BE493429A - - Google Patents
Info
- Publication number
- BE493429A BE493429A BE493429DA BE493429A BE 493429 A BE493429 A BE 493429A BE 493429D A BE493429D A BE 493429DA BE 493429 A BE493429 A BE 493429A
- Authority
- BE
- Belgium
- Prior art keywords
- hydrochloride
- isopropylbiguanide
- iodophenyl
- propylbiguanide
- methyl
- Prior art date
Links
- 238000000034 method Methods 0.000 claims description 10
- 150000004283 biguanides Chemical class 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 54
- UBBHRFLEDZWRNR-UHFFFAOYSA-N 1-(diaminomethylidene)-2-propan-2-ylguanidine Chemical compound CC(C)N=C(N)N=C(N)N UBBHRFLEDZWRNR-UHFFFAOYSA-N 0.000 description 14
- FAPXKQMFIRYKMF-UHFFFAOYSA-N 1-(diaminomethylidene)-2-propylguanidine Chemical compound CCCN=C(N)N=C(N)N FAPXKQMFIRYKMF-UHFFFAOYSA-N 0.000 description 12
- 150000001412 amines Chemical class 0.000 description 10
- OZMNTKIANCJQSO-UHFFFAOYSA-N 3-(diaminomethylidene)-1-methyl-1-propan-2-ylguanidine Chemical compound CC(C)N(C)C(=N)N=C(N)N OZMNTKIANCJQSO-UHFFFAOYSA-N 0.000 description 9
- 229940123208 Biguanide Drugs 0.000 description 8
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical class NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 8
- XWFPIJRFFLYWRN-UHFFFAOYSA-N 1-(diaminomethylidene)-2-ethylguanidine Chemical compound CCN=C(N)N=C(N)N XWFPIJRFFLYWRN-UHFFFAOYSA-N 0.000 description 7
- -1 alkyl radicals Chemical class 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 5
- BGTOZLLZUNEENO-UHFFFAOYSA-N 3-(diaminomethylidene)-1-methyl-1-propylguanidine Chemical compound CCCN(C)C(=N)N=C(N)N BGTOZLLZUNEENO-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical compound NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- BMKJPIBZJKDTGC-UHFFFAOYSA-N 1-(diaminomethylidene)-2-ethylguanidine;hydrochloride Chemical compound [Cl-].CC[NH2+]\C(N)=N\C(N)=N BMKJPIBZJKDTGC-UHFFFAOYSA-N 0.000 description 1
- XGYJEGYASMHSSX-UHFFFAOYSA-N 1-(diaminomethylidene)-2-propan-2-ylguanidine;hydrochloride Chemical compound [Cl-].CC(C)[NH2+]\C(N)=N\C(N)=N XGYJEGYASMHSSX-UHFFFAOYSA-N 0.000 description 1
- HGRYADBWOJPLHK-UHFFFAOYSA-N 1-(diaminomethylidene)-2-propylguanidine;hydrochloride Chemical compound [Cl-].CCC[NH2+]\C(N)=N\C(N)=N HGRYADBWOJPLHK-UHFFFAOYSA-N 0.000 description 1
- MOEFNEYLFDEODP-UHFFFAOYSA-N 1-(n'-methylcarbamimidoyl)-2-propylguanidine Chemical compound CCCN=C(N)NC(N)=NC MOEFNEYLFDEODP-UHFFFAOYSA-N 0.000 description 1
- HQTOGRJJEXEVDY-UHFFFAOYSA-N 2-(3,5-dimethoxy-4-propoxyphenyl)ethanamine;hydrochloride Chemical compound Cl.CCCOC1=C(OC)C=C(CCN)C=C1OC HQTOGRJJEXEVDY-UHFFFAOYSA-N 0.000 description 1
- CMEIYVWWZREFEM-UHFFFAOYSA-N 2-ethyl-1-(n'-ethylcarbamimidoyl)guanidine Chemical compound CCN=C(N)NC(N)=NCC CMEIYVWWZREFEM-UHFFFAOYSA-N 0.000 description 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 description 1
- BNXBAYBCIBKOAW-UHFFFAOYSA-N 3-(diaminomethylidene)-1-methyl-1-propylguanidine;hydrochloride Chemical compound Cl.CCCN(C)C(=N)N=C(N)N BNXBAYBCIBKOAW-UHFFFAOYSA-N 0.000 description 1
- 241000208818 Helianthus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 125000004799 bromophenyl group Chemical group 0.000 description 1
- XSEUMFJMFFMCIU-UHFFFAOYSA-N buformin Chemical compound CCCC\N=C(/N)N=C(N)N XSEUMFJMFFMCIU-UHFFFAOYSA-N 0.000 description 1
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 125000006303 iodophenyl group Chemical group 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- FBBDOOHMGLLEGJ-UHFFFAOYSA-N methane;hydrochloride Chemical compound C.Cl FBBDOOHMGLLEGJ-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE493429A true BE493429A (https=) |
Family
ID=137426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE493429D BE493429A (https=) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE493429A (https=) |
-
0
- BE BE493429D patent/BE493429A/fr unknown
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