)-ester.

Description

THERAPEUTIC SHISH MIXTURE FROM GLSHTIOI AND AVSHYUVI SADINENPYA

Recent research has shown that "destructive physico-chemical processes through freedom 'radicals, radical reactions and / or go through activated occipital oceans take a more significant place in the pathogenesis of many acute and mature chronic diseases, among other things. to mention arterial venous angiopathies, allergies, auto-aggression and tumor disease, etc. Free radical reactions and activated oxidation stages (DOS) »but also of radicals formed by ionizing lying of water-radiolysis, always lead to whispering and destruction in biomolecules (III, IIIA, enzymatic and structural proteins, unsaturated fatty acids, etc.), as well as to all cells and cellular parts through radical reaction phenomena of lipid defect * oidation, as in damage in the destruction of the membrane · Radical; the processes are in the eti ^ ogy of balls diseases! often they are linked to the cause of these diseases or sustained by radical correct reactions.

For gases, the reason "humans and animals can protect themselves with oproxidase-acting winters" such as superoxide * diumutase1 catalases and peroxidase "xytoprythma ^{in the} oculatory stages.

It is known (1) that to preserve the functionality of a lot, and to prevent the enzymes of the cellular community it is necessary to prevent the oxidative washings of the catalytic and allosteric centers and aa to maintain the optimal conformation of the reductive the reduced glutathione potential, i. its optimal »higher intra-ocular concentration is of paramount importance, by giving reduced glutathione to wash it or, in the case of impaired cellular exchange, to restore it again.

It is also known (2) that it may be more advantageous if the organism, instead of reduced glutathione, delivers a cross-linked thiol derivative of glutathione · The lead derivatives exhibit particularly good bio-susceptibility. Their penetration through biological harrows is particularly good. Important for the therapeutic effect of the H-group of gdutathione is, however, the pathway to the site of the knee impact requested by biological elements, and they cause difficulties for the enzymes involved in endogenous gluttony and <5.

Cw are known drugs (3) · which, as an integral part of the ingredient, contain anthocyanidin, such as cyanide, peoaidin, dolphinidin, petunidine »pelargonidine malvidine · of the vasculature or flushes therein, which are caused by a deterioration of the lipid or glutinous volume of the substances.

Reduced glutathione as a coenzyme (selective-curdling guttathioi-ι nerohohdsh) g as a cofactor (glutathioa-> -thioferase), as χ is an enzymatic scavenger and nuclei i'j; primary or secondary radicals »ι

- 3 as well as Av radicals detoxify »which they form in cellular exchange when exposed to energy-rich lies * However» when administered alone with reduced glutathione, it can be reduced to non-existent conditions »T® cm explained by the following:

- hunting genetically supplied with antioxidants, ie scaveng-easims (enshompetp);

• Insufficient biosynthesis of antioxidant eps in different parts and depending on certain adverse fauna in life (enai mopeip) | • oxidative wear ⁱⁿ reduced glutathione under special circumstances, such as intoxication, inflammatory processes, infections, deficiencies in non-enzymatic or enzymatic oakwings, with the extremely unfavorable possibility of forming thiyl radicals, glutathione disulfide or sulfonyl disulfide also glutathione-peroxisulfeno-redical:

• disorders in the de-novo-biosynthesis of endogenous reduced glut! OHJ • sport of excellence, cachexia®, debilitating diseases, old age.

These different states of water lead to shortages and changes in the biological space of the gauge in the mammals, the negative system of redoxpotential and to the otilloemia of redox-containing system, most notably enzymatic disorders, in particular "antiocoylating and glutotosulfonate." , to cell metabolism abnormalities »to mutations» to malignancies or cw to cell neurosis »

It has now been discovered that healing failures live to be avoided by using a combination of • # of reduced glutzione with actscans, and additionally thiolate thiolate as an added reduced shield or as a supplement.

The invention, therefore, is a mixture of therapeutically treating an animal and an organism which contains a reduced organism and takes an anthocyanin compound from the pelargongrin, phboshn | wild, cyanidin, nelvidine, letunidine, dolphinidine, or reducing glutathione may be substituted wholly or adzhao by at least one guldthioa derivative of the group of net - glutathionyl (thio) - ether, ethyl · glutathionyl - (, thio) Acetyl glutathionyl (thio) - ester, mono - phosphorus - oxel * glutathionyl (thio) - ether.

