BE633375A - - Google Patents
Info
- Publication number
- BE633375A BE633375A BE633375DA BE633375A BE 633375 A BE633375 A BE 633375A BE 633375D A BE633375D A BE 633375DA BE 633375 A BE633375 A BE 633375A
- Authority
- BE
- Belgium
- Prior art keywords
- cells
- bacteria
- vaccine
- lysis
- antigenic
- Prior art date
Links
- 229960005486 vaccines Drugs 0.000 claims description 98
- 210000004027 cells Anatomy 0.000 claims description 47
- 241000894006 Bacteria Species 0.000 claims description 44
- 230000009089 cytolysis Effects 0.000 claims description 37
- 230000002934 lysing Effects 0.000 claims description 37
- 230000000890 antigenic Effects 0.000 claims description 30
- 108090000790 Enzymes Proteins 0.000 claims description 29
- 102000004190 Enzymes Human genes 0.000 claims description 29
- 238000010438 heat treatment Methods 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 11
- 210000001938 protoplasts Anatomy 0.000 claims description 11
- 241000283690 Bos taurus Species 0.000 claims description 10
- 208000004396 Mastitis Diseases 0.000 claims description 10
- 241000295644 Staphylococcaceae Species 0.000 claims description 10
- DHMQDGOQFOQNFH-UHFFFAOYSA-N glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 9
- 241000607142 Salmonella Species 0.000 claims description 8
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims description 8
- 206010039447 Salmonellosis Diseases 0.000 claims description 8
- 239000000654 additive Substances 0.000 claims description 8
- 230000002797 proteolythic Effects 0.000 claims description 8
- 230000000996 additive Effects 0.000 claims description 6
- 230000002779 inactivation Effects 0.000 claims description 6
- 230000001717 pathogenic Effects 0.000 claims description 6
- 239000004471 Glycine Substances 0.000 claims description 5
- 235000001014 amino acid Nutrition 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 5
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 3
- 235000004279 alanine Nutrition 0.000 claims description 3
- 230000003053 immunization Effects 0.000 claims description 3
- 241000191967 Staphylococcus aureus Species 0.000 claims description 2
- 229940076185 Staphylococcus aureus Drugs 0.000 claims description 2
- 239000000080 wetting agent Substances 0.000 claims description 2
- 241000588832 Bordetella pertussis Species 0.000 claims 2
- 229940052491 Bordetella pertussis Drugs 0.000 claims 2
- 201000008827 tuberculosis Diseases 0.000 claims 2
- 238000011065 in-situ storage Methods 0.000 claims 1
- 229920001098 polystyrene-block-poly(ethylene/propylene) Polymers 0.000 description 62
- 239000000725 suspension Substances 0.000 description 15
- 229940110715 ENZYMES FOR TREATMENT OF WOUNDS AND ULCERS Drugs 0.000 description 12
- 229940114721 Enzymes FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM Drugs 0.000 description 12
- 229940093738 Enzymes for ALIMENTARY TRACT AND METABOLISM Drugs 0.000 description 12
- 229940019336 antithrombotic Enzymes Drugs 0.000 description 12
- 229940020899 hematological Enzymes Drugs 0.000 description 12
- 229940083249 peripheral vasodilators Enzymes Drugs 0.000 description 12
- 230000001580 bacterial Effects 0.000 description 9
- 239000002609 media Substances 0.000 description 9
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 8
- 229940088598 Enzyme Drugs 0.000 description 7
- 201000009910 diseases by infectious agent Diseases 0.000 description 7
- 239000006166 lysate Substances 0.000 description 7
- 230000000392 somatic Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 210000002966 Serum Anatomy 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 201000008297 typhoid fever Diseases 0.000 description 6
- 229920001817 Agar Polymers 0.000 description 5
- 239000000427 antigen Substances 0.000 description 5
- 108091007172 antigens Proteins 0.000 description 5
- 102000038129 antigens Human genes 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 241000304886 Bacilli Species 0.000 description 4
- 210000002421 Cell Wall Anatomy 0.000 description 4
- 241000206672 Gelidium Species 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- FPKOPBFLPLFWAD-UHFFFAOYSA-N Trinitrotoluene Chemical compound CC1=CC=C([N+]([O-])=O)C([N+]([O-])=O)=C1[N+]([O-])=O FPKOPBFLPLFWAD-UHFFFAOYSA-N 0.000 description 4
- 235000010419 agar Nutrition 0.000 description 4
- 102000004965 antibodies Human genes 0.000 description 4
- 108090001123 antibodies Proteins 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000005755 formation reaction Methods 0.000 description 4
- 230000036512 infertility Effects 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 231100000803 sterility Toxicity 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 231100000765 Toxin Toxicity 0.000 description 3
- HWKQNAWCHQMZHK-UHFFFAOYSA-N Trolnitrate Chemical compound [O-][N+](=O)OCCN(CCO[N+]([O-])=O)CCO[N+]([O-])=O HWKQNAWCHQMZHK-UHFFFAOYSA-N 0.000 description 3
- 102000004142 Trypsin Human genes 0.000 description 3
- 108090000631 Trypsin Proteins 0.000 description 3
- 239000000440 bentonite Substances 0.000 description 3
- 229910000278 bentonite Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 230000001681 protective Effects 0.000 description 3
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 108020003112 toxins Proteins 0.000 description 3
- 229960001322 trypsin Drugs 0.000 description 3
- 239000012588 trypsin Substances 0.000 description 3
