BE894860A - Therapeutique adjuvante par agent progestatif - Google Patents
Therapeutique adjuvante par agent progestatifInfo
- Publication number
- BE894860A BE894860A BE0/209365A BE209365A BE894860A BE 894860 A BE894860 A BE 894860A BE 0/209365 A BE0/209365 A BE 0/209365A BE 209365 A BE209365 A BE 209365A BE 894860 A BE894860 A BE 894860A
- Authority
- BE
- Belgium
- Prior art keywords
- admin
- dien
- acyloxy
- alpha
- breast cancer
- Prior art date
Links
- 206010006187 Breast cancer Diseases 0.000 title abstract 2
- 208000026310 Breast neoplasm Diseases 0.000 title abstract 2
- 125000004423 acyloxy group Chemical group 0.000 title 1
- -1 methyl pregna 4,6-dien Chemical compound 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- CKNOLMVLQUPVMU-XOMFLMSUSA-N Digitalin Natural products O(C)[C@H]1[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@@H]([C@H](O)C5)C5=CC(=O)OC5)CC4)CC3)CC2)[C@@H]1O CKNOLMVLQUPVMU-XOMFLMSUSA-N 0.000 abstract 1
- WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- CPFNIKYEDJFRAT-UHFFFAOYSA-N Strospasid Natural products OC1C(OC)C(O)C(C)OC1OC1CC(CCC2C3(CC(O)C(C3(C)CCC32)C=2COC(=O)C=2)O)C3(C)CC1 CPFNIKYEDJFRAT-UHFFFAOYSA-N 0.000 abstract 1
- CKNOLMVLQUPVMU-UHFFFAOYSA-N UNPD183315 Natural products O1C(C)C(OC2C(C(O)C(O)C(CO)O2)O)C(OC)C(O)C1OC(C1)CCC2(C)C1CCC(C1(CC3O)O)C2CCC1(C)C3C1=CC(=O)OC1 CKNOLMVLQUPVMU-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000005540 biological transmission Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- CKNOLMVLQUPVMU-YMMLYESFSA-N digitalin Chemical compound C1([C@@H]2[C@@]3(C)CC[C@H]4[C@H]([C@]3(C[C@@H]2O)O)CC[C@H]2[C@]4(C)CC[C@@H](C2)O[C@H]2[C@H](O)[C@H]([C@H]([C@@H](C)O2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)OC)=CC(=O)OC1 CKNOLMVLQUPVMU-YMMLYESFSA-N 0.000 abstract 1
- 229950004590 digitalin Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/719,558 US4370321A (en) | 1976-09-01 | 1976-09-01 | Progestational adjuvant therapy |
| AU89358/82A AU558559B2 (en) | 1976-09-01 | 1982-10-14 | Progestational adjuvant therapy |
| CA000413579A CA1205744A (en) | 1976-09-01 | 1982-10-15 | Progestational adjuvant therapy |
| FR8217377A FR2534476B1 (fr) | 1976-09-01 | 1982-10-18 | Complement prophylactique a base de 17a-acyloxy-6 methylpregna-4,6-diene-3,20-dione |
| JP57182210A JPS5973523A (ja) | 1976-09-01 | 1982-10-19 | 黄体ホルモン含有補助治療剤 |
| BE0/209365A BE894860A (fr) | 1976-09-01 | 1982-10-28 | Therapeutique adjuvante par agent progestatif |
| DE19823240044 DE3240044A1 (de) | 1976-09-01 | 1982-10-28 | Verwendung von 17(alpha)-acyloxy-6-methylpregna-4,6-dien-3,20-dionen zur bekaempfung von brustkrebs |
| GB08231069A GB2129297B (en) | 1976-09-01 | 1982-10-29 | Post-mastectomy treatment dosage units containing megestrol acetate |
| MY8231069A MY8800128A (en) | 1976-09-01 | 1988-12-30 | Preparation of post-masectomy treatment medicant |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/719,558 US4370321A (en) | 1976-09-01 | 1976-09-01 | Progestational adjuvant therapy |
| AU89358/82A AU558559B2 (en) | 1976-09-01 | 1982-10-14 | Progestational adjuvant therapy |
| CA000413579A CA1205744A (en) | 1976-09-01 | 1982-10-15 | Progestational adjuvant therapy |
| FR8217377A FR2534476B1 (fr) | 1976-09-01 | 1982-10-18 | Complement prophylactique a base de 17a-acyloxy-6 methylpregna-4,6-diene-3,20-dione |
| JP57182210A JPS5973523A (ja) | 1976-09-01 | 1982-10-19 | 黄体ホルモン含有補助治療剤 |