Reduced glutathione is found in its reduced form (G * M) in duck cells of human and mammalian animals, such as tripeptide, which is the ostium of three ashanoic acids glutamic acid, cystane and glycine and has the following structural formulas:

!

and reduced glutamate (gamengautamda ^ hh ^ eishemglitz)

The tola derivatives aa glutathione used according to the invention have the following structural formulas:

owls 2 / ^C h in ¹ -. , ' ^p HgM (¾ C sh f ¹ oooh 0 1 n - CHj

mega «gout18OneNt8o) <» tr respectively monometcl-thioether

CHg Η [-c% -cm _{3 5} ΐϊΒ3-Γ2718 "Μ0" ΒΗΤΜ0) · β? Βρ ACCORDING TO

khaoo ^ osfornoksel-glpa * eoh- (io) * ester of khfsloh

Antochashee ore »in many entrances and ahhh oe owe the red» violet · blue ate black-eyed coloring ma color milestones · fruits Heterocyclic 2 * fenchhromevol-multicircular systems with different freezing systems sugars vgliomozi * poentzh of avhokshshe I meant as aoocyanidai · Be can bark through hydrolysis where I thought oh sadrvdihe in the fruit of glucoside (see No. 0 27 40 346) and I had the following structural headlight>

«1 * 2 trivial name ^L 1SHO (iHiyah) and n pelargoidin 520 (orange-red) n axis. pheonadine 552 (red-yellow; and QH tsamgidan 535 (worm disease) wasp ₃ basic ₃ mzlvidin 542 (molotovs) he basic ₃ aotunadiv 543 (violet red) Oh Oh Delphiaidin 544 (bluish)

Antswack may exhibit good oceggers on the o * peroxide-anion radical (02), on hydrogen dragees (H ^) »ori hydroxyl radical (7n ·), on the alkoxonium radical (X 0 ·)» for perocoid »rad > Calla (10 0 ·) »for singlet oxygen (0 ^ (V ⁴ ·) and many other radicals · Anthocyanins may also, such as Photobiological Inhibitors, regulate and detoxify transient NSAIDs, thereby inhibiting cellular and molecular injury > reactions, radical and radical, too, regardless of how they are brazilian ·

The Atsians protect against carcinogenic aldehydes (4-hydroxy-hecoacal, 4-hydroxy * octal, 4 »hzhrokom * aonenal, pr fall, butano» dentanad »hexanal» 2,4-heptaddenal, even mondiad their formation within the dididoperok · sidating chain reactions · They thus detonated the ethanol-degrading acetaldehyde and the resulting cryo was heated to give methanol or otherwise present behind formaldehyde.

The anthocyanin compounds and the reduced glutathione and / or its thiol derivative axis complement the dose depending on the treatment in an optimal manner in many cell disorders and many disorders in cellular upregulation. In addition to quality healing! effect, by the combined administration of reduced glutathione n / t his / her anal compounds, together with anthocyanin compounds, produced a significantly better effect on the ratio of sliding function. Thioin radicals (C ·) »glutathione disulfide-anLon-cacal (C * - * C) and also glutathione-ceroxysulfenyl-radmkali (C- ϋ Ο ·) or do not allow to form or detoxify.

In addition, "the jacket does not reduce the oxidized glut" on (c- * -C) n to the inhibition and / or the detoxification of deaf thionic radicals »dawns in the axis: rye reaction cycle of the two products (glutathione and anthocyanins) »to the permanent regeneration of the radakal detsks« «1'1

Duunktsmc

The complementarity of the two product groups with the mixture agreed with the invention so optimally that reduced glutathione can completely restore and absorb its vital regulatory functions at the genetic and enzymatic levels and ultimately at all levels.

Reduced glutathione (C-H) reacts, inter alia, with quinone-forming glutathionyl-hydrochain-conjugates, which can reach the auto-latitude to the corresponding hydrochicone. The C-? - arrangement reduces the radical, electrophondone character of the shane by improving their hydrophilicity. You form such coyugajonas and »which I was of naked interest from a toxicological point of view» no limit inside »cocktail» both from the trench »and from the concentration to СН-. This is another therapeutic starting point for many phenomena logically so different-looking observations. · First and foremost, the combination of reduced glutathione and its arbitrary antocmakage effects. same so there g lechebezh affect prya initiated different personal way radikalni- and radaalnoverihsh effects (heat _{is a} chemical mozhshchno * zhvfektszhozyo-toksichzho »due to irradiation and another *)» but ozho case for n you toobimichao so important phenomenon to your lipid necrotation · mixture oadlano zobretechia to a large extent zuzhmentelnaya meshreviave (cross ties) biobiolacia (ozeria tissue »protein, Diao) ) · In addition, it protects from lipadeproxidativo the formation of pathogen-induced polynauropathic degenerators at the periphery, and the central nervous system in satsosh prevents the formation of aa daaofuxin or its arrays. In addition, "just behind this combination of glutathiasis and anthociosis, it is an obstacle to anti-denaturation and bradytrophic tissues," such as the sternum, the corpse, and the vitreous ·

An even greater increase in activity is obtained in addition to Vitamin B (alpha-tocopherolacetate) and / or vitamin A and / or beta-carotene / clen and / or 1-cisadine in the mixture according to the invention.

