BG48098A3 - Method for preparing of optically active /-/- oxabicyclo /3.3.0/ oktanolones - Google Patents

Method for preparing of optically active /-/- oxabicyclo /3.3.0/ oktanolones

Info

Publication number
BG48098A3
BG48098A3 BG84850A BG8485088A BG48098A3 BG 48098 A3 BG48098 A3 BG 48098A3 BG 84850 A BG84850 A BG 84850A BG 8485088 A BG8485088 A BG 8485088A BG 48098 A3 BG48098 A3 BG 48098A3
Authority
BG
Bulgaria
Prior art keywords
oxabicyclo
oktanolones
preparing
optically active
saponified
Prior art date
Application number
BG84850A
Inventor
Karl Petzoldt
Helmut Dahl
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of BG48098A3 publication Critical patent/BG48098A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)

Abstract

Process for the manufacture of (-)-oxabicyclo[3.3.0]octanolones of formula (-)-I, where R is hydrogen or the residue (a), in which R1 has the notation of a hydrogen, alkyl with 1-7 C atoms, or phenyl. The process is characterized in that a racemic oxabicyclo[3.3.0]-octanolone-acylate of formula (+/-)-II, where R1 has the above notation, is subjected to a stereo-specific acylate hydrolysis and the (-)-I (R = (a)) is separated from the saponified (+)-I (R = H) or the saponified (-)-I (R = H) is separated from the unsaponified (+)-II.
BG84850A 1986-11-13 1988-07-12 Method for preparing of optically active /-/- oxabicyclo /3.3.0/ oktanolones BG48098A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863638762 DE3638762A1 (en) 1986-11-13 1986-11-13 RACEMAT CLEAVAGE OF 7 (ALPHA) -ACYLOXY-6SS-HYDROXY-METHYL-2-OXABICYCLO (3.3.0) OCTAN-3-ONES BY STEREO-SPECIFIC ENZYMATIC ACYLATE HYDROLYSIS
PCT/DE1987/000520 WO1988003570A1 (en) 1986-11-13 1987-11-12 RACEMIC SEPARATION OF 7alpha-ACYLOXY-6beta-HYDROXYMETHYL-2-OXABICYCLO[3.3.0]OCTANE-3-ONES BY STEREO-SPECIFIC ENZYMATIC ACYLATE HYDROLYSIS

Publications (1)

Publication Number Publication Date
BG48098A3 true BG48098A3 (en) 1990-11-15

Family

ID=6313862

Family Applications (1)

Application Number Title Priority Date Filing Date
BG84850A BG48098A3 (en) 1986-11-13 1988-07-12 Method for preparing of optically active /-/- oxabicyclo /3.3.0/ oktanolones

Country Status (11)

Country Link
EP (1) EP0271433B1 (en)
JP (1) JPH01501360A (en)
AT (1) ATE85084T1 (en)
BG (1) BG48098A3 (en)
CS (1) CS268841B2 (en)
DD (1) DD279689A5 (en)
DE (2) DE3638762A1 (en)
ES (1) ES2053577T3 (en)
GR (1) GR3007127T3 (en)
HU (1) HU202289B (en)
WO (1) WO1988003570A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9108376D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Cyclopentenes
US5840923A (en) * 1992-04-21 1998-11-24 Chiroscience Limited Chiral cyclopentene derivatives and their preparation
JPH08505835A (en) * 1992-04-21 1996-06-25 カイロサイエンス・リミテッド Chiral cyclopentene derivatives and their production
US5215918A (en) * 1992-06-19 1993-06-01 Bend Research, Inc. Enantiomeric enrichment of (R,S)-3-quinuclidinol
DE4435242A1 (en) * 1994-10-04 1996-04-11 Hoechst Ag Process for the enzymatic separation of enantiomers of rac-2-oxotricyclo 2,2,1,0 · 3 ·, · 5 · -heptan-7-carboxylic acid or the -carboxylic acid ester
ATE346159T1 (en) 2000-05-08 2006-12-15 Pfizer Prod Inc ENZYMATIC CLEAVAGE OF SELECTIVE MODULATORS OF THE ESTROGEN RECEPTOR

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE431750B (en) * 1977-05-26 1984-02-27 Chinoin Gyogyszer Es Vegyeszet PROCEDURE FOR THE PREPARATION OF BICYCLIC LACTON DIODE DERIVATIVES
DE3021895A1 (en) * 1980-06-06 1981-12-24 Schering Ag Berlin Und Bergkamen, 1000 Berlin NEW METHOD FOR PRODUCING CARBACYCLIN INTERMEDIATE PRODUCTS
DE3465185D1 (en) * 1983-05-25 1987-09-10 Sumitomo Chemical Co Process for producing optically active cyclopentenolones
JPS61280294A (en) * 1985-06-04 1986-12-10 Nisshin Flour Milling Co Ltd Optically active carbacycline intermediate and production thereof

Also Published As

Publication number Publication date
EP0271433B1 (en) 1993-01-27
DD279689A5 (en) 1990-06-13
DE3783885D1 (en) 1993-03-11
GR3007127T3 (en) 1993-07-30
JPH01501360A (en) 1989-05-18
CS268841B2 (en) 1990-04-11
CS815087A2 (en) 1989-08-14
EP0271433A1 (en) 1988-06-15
WO1988003570A1 (en) 1988-05-19
DE3638762A1 (en) 1988-05-26
HUT47155A (en) 1989-01-30
HU202289B (en) 1991-02-28
ES2053577T3 (en) 1994-08-01
ATE85084T1 (en) 1993-02-15

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