BE861639A - Procede de conversion de 3-methylene cephalosporines en 3-heterothiomethyl cephalosporines - Google Patents

Procede de conversion de 3-methylene cephalosporines en 3-heterothiomethyl cephalosporines

Info

Publication number
BE861639A
BE861639A BE183281A BE183281A BE861639A BE 861639 A BE861639 A BE 861639A BE 183281 A BE183281 A BE 183281A BE 183281 A BE183281 A BE 183281A BE 861639 A BE861639 A BE 861639A
Authority
BE
Belgium
Prior art keywords
cephalosporins
heterothiomethyl
converting
methylene
methylene cephalosporins
Prior art date
Application number
BE183281A
Other languages
English (en)
French (fr)
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of BE861639A publication Critical patent/BE861639A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE183281A 1976-12-08 1977-12-08 Procede de conversion de 3-methylene cephalosporines en 3-heterothiomethyl cephalosporines BE861639A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/748,426 US4129731A (en) 1976-12-08 1976-12-08 Process for converting 3-methylene cephalosporins to 3-heterothiomethyl cephalosporins

Publications (1)

Publication Number Publication Date
BE861639A true BE861639A (fr) 1978-06-08

Family

ID=25009398

Family Applications (1)

Application Number Title Priority Date Filing Date
BE183281A BE861639A (fr) 1976-12-08 1977-12-08 Procede de conversion de 3-methylene cephalosporines en 3-heterothiomethyl cephalosporines

Country Status (11)

Country Link
US (1) US4129731A (US06521211-20030218-C00004.png)
JP (1) JPS5373597A (US06521211-20030218-C00004.png)
AU (1) AU511186B2 (US06521211-20030218-C00004.png)
BE (1) BE861639A (US06521211-20030218-C00004.png)
CA (1) CA1087169A (US06521211-20030218-C00004.png)
CH (1) CH626089A5 (US06521211-20030218-C00004.png)
DE (1) DE2754742C2 (US06521211-20030218-C00004.png)
FR (1) FR2373549A1 (US06521211-20030218-C00004.png)
GB (1) GB1591460A (US06521211-20030218-C00004.png)
IE (1) IE46175B1 (US06521211-20030218-C00004.png)
NL (1) NL7712900A (US06521211-20030218-C00004.png)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4311837A (en) * 1979-05-01 1982-01-19 Eli Lilly And Company Certain heterocyclic thiomethyl derivatives of 7-(dihalogenated phenylthioacetamido)cephalosporanic acids useful in the treatment of infections caused by _Streptococcus faecalis
NL8005041A (nl) * 1980-09-05 1982-04-01 Gist Brocades Nv Werkwijze voor de bereiding van thioethers, alsmede gesilyleerde thiolen voor toepassing bij deze werkwijze.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3275626A (en) * 1962-07-31 1966-09-27 Lilly Co Eli Penicillin conversion via sulfoxide
US3929775A (en) * 1970-12-08 1975-12-30 Takeda Chemical Industries Ltd Process for producing cephalosporin derivatives
CS183696B2 (en) * 1971-02-25 1978-07-31 Robert R Chauvette Method for producing derivatives of 3-methyl-delta up3-cephem-4-carboxylic acid
JPS515396B1 (US06521211-20030218-C00004.png) * 1971-04-05 1976-02-19
US3883518A (en) * 1972-05-15 1975-05-13 Merck & Co Inc 3-Methylene cephalosporins
US3925372A (en) * 1973-02-23 1975-12-09 Lilly Co Eli Alpha-aminoacyl-3-halo cephalosporins
US3962227A (en) * 1973-02-23 1976-06-08 Eli Lilly And Company 3-halo cephalosporins
US3941779A (en) * 1973-11-12 1976-03-02 E. R. Squibb & Sons, Inc. Method for producing 2-(substituted thio)-3-cephem derivatives
US3968109A (en) * 1973-11-23 1976-07-06 E. R. Squibb & Sons, Inc. Production of 2-(thio substituted)cephalosporin sulfoxides and 2-(thio substituted)cephalosporins
US4049806A (en) * 1975-08-15 1977-09-20 Syntex (U.S.A.) Inc. Cephalosporin type antibacterials
US4039534A (en) * 1975-11-17 1977-08-02 E. R. Squibb & Sons, Inc. 4-Thio substituted-Δ2 -cephalosporin intermediates

Also Published As

Publication number Publication date
JPS6118554B2 (US06521211-20030218-C00004.png) 1986-05-13
JPS5373597A (en) 1978-06-30
CH626089A5 (US06521211-20030218-C00004.png) 1981-10-30
IE46175L (en) 1978-06-08
GB1591460A (en) 1981-06-24
IE46175B1 (en) 1983-03-23
AU511186B2 (en) 1980-07-31
DE2754742A1 (de) 1978-06-15
US4129731A (en) 1978-12-12
DE2754742C2 (de) 1986-04-30
FR2373549B1 (US06521211-20030218-C00004.png) 1980-12-05
NL7712900A (nl) 1978-06-12
FR2373549A1 (fr) 1978-07-07
AU3038677A (en) 1979-05-17
CA1087169A (en) 1980-10-07

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: E.R. SQUIBB & SONS INC.

Effective date: 19931231