BG101602A - Pharmaceutical piperazine compounds - Google Patents

Pharmaceutical piperazine compounds

Info

Publication number
BG101602A
BG101602A BG101602A BG10160297A BG101602A BG 101602 A BG101602 A BG 101602A BG 101602 A BG101602 A BG 101602A BG 10160297 A BG10160297 A BG 10160297A BG 101602 A BG101602 A BG 101602A
Authority
BG
Bulgaria
Prior art keywords
group
value
nco2r11
c6alkyl
alkenyl
Prior art date
Application number
BG101602A
Other languages
Bulgarian (bg)
Inventor
Philip ASHWORTH
Sukhjit Hunjan
Ian PRETSWELL
Hamish Rider
Stephen Brocchini
Original Assignee
Xenova Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenova Limited filed Critical Xenova Limited
Publication of BG101602A publication Critical patent/BG101602A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to piperazine derivatives having theformulawhere R1 is (I) groupwhere p has the value of 0 or 2; each of Ra to Re can be the sameor different and is individually selected from hydrogen, C1-C6alkyl, unsubstituted or substituted by one or more halogen atoms,C2-C6 alkenyl, C1-C6 alkoxy, C1-C6 alkylthio, halogen, nitro,optionally substituted phenyl, cyano, -CH2OH, -CH2COOH, -CO2R11, -NHCOR11, -NHSO2R13, -SO2R13, -CON(R11R12), -SOR13, -SO2N(R11R12),N(R11R12), -O(CH2)nN(R11R12), -O(CH2)nCO2R11, -OCOR11, -CH2OCOR11,-CH2NHCOR11, -CH2NHCOOR13, -CH2SR11, -CH2SOR11, -CH2S(0)mR13 wherem has the value of 1 or 2, -CH2NHCO(CH2)nOCO2R11, N(R11)COR12,-NHCOCF3, -NHCO(CH2)nCO2R11, -NHCO(CO2)nOCOR11 andNHCO(CH2)nCO2R11, where n has the value from 1 to 6, every one ofR11 and R12 is separately hydrogen or C1-C6 alkyl and R13 is C1-C6alkyl; or each of Ra an Rb, Rb and Rc, Rc and Rd and Rd and Retogether form methyleneoxygroup or together with carbon atoms towhich they are bound form a benzyl nucleus which optionally issubstituted; (II) 5- or 6-member heterocyclic group containing atleast one heteroatom selected from O,N and S which group can bebound by benzene nucleus; (III) C1-C6 alkyl group or C5-C7cycloalkyl group; or (IV) C5-C7 cycloalkanyl which isunsubstituted or substituted by C2-C6 alkenyl; R2 meaning H, C1-C6alkyl, optionally substituted by group -N(R11R12) as definedabove, C3-C6 cycloalkyl, C2-C6 alkenyl, -COOR11 where R11 isdefined above, or phenyl group (I) but different from hydrogenwhen R1 is unsubstituted phenyl; and one of R3 and R4 is hydrogenand the other is a group with formulawhere q has the value from 1 to 4, r is 0 or 1, and R5 & R6 whichcan be the same or different are each hydrogen or C1-C6 alkoxy orR5 & R6 togehter form methyleneoxygroup; and ---- is double bondor when R1 is defined as (I), being double or single bond; or to apharmaceutically acceptable salt thereof, as modulator ofpolymedicamentous resistence.
BG101602A 1994-12-23 1997-06-11 Pharmaceutical piperazine compounds BG101602A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9426224.3A GB9426224D0 (en) 1994-12-23 1994-12-23 Pharmaceutical compounds
PCT/GB1995/003027 WO1996020190A1 (en) 1994-12-23 1995-12-22 Piperazine 2,5 dione derivatives as modulators of multi-drug resistance

Publications (1)

Publication Number Publication Date
BG101602A true BG101602A (en) 1998-02-27

Family

ID=10766589

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101602A BG101602A (en) 1994-12-23 1997-06-11 Pharmaceutical piperazine compounds

Country Status (19)