| BE0/209365A BE894860A (fr) | 1976-09-01 | 1982-10-28 | Therapeutique adjuvante par agent progestatif |
| DE19823240044 DE3240044A1 (de) | 1976-09-01 | 1982-10-28 | Verwendung von 17(alpha)-acyloxy-6-methylpregna-4,6-dien-3,20-dionen zur bekaempfung von brustkrebs |
| GB08231069A GB2129297B (en) | 1976-09-01 | 1982-10-29 | Post-mastectomy treatment dosage units containing megestrol acetate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE894860A true BE894860A (fr) | 1983-04-28 |
Family
ID=36764617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/209365A BE894860A (fr) | 1976-09-01 | 1982-10-28 | Therapeutique adjuvante par agent progestatif |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4370321A (enExample) |
| JP (1) | JPS5973523A (enExample) |
| AU (1) | AU558559B2 (enExample) |
| BE (1) | BE894860A (enExample) |
| CA (1) | CA1205744A (enExample) |
| DE (1) | DE3240044A1 (enExample) |
| FR (1) | FR2534476B1 (enExample) |
| GB (1) | GB2129297B (enExample) |
| MY (1) | MY8800128A (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338732A (en) * | 1991-06-18 | 1994-08-16 | Bristol-Myers Squibb Company | Megestrol acetate formulation |
| US6268356B1 (en) | 1998-04-20 | 2001-07-31 | Pharmaceutical Resources, Inc. | Flocculated suspension of megestrol acetate |
| US6028065A (en) * | 1998-04-20 | 2000-02-22 | Pharmaceutical Resources, Inc. | Flocculated suspension of megestrol acetate |
| US6656505B2 (en) * | 2000-07-21 | 2003-12-02 | Alpharma Uspd Inc. | Method for forming an aqueous flocculated suspension |
| DK1669074T3 (da) | 2004-12-01 | 2010-09-27 | Par Pharmaceuticals Inc | Anvendelse af megestrolacetat til forbedring af hjertefunktion og behandling af hjerteinsufficiens |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB870286A (en) * | 1958-11-04 | 1961-06-14 | British Drug Houses Ltd | Improvements in or relating to 6-methyl-3-oxo-í~-steroid compounds |
| US3453297A (en) * | 1968-07-24 | 1969-07-01 | Merck & Co Inc | 17alpha-lower alkoxy-pregna-4,6-diene-3,20-dione steroids |
| US3591689A (en) * | 1969-06-04 | 1971-07-06 | Mead Johnson & Co | Progestational composition in oral dosage form |
| ZA716118B (en) * | 1970-10-05 | 1972-05-31 | Richardson Merrell Inc | Contraception |
| GB1558472A (en) * | 1976-01-22 | 1980-01-03 | Leo Ab | 17-esters of 17- hydroxy gestogens |
-
1976
- 1976-09-01 US US05/719,558 patent/US4370321A/en not_active Expired - Lifetime
-
1982
- 1982-10-14 AU AU89358/82A patent/AU558559B2/en not_active Expired
- 1982-10-15 CA CA000413579A patent/CA1205744A/en not_active Expired
- 1982-10-18 FR FR8217377A patent/FR2534476B1/fr not_active Expired
- 1982-10-19 JP JP57182210A patent/JPS5973523A/ja active Granted
- 1982-10-28 DE DE19823240044 patent/DE3240044A1/de not_active Ceased
- 1982-10-28 BE BE0/209365A patent/BE894860A/fr unknown
- 1982-10-29 GB GB08231069A patent/GB2129297B/en not_active Expired
-
1988
- 1988-12-30 MY MY8231069A patent/MY8800128A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4370321A (en) | 1983-01-25 |
| FR2534476B1 (fr) | 1987-07-31 |
| CA1205744A (en) | 1986-06-10 |
| AU8935882A (en) | 1984-04-19 |
| JPH0372605B2 (enExample) | 1991-11-19 |
| GB2129297A (en) | 1984-05-16 |
| MY8800128A (en) | 1988-12-31 |
| AU558559B2 (en) | 1987-02-05 |
| JPS5973523A (ja) | 1984-04-25 |
| DE3240044A1 (de) | 1984-05-03 |
| GB2129297B (en) | 1986-05-29 |
| FR2534476A1 (fr) | 1984-04-20 |
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