Particularly suitable is an oral formulation of my own according to the invention wherein the daily therapeutic dose is in the range of 50 mg to 2400 mg ·

The composition of the invention is based on the aforementioned wide range of pharmacologically useful therapeutics. The application of hjt © is appropriate among others in the following cases:

* for the treatment of cancers of any origin »also for malignancies and blood cells in the primary

- aa replace © and regulate your metabolism spa behavior in cancer therapies, chemotherapy, radiation therapy * / t natural therapy * * for prophylaxis in the treatment of "meta-recurrence in malignant tumors" Ajayiyiyiya * · *

- for the treatment of hapatopati, in particular asgm and chronic diseases of hepatitis such as chemical-toxzek in infectious-current hepatitis, hepatitis archived by viruses, rickettsiae, bacteria or protozoa, as in chronic-aggressive hepatitis * and liver cirrhosis of any origin,

- for the treatment of disorders of the immune protective bone enveloped in the area of iatural-yier cells, monocytes, macrophages, granulocent, T- and Vlinfocinti, scam cells, as well as in disorders of kimplefactors * in the synthesis of antibodies,

- for the treatment of complex disorders of ov bio-synthesis in

T-germ cells, macrophages and other cells.

- for the treatment of cardiomyopathies of any origin, as well as for other treatments, any form of coronary myeloma, angina, prevention of cardiac infarction, and emergency therapy for cardiac infarction together are other emergency medicines, • for the treatment of acquired and congenital disorders of the echo »

- for the treatment of neurological observations of inflammatory, allergic cli degenerative origin,

- for treatment with any fersh? blood cell disease, anemia, leukopenia, lymphopaetes and thrombosis,

- a prophylaxis against damage to the eye, toxic disorders and frostbite in the vitreous, as well as • 10 · cataract prevention,

- for the treatment of any form of re-oxidation or non-oxidative stress, for example, performing oxygen therapy in activated oxygen stages (oxygen radicals), as well as aa employed Drl applying oxygen therapy, oxygen therapy, therapy with POT · therapy,

- nri intoxications that lead to the human body through the delivery of cadmium veshchash to biomolecular and tissue damage * • as a laxative therapy for lmc treatment, nontreatment treatment, as well as to reduce nausea and nausea prevention. others> them,

- after anesthesia, especially after complete anesthesia for coiled heart and liver damage, • during intoxication with xenomotics, in particular toxic trace elements and heavy metals, • for the treatment of disorders of the proliferation and differentiation of epithelial tissues, endothelium and mucosa ·

- for the treatment of pathophysiological and variously occurring arthro »sclerosis, • as a primary and additional treatment for allergy, • for the treatment of impotence, is also impotence generandm, as well as disorders in fertility and the lot option of any age,

- in premature aging, we wear out all the tissues as well as skin and connective tissue from old age, as well as for prevention of activities and habits that lead to harmful aging or premature wear of organs and tissues *

Claims (7)

Patent nattling 1. A mixture containing glutathione and one anthocyanin compound of pear pelargonidan, peyde, cyanide, malignant "petuivdia", dalfudud for the treatment of the human or animal organism, 2. Mixture containing at least one thiol-producing non-glutathione grunt® of methyl-glutthylsulfonyl-cetis-ether-tetrahydrothio-ether! mono-acetylmutthiol thio) -ester, loco * phosphoric acid * glutathione (yes) -ester and at least one anthocyanin compound of the peppermint group, peohyadia, cyanide, malvidine, petuquid, dolphinidia, for the treatment of human, or human 3. Mixture containing reduced glutathione and at least one glutathione derivative of the methyl-glutathione octo-ether group | ethyl glutathione ether, methylsulfonyl * glutathione2 (tco) -ester, mono-phosphorous-acid-thio-ester and at least one 8-nococyanine compound of the pellargonidine, peonide, cyanide, cyanide, cyanide, cyanide, cyanide, cyanide dolphinide is used to treat goose bumps in animal organisms. A composition according to claim 1 _t 2 or 3, further comprising vitamin 2 and / or vitamin A. A mixture according to claim 1,2,3 or ft, further comprising - -carotene. A mixture according to claims 1, 2,3, 4, 5, characterized in that it further comprises selenium, A mixture according to claim 1,2,3,4,5ηπη6, characterized by!