BG1452U1 - Composition of natural products for mastitis treatment - Google Patents

Abstract

The utility model covers compositions of natural products for mastitis treatment intended for veterinary medicine. Usage of such products in veterinary medicine will provide a new solution of the major problems existing in the traditional antibiotic treatment of mastitis in cows, as well as in the natural products developed up to now. The compositions for treating mastitis in cows comprise, in weight percentage: natural products equivalent to the activity of biologically active substances, independently or in combination from 0,1 to 20,0

Description

Technical field

The utility model refers to a composition of natural mastitis treatment products for veterinary use.

The use of these products in veterinary medicine provides a new solution to the major problems that exist in traditional antibiotic treatment of mastitis in cows, as well as in natural products developed so far.

BACKGROUND OF THE INVENTION

It is known that dairy cows, whose main purpose is dairy farming, are subject to a number of diseases that can impair their productivity and make them unable to perform their essential function. Mastitis is one of the most economically problematic diseases. Inflammation of the mammary gland is manifested by cumulative economic losses, resulting in the accumulation of losses from treatment, deterioration of milk quality, reduction of milk yield and premature rejection.

The use of antibacterial agents (antibiotics and chemotherapeutics) for the treatment of mastitis in animals is known.

Various approaches are also known for the treatment of mastitis in cows other than antibacterial therapy, incl. acupuncture, homeopathy, phytotherapy, chiropraxis and more.

Various methods and compositions are known for the treatment of the mammary gland and the remediation (exterior treatment) of udder and tits with natural products US 7078062; Patent Application Publication 2003 / US 0113385 Al; US 5061491; US 5846543.

The main problems with the known products so far are:

- resistance to antimicrobial agents (antibiotics and chemotherapeutics) of pathogens causing mastitis, demonstrated by a large number of studies in dairy cows;

- non-compliance by the milk producers with the regulated withdrawal periods for milk (deadlines for which milk should not be used due to the presence of residues of antibiotics and chemotherapists) in the use of antimastotic products containing antibiotics and chemotherapeutics which may have an adverse effect, on the one hand, to human consumers and, on the other, to impede the technological processing of milk into dairy products;

- the lack of well-defined qualitative and quantitative composition, with respect to the biologically active substances contained, in the herbal medicine used so far, which does not always lead to positive and repetitive results;

- many natural medicines are combined with antibiotics.

The technical nature of the utility model

The essence of the utility model is a composition of natural mastitis treatment products with precisely defined quantitative and qualitative composition of the biologically active substances included therein, which ensures repeatability of results. The products thus obtained guarantee high efficiency in controlling mastitis in cows and overcoming the disadvantages indicated in the prior art. The formulations obtained according to the utility model are included in wt. %: natural products from 0.1 to 20.0 - chamomile (Matricaria chamomilla L.), tea tree (Melaleuca alternifolia), mother liquor (Melissa officinalis L.), mint (Mentha piperita L.), thyme (Thymus serpilum L.) ), oregano (Origanum vulgaris L), lavender (Lavandula angustifolia Mill.), Rosemary (Rosmarinus officinalis L.), grapefruit (Citrus grandis), juniper (Juniperus communis L), sage (Salvia officinalis L.), anise (Pimpinella) anisum L.), rose (Rosa damascena Mill.), calendula (Cledula officinalis L.), white yarrow (Achillea millefolium L.), equated to the activity of biologically active substances; carriers - from 1,0 to 98,0 vegetable fats (fatty oils) - sunflower oil, olive oil, sesame oil, soybean oil, coconut oil, palm oil and from 1,0 to 50,0 waxes and mineral oils - white petroleum jelly , liquid paraffin, hard paraffin, white beeswax, yellow beeswax, cetyl alcohol, stearic

1452 Ul alcohol, propylene glycol, glycerolformal, polyethylene glycols (PEG) 400,1000,1500 or 4000; surfactants from 0.2 to 10.0 polysorbate 80, macrogolglycerol ricinoleates, macrogolglycerol hydroxystearates, lanolin; vitamins from 0.0001 to 1.0 - Vitamin A (Retinol palmitate, acetate, propionate), Vitamin E (tocopherol acetate); antioxidants from 0.001 to 0.05 butyl hydroxytoluene, butyl hydroxyanisole, ascorbic acid esters (palmitic, stearic esters), gallic acid esters (propyl, octyl and dodecyl); preservatives from 0.001 to 10.0 - methyl parahydroxybenzoate, propyl parahydroxybenzoate; butyl parahydroxybenzoate, sorbic acid, benzoic acid, polyvinylbutyl ester.

The formulations are stable and administered in the form of intramammary syringes that provide good penetration into the mammary gland.

Examples of implementation of the utility model

The following examples illustrate the effect of a utility model, but should not be construed as limiting it in any way.

The component compositions of natural products for the treatment of mastitis in cows are described in Examples 1 to 6.

The sequence of technological operations is as follows:

1. Carriers and surfactants melt at 70-80 ° C.

2. To the mixture of item 1, with continuous stirring, antioxidants and preservatives are added.

3. The mixture of item 2 is cooled to a temperature of 40-60 ° C and vitamins are added to it with continuous stirring.

4. To the mixture of item 3, with continuous stirring, are added the natural products which are previously characterized and standardized with respect to the biologically active substances incorporated therein by gas chromatography.

5. The resulting compositions are dosed in 10 g intermam syringes and stored at room temperature.

Depending on the type and severity of mastitis, treatment is individually tailored and one of the following compositions is administered.

