BE864459A - Reaction de deplacement du groupement acetoxy, et de ses derives, des cephalosporines par un agent nucleophile soufre - Google Patents

Reaction de deplacement du groupement acetoxy, et de ses derives, des cephalosporines par un agent nucleophile soufre

Info

Publication number
BE864459A
BE864459A BE1008733A BE1008733A BE864459A BE 864459 A BE864459 A BE 864459A BE 1008733 A BE1008733 A BE 1008733A BE 1008733 A BE1008733 A BE 1008733A BE 864459 A BE864459 A BE 864459A
Authority
BE
Belgium
Prior art keywords
cephalosporins
derivatives
displacement
reaction
acetoxy group
Prior art date
Application number
BE1008733A
Other languages
English (en)
French (fr)
Inventor
L D Hatfield
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BE864459A publication Critical patent/BE864459A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
BE1008733A 1977-03-07 1978-03-01 Reaction de deplacement du groupement acetoxy, et de ses derives, des cephalosporines par un agent nucleophile soufre BE864459A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77501877A 1977-03-07 1977-03-07

Publications (1)

Publication Number Publication Date
BE864459A true BE864459A (fr) 1978-09-01

Family

ID=25103070

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1008733A BE864459A (fr) 1977-03-07 1978-03-01 Reaction de deplacement du groupement acetoxy, et de ses derives, des cephalosporines par un agent nucleophile soufre

Country Status (4)

Country Link
US (1) US4144391A (xx)
BE (1) BE864459A (xx)
SU (1) SU919596A3 (xx)
ZA (1) ZA781258B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565941A (en) * 1977-02-08 1980-04-23 Toyama Chemical Co Ltd Process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids
US4314059A (en) * 1978-03-09 1982-02-02 Chisei Shibuya Process for preparing cephalosporin compounds
DK225179A (da) * 1978-06-22 1979-12-23 Chugai Pharmaceutical Co Ltd Fremgangsmaade til fremstilling af cephalosporinderivater
JPS6027677B2 (ja) * 1978-07-06 1985-06-29 富山化学工業株式会社 ７−置換又は非置換アミノ−３−置換チオメチルセフエムカルボン酸類の新規製造法
JPS5543043A (en) * 1978-09-22 1980-03-26 Sankyo Co Ltd Preparation of 3-substituted thiomethylcephalosporin derivative
JPS55139387A (en) * 1979-04-19 1980-10-31 Yamanouchi Pharmaceut Co Ltd Novel synthetic method of 7-amino-3-heterocyclic thiomethyl-delta3-carboxylic acids
US4349672A (en) * 1979-11-29 1982-09-14 Hoffmann-La Roche Inc. Cephalosporin derivatives
JPS56118085A (en) * 1980-02-25 1981-09-16 Takeda Chem Ind Ltd 2-methylcephalosporin derivative and its preparation
EP0047014B1 (en) * 1980-09-02 1986-01-15 Asahi Kasei Kogyo Kabushiki Kaisha Novel thioesters and process for the preparation of the same
US6166254A (en) * 1998-11-24 2000-12-26 Silicon Valley Chemlabs, Inc. Method of manufacturing high purity amidoximes from hydroxylamine and nitriles
US20030135041A1 (en) * 2002-01-04 2003-07-17 Orchid Chemicals & Pharmaceuticals Limited, India Synthesis of ceftiofur intermediate
EP1394262A1 (en) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. An enzymatic process for preparing beta-lactams
CN102532166A (zh) * 2010-12-27 2012-07-04 江苏九寿堂生物制品有限公司 一种精制头孢替唑酸制备方法
CN113512046B (zh) * 2021-03-31 2023-04-25 西南大学 C-7位卤代酰基头孢化合物、制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1012943A (en) * 1961-05-16 1965-12-15 Glaxo Lab Ltd Improvements in or relating to antibiotics
GB1241657A (en) * 1967-08-21 1971-08-04 Glaxo Lab Ltd Improvements in or relating to cephalosporin compounds
GB1277415A (en) * 1968-06-14 1972-06-14 Glaxo Lab Ltd Improvements in or relating to cephalosporin derivatives
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds
US3776907A (en) * 1972-06-12 1973-12-04 Bristol Myers Co 7-(d-(alpha-amino-alpha-phenyl-,2-thienyl-and 3-thienyl-acetamido))-3-(1,2,3-thiadiazol-4-or 5-yl)-carbonylthiomethyl-3-cephem-4-carboxylic acids

Also Published As

Publication number Publication date
SU919596A3 (ru) 1982-04-07
ZA781258B (en) 1979-10-31
US4144391A (en) 1979-03-13

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: ELI LILLY AND CY

Effective date: 19980301