Country Link
EP (1) EP0799222A1 (en)
JP (1) JPH10511384A (en)
CN (1) CN1175253A (en)
AU (1) AU698828B2 (en)
BG (1) BG101602A (en)
BR (1) BR9510410A (en)
CA (1) CA2207500A1 (en)
CZ (1) CZ190097A3 (en)
FI (1) FI972660A (en)
GB (1) GB9426224D0 (en)
HU (1) HUT77943A (en)
IL (1) IL116525A0 (en)
NO (1) NO972937D0 (en)
NZ (1) NZ297847A (en)
PL (1) PL320916A1 (en)
SK (1) SK83697A3 (en)
TW (1) TW358094B (en)
WO (1) WO1996020190A1 (en)
ZA (1) ZA9510909B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100354265C (en) * 1996-10-18 2007-12-12 埃克森诺瓦有限公司 Pharmaceutical compounds
GB9717576D0 (en) * 1997-08-19 1997-10-22 Xenova Ltd Pharmaceutical compounds
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
ES2255311T3 (en) 1998-10-08 2006-06-16 Smithkline Beecham Plc USEFUL TETRAHYDROBENZAZEPIN DERIVATIVES AS MODULATORS OF D3 DOPAMINE RECEPTORS (ANTI-PSYCHOTIC AGENTS).
IL150430A0 (en) * 2000-01-18 2002-12-01 Nereus Pharmaceuticals Inc Cell division inhibitors and process for producing the same
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US7919497B2 (en) 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
US7935704B2 (en) 2003-08-01 2011-05-03 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
ES2295695T3 (en) 2002-08-02 2008-04-16 Nereus Pharmaceuticals, Inc. DEHYDROPHENYLHYSINAS AND ITS ANALOGS AND THE SYNTHESIS OF DEHYDROPHENYLHYTHINES AND THEIR ANALOGS.
US8129527B2 (en) 2006-11-03 2012-03-06 Nereus Pharmacuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
CN103396372B (en) * 2013-08-09 2015-05-20 中国科学院南海海洋研究所 2,5-diketopiperazine derivative, as well as preparation method and application thereof in preparing control agent for resisting marine fouling organisms
MX2017011374A (en) 2015-03-06 2018-01-23 Beyondspring Pharmaceuticals Inc Method of treating cancer associated with a ras mutation.
WO2016144636A1 (en) 2015-03-06 2016-09-15 Beyondspring Pharmaceuticals, Inc. Method of treating a brain tumor
CN109516981B (en) 2015-07-13 2019-10-22 大连万春布林医药有限公司 Pune's cloth woods composition
KR20180105685A (en) 2016-02-08 2018-09-28 비욘드스프링 파마수티컬스, 인코포레이티드. Composition containing tucaresol or analog thereof
KR20190015361A (en) 2016-06-06 2019-02-13 비욘드스프링 파마수티컬스, 인코포레이티드. Compositions and methods for reducing neutropenia
JP2020503363A (en) 2017-01-06 2020-01-30 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド Tubulin binding compounds and their therapeutic use
CA3052190A1 (en) 2017-02-01 2018-08-09 Beyondspring Pharmaceuticals, Inc. Method of reducing neutropenia
CA3089226A1 (en) 2018-01-24 2019-08-01 Beyondspring Pharmaceuticals, Inc. Composition and method for reducing thrombocytopenia via the administration of plinabulin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001408A1 (en) * 1992-07-10 1994-01-20 Laboratoires Glaxo S.A. Anilide derivatives
GB9217331D0 (en) * 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
CZ190097A3 (en) 1998-01-14
CN1175253A (en) 1998-03-04
BR9510410A (en) 1999-09-08
PL320916A1 (en) 1997-11-10
CA2207500A1 (en) 1996-07-04
NZ297847A (en) 1999-04-29
GB9426224D0 (en) 1995-02-22
NO972937L (en) 1997-06-23
WO1996020190A1 (en) 1996-07-04
AU698828B2 (en) 1998-11-05
EP0799222A1 (en) 1997-10-08
HUT77943A (en) 1998-12-28
TW358094B (en) 1999-05-11
AU4310096A (en) 1996-07-19
SK83697A3 (en) 1998-05-06
JPH10511384A (en) 1998-11-04
ZA9510909B (en) 1996-08-30
FI972660A0 (en) 1997-06-19
FI972660A (en) 1997-08-22
NO972937D0 (en) 1997-06-23
IL116525A0 (en) 1996-03-31

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