BE517976A - - Google Patents

Info

Publication number

BE517976A

BE517976A BE517976DA BE517976A BE 517976 A BE517976 A BE 517976A BE 517976D A BE517976D A BE 517976DA BE 517976 A BE517976 A BE 517976A

Authority

BE

Belgium

Prior art keywords

glutamic acid

solution

crystals

monoclinic

monoclinic crystals

Prior art date

Links

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• 239000013078 crystal Substances 0.000 claims description 117
• 239000000243 solution Substances 0.000 claims description 104
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 93
• 235000013922 glutamic acid Nutrition 0.000 claims description 93
• 239000004220 glutamic acid Substances 0.000 claims description 93
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 63
• RPAJSBKBKSSMLJ-DFWYDOINSA-N (2s)-2-aminopentanedioic acid;hydrochloride Chemical compound Cl.OC(=O)[C@@H](N)CCC(O)=O RPAJSBKBKSSMLJ-DFWYDOINSA-N 0.000 claims description 35
• 229960003707 glutamic acid hydrochloride Drugs 0.000 claims description 35
• LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims description 35
• 239000004223 monosodium glutamate Substances 0.000 claims description 35
• 235000013923 monosodium glutamate Nutrition 0.000 claims description 35
• 239000002002 slurry Substances 0.000 claims description 18
• 238000000034 method Methods 0.000 claims description 17
• 238000002425 crystallisation Methods 0.000 claims description 15
• 230000008025 crystallization Effects 0.000 claims description 15
• 238000003756 stirring Methods 0.000 claims description 15
• 238000004519 manufacturing process Methods 0.000 claims description 13
• 239000000203 mixture Substances 0.000 claims description 12
• 239000003153 chemical reaction reagent Substances 0.000 claims description 11
• 239000007864 aqueous solution Substances 0.000 claims description 10
• 238000010979 pH adjustment Methods 0.000 claims description 10
• 238000010924 continuous production Methods 0.000 claims description 9
• 238000013019 agitation Methods 0.000 claims description 8
• 238000002156 mixing Methods 0.000 claims description 3
• 230000015572 biosynthetic process Effects 0.000 claims description 2
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 85
• 229960002989 glutamic acid Drugs 0.000 description 80
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 16
• 235000011121 sodium hydroxide Nutrition 0.000 description 16
• 239000002253 acid Substances 0.000 description 12
• 239000000047 product Substances 0.000 description 8
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
• 238000010899 nucleation Methods 0.000 description 4
• 239000000126 substance Substances 0.000 description 4
• KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
• 238000005119 centrifugation Methods 0.000 description 3
• 239000000706 filtrate Substances 0.000 description 3
• 238000001914 filtration Methods 0.000 description 3
• 230000007062 hydrolysis Effects 0.000 description 3
• 238000006460 hydrolysis reaction Methods 0.000 description 3
• 230000004048 modification Effects 0.000 description 3
• 238000012986 modification Methods 0.000 description 3
• 238000002360 preparation method Methods 0.000 description 3
• 239000002994 raw material Substances 0.000 description 3
• 108010082495 Dietary Plant Proteins Proteins 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
• 241000209140 Triticum Species 0.000 description 2
• 235000021307 Triticum Nutrition 0.000 description 2
• 239000003513 alkali Substances 0.000 description 2
• 239000003518 caustics Substances 0.000 description 2
• 239000000428 dust Substances 0.000 description 2
• 230000002349 favourable effect Effects 0.000 description 2
• 229940049906 glutamate Drugs 0.000 description 2
• 229930195712 glutamate Natural products 0.000 description 2
• 229910052500 inorganic mineral Inorganic materials 0.000 description 2
• 235000010755 mineral Nutrition 0.000 description 2
• 239000011707 mineral Substances 0.000 description 2
• 239000012452 mother liquor Substances 0.000 description 2
• 150000003839 salts Chemical class 0.000 description 2
• 229920006395 saturated elastomer Polymers 0.000 description 2
• 239000012047 saturated solution Substances 0.000 description 2
• 239000007858 starting material Substances 0.000 description 2
• QNRATNLHPGXHMA-XZHTYLCXSA-N (r)-(6-ethoxyquinolin-4-yl)-[(2s,4s,5r)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]methanol;hydrochloride Chemical compound Cl.C([C@H]([C@H](C1)CC)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OCC)C=C21 QNRATNLHPGXHMA-XZHTYLCXSA-N 0.000 description 1
• 235000016068 Berberis vulgaris Nutrition 0.000 description 1
• 241000335053 Beta vulgaris Species 0.000 description 1
• 108010068370 Glutens Proteins 0.000 description 1
• KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 239000012670 alkaline solution Substances 0.000 description 1
• 235000021120 animal protein Nutrition 0.000 description 1
• 238000010923 batch production Methods 0.000 description 1
• 239000005018 casein Substances 0.000 description 1
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
• 235000021240 caseins Nutrition 0.000 description 1
• 239000012141 concentrate Substances 0.000 description 1
• 238000001816 cooling Methods 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• 230000001747 exhibiting effect Effects 0.000 description 1
• 238000004880 explosion Methods 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 239000012634 fragment Substances 0.000 description 1
• 235000021312 gluten Nutrition 0.000 description 1
• SYUXAJSOZXEFPP-UHFFFAOYSA-N glutin Natural products COc1c(O)cc2OC(=CC(=O)c2c1O)c3ccccc3OC4OC(CO)C(O)C(O)C4O SYUXAJSOZXEFPP-UHFFFAOYSA-N 0.000 description 1
• 239000012535 impurity Substances 0.000 description 1
• 238000011081 inoculation Methods 0.000 description 1
• 230000001788 irregular Effects 0.000 description 1
• 239000000463 material Substances 0.000 description 1
• 230000015654 memory Effects 0.000 description 1
• 235000013379 molasses Nutrition 0.000 description 1
• 230000003287 optical effect Effects 0.000 description 1
• 150000002894 organic compounds Chemical class 0.000 description 1
• 230000001590 oxidative effect Effects 0.000 description 1
• 238000004806 packaging method and process Methods 0.000 description 1
• 230000000704 physical effect Effects 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 230000000717 retained effect Effects 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 239000011550 stock solution Substances 0.000 description 1
• 238000003860 storage Methods 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• 230000037303 wrinkles Effects 0.000 description 1