BE841266A - ANTITUMOR GLUCOSIDES AND THEIR PREPARATION PROCESS - Google Patents

ANTITUMOR GLUCOSIDES AND THEIR PREPARATION PROCESS

Info

Publication number
BE841266A
BE841266A BE166557A BE166557A BE841266A BE 841266 A BE841266 A BE 841266A BE 166557 A BE166557 A BE 166557A BE 166557 A BE166557 A BE 166557A BE 841266 A BE841266 A BE 841266A
Authority
BE
Belgium
Prior art keywords
glucosides
antitumor
preparation process
preparation
antitumor glucosides
Prior art date
Application number
BE166557A
Other languages
French (fr)
Inventor
F Arcamone
A Bargiotti
A Di Marco
S Penco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BE841266A publication Critical patent/BE841266A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • G—PHYSICS
    • G04—HOROLOGY
    • G04B—MECHANICALLY-DRIVEN CLOCKS OR WATCHES; MECHANICAL PARTS OF CLOCKS OR WATCHES IN GENERAL; TIME PIECES USING THE POSITION OF THE SUN, MOON OR STARS
    • G04B37/00—Cases
    • G04B37/0008—Cases for pocket watches and wrist watches
    • G04B37/0025—Cases for pocket watches and wrist watches with cover or bottom with a spring (savonette) bench watches opening or closing with spring action G04B37/0463
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
BE166557A 1975-04-30 1976-04-29 ANTITUMOR GLUCOSIDES AND THEIR PREPARATION PROCESS BE841266A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB18098/75A GB1506200A (en) 1975-04-30 1975-04-30 Glycosides

Publications (1)

Publication Number Publication Date
BE841266A true BE841266A (en) 1976-10-29

Family

ID=10106621

Family Applications (1)

Application Number Title Priority Date Filing Date
BE166557A BE841266A (en) 1975-04-30 1976-04-29 ANTITUMOR GLUCOSIDES AND THEIR PREPARATION PROCESS

Country Status (16)

Country Link
US (1) US4112076A (en)
JP (1) JPS51133262A (en)
AT (1) AT345457B (en)
AU (1) AU500439B2 (en)
BE (1) BE841266A (en)
CA (1) CA1061335A (en)
CH (1) CH541176A4 (en)
DE (1) DE2618822C3 (en)
DK (1) DK150203C (en)
ES (1) ES447433A1 (en)
FR (1) FR2309234A1 (en)
GB (1) GB1506200A (en)
NL (1) NL179587C (en)
SE (2) SE431875B (en)
SU (1) SU728719A3 (en)
ZA (1) ZA762562B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2374333A1 (en) * 1976-12-20 1978-07-13 Inst Int Pathologie Cellulaire Antitumoural (N)-acyl daunorubicin or adriamycin derivs. - e.g. (N)-citraconyl daunorubicin, prepd. by acylation with corresp. acid anhydride
GB1550879A (en) * 1976-12-22 1979-08-22 Farmaceutici Italia Antitumour glycosides
GB1567392A (en) * 1977-02-22 1980-05-14 Farmaceutici Italia Daunorubicin derivatives
US4201773A (en) * 1978-07-26 1980-05-06 The United States Of America As Represented By The Department Of Health, Education And Welfare 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
IT1196402B (en) * 1978-11-21 1988-11-16 Erba Farmitalia ANTI-TUMORAL ANTIBIOTICS
NL8001417A (en) * 1979-03-17 1980-09-19 Erba Farmitalia ANTITUMORGLYCOSIDES.
JPS5673039A (en) * 1979-08-20 1981-06-17 Hoffmann La Roche Naphthacene derivative
ATE1101T1 (en) * 1979-09-01 1982-06-15 Farmitalia Carlo Erba S.P.A. ANTHRACYCLINE GLYCOSIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM.
US4345068A (en) * 1979-11-22 1982-08-17 Farmitalia Carlo Erba S.P.A. Process for the preparation of 4'-epidaunorubicin, 3',4'-diepidaunorubicin, their doxorubicin analogs, and intermediates used in said process
US4301276A (en) * 1980-03-07 1981-11-17 Purdue University Synthesis of daunosamine hydrochloride and intermediates used in its preparation
US4298726A (en) * 1980-03-07 1981-11-03 Purdue University Synthesis of N-benzoyl-L-ristosamine and intermediates used in its preparation
US4345070A (en) * 1980-09-29 1982-08-17 Farmitalia Carlo Erba S.P.A. Process for the preparation of 4'-deoxy-daunorubicin and 4'-deoxy-doxorubicin
US5138042A (en) * 1981-05-28 1992-08-11 Farmitalia Carlo Erba S.P.A. 6-deoxyanthracyclines
NL8203548A (en) * 1981-09-18 1983-04-18 Erba Farmitalia 3'-DESAMINO ANALOGUE OF GLYCOSIDE ANTRACYCLINE ANTIBIOTICS, METHOD FOR THEIR PREPARATION, PREPARATIONS AND USE THEREOF.
GB8426672D0 (en) * 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
GB2196626B (en) * 1986-10-15 1990-09-19 Erba Farmitalia Antitumor anthracycline glycosides, their preparation, intermediates thereof, and compositions and use therefor
DE3641835A1 (en) * 1986-12-08 1988-06-16 Behringwerke Ag CYTOSTATICALLY EFFECTIVE ANTHRACYCLINE DERIVATIVES
GB8803076D0 (en) * 1988-02-10 1988-03-09 Erba Carlo Spa 3'-deamino-4'-deoxy-4'-amino anthracyclines
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
CN100412084C (en) * 2003-07-02 2008-08-20 獀洛克斯股份有限公司 Thermally stable crystalline epirubicin hydrochloride and method of making the same
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
DE06848583T1 (en) * 2005-12-13 2011-03-17 Solux Corporation, San Diego PROCESS FOR THE PREPARATION OF 4-DEMETHYLDAUNORUBICIN
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
PL2301943T3 (en) 2009-09-08 2014-06-30 Heraeus Precious Metals Gmbh Crystallization of epidaunorubicin x HCI
DE102011103751A1 (en) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Crystallization of epirubicin hydrochloride
DE102011111991A1 (en) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh New cyclosporin derivatives
CN103204888B (en) * 2012-01-15 2016-08-17 山东新时代药业有限公司 A kind of preparation method of intermediate of epirubicin hydrochloride
TWI712611B (en) 2015-03-30 2020-12-11 日商明治製菓藥業股份有限公司 The manufacturing method of pantoxin and its novel manufacturing intermediate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
GB1467383A (en) * 1974-06-12 1977-03-16 Farmaceutici Italia Daunomycin analogues
GB1470860A (en) * 1974-10-29 1977-04-21 Farmaceutici Italia Anthracycline glycosides

