BE494362A - - Google Patents
Info
- Publication number
- BE494362A BE494362A BE494362DA BE494362A BE 494362 A BE494362 A BE 494362A BE 494362D A BE494362D A BE 494362DA BE 494362 A BE494362 A BE 494362A
- Authority
- BE
- Belgium
- Prior art keywords
- ethyl
- propoxybenzoate
- hydroxy
- under
- hydrochloride
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 claims description 7
- 230000000875 corresponding Effects 0.000 claims description 4
- 239000003589 local anesthetic agent Substances 0.000 claims description 4
- BRLQWZUYTZBJKN-UHFFFAOYSA-N epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims description 3
- 229960005015 Local anesthetics Drugs 0.000 claims description 2
- 229940083877 Local anesthetics for treatment of hemorrhoids and anal fissures for topical use Drugs 0.000 claims description 2
- 239000003513 alkali Substances 0.000 claims description 2
- 229940064003 local anesthetic throat preparations Drugs 0.000 claims description 2
- 230000001264 neutralization Effects 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 150000002118 epoxides Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- OXOWWPXTTOCKKU-UHFFFAOYSA-M 2-propoxybenzoate Chemical compound CCCOC1=CC=CC=C1C([O-])=O OXOWWPXTTOCKKU-UHFFFAOYSA-M 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
- 239000002585 base Substances 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- -1 propoxybenzoate hydrochloride Chemical compound 0.000 description 4
- HPNMFZURTQLUMO-UHFFFAOYSA-N Diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 125000004432 carbon atoms Chemical group C* 0.000 description 3
- 239000004593 Epoxy Substances 0.000 description 2
- NUVBSKCKDOMJSU-UHFFFAOYSA-N Ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 230000003444 anaesthetic Effects 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 2
- 229940043351 ethyl-p-hydroxybenzoate Drugs 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-Hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 210000004400 Mucous Membrane Anatomy 0.000 description 1
- XCRBXWCUXJNEFX-UHFFFAOYSA-N Peroxybenzoic acid Chemical compound OOC(=O)C1=CC=CC=C1 XCRBXWCUXJNEFX-UHFFFAOYSA-N 0.000 description 1
- 235000009499 Vanilla fragrans Nutrition 0.000 description 1
- 240000006722 Vanilla planifolia Species 0.000 description 1
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 1
- WFDIJRYMOXRFFG-UHFFFAOYSA-N acetic anhydride Substances CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000004442 acylamino group Chemical group 0.000 description 1
- 230000001476 alcoholic Effects 0.000 description 1
- 125000000033 alkoxyamino group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000010531 catalytic reduction reaction Methods 0.000 description 1
- 125000003700 epoxy group Chemical group 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- OQCZRDWKZXSHGS-ZHZULCJRSA-N ethyl (2Z)-2-[(2-acetyloxyphenyl)methylidene]-7-methyl-3-oxo-5-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate Chemical compound O=C1N2C(C=3C=CC=CC=3)C(C(=O)OCC)=C(C)N=C2S\C1=C/C1=CC=CC=C1OC(C)=O OQCZRDWKZXSHGS-ZHZULCJRSA-N 0.000 description 1
- ISQXCDWJOAJLLA-UHFFFAOYSA-N ethyl 2-propoxybenzoate Chemical compound CCCOC1=CC=CC=C1C(=O)OCC ISQXCDWJOAJLLA-UHFFFAOYSA-N 0.000 description 1
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 150000005165 hydroxybenzoic acids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 238000006396 nitration reaction Methods 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N propylene oxide Chemical class CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE494362A true BE494362A (de) |
Family
ID=138133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE494362D BE494362A (de) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE494362A (de) |
-
0
- BE BE494362D patent/BE494362A/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0245156B1 (de) | Herstellung von Fibraten | |
| CH375017A (fr) | Procédé de préparation de nouveaux dérivés de l'imidazole | |
| EP0515541B1 (de) | Verfahren zur herstellung von (2r,3r)-cis-beta-phenyl-glycidil-säure | |
| EP0729936A1 (de) | Verfahren zur Synthese der alpha-substiuierten Akrylsäuren und deren Verwendung | |
| EP0021940B1 (de) | Aminoderivate von Benzothiazol, Verfahren zu ihrer Herstellung und ihre Anwendung in der Heilkunde | |
| EP0515540B1 (de) | Beta-phenylisoserinderivate, ihre herstellung und ihre anwendung | |
| EP0122827B1 (de) | 1-(2-Ethoxycarbonyl-4-phenylalkylamido)-3-amino-2-Propanole, deren Herstellungen und deren pharmazeutische Verwendungen | |
| BE494362A (de) | ||
| FR2695125A1 (fr) | Nouveaux composés poly-iodés, procédé de préparation, produit de contraste les contenant. | |
| CH624089A5 (de) | ||
| EP0288647B1 (de) | Derivate von 5-[2-(1-Pyrrolidinyl)-äthoxy]-p-cymen, Verfahren zu ihrer Herstellung und diese Derivate enthaltende Arzneimittel | |
| EP0037781A1 (de) | Phenyl-alcoxy-propanolamine, ihre Herstellung und ihre Verwendung als Heilmittel | |
| BE541651A (de) | ||
| EP0008256A2 (de) | Indan-essigsäureester, ihre Bereitung und diese enthaltende Arzneimittel | |
| EP0057141B1 (de) | Ester von Halogenbiphenylcarboxylaten, deren Herstellungsverfahren und deren Verwendung als Arzneimittel | |
| CH468343A (fr) | Procédé de préparation d'hydroxy-diamines | |
| CH513821A (fr) | Procédé de préparation de mandélamidoximes | |
| FR2555169A2 (fr) | Nouveaux (carbethoxy-2 benzalkylamido-4 phenoxyl)-1 amino-3 propanols-2, leurs preparations et leurs utilisations en therapeutique | |
| BE558138A (de) | ||
| FR2530245A1 (fr) | Nouveaux 1-(2-carbalkoxy 4-(thienyl-alkylamido)phenoxy) 3-amino 2-propanols, leur preparation et leurs applications en therapeutique | |
| FR2750425A1 (fr) | Preparation de derives de 3-amino-isoxazole et nouveaux 3-amino-isoxazoles intermediaires | |
| BE572290A (de) | ||
| FR2485006A1 (fr) | Derives d'amidoximes, leur preparation et leur application en therapeutique | |
| BE684910A (de) | ||
| FR2542737A1 (fr) | Nouveaux (carbethoxy-2 benzalkylamido-4 phenoxy)-1 amino-3 propanols-2, leurs preparations et leurs utilisations en therapeutique |