BG108165A - Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone - Google Patents

Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone

Info

Publication number
BG108165A
BG108165A BG108165A BG10816503A BG108165A BG 108165 A BG108165 A BG 108165A BG 108165 A BG108165 A BG 108165A BG 10816503 A BG10816503 A BG 10816503A BG 108165 A BG108165 A BG 108165A
Authority
BG
Bulgaria
Prior art keywords
gonadotropin
isoquinoline
antagonists
quinoline
releasing hormone
Prior art date
Application number
BG108165A
Other languages
Bulgarian (bg)
Inventor
Peter Strehlke
Peter Droescher
Ulrich Buehmann
Norbert Schmees
Peter Muhn
Holger Hess-Stumpp
Roland Kuehne
Eckhard Guenther
Emmanuel Polymeropoulos
Antonius M. Ter Laak
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2001108271 external-priority patent/DE10108271A1/en
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of BG108165A publication Critical patent/BG108165A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

Abstract

The invention relates to novel quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone.
BG108165A 2001-02-21 2003-09-09 Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone BG108165A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2001108271 DE10108271A1 (en) 2001-02-21 2001-02-21 New oxo substituted quinoline, isoquinoline and phthalazine derivatives useful as GnRH antagonists in male fertility control, female infertility and contraception and tumor control
US27491401P 2001-03-13 2001-03-13
PCT/EP2002/001882 WO2002066437A1 (en) 2001-02-21 2002-02-21 Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone

Publications (1)

Publication Number Publication Date
BG108165A true BG108165A (en) 2004-08-31

Family

ID=26008581

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108165A BG108165A (en) 2001-02-21 2003-09-09 Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone

Country Status (17)

Country Link
EP (1) EP1362034A1 (en)
JP (1) JP2004528298A (en)
CN (1) CN1496354A (en)
AU (1) AU2002247737B2 (en)
BG (1) BG108165A (en)
BR (1) BR0207451A (en)
CA (1) CA2438709A1 (en)
CZ (1) CZ20032514A3 (en)
HU (1) HUP0303219A2 (en)
IL (1) IL157303A0 (en)
MX (1) MXPA03007348A (en)
NO (1) NO325675B1 (en)
NZ (1) NZ527597A (en)
PL (1) PL367285A1 (en)
RU (1) RU2280031C2 (en)
SK (1) SK11622003A3 (en)
WO (1) WO2002066437A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015023328A2 (en) * 2013-03-13 2017-07-18 Flatley Discovery Lab pyridazinone compounds and methods for treating cystic fibrosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0876349B1 (en) * 1995-10-19 2002-09-11 Takeda Chemical Industries, Ltd. Quinoline derivatives as gnrh antagonists
CA2254974A1 (en) * 1996-05-20 1997-11-27 Mark Goulet Antagonists of gonadotropin releasing hormone

Also Published As

Publication number Publication date
NO20033698D0 (en) 2003-08-20
SK11622003A3 (en) 2004-01-08
PL367285A1 (en) 2005-02-21
RU2280031C2 (en) 2006-07-20
AU2002247737B2 (en) 2006-05-18
CA2438709A1 (en) 2002-08-29
CZ20032514A3 (en) 2004-05-12
IL157303A0 (en) 2004-02-19
BR0207451A (en) 2004-06-01
NZ527597A (en) 2004-10-29
JP2004528298A (en) 2004-09-16
MXPA03007348A (en) 2003-12-04
WO2002066437A1 (en) 2002-08-29
CN1496354A (en) 2004-05-12
NO20033698L (en) 2003-10-20
NO325675B1 (en) 2008-07-07
EP1362034A1 (en) 2003-11-19
HUP0303219A2 (en) 2003-12-29
RU2003128647A (en) 2005-03-27

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