BE901598A - ACTIVATOR OF PLASMINOGENE KYM. - Google Patents

ACTIVATOR OF PLASMINOGENE KYM.

Info

Publication number
BE901598A
BE901598A BE0/214409A BE214409A BE901598A BE 901598 A BE901598 A BE 901598A BE 0/214409 A BE0/214409 A BE 0/214409A BE 214409 A BE214409 A BE 214409A BE 901598 A BE901598 A BE 901598A
Authority
BE
Belgium
Prior art keywords
kym
plasminogene
activator
plasminogen activator
thrombi
Prior art date
Application number
BE0/214409A
Other languages
French (fr)
Inventor
M Imada
Y Yoshiyama
M Oda
Original Assignee
Meiji Milk Products Company Lt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Milk Products Company Lt filed Critical Meiji Milk Products Company Lt
Publication of BE901598A publication Critical patent/BE901598A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Activeur de plasminogène (désigné par PA-KYM) du type activeur de plasminogène tissulaire. On le prépare par culture de cellules mutantes KYM-A dérivées des cellules du rhabdomyosarcome humain. Il présente l'avantage sur l'urokinase de n'agir que sur les thrombus, sans provoquer d'hémorragies.Plasminogen activator (designated by PA-KYM) of the tissue plasminogen activator type. It is prepared by culturing KYM-A mutant cells derived from human rhabdomyosarcoma cells. It has the advantage on urokinase of acting only on thrombi, without causing hemorrhages.

BE0/214409A 1984-01-30 1985-01-29 ACTIVATOR OF PLASMINOGENE KYM. BE901598A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59013397A JPS60158115A (en) 1984-01-30 1984-01-30 Plasminogen-activator kym and its preparation

Publications (1)

Publication Number Publication Date
BE901598A true BE901598A (en) 1985-07-29

Family

ID=11831979

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214409A BE901598A (en) 1984-01-30 1985-01-29 ACTIVATOR OF PLASMINOGENE KYM.

Country Status (7)

Country Link
JP (1) JPS60158115A (en)
BE (1) BE901598A (en)
CA (1) CA1275062A (en)
DE (1) DE3502760A1 (en)
FR (1) FR2558848B1 (en)
GB (1) GB2153366B (en)
NL (1) NL8500132A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6427472A (en) * 1987-07-21 1989-01-30 Meiji Milk Prod Co Ltd Production of human tissue plasminogen activator and cell strain using therein

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3015699C2 (en) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Manufacture of a plasminogen activator
JPH0734743B2 (en) * 1979-11-13 1995-04-19 バスキユラー・ラボラトリー・インコーポレーテツド Plasminogen activator
NL8003402A (en) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw NEW PLASMINOGEN ACTIVATOR AND PHARMACEUTICAL PREPARATION WITH THROMBOLYTIC ACTION.
JPS5852634B2 (en) * 1980-12-05 1983-11-24 株式会社林原生物化学研究所 Production method of urokinase
IL63317A (en) * 1981-07-15 1985-05-31 Yeda Res & Dev Production of plasminogen activator
ZA831399B (en) * 1982-03-05 1984-02-29 Health Lab Service Board New fibrinolytic enzymes and methods for their production and pharmaceutical compositions containing them
JPS5913732A (en) * 1982-07-16 1984-01-24 Mitsui Toatsu Chem Inc Thrombolytic agent
JPS5951220A (en) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd Novel plasminogen-activator, its preparation and drug containing the same

Also Published As

Publication number Publication date
JPH0569506B2 (en) 1993-10-01
JPS60158115A (en) 1985-08-19
CA1275062A (en) 1990-10-09
GB2153366B (en) 1988-05-18
FR2558848A1 (en) 1985-08-02
GB8501532D0 (en) 1985-02-20
NL8500132A (en) 1985-08-16
DE3502760A1 (en) 1985-08-08
FR2558848B1 (en) 1989-06-09
GB2153366A (en) 1985-08-21

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: MEIJI MILK PRODUCTS CY LTD

Effective date: 19920131