BE775610Q - Benzamidoalkylpiperazine derivs - Google Patents

Benzamidoalkylpiperazine derivs

Info

Publication number
BE775610Q
BE775610Q BE775610A BE775610A BE775610Q BE 775610 Q BE775610 Q BE 775610Q BE 775610 A BE775610 A BE 775610A BE 775610 A BE775610 A BE 775610A BE 775610 Q BE775610 Q BE 775610Q
Authority
BE
Belgium
Prior art keywords
emi
benzamidoalkylpiperazine
derivs
halogen
acid chloride
Prior art date
Application number
BE775610A
Other languages
French (fr)
Inventor
R Eche
J De Antoni
Original Assignee
Bruneau & Cie Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bruneau & Cie Lab filed Critical Bruneau & Cie Lab
Application granted granted Critical
Publication of BE775610Q publication Critical patent/BE775610Q/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

(A) 1st. Addn. to the principal patent of 19.7.67 relating to cpds. (I) X = NO2, halogen, esp. F or Cl R = H, halogen, Me, OMe n = 2-5 in which R may now = CF3. (B) Intermediates of formula (II), below, where R = 4-F and 3-CF3. As analgesics and CNS-depressants. As described in the principle patent, i.e. by reacting an acid chloride or ester corresp. to:.

Description

       

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 <EMI ID=4.1>   <EMI ID=5.1> 
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 <EMI ID=10.1> 

  

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dans laquelle 

  
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nant pas plus de trois atones de carbone ou un

  
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 <EMI ID=15.1> 
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 <EMI ID=17.1> 

  
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du sulfate de sodium., le chloroforme est ensuite évaporé sous -

  
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 <EMI ID=27.1>  

  
 <EMI ID=28.1>  <EMI ID=29.1>  <EMI ID=30.1> 
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 Les exemples suivants., non limitatifs, illutrent ces préparations. 

  
 <EMI ID=33.1> 

  
nutes, avec agitation, une solution de 15,8 g de chlorure d'aci-

  
 <EMI ID=34.1> 

  
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agite pendant 15 heures à la température ambiante , le produit

  
 <EMI ID=36.1> 

  
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posé basique en solution dans l'Sthanol par un équivalent d'acide chlorhydrique en solution dans le même alcool. Son point de

  
 <EMI ID=39.1> 

  
Procédé b 

  
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,Les composes correspondants sont consignes dans le tableau suivent : 

  
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dans les mêmes conditions que sous a). Les. constantes du pro-  duit obtenu sont les suivantes : 

  
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 <EMI ID=59.1> 
 <EMI ID=60.1> 
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 <EMI ID=63.1>  

  

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   <EMI ID = 1.1>

  
 <EMI ID = 2.1>

  

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 <EMI ID = 9.1>

  
 <EMI ID = 10.1>

  

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in which

  
 <EMI ID = 12.1>

  
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having no more than three carbon atoms or one

  
 <EMI ID = 14.1>
 <EMI ID = 15.1>
 <EMI ID = 16.1>

  
 <EMI ID = 17.1>

  
 <EMI ID = 18.1>

  
 <EMI ID = 19.1>

  
 <EMI ID = 20.1>

  
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 <EMI ID = 22.1>

  
 <EMI ID = 23.1>

  
 <EMI ID = 24.1>

  
 <EMI ID = 25.1>

  
sodium sulfate., the chloroform is then evaporated under -

  
 <EMI ID = 26.1>

  
 <EMI ID = 27.1>

  
 <EMI ID = 28.1> <EMI ID = 29.1> <EMI ID = 30.1>
 <EMI ID = 31.1>
 
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 The following non-limiting examples illutrent these preparations.

