BE900277A - Composes pour abaisser les taux lipidiques. - Google Patents
Composes pour abaisser les taux lipidiques.Info
- Publication number
- BE900277A BE900277A BE0/213430A BE213430A BE900277A BE 900277 A BE900277 A BE 900277A BE 0/213430 A BE0/213430 A BE 0/213430A BE 213430 A BE213430 A BE 213430A BE 900277 A BE900277 A BE 900277A
- Authority
- BE
- Belgium
- Prior art keywords
- compounds
- thioxomethyl
- methylglycine
- naphthalenyl
- methoxy
- Prior art date
Links
- 150000002632 lipids Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- GFPLMVUVCPPPGZ-UHFFFAOYSA-N 2-[(5-bromonaphthalene-1-carbothioyl)-methylamino]acetic acid Chemical compound C1=CC=C2C(C(=S)N(CC(O)=O)C)=CC=CC2=C1Br GFPLMVUVCPPPGZ-UHFFFAOYSA-N 0.000 abstract 1
- OYHVGICZORMMCH-UHFFFAOYSA-N 2-[[6-methoxy-5-(trifluoromethylsulfanyl)naphthalene-1-carbothioyl]-methylamino]acetic acid Chemical compound OC(=O)CN(C)C(=S)C1=CC=CC2=C(SC(F)(F)F)C(OC)=CC=C21 OYHVGICZORMMCH-UHFFFAOYSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- -1 salt hydroxide Chemical class 0.000 abstract 1
- LUBHDINQXIHVLS-UHFFFAOYSA-N tolrestat Chemical compound OC(=O)CN(C)C(=S)C1=CC=CC2=C(C(F)(F)F)C(OC)=CC=C21 LUBHDINQXIHVLS-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Utilisation, pour faire baisser les taux lipidiques chez un mammifère, d'un dérivé de N-naphtloyl-glycine comprenant la N-((5-(trifluorométhyl)-6-méthoxy-1-naphtalényl)thioxométhyl)-N-méthylglycine, la N-((5-bromo-1-naphtalényl)thioxométhyl)-N-méthylglycine, la N-((6-méthoxy-5-(trifluorométhylthio)-1-naphtalényl)thioxométhyl)-N-méthylglycine ou le sel interne hydroxyde de 5-hydroxy-2-(5-(trifluorométhyl)-6-méthoxy-1-napthtalényl)-3-méthylthiazolium,éventuellement associé à un autre principe actif.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/518,997 US4492706A (en) | 1983-08-01 | 1983-08-01 | Method of lowering lipid levels |
Publications (1)
Publication Number | Publication Date |
---|---|
BE900277A true BE900277A (fr) | 1985-02-01 |
Family
ID=24066357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/213430A BE900277A (fr) | 1983-08-01 | 1984-08-01 | Composes pour abaisser les taux lipidiques. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4492706A (fr) |
EP (1) | EP0132994B1 (fr) |
JP (1) | JPS6056920A (fr) |
AT (1) | ATE34661T1 (fr) |
BE (1) | BE900277A (fr) |
DE (1) | DE3428230A1 (fr) |
IT (1) | IT1206130B (fr) |
PH (1) | PH21601A (fr) |
ZA (1) | ZA845723B (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0310931A3 (fr) * | 1987-10-08 | 1990-10-03 | Ethyl Corporation | Nourriture pour volailles |
JPH01263367A (ja) * | 1988-04-14 | 1989-10-19 | Kajima Corp | ダイビングプール |
US4921710A (en) * | 1988-07-21 | 1990-05-01 | Iowa State University Research Foundation, Inc. | Method of converting cholesterol in food to coprostanol |
US5972685A (en) * | 1988-07-21 | 1999-10-26 | Iowa State University Research Foundation, Inc. | Oral administration of coprostanol producing microorganisms to humans to decrease plasma cholesterol concentration |
JP2551951Y2 (ja) * | 1990-09-18 | 1997-10-27 | 三菱自動車工業株式会社 | レーザ焼入処理した内面を有するシリンダ |
US5391551A (en) * | 1993-05-10 | 1995-02-21 | Pfizer Inc. | Method of lowering blood lipid levels |
US5674488A (en) * | 1994-10-07 | 1997-10-07 | Reich; John J. | Method for prevention and treatment of hyperchlolesterolemia by in vivo hydrogenation of cholesterol |
US6127367A (en) * | 1996-02-29 | 2000-10-03 | Pfizer, Inc. | Method of reducing tissue damage associated with non-cardiac ischemia |
WO1999034794A1 (fr) * | 1998-01-12 | 1999-07-15 | Lipogenics, Inc. | Procedes de traitement de la dyslipidemie diabetique au moyen de tocotrienols |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU544067B2 (en) * | 1981-03-02 | 1985-05-16 | Wyeth-Ayerst Canada Inc. | Thioamides and amides. treatment of diabetes |
CA1191156A (fr) * | 1981-10-15 | 1985-07-30 | Francesco Bellini | N-((6-(alcoxy inferieur)-5-(trifluoromethylthio)-1- naphtalenyl)-thioxomethyl)-n-(alcoyle interieur) glycines |
CA1176269A (fr) * | 1981-03-02 | 1984-10-16 | Kazimir Sestanj | Derives de n-naphtoylglycine |
US4446150A (en) * | 1982-09-21 | 1984-05-01 | Ayerst, Mckenna & Harrison, Inc. | Naphthalenylthiazole derivatives |
-
1983
- 1983-08-01 US US06/518,997 patent/US4492706A/en not_active Expired - Lifetime
-
1984
- 1984-07-19 AT AT84304919T patent/ATE34661T1/de not_active IP Right Cessation
- 1984-07-19 EP EP84304919A patent/EP0132994B1/fr not_active Expired
- 1984-07-24 ZA ZA845723A patent/ZA845723B/xx unknown
- 1984-07-31 DE DE3428230A patent/DE3428230A1/de not_active Withdrawn
- 1984-07-31 JP JP59162772A patent/JPS6056920A/ja active Pending
- 1984-08-01 PH PH31058A patent/PH21601A/en unknown
- 1984-08-01 IT IT8422178A patent/IT1206130B/it active
- 1984-08-01 BE BE0/213430A patent/BE900277A/fr not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE3428230A1 (de) | 1985-02-21 |
US4492706A (en) | 1985-01-08 |
IT8422178A0 (it) | 1984-08-01 |
EP0132994A1 (fr) | 1985-02-13 |
ZA845723B (en) | 1986-03-26 |
IT1206130B (it) | 1989-04-14 |
EP0132994B1 (fr) | 1988-06-01 |
PH21601A (en) | 1987-12-11 |
ATE34661T1 (de) | 1988-06-15 |
JPS6056920A (ja) | 1985-04-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: AMERICAN HOME PRODUCTS CORP. Effective date: 19890831 |