BE446911A - - Google Patents

Info

Publication number

BE446911A

BE446911A BE446911DA BE446911A BE 446911 A BE446911 A BE 446911A BE 446911D A BE446911D A BE 446911DA BE 446911 A BE446911 A BE 446911A

Authority

BE

Belgium

Prior art keywords

sulfanilamide

compound

grams

potassium rhodanide

alcohol

Prior art date

Links

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• 150000001875 compounds Chemical class 0.000 claims description 12
• FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 claims description 10
• 229940124530 sulfonamide Drugs 0.000 claims description 10
• ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 claims description 7
• 238000002844 melting Methods 0.000 claims description 4
• 230000008018 melting Effects 0.000 claims description 4
• 238000004090 dissolution Methods 0.000 claims description 2
• 239000003960 organic solvent Substances 0.000 claims description 2
• 238000002425 crystallisation Methods 0.000 claims 1
• 230000008025 crystallization Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
• 239000013078 crystal Substances 0.000 description 3
• 239000002904 solvent Substances 0.000 description 3
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
• 238000000034 method Methods 0.000 description 2
• 240000000254 Agrostemma githago Species 0.000 description 1
• 235000009899 Agrostemma githago Nutrition 0.000 description 1
• MQJKPEGWNLWLTK-UHFFFAOYSA-N Dapsone Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=C1 MQJKPEGWNLWLTK-UHFFFAOYSA-N 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• 230000000996 additive effect Effects 0.000 description 1
• 150000001450 anions Chemical class 0.000 description 1
• 230000000844 anti-bacterial effect Effects 0.000 description 1
• 230000000973 chemotherapeutic effect Effects 0.000 description 1
• 238000001816 cooling Methods 0.000 description 1
• 239000012043 crude product Substances 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 239000012535 impurity Substances 0.000 description 1
• 239000000203 mixture Substances 0.000 description 1
• 239000012452 mother liquor Substances 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 238000002360 preparation method Methods 0.000 description 1
• 239000000047 product Substances 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 241000894007 species Species 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 230000008961 swelling Effects 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1