BE902611A - DERIVATIVES OF 4, 5, 6, 7-TETRAHYDROIMIDAZO 4, 5-C PYRIDINE. - Google Patents

DERIVATIVES OF 4, 5, 6, 7-TETRAHYDROIMIDAZO 4, 5-C PYRIDINE.

Info

Publication number
BE902611A
BE902611A BE0/215149A BE215149A BE902611A BE 902611 A BE902611 A BE 902611A BE 0/215149 A BE0/215149 A BE 0/215149A BE 215149 A BE215149 A BE 215149A BE 902611 A BE902611 A BE 902611A
Authority
BE
Belgium
Prior art keywords
tetrahydroimidazo
pyridine
alkyl
derivatives
alkenyl
Prior art date
Application number
BE0/215149A
Other languages
French (fr)
Inventor
U Scarponi
R De Castiglione
A Verini
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE902611A publication Critical patent/BE902611A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Dérivé de 4,5,6,7-tétrahydroimidazo/ 4,5-c /pyridine exerçant une activité antivirale et répondant à la formule générale (I) : où R1 = H ; alcényle en C2-C4, alkyle en C2-C4, alkyle en C1-C4 ou benzyle; R2, R3 et R4 = H, alcényle en C2-C4, alkyle en C1-C4, cyclo-alkyle en C3-C7, phényle ou benzyle ; R6 et R7 = H, alcényle en C2-C4, alkyle en C1-C4, cycloalkyle en C3-C7, phényle ou benzyle ; R5 = -C (O)-R2, -C(O)-OR2, R2 ou C (Y)-NH-R6 ; Y = O ou S.Derivative of 4,5,6,7-tetrahydroimidazo / 4,5-c / pyridine exerting an antiviral activity and corresponding to the general formula (I): where R1 = H; C2-C4 alkenyl, C2-C4 alkyl, C1-C4 alkyl or benzyl; R2, R3 and R4 = H, C2-C4 alkenyl, C1-C4 alkyl, C3-C7 cycloalkyl, phenyl or benzyl; R6 and R7 = H, C2-C4 alkenyl, C1-C4 alkyl, C3-C7 cycloalkyl, phenyl or benzyl; R5 = -C (O) -R2, -C (O) -OR2, R2 or C (Y) -NH-R6; Y = O or S.

BE0/215149A 1985-01-22 1985-06-07 DERIVATIVES OF 4, 5, 6, 7-TETRAHYDROIMIDAZO 4, 5-C PYRIDINE. BE902611A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858501542A GB8501542D0 (en) 1985-01-22 1985-01-22 4 5 6 7-tetrahydro-imidazo(4 5-clpyridine derivatives

Publications (1)

Publication Number Publication Date
BE902611A true BE902611A (en) 1985-09-30

Family

ID=10573211

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215149A BE902611A (en) 1985-01-22 1985-06-07 DERIVATIVES OF 4, 5, 6, 7-TETRAHYDROIMIDAZO 4, 5-C PYRIDINE.

Country Status (4)

Country Link
JP (1) JPS61167687A (en)
BE (1) BE902611A (en)
DE (1) DE3521303A1 (en)
GB (2) GB8501542D0 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812462A (en) * 1986-04-01 1989-03-14 Warner-Lambert Company 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
US4816463A (en) * 1986-04-01 1989-03-28 Warner-Lambert Company Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002534511A (en) 1999-01-18 2002-10-15 ノボ ノルディスク アクティーゼルスカブ Substituted imidazoles, their preparation and use
US6908926B1 (en) 1999-04-16 2005-06-21 Novo Nordisk A/S Substituted imidazoles, their preparation and use
AU2002214505A1 (en) * 2000-11-09 2002-05-21 Biovitrum Ab New use of 4, 5, 6, 7-tetrahydroimidazo-(4,5-c)pyridine derivatives
GB0215293D0 (en) * 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
US7071355B2 (en) 2002-12-23 2006-07-04 4 Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
US7247736B2 (en) 2002-12-23 2007-07-24 4Sc Ag Method of identifying inhibitors of DHODH
US7365094B2 (en) 2002-12-23 2008-04-29 4Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
US20050222198A1 (en) * 2003-12-22 2005-10-06 K.U. Leuven Research & Development, Gerhard Puerstinger And Gilead Sciences, Inc. Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
JP5014129B2 (en) 2004-07-27 2012-08-29 ギリアード サイエンシーズ， インコーポレイテッド Imidazo [4,5-d] pyrimidines, their use and methods of preparation
EP1841765B1 (en) 2004-12-21 2009-03-25 Gilead Sciences, Inc. Imidazo[4,5-c]pyridine compound and method of antiviral treatment
US7754720B2 (en) 2006-07-07 2010-07-13 Gilead Sciences, Inc. Pyridazine compound and use thereof
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
AU2016291754A1 (en) * 2015-07-16 2018-02-08 Loma Linda University Compositions for preventing cancers associated with human papilloma viruses
CN108699059B (en) 2016-03-08 2021-06-18 诺华股份有限公司 Tricyclic compounds useful for treating orthomyxovirus infections
JOP20170169A1 (en) 2016-08-29 2019-01-30 Novartis Ag Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections
UA126253C2 (en) 2018-02-28 2022-09-07 Новартіс Аг 10-(di(phenyl)methyl)-4-hydroxy-8,9,9a,10-tetrahydro-7h-pyrrolo[1 ',2':4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812462A (en) * 1986-04-01 1989-03-14 Warner-Lambert Company 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
US4816463A (en) * 1986-04-01 1989-03-28 Warner-Lambert Company Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity

Also Published As

Publication number Publication date
GB2158440A (en) 1985-11-13
JPS61167687A (en) 1986-07-29
GB2158440B (en) 1988-06-02
GB8514278D0 (en) 1985-07-10
DE3521303A1 (en) 1985-10-31
GB8501542D0 (en) 1985-02-20

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FARMITALIA CARLO ERBA S.P.A.

Effective date: 19920630