  
 <EMI ID = 33.1>

  
nutes, with stirring, a solution of 15.8 g of acid chloride

  
 <EMI ID = 34.1>

  
 <EMI ID = 35.1>

  
stirred for 15 hours at room temperature, the product

  
 <EMI ID = 36.1>

  
 <EMI ID = 37.1>

  
 <EMI ID = 38.1>

  
laid basic in solution in Sthanol with one equivalent of hydrochloric acid in solution in the same alcohol. Its point

  
 <EMI ID = 39.1>

  
Method b

  
 <EMI ID = 40.1>

  
 <EMI ID = 41.1> <EMI ID = 42.1>

  
 <EMI ID = 43.1>

  
 <EMI ID = 44.1>

  
 <EMI ID = 45.1>

  
, The corresponding compounds are indicated in the following table:

  
 <EMI ID = 46.1>

  

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 <EMI ID = 48.1>

  

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 <EMI ID = 50.1>
 <EMI ID = 51.1>
  <EMI ID = 52.1>

  

 <EMI ID = 53.1>
 

  

 <EMI ID = 54.1>


  

 <EMI ID = 55.1>


  
 <EMI ID = 56.1>

  
under the same conditions as under a). The. constants of the product obtained are as follows:

  
 <EMI ID = 57.1>

  
 <EMI ID = 58.1>

  
 <EMI ID = 59.1>
 <EMI ID = 60.1>
 <EMI ID = 61.1>

  

 <EMI ID = 62.1>


  
 <EMI ID = 63.1>

  

 <EMI ID = 64.1>

Claims (1)

<EMI ID=65.1> <EMI ID = 65.1> <EMI ID=66.1> <EMI ID = 66.1> <EMI ID=67.1> <EMI ID = 67.1> <EMI ID=68.1> <EMI ID = 68.1> chlore, et peut exister.. plusieurs fois sur le chlorine, and may exist .. several times on the <EMI ID=69.1> <EMI ID = 69.1> <EMI ID=70.1> <EMI ID = 70.1> <EMI ID=71.1> <EMI ID=72.1> <EMI ID=73.1> <EMI ID = 71.1> <EMI ID = 72.1> <EMI ID = 73.1> <EMI ID=74.1> <EMI ID=75.1> <EMI ID = 74.1> <EMI ID = 75.1> <EMI ID=76.1> <EMI ID = 76.1> <EMI ID=77.1> <EMI ID = 77.1> <EMI ID=78.1> <EMI ID = 78.1> <EMI ID=79.1> <EMI ID = 79.1>
BE775610A 1967-07-19 1971-11-19 Benzamidoalkylpiperazine derivs BE775610Q (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR114791A FR1537901A (en) 1967-07-19 1967-07-19 Amide derivatives of halogeno and nitro benzoic acids and their preparation
FR135764A FR93884E (en) 1967-07-19 1968-01-12 Amide derivatives of halogeno and nitro benzoic acids and their preparation.

Publications (1)

Publication Number Publication Date
BE775610Q true BE775610Q (en) 1972-03-16

Family

ID=32929144

Family Applications (1)

Application Number Title Priority Date Filing Date
BE775610A BE775610Q (en) 1967-07-19 1971-11-19 Benzamidoalkylpiperazine derivs

Country Status (2)

Country Link
BE (1) BE775610Q (en)
FR (2) FR1537901A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0104614A1 (en) * 1982-09-24 1984-04-04 Chugai Seiyaku Kabushiki Kaisha Phenylpiperazine derivatives and process for producing the same

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846430A (en) * 1968-01-12 1974-11-05 Bruneau & Cie Lab 1-(2-methoxy-phenyl)-4-{8 2-(4-fluoro-benzamido)-ethyl{9 -piperazine
IE911774A1 (en) * 1990-06-11 1991-12-18 Akzo Nv Pyridinylpiperazine derivatives
SE9201138D0 (en) * 1992-04-09 1992-04-09 Astra Ab NOVEL PHTHALIMIDOALKYL PIPERAZINES
IT1266582B1 (en) * 1993-07-30 1997-01-09 Recordati Chem Pharm (DI) AZACYLO-HEXANIC AND DIAZACYLO-HEPTANIC DERIVATIVES
US5659033A (en) * 1995-09-13 1997-08-19 Neurogen Corporation N-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0104614A1 (en) * 1982-09-24 1984-04-04 Chugai Seiyaku Kabushiki Kaisha Phenylpiperazine derivatives and process for producing the same

Also Published As

Publication number Publication date
FR93884E (en) 1969-05-30
FR1537901A (en) 1968-08-30

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