- 229940064005 Antibiotic throat preparations Drugs 0.000 description 2
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 description 2
- 229940042052 Antibiotics for systemic use Drugs 0.000 description 2
- 229940042786 Antitubercular Antibiotics Drugs 0.000 description 2
- 229960001212 BACTERIAL VACCINES Drugs 0.000 description 2
- 241000588807 Bordetella Species 0.000 description 2
- 229940093922 Gynecological Antibiotics Drugs 0.000 description 2
- 102000016943 Muramidase Human genes 0.000 description 2
- 108010014251 Muramidase Proteins 0.000 description 2
- 229940049954 Penicillin Drugs 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 102000035443 Peptidases Human genes 0.000 description 2
- 108091005771 Peptidases Proteins 0.000 description 2
- 229940024999 Proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 2
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 description 2
- 241001467018 Typhis Species 0.000 description 2
- 206010061393 Typhus Diseases 0.000 description 2
- 206010068760 Ulcers Diseases 0.000 description 2
- 238000009632 agar plate Methods 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229960000626 benzylpenicillin Drugs 0.000 description 2
- 230000003115 biocidal Effects 0.000 description 2
- 239000006161 blood agar Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229920003013 deoxyribonucleic acid Polymers 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 229940079866 intestinal antibiotics Drugs 0.000 description 2
- 229960000274 lysozyme Drugs 0.000 description 2
- 239000004325 lysozyme Substances 0.000 description 2
- 235000010335 lysozyme Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 239000006916 nutrient agar Substances 0.000 description 2
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 description 2
- 230000002829 reduced Effects 0.000 description 2
- 231100000486 side effect Toxicity 0.000 description 2
- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 238000005429 turbidity Methods 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 208000006673 Asthma Diseases 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 210000000170 Cell Membrane Anatomy 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 101710034658 DNASE1 Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 210000004072 Lung Anatomy 0.000 description 1
- 241000283898 Ovis Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 206010040550 Shigella infection Diseases 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 229940105648 Soma Drugs 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 206010061372 Streptococcal infection Diseases 0.000 description 1
- 240000000054 Tropaeolum tuberosum Species 0.000 description 1
- 235000018963 Tropaeolum tuberosum Nutrition 0.000 description 1
- 241000233948 Typha Species 0.000 description 1
- 229960000155 Typhoid Vaccines Drugs 0.000 description 1
- 229960001266 Typhoid vaccines Drugs 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000001154 acute Effects 0.000 description 1
- 230000000240 adjuvant Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 231100000494 adverse effect Toxicity 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229920002892 amber Polymers 0.000 description 1
- 230000000844 anti-bacterial Effects 0.000 description 1
- 235000020127 ayran Nutrition 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 125000000853 cresyl group Chemical class C1(=CC=C(C=C1)C)* 0.000 description 1
- 230000004059 degradation Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000001627 detrimental Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000000415 inactivating Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 230000002147 killing Effects 0.000 description 1
- 230000001665 lethal Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000002035 prolonged Effects 0.000 description 1
- 229910052704 radon Inorganic materials 0.000 description 1
- SYUHGPGVQRZVTB-UHFFFAOYSA-N radon(0) Chemical compound [Rn] SYUHGPGVQRZVTB-UHFFFAOYSA-N 0.000 description 1
- 230000000717 retained Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000010414 supernatant solution Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000001973 thioglycolate broth Substances 0.000 description 1
- 239000007143 thioglycolate medium Substances 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000001131 transforming Effects 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 230000003313 weakening Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE633375A true BE633375A (ja) |
Family
ID=200952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE633375D BE633375A (ja) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE633375A (ja) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2446111A1 (fr) * | 1979-01-12 | 1980-08-08 | Hours Michel | Procede de preparation d'antigenes et vaccins obtenus selon ce procede |
| EP0255755A2 (en) * | 1986-06-05 | 1988-02-10 | Baylor College of Medicine | Vaccine preparation |
-
0
- BE BE633375D patent/BE633375A/fr unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2446111A1 (fr) * | 1979-01-12 | 1980-08-08 | Hours Michel | Procede de preparation d'antigenes et vaccins obtenus selon ce procede |
| EP0255755A2 (en) * | 1986-06-05 | 1988-02-10 | Baylor College of Medicine | Vaccine preparation |
| EP0255755A3 (en) * | 1986-06-05 | 1988-05-25 | Baylor College of Medicine | Vaccine preparation |
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