AU4310096A - Piperazine 2,5 dione derivatives as modulators of multi-drug resistance - Google Patents
Piperazine 2,5 dione derivatives as modulators of multi-drug resistanceInfo
- Publication number
- AU4310096A AU4310096A AU43100/96A AU4310096A AU4310096A AU 4310096 A AU4310096 A AU 4310096A AU 43100/96 A AU43100/96 A AU 43100/96A AU 4310096 A AU4310096 A AU 4310096A AU 4310096 A AU4310096 A AU 4310096A
- Authority
- AU
- Australia
- Prior art keywords
- modulators
- piperazine
- drug resistance
- dione derivatives
- dione
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9426224 | 1994-12-23 | ||
| GBGB9426224.3A GB9426224D0 (en) | 1994-12-23 | 1994-12-23 | Pharmaceutical compounds |
| PCT/GB1995/003027 WO1996020190A1 (en) | 1994-12-23 | 1995-12-22 | Piperazine 2,5 dione derivatives as modulators of multi-drug resistance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU4310096A true AU4310096A (en) | 1996-07-19 |
| AU698828B2 AU698828B2 (en) | 1998-11-05 |
Family
ID=10766589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU43100/96A Ceased AU698828B2 (en) | 1994-12-23 | 1995-12-22 | Piperazine 2,5 dione derivatives as modulators of multi-drug resistance |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0799222A1 (en) |
| JP (1) | JPH10511384A (en) |
| CN (1) | CN1175253A (en) |
| AU (1) | AU698828B2 (en) |
| BG (1) | BG101602A (en) |
| BR (1) | BR9510410A (en) |
| CA (1) | CA2207500A1 (en) |
| CZ (1) | CZ190097A3 (en) |
| FI (1) | FI972660A (en) |
| GB (1) | GB9426224D0 (en) |
| HU (1) | HUT77943A (en) |
| IL (1) | IL116525A0 (en) |
| NO (1) | NO972937L (en) |
| NZ (1) | NZ297847A (en) |
| PL (1) | PL320916A1 (en) |
| SK (1) | SK83697A3 (en) |
| TW (1) | TW358094B (en) |
| WO (1) | WO1996020190A1 (en) |
| ZA (1) | ZA9510909B (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0001531A3 (en) * | 1996-10-18 | 2000-09-28 | Xenova Ltd Slough | Anthranilic acid derivatives as multi drug resistance modulators |
| GB9717576D0 (en) * | 1997-08-19 | 1997-10-22 | Xenova Ltd | Pharmaceutical compounds |
| GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| ATE316969T1 (en) | 1998-10-08 | 2006-02-15 | Smithkline Beecham Plc | TETRAHYDROBENZAZEPINE DERIVATIVES USABLE AS DOPAMINE D3 RECEPTOR MODULATORS (ANTIPSYCHOTIC AGENTS) |
| CA2403790C (en) * | 2000-01-18 | 2011-09-27 | Nereus Pharmaceuticals, Inc. | A cell division inhibitor and a production method thereof |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| BRPI0313363A8 (en) | 2002-08-02 | 2019-01-02 | Beyondspring Pharmaceuticals Inc | dehydrophenylhistines and their analogues, and their synthesis |
| US7935704B2 (en) | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| US8129527B2 (en) | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| CN103396372B (en) * | 2013-08-09 | 2015-05-20 | 中国科学院南海海洋研究所 | 2,5-diketopiperazine derivative, as well as preparation method and application thereof in preparing control agent for resisting marine fouling organisms |
| EP3265091A4 (en) | 2015-03-06 | 2018-08-01 | Beyondspring Pharmaceuticals Inc. | Method of treating a brain tumor |
| JP6769982B2 (en) | 2015-03-06 | 2020-10-14 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | How to treat cancer associated with RAS mutations |
| ES2910035T3 (en) | 2015-07-13 | 2022-05-11 | Beyondspring Pharmaceuticals Inc | Plinabulin Compositions |
| CA3013467A1 (en) | 2016-02-08 | 2017-08-17 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
| CN109475524A (en) | 2016-06-06 | 2019-03-15 | 万春药业公司 | For reducing the composition and method of neutrophilic granulocytopenia |
| US11633393B2 (en) | 2017-01-06 | 2023-04-25 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
| US11400086B2 (en) | 2017-02-01 | 2022-08-02 | Beyondspring Pharmaceuticals, Inc. | Method of reducing chemotherapy-induced neutropenia |
| JP7350015B2 (en) | 2018-01-24 | 2023-09-25 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | Compositions and methods for reducing thrombocytopenia due to administration of plinabulin |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2718830B2 (en) * | 1992-07-10 | 1998-02-25 | ラボラトワール、グラクソ、ソシエテ、アノニム | Anilide derivative |
| GB9217331D0 (en) * | 1992-08-14 | 1992-09-30 | Xenova Ltd | Pharmaceutical compounds |
-
1994
- 1994-12-23 GB GBGB9426224.3A patent/GB9426224D0/en active Pending
-
1995
- 1995-12-21 ZA ZA9510909A patent/ZA9510909B/en unknown
- 1995-12-22 AU AU43100/96A patent/AU698828B2/en not_active Ceased
- 1995-12-22 CN CN95197672A patent/CN1175253A/en active Pending
- 1995-12-22 CZ CZ971900A patent/CZ190097A3/en unknown
- 1995-12-22 JP JP8520301A patent/JPH10511384A/en active Pending
- 1995-12-22 CA CA002207500A patent/CA2207500A1/en not_active Abandoned
- 1995-12-22 NZ NZ297847A patent/NZ297847A/en unknown
- 1995-12-22 PL PL95320916A patent/PL320916A1/en unknown
- 1995-12-22 IL IL11652595A patent/IL116525A0/en unknown
- 1995-12-22 SK SK836-97A patent/SK83697A3/en unknown
- 1995-12-22 WO PCT/GB1995/003027 patent/WO1996020190A1/en not_active Application Discontinuation
- 1995-12-22 BR BR9510410-0A patent/BR9510410A/en not_active Application Discontinuation
- 1995-12-22 EP EP95941797A patent/EP0799222A1/en not_active Withdrawn
- 1995-12-22 HU HU9800398A patent/HUT77943A/en unknown
- 1995-12-23 TW TW084113836A patent/TW358094B/en active
-
1997
- 1997-06-11 BG BG101602A patent/BG101602A/en unknown
- 1997-06-19 FI FI972660A patent/FI972660A/en unknown
- 1997-06-23 NO NO972937A patent/NO972937L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL320916A1 (en) | 1997-11-10 |
| NZ297847A (en) | 1999-04-29 |
| FI972660A0 (en) | 1997-06-19 |
| NO972937D0 (en) | 1997-06-23 |
| CN1175253A (en) | 1998-03-04 |
| IL116525A0 (en) | 1996-03-31 |
| BG101602A (en) | 1998-02-27 |
| TW358094B (en) | 1999-05-11 |
| WO1996020190A1 (en) | 1996-07-04 |
| EP0799222A1 (en) | 1997-10-08 |
| NO972937L (en) | 1997-06-23 |
| FI972660A (en) | 1997-08-22 |
| JPH10511384A (en) | 1998-11-04 |
| AU698828B2 (en) | 1998-11-05 |
| GB9426224D0 (en) | 1995-02-22 |
| ZA9510909B (en) | 1996-08-30 |
| HUT77943A (en) | 1998-12-28 |
| BR9510410A (en) | 1999-09-08 |
| CZ190097A3 (en) | 1998-01-14 |
| SK83697A3 (en) | 1998-05-06 |
| CA2207500A1 (en) | 1996-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |