BE776645A - Nouveaux derives d'acides n-(cyano-3 diphenyl-3,3 propyl) phenyl-4 piperidinecarboxyliques-4, utiles notamment comme agents antidiarrheiques, et leur procede de preparation - Google Patents

Nouveaux derives d'acides n-(cyano-3 diphenyl-3,3 propyl) phenyl-4 piperidinecarboxyliques-4, utiles notamment comme agents antidiarrheiques, et leur procede de preparation

Info

Publication number
BE776645A
BE776645A BE776645A BE776645A BE776645A BE 776645 A BE776645 A BE 776645A BE 776645 A BE776645 A BE 776645A BE 776645 A BE776645 A BE 776645A BE 776645 A BE776645 A BE 776645A
Authority
BE
Belgium
Prior art keywords
diphenyl
cyano
propyl
phenyl
preparation
Prior art date
Application number
BE776645A
Other languages
English (en)
Inventor
F B Briggs
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of BE776645A publication Critical patent/BE776645A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE776645A 1970-12-16 1971-12-13 Nouveaux derives d'acides n-(cyano-3 diphenyl-3,3 propyl) phenyl-4 piperidinecarboxyliques-4, utiles notamment comme agents antidiarrheiques, et leur procede de preparation BE776645A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5968670A GB1356117A (en) 1970-12-16 1970-12-16 1-3-cyano-3,3-diphenylpropyl-4-phenylpiperidine-4-carboxylic acid derivatives
GB5739071A GB1356118A (en) 1970-12-16 1970-12-16 1-3-cyano-3,3-diphenylpropyl-4-phenylpiperidine-4-carboxylic acid derivatives

Publications (1)

Publication Number Publication Date
BE776645A true BE776645A (fr) 1972-06-13

Family

ID=26267682

Family Applications (2)

Application Number Title Priority Date Filing Date
BE776644A BE776644A (fr) 1970-12-16 1971-12-13 Nouveaux n-(-n-(cyano-3 diphenyl-3,3 propyl) phenyl-4 piperidinecarbonyloxy-4 amides utiles notamment comme agents antidiarrheiques et leur procede de preparation
BE776645A BE776645A (fr) 1970-12-16 1971-12-13 Nouveaux derives d'acides n-(cyano-3 diphenyl-3,3 propyl) phenyl-4 piperidinecarboxyliques-4, utiles notamment comme agents antidiarrheiques, et leur procede de preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BE776644A BE776644A (fr) 1970-12-16 1971-12-13 Nouveaux n-(-n-(cyano-3 diphenyl-3,3 propyl) phenyl-4 piperidinecarbonyloxy-4 amides utiles notamment comme agents antidiarrheiques et leur procede de preparation

Country Status (11)

Country Link
US (2) US3847923A (fr)
JP (2) JPS55127388A (fr)
AU (2) AU472024B2 (fr)
BE (2) BE776644A (fr)
CA (1) CA947296A (fr)
CH (4) CH572923A5 (fr)
DE (2) DE2161827A1 (fr)
FR (2) FR2118060B1 (fr)
GB (2) GB1356117A (fr)
MY (1) MY7800052A (fr)
NL (2) NL7117061A (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959275A (en) * 1970-12-16 1976-05-25 G. D. Searle & Co. Fused ring N-[1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carbonyloxy]imides
US4002618A (en) * 1976-02-23 1977-01-11 G. D. Searle & Co. 2,2-Diphenyl-5-(4-substituted-piperidino)-3-trans-pentenenitriles
US3996214A (en) * 1976-02-23 1976-12-07 G. D. Searle & Co. 5-(1,1-Diphenyl-4-(cyclic amino) but-2-trans-en-1-yl)-2-alkyl-1,3,4-oxadiazoles and intermediates thereto
US4824853A (en) * 1985-10-11 1989-04-25 Janssen Pharmaceutica N.V. α,α-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, N-oxides and method of treating diarrhea
JP2627278B2 (ja) * 1987-10-20 1997-07-02 三洋電機株式会社 電動式床用吸込具
JPH08504435A (ja) * 1992-12-14 1996-05-14 メルク シヤープ エンド ドーム リミテツド タキキニン受容体拮抗剤としての４−アミノメチル／チオメチル／スルホニルメチル−４−フェニルピペリジン
ATE453621T1 (de) * 2002-07-03 2010-01-15 Glaxo Group Ltd Substituierte 4-phenylpiperidinamide als tachykininantagonisten und serotoninwiederaufnahmehemmer
GB0310724D0 (en) * 2003-05-09 2003-06-11 Glaxo Group Ltd Chemical compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539579A (en) * 1967-11-22 1970-11-10 Janssen Pharm 1 - (3 - cyano - 3,3 - diphenyl - propyl) - 4- phenyl - piperidine - 4 - carboxylic acid esters

Also Published As

Publication number Publication date
FR2118060B1 (fr) 1975-10-31
DE2161827A1 (de) 1972-07-06
AU472024B2 (en) 1976-05-13
CH572920A5 (fr) 1976-02-27
CA947296A (en) 1974-05-14
NL7117061A (fr) 1972-06-20
DE2161865A1 (de) 1972-07-06
NL7117062A (fr) 1972-06-20
JPS566429B2 (fr) 1981-02-10
GB1356118A (en) 1974-06-12
CH572922A5 (fr) 1976-02-27
JPS564556B2 (fr) 1981-01-30
GB1356117A (en) 1974-06-12
CH572923A5 (fr) 1976-02-27
US3847923A (en) 1974-11-12
FR2118061B1 (fr) 1975-10-10
FR2118060A1 (fr) 1972-07-28
JPS55120584A (en) 1980-09-17
JPS55127388A (en) 1980-10-02
AU3678471A (en) 1973-06-14
BE776644A (fr) 1972-06-13
US3843646A (en) 1974-10-22
FR2118061A1 (fr) 1972-07-28
AU468832B2 (en) 1976-01-22
AU3678371A (en) 1973-06-14
CH572037A5 (fr) 1976-01-30
MY7800052A (en) 1978-12-31

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