BE522518A - - Google Patents
Info
- Publication number
- BE522518A BE522518A BE522518DA BE522518A BE 522518 A BE522518 A BE 522518A BE 522518D A BE522518D A BE 522518DA BE 522518 A BE522518 A BE 522518A
- Authority
- BE
- Belgium
- Prior art keywords
- suspensions
- penicillin
- ampoules
- stability
- oxygen
- Prior art date
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- 239000007900 aqueous suspension Substances 0.000 claims description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 12
- 239000001301 oxygen Substances 0.000 claims description 12
- 229910052760 oxygen Inorganic materials 0.000 claims description 12
- 239000011261 inert gas Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- WHRVRSCEWKLAHX-LQDWTQKMSA-N benzylpenicillin procaine Chemical compound [H+].CCN(CC)CCOC(=O)C1=CC=C(N)C=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 WHRVRSCEWKLAHX-LQDWTQKMSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000725 suspension Substances 0.000 description 18
- 150000002960 penicillins Chemical class 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 6
- 229930182555 Penicillin Natural products 0.000 description 4
- 230000004071 biological effect Effects 0.000 description 3
- -1 ester iodide Chemical class 0.000 description 3
- 229940049954 penicillin Drugs 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 2
- 229960004919 procaine Drugs 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE522518A true BE522518A (enrdf_load_stackoverflow) |
Family
ID=157763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE522518D BE522518A (enrdf_load_stackoverflow) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE522518A (enrdf_load_stackoverflow) |
-
0
- BE BE522518D patent/BE522518A/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1446373B1 (fr) | Procede de preparation d'une composition contenant au moins un produit de deshydratation interne d'un sucre hydrogene | |
| CA2462557A1 (en) | Method of stabilizing reduced coenzyme q10 | |
| WO2018146210A1 (fr) | Procede de purification de la vanilline naturelle | |
| DE2608255C2 (de) | Verfahren zur Gewinnung von optisch reinem N-Acetyl-L-methionin | |
| FR2562538A1 (fr) | Procede de recristallisation d'explosifs brisants | |
| US7387884B2 (en) | Yeast extract solution for cell-free protein synthesis, method for preparation thereof and method for cell-free protein synthesis using same | |
| FR2487344A1 (fr) | Emulsion aqueuse stable de peroxydes organiques | |
| EP0061949B1 (fr) | Produit et procédé permettant la désacidification dans des liquides divers, plus particulièrement l'élimination de l'acide malique des moûts et vins | |
| FR2701489A1 (fr) | Procédé de production d'acide L-glutamique par fermentation. | |
| BE522518A (enrdf_load_stackoverflow) | ||
| CN87101146A (zh) | 改进的玉米浸泡液 | |
| CA2137783A1 (en) | Stable moulding or spinning compound containing cellulose | |
| JP2003533213A (ja) | 糖を含有する植物原材料からの糖または糖含有物の生成のための方法 | |
| JP4076877B2 (ja) | 高酸度食酢の製造方法 | |
| CN1107449C (zh) | 果蔬贮藏用的液体防腐保鲜剂及其制备方法 | |
| EP0114769B1 (fr) | Procédé de production de méthane par fermentation anaérobie | |
| CH327118A (fr) | Procédé de préparation d'une suspension aqueuse d'un sel de pénicilline | |
| EP0200648B1 (fr) | Procédé et appareil pour l'hydrolyse enzymatique de corps gras | |
| FR2855528A1 (fr) | Procede de maintien ou d'amelioration d'activite de nitrile hydratase et procede de production d'un amide a partir d'un nitrile | |
| US5023319A (en) | Stabilization of modified rosin | |
| CA2080146C (fr) | Stabilisation du 1, 1-dichloro-1- fluoroethane | |
| CA1091863A (fr) | Sels metalliques stabilises de l'acide ethylene bis dithiocarbamique, compositions les contenant, compositions stabilisees de procede de stabilisation | |
| Aldae et al. | The shelf-life of young white wines | |
| BE533298A (enrdf_load_stackoverflow) | ||
| BE502327A (enrdf_load_stackoverflow) |