BE742073A - Polycatechine medicaments - Google Patents
Polycatechine medicamentsInfo
- Publication number
- BE742073A BE742073A BE742073DA BE742073A BE 742073 A BE742073 A BE 742073A BE 742073D A BE742073D A BE 742073DA BE 742073 A BE742073 A BE 742073A
- Authority
- BE
- Belgium
- Prior art keywords
- catechin
- sep
- complex
- epicatechin
- desc
- Prior art date
Links
- 239000003814 drug Substances 0.000 title description 4
- 229950001002 cianidanol Drugs 0.000 claims abstract description 13
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims abstract description 12
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000005487 catechin Nutrition 0.000 claims abstract description 11
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 claims abstract description 8
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 claims abstract description 8
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000012734 epicatechin Nutrition 0.000 claims abstract description 8
- 239000004480 active ingredient Substances 0.000 claims abstract description 3
- 239000008298 dragée Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 3
- 241000699670 Mus sp. Species 0.000 abstract description 2
- 206010038923 Retinopathy Diseases 0.000 abstract description 2
- 206010007191 Capillary fragility Diseases 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 206010009887 colitis Diseases 0.000 abstract 1
- 201000005917 gastric ulcer Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 3
- 229910052753 mercury Inorganic materials 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 206010037549 Purpura Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 206010047073 Vascular fragility Diseases 0.000 description 2
- 210000004100 adrenal gland Anatomy 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 230000004856 capillary permeability Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 239000012154 double-distilled water Substances 0.000 description 2
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 2
- 235000005493 rutin Nutrition 0.000 description 2
- 229960004555 rutoside Drugs 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- COXVTLYNGOIATD-HVMBLDELSA-N CC1=C(C=CC(=C1)C1=CC(C)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S(O)(=O)=O)S(O)(=O)=O)\N=N\C1=CC=C2C(=CC(=C(N)C2=C1O)S(O)(=O)=O)S(O)(=O)=O Chemical compound CC1=C(C=CC(=C1)C1=CC(C)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S(O)(=O)=O)S(O)(=O)=O)\N=N\C1=CC=C2C(=CC(=C(N)C2=C1O)S(O)(=O)=O)S(O)(=O)=O COXVTLYNGOIATD-HVMBLDELSA-N 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 241000287531 Psittacidae Species 0.000 description 1
- 241001672981 Purpura Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000001045 blue dye Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229960003699 evans blue Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940047135 glycate Drugs 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 210000004705 lumbosacral region Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 206010034754 petechiae Diseases 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 244000089265 zong er cha Species 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
- C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR174899A FR7760M (cs) | 1968-11-22 | 1968-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE742073A true BE742073A (en) | 1970-05-21 |
Family
ID=8657269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE742073D BE742073A (en) | 1968-11-22 | 1969-11-21 | Polycatechine medicaments |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE742073A (cs) |
| FR (1) | FR7760M (cs) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0003274A1 (de) * | 1977-11-25 | 1979-08-08 | Zyma SA | o-Substituierte Derivate des (+)-Cyanidin-3-ols,Verfahren zu ihrer Herstellung, sowie diese Verbindungen enthaltende pharmazeutische Zusammensetzungen und deren Herstellung |
| US4507314A (en) * | 1983-07-20 | 1985-03-26 | Midit, Societe Fiduciaire | Drug for treating affections provoked by a too high histamine level, of the gastroduodenal mucosa and allergic affections |
| US5318986A (en) * | 1989-10-19 | 1994-06-07 | Mitsui Norin Co., Ltd. | Method of inhibiting the activity of α-amylase |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01501791A (ja) * | 1986-11-19 | 1989-06-22 | ケメックス ファーマシューティカルズ，インコーポレイティド | 薬理学的に活性な化合物およびそれらの混合物、有機組成物および金属塩類 |
-
1968
- 1968-11-22 FR FR174899A patent/FR7760M/fr not_active Expired
-
1969
- 1969-11-21 BE BE742073D patent/BE742073A/fr not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0003274A1 (de) * | 1977-11-25 | 1979-08-08 | Zyma SA | o-Substituierte Derivate des (+)-Cyanidin-3-ols,Verfahren zu ihrer Herstellung, sowie diese Verbindungen enthaltende pharmazeutische Zusammensetzungen und deren Herstellung |
| US4507314A (en) * | 1983-07-20 | 1985-03-26 | Midit, Societe Fiduciaire | Drug for treating affections provoked by a too high histamine level, of the gastroduodenal mucosa and allergic affections |
| US5318986A (en) * | 1989-10-19 | 1994-06-07 | Mitsui Norin Co., Ltd. | Method of inhibiting the activity of α-amylase |
Also Published As
| Publication number | Publication date |
|---|---|
| FR7760M (cs) | 1970-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0939654B1 (fr) | Utilisation des inhibiteurs de no synthase et des piegeurs des formes reactives de l'oxygene pour le traitement de l'ischemie | |
| US4401653A (en) | Combination of rapamycin and picibanil for the treatment of tumors | |
| Kligman | Dimethyl sulfoxide—part 2 | |
| US20140079631A1 (en) | Anti-inflammatory particles | |
| JPS6242973A (ja) | Ｌ−リジンピルベ−ト及びｌ−ヒスチジンピルベ−ト | |
| US5242905A (en) | Pharmaceutical compositions for the treatment of psoriasis | |
| BE742073A (en) | Polycatechine medicaments | |
| CA1340005C (en) | Pharmaceutical composition for the treatment of psoriasis | |
| US5214196A (en) | Diethyl ester of di-glycyl fumaramide | |
| ES2509143T3 (es) | Tratamiento de una septicemia con 5-etil-1-fenil-2(1H)-piridona | |
| JPH05271088A (ja) | 皮膚疾患・免疫反応による組織障害改善治療剤 | |
| BE726774A (cs) | ||
| EP0280593B1 (fr) | Composition à base d'acide aminé et de vitamines utilisable en thérapeutique cancérologique | |
| US4824673A (en) | New drugs based on extracts of algae, and corresponding formulations | |
| JP2014152171A (ja) | 新規生理活性組成物 | |
| Metz et al. | Vitamin C allergy of the delayed type | |
| MXPA06006717A (es) | Agentes de combinacion de chp-gencitabina y su uso como agentes anti-tumorales, especialmente como agentes anti-metastatizacion. | |
| RU2257197C1 (ru) | Вагинальные суппозитории, обладающие контрацептивным действием | |
| McGinty et al. | The ulcer-inhibiting action of pyrogens | |
| US3558600A (en) | Alkyl sulfate salts of 1-(p-chlorobenzhydryl)-4-methylhomopiperazines | |
| RU2141330C1 (ru) | Церебропротектор при энцефалопатии | |
| CN117159740B (zh) | 一种雷公藤甲素抗体药物偶联物及其制备方法和应用 | |
| US4049791A (en) | Prolonged acting appetite suppressant and anti-obesity compositions containing amphetamine adipate, dextroamphetamine adipate, amphetamine sulfate and dextroamphetamine sulfate as the active agents | |
| TWI815771B (zh) | 硝化[6,6,6]三環衍生化合物用以製備供選擇性抑制口腔癌細胞生長的藥物的用途 | |
| TWI841431B (zh) | 斯文豪蒂殼海綿萃取物用以製備供選擇性抑制口腔癌細胞生長的藥物的用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: SOC. FRANC. DE RECHERCHE MEDICALE Effective date: 19881130 Owner name: SCIENCE UNION ET CIE Effective date: 19881130 |