BE902344A - ANTHRACYCLINE / ANIONIC POLYMER CONJUGATES. - Google Patents

ANTHRACYCLINE / ANIONIC POLYMER CONJUGATES.

Info

Publication number
BE902344A
BE902344A BE0/214956A BE214956A BE902344A BE 902344 A BE902344 A BE 902344A BE 0/214956 A BE0/214956 A BE 0/214956A BE 214956 A BE214956 A BE 214956A BE 902344 A BE902344 A BE 902344A
Authority
BE
Belgium
Prior art keywords
anionic polymer
anthracycline
polymer conjugates
new
products
Prior art date
Application number
BE0/214956A
Other languages
French (fr)
Inventor
F Zunino
R A Gambetta
S Penco
Original Assignee
Erba Farmitalia
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia, Ist Naz Stud Cura Dei Tumori filed Critical Erba Farmitalia
Publication of BE902344A publication Critical patent/BE902344A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Nouveaux produits conjugués de doxorubicine et de ses analogues avec un polymère anionique. Le polymère anionique utilisé est un copolymère de pyranne (cyclopolymère 1,2 régulièrement alterné d'éther divinylique et d'anhydride maléique, également connu sous l'appellation 'DVE-MA') sous sa forme polycarboxylate. La liaison des agents antitumeurs au polymère est effectuée par une liaison ester obtenue par substitution nucléophile sur leurs dérivés 14-bromo. Etant donné qu'ils sont libérés lentement 'in vivo', les nouveaux produits conjugués améliorent considérablement le comportement pharmacocinétique et l'efficacité thérapeutique des agents antitumeurs.New conjugated products of doxorubicin and its analogs with an anionic polymer. The anionic polymer used is a copolymer of pyran (cyclopolymer 1,2 regularly alternated with divinyl ether and maleic anhydride, also known under the name 'DVE-MA') in its polycarboxylate form. The binding of antitumor agents to the polymer is carried out by an ester bond obtained by nucleophilic substitution on their 14-bromo derivatives. Since they are released slowly 'in vivo', the new conjugate products considerably improve the pharmacokinetic behavior and the therapeutic efficacy of anti-tumor agents.

BE0/214956A 1984-05-25 1985-05-03 ANTHRACYCLINE / ANIONIC POLYMER CONJUGATES. BE902344A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848413464A GB8413464D0 (en) 1984-05-25 1984-05-25 Anthracycline-anionic polymer conjugates

Publications (1)

Publication Number Publication Date
BE902344A true BE902344A (en) 1985-09-02

Family

ID=10561522

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214956A BE902344A (en) 1984-05-25 1985-05-03 ANTHRACYCLINE / ANIONIC POLYMER CONJUGATES.

Country Status (4)

Country Link
JP (1) JPS6156128A (en)
BE (1) BE902344A (en)
DE (1) DE3515178A1 (en)
GB (2) GB8413464D0 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378456A (en) * 1993-03-25 1995-01-03 American Cyanamid Company Antitumor mitoxantrone polymeric compositions
EP0710689A2 (en) 1994-11-01 1996-05-08 American Cyanamid Company Polymeric antitumor agents

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU46858B (en) * 1987-03-11 1994-06-24 Farmitalia Carlo Erba S.R.L. PROCEDURE FOR OBTAINING IMMUNOGLOBULIN CONJUGATES
DE3853493T2 (en) * 1987-05-28 1995-07-27 Hiroshi Maeda Superoxide dismutase derivatives, process for their preparation and their use as medicines.
IT1230505B (en) * 1988-10-11 1991-10-25 Sicor Spa PROCEDURE FOR THE CONVERSION OF DAUNORUBICINA IN DOXORUBICINA.
EP0408019A3 (en) * 1989-07-12 1992-10-14 Union Carbide Chemicals And Plastics Company, Inc. Pharmaceutical active derivative delivery systems

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1602967A (en) * 1977-07-16 1981-11-18 Hercules Inc Reaction prodcut of methotrexate with divinyl ether and maleic anhydride copolymer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378456A (en) * 1993-03-25 1995-01-03 American Cyanamid Company Antitumor mitoxantrone polymeric compositions
EP0710689A2 (en) 1994-11-01 1996-05-08 American Cyanamid Company Polymeric antitumor agents

Also Published As

Publication number Publication date
DE3515178A1 (en) 1985-11-28
GB2158078B (en) 1987-09-16
JPS6156128A (en) 1986-03-20
GB8413464D0 (en) 1984-07-04
GB2158078A (en) 1985-11-06
GB8510222D0 (en) 1985-05-30

Similar Documents

Publication Publication Date Title
EP0495265B1 (en) Acid-labile linker molecules
MY104944A (en) Anthracycline immunoconjugates having a novel linker and methods for their production
AU611196B2 (en) Modified antibodies for enhanced clearance
US5010176A (en) Antibody-drug conjugates
BE902344A (en) ANTHRACYCLINE / ANIONIC POLYMER CONJUGATES.
JPS61243026A (en) Polymerizable drug and manufacture
DK0398305T3 (en) Anthracycline conjugate with a novel linker and methods of preparation thereof
JPH07149666A (en) Pro-prodrug, preparation and use thereof
WO1997012895A1 (en) Novel anthracycline compound derivatives and medicinal preparations containing the same
US5208323A (en) Coupling of an anti-tumor to an antibody using glutaraldehyde preactivated anti-tumor agent
Duncan N-(2-Hydroxypropyl) methacrylamide copolymer conjugates
Zunino et al. Poly (carboxylic acid) polymers as carriers for anthracyclines
GB1446536A (en) Pharmaceutically active compositions
Říhová et al. Action of polymeric prodrugs based on N-(2-hydroxypropyl)-methacrylamide copolymers. II. Body distribution and T-cell accumulation of free and polymer-bound [125I] daunomycin
Williamson et al. Trypanocidal activity of daunorubicin and related compounds
Takahashi et al. Isolation and hypoglycemic activity of saccharans A, B, C, D, E and F, glycans of Saccharum officinarum Stalks1
IL100218A (en) Anthracycline conjugates with acetalic linker their preparation and pharmaceutical compositions containing them
CA1252719A (en) METHOD FOR THE PREPARATION OF CONJUGATES OF ADENINE-9- .beta.-ARABINOFURANOSIDE 5' MONOPHOSPHATE WITH LACTOSAMINATED HUMAN ALBUMIN, THE CONJUGATES OBTAINED AND THERAPEUTICALLY ACTIVE COMPOSITION CONTAINING THEM
Dimitrijevic et al. Synthesis and characterization of N-(2-Hydroxypropyl)-methacrylamide (HPMA) copolymer-emetine conjugates
IL117564A (en) Pharmaceutical and diagnostic compositions containing lysine derivatives
Ogura et al. Induction of activated macrophages by IP injection of mitomycin C in rats and mice
Pagé et al. Daunorubicin-albumin copolymer targeting to phagocytic mouse leukemia cells in vitro and in vivo
WO1991001757A1 (en) Coupling of an anti-tumor to an antibody using glutaraldehyde preactivated anti-tumor agent

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FARMITALIA CARLO ERBA S.P.A.

Effective date: 19880531

Owner name: ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI T

Effective date: 19880531