Also Published As

Publication number Publication date
AT345457B (en) 1978-09-25
FR2309234B1 (en) 1978-08-25
ATA302676A (en) 1978-01-15
CH624125A (en) 1981-07-15
SE8001615L (en) 1980-02-29
FR2309234A1 (en) 1976-11-26
SE7604908L (en) 1976-10-31
NL7604049A (en) 1976-11-02
NL179587B (en) 1986-05-01
SE436884B (en) 1985-01-28
CH541176A4 (en) 1981-07-15
AU500439B2 (en) 1979-05-24
AU1339076A (en) 1977-11-03
JPS5619878B2 (en) 1981-05-09
SE431875B (en) 1984-03-05
GB1506200A (en) 1978-04-05
DK150203B (en) 1987-01-05
ZA762562B (en) 1977-04-27
SU728719A3 (en) 1980-04-15
DE2618822B2 (en) 1982-09-16
CA1061335A (en) 1979-08-28
NL179587C (en) 1986-10-01
ES447433A1 (en) 1977-07-01
DK150203C (en) 1987-11-02
DE2618822A1 (en) 1976-11-11
DK189676A (en) 1976-10-31
US4112076A (en) 1978-09-05
DE2618822C3 (en) 1983-04-28
JPS51133262A (en) 1976-11-18

Similar Documents

Publication Publication Date Title
BE841266A (en) ANTITUMOR GLUCOSIDES AND THEIR PREPARATION PROCESS
FR2331584A1 (en) POLY (ARYLATO-SULFONES) AND THEIR PREPARATION PROCESS
FR2302748A1 (en) NEW ANTIBIOTIC SUBSTANCES NAMED TEICHOMYCINS AND THEIR PREPARATION PROCESS
BE846548A (en) NEW ANTITUMOR GLYCOSIDES OF THE ANTHRACYCLINE SERIES AND PROCESS FOR THEIR PREPARATION
BE839390A (en) METAL PHOSPHITE MONOESTERS AND THEIR PREPARATION PROCESS
LU79036A1 (en) STEROIDS-11BETA-SUBSTITUTES AND PROCESS FOR THEIR PREPARATION
BE847090A (en) 15-STEROIDS, AND THEIR PREPARATION PROCESS
FR2289203A1 (en) ANTITUMOR GLUCOSIDES AND THEIR PREPARATION PROCESS
FR2299032A1 (en) TETRAHYDROISOQUINOLEINE DERIVATIVES AND THEIR PREPARATION PROCESS
FR2301521A1 (en) NEW N-ACYL-N-NORSALUTARIDINES AND THEIR PREPARATION PROCESS
FR2312258A1 (en) LUCKNOMYCIN AND ITS PREPARATION PROCESS
BE830814A (en) N-ALKYL-IMINOALANES OLIGOMERES AND THEIR PREPARATION PROCESS
FR2347370A1 (en) 7-AMINO-3-TETRAZOLYL SUBSTITUE-THIOMETHYL-CEPHALOSPORINS AND THEIR PREPARATION PROCESS
FR2299865A1 (en) ARYLMETHYL-1 IMIDAZOLIDONES-2 AND THEIR PREPARATION PROCESS
BE873630A (en) NEW FORTIMICIN B DERIVATIVES AND THEIR PREPARATION PROCESS
BE846402A (en) 4-HYDROXYMETHYL-2-PYRROLIDINONES AND THEIR PREPARATION PROCESS
FR2329631A1 (en) NEW POLYHYDROXYPHENOLS AND THEIR PREPARATION PROCESS
BE826139A (en) 11BETA-FLUORO-ANDROSTENES AND THEIR PREPARATION PROCESS
FR2319377A1 (en) FORTIMICIN C AND ITS PREPARATION PROCESS
BE832855R (en) ADENOSINES N6 - SUBSTITUTES AND THEIR PREPARATION PROCESS
FR2329267A2 (en) STYRYLAMIDINES AND THEIR PREPARATION PROCESS
BE824179A (en) BIS-DIHALOGENO-S-TRIAZINYL-UREES AND THEIR PREPARATION PROCESS
FR2313073A1 (en) 5-CHOLESTENES 6-AMINOMETHYLES AND 3-OXYGENS AND THEIR PREPARATION PROCESS
FR2311537A1 (en) 3-NITROPYRAZOLE DERIVATIVES AND THEIR PREPARATION PROCESS
FR2309230A1 (en) TRIAZOLOCYCLOALKYLTHIADIAZINE DERIVATIVES AND THEIR PREPARATION PROCESS

Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: SOCIETA FARMACEUTICI ITALIA S.P.A.

Effective date: 19960429