BG102535A - Dihydrate of (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate of 4,10 beta-diacetoxy-2 alpha-benzoyloxy-5 beta, 20-epoxy-1-hydroxy-9-oxo-19-nor-cyclopropa[g]tax-11-ene 13-alpha -yl and method for its preparaton - Google Patents

Dihydrate of (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate of 4,10 beta-diacetoxy-2 alpha-benzoyloxy-5 beta, 20-epoxy-1-hydroxy-9-oxo-19-nor-cyclopropa[g]tax-11-ene 13-alpha -yl and method for its preparaton

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Publication number
BG102535A
BG102535A BG102535A BG10253598A BG102535A BG 102535 A BG102535 A BG 102535A BG 102535 A BG102535 A BG 102535A BG 10253598 A BG10253598 A BG 10253598A BG 102535 A BG102535 A BG 102535A
Authority
BG
Bulgaria
Prior art keywords
beta
alpha
hydroxy
cyclopropa
preparaton
Prior art date
Application number
BG102535A
Other languages
Bulgarian (bg)
Other versions
BG63010B1 (en
Inventor
Eric Didier
Michel Lavigne
Jean-Rene Authelin
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9485512&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG102535(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of BG102535A publication Critical patent/BG102535A/en
Publication of BG63010B1 publication Critical patent/BG63010B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The compound is produced by its cystallization fromaqueous-alcoholic or aqueous-acetonic solution.6 claims
BG102535A 1995-12-14 1998-06-12 Dihydrate of (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate of 4,10-beta-diacetoxy-2-alpha-benzoyloxy-5-beta, 20-epoxy-1-hydroxy-9-oxo-19-nor-cyclopropa[g]tax-11-en13-alpha -yl and method for its preparaton BG63010B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9514841A FR2742438B1 (en) 1995-12-14 1995-12-14 (2R, 3S) DIHYDRATE -3-TERT-BUTOXYCARBONYLAMINO-2-HYDROXY- 3-PHENYLPROPIONATE OF 4,10BETA-DIACETOXY-2ALPHA-BENZOYLOXY- 5BETA, 2O-EPOXY-1-HYDROX CYCLOPROPA (G) TAX-11- ENE-13ALPHA-YLE, AND PREPARATION METHOD THEREOF
PCT/FR1996/001957 WO1997021695A1 (en) 1995-12-14 1996-12-09 4,10β-DIACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1-HYDROXY-9-OXO-19-NOR-CYCLOPROPA[G]TAX-11-ENE-13α-YL (2R,3S)-TERT-BUTOXYCARBONYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DIHYDRATE, AND METHOD FOR PREPARING SAME

Publications (2)

Publication Number Publication Date
BG102535A true BG102535A (en) 1999-08-31
BG63010B1 BG63010B1 (en) 2001-01-31

Family

ID=9485512

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102535A BG63010B1 (en) 1995-12-14 1998-06-12 Dihydrate of (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate of 4,10-beta-diacetoxy-2-alpha-benzoyloxy-5-beta, 20-epoxy-1-hydroxy-9-oxo-19-nor-cyclopropa[g]tax-11-en13-alpha -yl and method for its preparaton

Country Status (37)

Country Link
EP (1) EP0876361B1 (en)
JP (1) JP4059351B2 (en)
KR (1) KR100429330B1 (en)
CN (1) CN101113143A (en)
AR (1) AR004380A1 (en)
AT (1) ATE204573T1 (en)
AU (1) AU713086C (en)
BG (1) BG63010B1 (en)
BR (1) BR9611957A (en)
CA (1) CA2236545C (en)
CO (1) CO4810227A1 (en)
CZ (1) CZ288998B6 (en)
DE (1) DE69614716T2 (en)
DK (1) DK0876361T3 (en)
DZ (1) DZ2140A1 (en)
EA (1) EA000668B1 (en)
ES (1) ES2162123T3 (en)
FR (1) FR2742438B1 (en)
GR (1) GR3036437T3 (en)
HU (1) HU224962B1 (en)
IL (1) IL124766A (en)
IN (1) IN185809B (en)
MY (1) MY115886A (en)
NO (1) NO317356B1 (en)
NZ (1) NZ323964A (en)
OA (1) OA11012A (en)
PL (1) PL187613B1 (en)
PT (1) PT876361E (en)
RO (1) RO115880B1 (en)
SK (1) SK282512B6 (en)
TN (1) TNSN96157A1 (en)
TR (1) TR199801087T2 (en)
TW (1) TW358093B (en)
UA (1) UA55401C2 (en)
UY (1) UY24387A1 (en)
WO (1) WO1997021695A1 (en)
ZA (1) ZA9610200B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102851740A (en) * 2011-06-30 2013-01-02 复旦大学 Fluorinated docetaxel crystal and its preparation method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2698871B1 (en) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa New taxoids, their preparation and the pharmaceutical compositions containing them.

Also Published As

Publication number Publication date
DZ2140A1 (en) 2002-07-23
BR9611957A (en) 1999-02-17
IN185809B (en) 2001-05-05
AU713086B2 (en) 1999-11-25
AU713086C (en) 2002-09-19
DE69614716T2 (en) 2002-06-27
CZ288998B6 (en) 2001-10-17
OA11012A (en) 2003-03-06
UY24387A1 (en) 2001-08-27
EA199800452A1 (en) 1998-12-24
ES2162123T3 (en) 2001-12-16
PT876361E (en) 2001-11-30
AR004380A1 (en) 1998-11-04
EP0876361A1 (en) 1998-11-11
NO982561D0 (en) 1998-06-04
ZA9610200B (en) 1997-06-23
PL327451A1 (en) 1998-12-07
JP2000501722A (en) 2000-02-15
TNSN96157A1 (en) 2005-03-15
DE69614716D1 (en) 2001-09-27
NO317356B1 (en) 2004-10-18
DK0876361T3 (en) 2001-10-08
FR2742438B1 (en) 1998-01-16
IL124766A (en) 2001-03-19
WO1997021695A1 (en) 1997-06-19
MX9804604A (en) 1998-10-31
CO4810227A1 (en) 1999-06-30
JP4059351B2 (en) 2008-03-12
RO115880B1 (en) 2000-07-28
KR100429330B1 (en) 2005-01-13
NO982561L (en) 1998-06-04
HU224962B1 (en) 2006-04-28
FR2742438A1 (en) 1997-06-20
EP0876361B1 (en) 2001-08-22
CZ183098A3 (en) 1998-09-16
UA55401C2 (en) 2003-04-15
ATE204573T1 (en) 2001-09-15
SK282512B6 (en) 2002-10-08
EA000668B1 (en) 2000-02-28
TW358093B (en) 1999-05-11
HUP9904048A3 (en) 2001-08-28
SK79098A3 (en) 1998-11-04
CA2236545A1 (en) 1997-06-19
NZ323964A (en) 2000-01-28
CN101113143A (en) 2008-01-30
PL187613B1 (en) 2004-08-31
KR19990072107A (en) 1999-09-27
TR199801087T2 (en) 1998-09-21
BG63010B1 (en) 2001-01-31
GR3036437T3 (en) 2001-11-30
IL124766A0 (en) 1999-01-26
MY115886A (en) 2003-09-30
AU1101397A (en) 1997-07-03
HUP9904048A1 (en) 2001-04-28
CA2236545C (en) 2007-01-30

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