EXAMPLE 1:

Composition

Natural product

Vitamin A (palmitate, acetate, propionate) Vitamin E acetate

Surfactants Antioxidant

Preservative

Beeswax

Quantity,

I ___% I

L ^ 0-20.0

0,0001- 0,1 0,001-1,00 j 0,2 -10,0 '_ W ^{1/0' 5} 0,001- 10,0 ί '' θ ^{"5 '0} _ ¹

Vegetable oil (sunflower, olive, sesame, soy) up to 100

1452 Ul

EXAMPLE 2:

Composition Quantity,% A combination of natural products 1,0-20,0 Vitamin A (palmitate, acetate, propionate) 0,0001-0,1 Vitamin E acetate 0,001-1,00 Surfactants 0.2 -10.0 Antioxidant 0.001- 0.5 Preservative 0,001-10,0 Beeswax 1,0-5,0

up to 100

Vegetable oil (sunflower, olive, sesame, soy)

EXAMPLE 3: Composition Quantity, % Natural product 1.0 - 20.0 Vitamin A (palmitate, acetate, propionate) 0.0001- 0.1 Vitamin E acetate 0,001-1,00 Surfactants 0.2 -10.0 Antioxidant 0.001- 0.5 Preservative 0,001-10,0 Polyethylene glycol 1000 1,0-10,0 Polyethylene glycol 400 up to 100

EXAMPLE 4:

Composition Quantity, % A combination of natural products 1,0-20,0 Vitamin A (palmitate, acetate, propionate) 0,0001-0,1 Vitamin E acetate 0.001- 1.00 Surfactants 0,2-10,0 Antioxidant 0,001-0,5 Preservative 0,001-10,0 Polyethylene glycol 1000 1,0-10,0 Polyethylene glycol 400 K100

1452 Sh

EXAMPLE 5:

Composition

Natural product ____

Vitamin A (palmitate, acetate, propionate) Vitamin E acetate

Surfactants

Antioxidant

Preservative

Petroleum jelly, petroleum jelly

Liquid paraffin ^P Quantity,]

J __________......_ i

1,0-20,0

0.0001 - 0J_ £ 0.001 -1.00 0.2-10.0;

0.001- 0.5 ο, οοι- ιο, ο;

1.0-10.0 to 100

EXAMPLE 6:

<Composition ί

A combination of natural products

Vitamin A (palmitate, acetate, propionate)

Vitamin E acetate

Surfactants! Antioxidant

Preservative

Petroleum jelly, petroleum jelly

I Liquid paraffin

Quantity,%

1,0-20,0

0.0001 - 0.1

0.001 -1.00

0.2 -10.0

0.001- 0.5

0,001-10,0

1.0-10.0 to 100

The results of in vitro microbiological studies to determine the minimum inhibitory concentrations of MIC (required 40 smoke test for complex evaluation of antimicrobial action) on terrestrial pathogenic strains of microorganisms such as Staphylococcus aureus, Streptococcus uberis, Streptococcus escalactia etc. isolated from the mammary gland of mastically ill cows with the described compositions in Examples 1 to 6, it is reasonable to conclude that the compositions used exhibit pronounced antibacterial activity. 50

Claims (6)

Claims Composition of natural mastitis treatment products, characterized in that it contains by weight. %: natural product of Matricaria chamomilla L., Melaleuca altemifolia, Melissa officinalis L., Mentha piperita L., Thymus serpilum L., Origanum vulgaris L., Lavandula angustifoliaMill., Rosmarinus officinalis L., Citrus grandis, Juniperus communis L., Salvia officinalis L., Pimpinella anisum L., Rosa damascena Mill., Cledula officinalis L., Achillea millefolium L., equated to the activity of biologically active substances, alone or in combination from 0.1 to 20.0; carriers - vegetable fats, waxes and mineral oils from 1.0 to 98.0; surfactants from 0.2 to 10.0; vitamins from 0.0001 to 1.0; antioxidants from 0.001 5 to 0.05; preservatives from 0.001 to 10.0. Composition of natural mastitis treatment products according to claim 1, characterized in that vegetable fats are used as carriers - sunflower oil, 10 linseed oil, sesame oil, soybean oil, coconut oil, palm oil, waxes and mineral oils - white petrolatum, liquid paraffin, hard paraffin, white beeswax, yellow beeswax, cetyl alcohol, stearic alcohol, prop-15 lenglycol, glycerolformal, polyethylene glycols - 400, 1000, 1500 or 4000. Composition of natural mastitis treatment products according to claim 1, characterized in that polysorbate 80, macrogolglycerol ricinoleates, macrogolglycerol hydroxystearates, lanolin are used as surfactants. Composition of natural mastitis treatment products according to claim 1, characterized in that vitamin A, vitamin E. are used as vitamins. Composition of natural mastitis treatment products according to claim 1, characterized in that butyl hydroxytoluene, butyl hydroxyanisole, ascorbic acid esters, gallic acid esters are used as antioxidants. Composition of natural mastitis treatment products according to claim 1, characterized in that methyl parahydroxybenzoate, propyl parahydroxybenzoate, butyl parahydroxybenzoate, sorbic acid, benzoic acid, polyvinylbutyl ester are used as preservatives. Literature 1. US 7078062. 2. Patent Application Publication 2003 / US 0113385 Al. 3. US 5061491. 4. U.S. 5846543.