BE801006A - Synthese de l'acide n(5)-methyltetrahydrohomofolique et autres derives hydrogenes de l'acide homofolique - Google Patents

Synthese de l'acide n(5)-methyltetrahydrohomofolique et autres derives hydrogenes de l'acide homofolique

Info

Publication number
BE801006A
BE801006A BE132349A BE132349A BE801006A BE 801006 A BE801006 A BE 801006A BE 132349 A BE132349 A BE 132349A BE 132349 A BE132349 A BE 132349A BE 801006 A BE801006 A BE 801006A
Authority
BE
Belgium
Prior art keywords
acid
hydrogenic
synthesis
derivatives
methyltetrahydrohomofolic
Prior art date
Application number
BE132349A
Other languages
English (en)
Inventor
R L Knott
A T Rigby
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Publication of BE801006A publication Critical patent/BE801006A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
BE132349A 1972-06-16 1973-06-15 Synthese de l'acide n(5)-methyltetrahydrohomofolique et autres derives hydrogenes de l'acide homofolique BE801006A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US263559A US3870719A (en) 1972-06-16 1972-06-16 Synthesis of n-5-methyltetrahydrohomofolic acid and related reduced derivatives of homofolic acid

Publications (1)

Publication Number Publication Date
BE801006A true BE801006A (fr) 1973-10-01

Family

ID=23002269

Family Applications (1)

Application Number Title Priority Date Filing Date
BE132349A BE801006A (fr) 1972-06-16 1973-06-15 Synthese de l'acide n(5)-methyltetrahydrohomofolique et autres derives hydrogenes de l'acide homofolique

Country Status (19)

Country Link
US (2) US3870719A (fr)
JP (1) JPS5541234B2 (fr)
AT (1) AT329201B (fr)
AU (1) AU476569B2 (fr)
BE (1) BE801006A (fr)
CA (1) CA1004672A (fr)
CH (1) CH582178A5 (fr)
CS (1) CS169842B2 (fr)
DE (1) DE2330984A1 (fr)
DK (1) DK143028C (fr)
FR (1) FR2194708B1 (fr)
GB (1) GB1403850A (fr)
HU (1) HU166235B (fr)
NL (1) NL7307992A (fr)
NO (1) NO139890C (fr)
PL (1) PL89778B1 (fr)
RO (1) RO66639A (fr)
SE (1) SE404367B (fr)
YU (1) YU36958B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124452A (en) * 1978-07-10 1992-06-23 Bioresearch S.P.A. Process for producing d,1-5-methyltetrahydrofolic acid and its salts
US5223500A (en) * 1977-02-22 1993-06-29 Bioresearch S.P.A. Stable pharmaceutical composition of alkaline or alkaline earth 5-methyl tetrahydrofolate
US4148999A (en) * 1977-08-22 1979-04-10 The Government Of The United States Of America Preparation and purification of citrovorum factor
US4665176A (en) * 1984-10-23 1987-05-12 Mitsui Toatsu Chemicals, Incorporated Process for the preparation of 5,6,7,8-tetrahydrofolic acid
EP1229934B1 (fr) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions et methodes de traitement du cancer utilisant des immunoconjugues et des agents chimiotherapeutiques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2737515A (en) * 1951-06-30 1956-03-06 American Cyanamid Co Salts of substituted tetrahydroformyl pteroyl amino acids
US2790802A (en) * 1954-05-06 1957-04-30 American Cyanamid Co Substituted tetrahydropteridines and method of preparing the same
US3468886A (en) * 1967-10-23 1969-09-23 Us Health Education & Welfare Tetrahydrohomofolic acid sulfate and synthesis thereof

Also Published As

Publication number Publication date
US3983118A (en) 1976-09-28
GB1403850A (en) 1975-08-28
PL89778B1 (fr) 1976-12-31
YU36958B (en) 1984-08-31
DK143028C (da) 1981-11-02
JPS4949992A (fr) 1974-05-15
YU158073A (en) 1982-06-18
AU5671873A (en) 1974-12-12
NO139890C (no) 1979-05-30
SE404367B (sv) 1978-10-02
JPS5541234B2 (fr) 1980-10-22
RO66639A (fr) 1982-05-10
ATA529073A (de) 1975-07-15
DE2330984A1 (de) 1974-01-03
NL7307992A (fr) 1973-12-18
HU166235B (fr) 1975-02-28
CS169842B2 (fr) 1976-07-29
DK143028B (da) 1981-03-16
AU476569B2 (en) 1976-09-30
CH582178A5 (fr) 1976-11-30
US3870719A (en) 1975-03-11
CA1004672A (en) 1977-02-01
FR2194708B1 (fr) 1978-05-26
FR2194708A1 (fr) 1974-03-01
AT329201B (de) 1976-04-26
NO139890B (no) 1979-02-19

Similar Documents

Publication Publication Date Title
BE836528A (fr) Nouveaux derives d'acide 3-amino- indazolecarboxylique
FR2286147A1 (fr) Nouveaux derives d'acetylphosphonate de dimethyle
BE815330A (fr) Derives de l'acide mycophenolique
BE812772A (fr) Derives de l'acide 2-anilino-nicotinique
BE796519A (fr) Nouveaux derives de l'acide quinoleineacetique et leurs procedes de preparation
BE801246A (fr) Nouveaux derives de l'acide quinaldique et leur preparation
BE809722A (fr) Synthese d'acide-lactones et de leurs derives
BE782366A (fr) Nouveaux derives de l'acide cephalosporanique
BE812743A (fr) Derives de l'acide oxamique
BE819640A (fr) Nouveaux derives de l'acide phenylbenzoique
BE802356A (fr) Derives de l'acide succinique
BE801006A (fr) Synthese de l'acide n(5)-methyltetrahydrohomofolique et autres derives hydrogenes de l'acide homofolique
BE821557A (fr) Nouveaux derives de l'acide indane-5-acetique
BE822729A (fr) Nouveaux derives de l'acide lysergique
BE797017A (fr) Nouveaux amides de l'acide apovincaminique
BE808087A (fr) Preparation d'acide glyoxylique
BE768866A (fr) Inhibition de la synthese d'acide gras
BE808591A (fr) Derives d'acide amidomethane-phosphonique
BE802719A (fr) Derives de l'acide 9-hydroxy-13-trans-prostenoique
BE796999A (fr) Derives d'acide octanoique et leur preparation
BE811209A (fr) Nouveaux derives de l'acide phenylacetique
BE804508A (fr) Nouveaux derives de l'acide glycyrrhetinique
BE808969A (fr) Nouveaux derives de l'acide prostanoique
BE823172A (fr) Acide 2-halopropionique et ses derives
BE802345A (fr) Nouveau derive d'acide 1,4-dihydro-1-substitute-4-oxo-3-quinoleine-carboxylique

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: GOUVERNEMENT DES ETATS-UNIS D AMERIQUE

Effective date: 19840615