BE438274A - - Google Patents

Info

Publication number

BE438274A

BE438274A BE438274DA BE438274A BE 438274 A BE438274 A BE 438274A BE 438274D A BE438274D A BE 438274DA BE 438274 A BE438274 A BE 438274A

Authority

BE

Belgium

Prior art keywords

acid

parts

mouse

weight

azo

Prior art date

Links

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• 239000000987 azo dye Substances 0.000 claims description 6
• 238000002360 preparation method Methods 0.000 claims description 4
• 238000000034 method Methods 0.000 claims description 3
• XIQKALDENTUXBY-UHFFFAOYSA-N 4-hydroxynaphthalene-1,5-disulfonic acid Chemical compound C1=CC(S(O)(=O)=O)=C2C(O)=CC=C(S(O)(=O)=O)C2=C1 XIQKALDENTUXBY-UHFFFAOYSA-N 0.000 claims description 2
• 239000000975 dye Substances 0.000 claims 1
• XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
• TVZISJTYELEYPI-UHFFFAOYSA-N hypodiphosphoric acid Chemical compound OP(O)(=O)P(O)(O)=O TVZISJTYELEYPI-UHFFFAOYSA-N 0.000 claims 1
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
• 239000000047 product Substances 0.000 description 4
• 239000000243 solution Substances 0.000 description 4
• 239000002253 acid Substances 0.000 description 3
• BGYSJUFVJUJSOL-UHFFFAOYSA-M neosalvarsan Chemical compound [Na+].C1=C(O)C(N)=CC(\[As]=[As]\C=2C=C(NCS([O-])=O)C(O)=CC=2)=C1 BGYSJUFVJUJSOL-UHFFFAOYSA-M 0.000 description 3
• 230000002349 favourable effect Effects 0.000 description 2
• 231100000682 maximum tolerated dose Toxicity 0.000 description 2
• 230000001225 therapeutic effect Effects 0.000 description 2
• 201000002311 trypanosomiasis Diseases 0.000 description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
• ZYECOAILUNWEAL-NUDFZHEQSA-N (4z)-4-[[2-methoxy-5-(phenylcarbamoyl)phenyl]hydrazinylidene]-n-(3-nitrophenyl)-3-oxonaphthalene-2-carboxamide Chemical compound COC1=CC=C(C(=O)NC=2C=CC=CC=2)C=C1N\N=C(C1=CC=CC=C1C=1)/C(=O)C=1C(=O)NC1=CC=CC([N+]([O-])=O)=C1 ZYECOAILUNWEAL-NUDFZHEQSA-N 0.000 description 1
• ZCZNGRXPMRPERV-UHFFFAOYSA-N 4,4'-diarsene-1,2-diylbis(2-aminophenol) Chemical compound C1=C(O)C(N)=CC([As]=[As]C=2C=C(N)C(O)=CC=2)=C1 ZCZNGRXPMRPERV-UHFFFAOYSA-N 0.000 description 1
• KWSLGOVYXMQPPX-UHFFFAOYSA-N 5-[3-(trifluoromethyl)phenyl]-2h-tetrazole Chemical compound FC(F)(F)C1=CC=CC(C2=NNN=N2)=C1 KWSLGOVYXMQPPX-UHFFFAOYSA-N 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
• 241000223089 Trypanosoma equiperdum Species 0.000 description 1
• 235000005811 Viola adunca Nutrition 0.000 description 1
• 240000009038 Viola odorata Species 0.000 description 1
• 235000013487 Viola odorata Nutrition 0.000 description 1
• 235000002254 Viola papilionacea Nutrition 0.000 description 1
• 239000012670 alkaline solution Substances 0.000 description 1
• XKNKHVGWJDPIRJ-UHFFFAOYSA-N arsanilic acid Chemical compound NC1=CC=C([As](O)(O)=O)C=C1 XKNKHVGWJDPIRJ-UHFFFAOYSA-N 0.000 description 1
• 229950002705 arsanilic acid Drugs 0.000 description 1
• 239000007795 chemical reaction product Substances 0.000 description 1
• 208000015181 infectious disease Diseases 0.000 description 1
• 238000007912 intraperitoneal administration Methods 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 239000002244 precipitate Substances 0.000 description 1
• 231100000916 relative toxicity Toxicity 0.000 description 1
• 229910001379 sodium hypophosphite Inorganic materials 0.000 description 1
• 231100001274 therapeutic index Toxicity 0.000 description 1
• 238000002560 therapeutic procedure Methods 0.000 description 1
• 231100000331 toxic Toxicity 0.000 description 1
• 230000002588 toxic effect Effects 0.000 description 1