BE2017C049I2 - - Google Patents

Download PDF

Info

Publication number
BE2017C049I2
BE2017C049I2 BE2017C049C BE2017C049C BE2017C049I2 BE 2017C049 I2 BE2017C049 I2 BE 2017C049I2 BE 2017C049 C BE2017C049 C BE 2017C049C BE 2017C049 C BE2017C049 C BE 2017C049C BE 2017C049 I2 BE2017C049 I2 BE 2017C049I2
Authority
BE
Belgium
Application number
BE2017C049C
Other languages
French (fr)
Original Assignee
Wyeth Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29401497&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2017C049(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Holdings Llc filed Critical Wyeth Holdings Llc
Publication of BE2017C049I2 publication Critical patent/BE2017C049I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Plant Pathology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
BE2017C049C 2002-05-02 2017-11-16 BE2017C049I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37744002P 2002-05-02 2002-05-02
EP03724432.4A EP1507556B1 (en) 2002-05-02 2003-05-02 Calicheamicin derivative-carrier conjugates

Publications (1)

Publication Number Publication Date
BE2017C049I2 true BE2017C049I2 (en) 2022-08-09

Family

ID=29401497

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2017C049C BE2017C049I2 (en) 2002-05-02 2017-11-16

Country Status (33)

Country Link
US (6) US8153768B2 (en)
EP (3) EP1507556B1 (en)
JP (5) JP5153057B2 (en)
KR (2) KR101062628B1 (en)
CN (1) CN100482277C (en)
AU (2) AU2003231293A1 (en)
BE (1) BE2017C049I2 (en)
BR (3) BRPI0309868B8 (en)
CA (2) CA2871117A1 (en)
CR (3) CR7557A (en)
CY (4) CY1116634T1 (en)
DK (3) DK3127553T3 (en)
EC (1) ECSP045445A (en)
ES (3) ES2593304T3 (en)
FR (1) FR17C1054I2 (en)
HU (4) HUE027590T2 (en)
IL (2) IL164946A (en)
LT (3) LT3127553T (en)
LU (1) LUC00044I2 (en)
MX (1) MXPA04010792A (en)
NL (1) NL300903I2 (en)
NO (3) NO339730B1 (en)
NZ (2) NZ573563A (en)
PH (2) PH12013501159A1 (en)
PL (5) PL224001B1 (en)
PT (3) PT3127553T (en)
RU (3) RU2422157C3 (en)
SG (3) SG10201700289RA (en)
SI (3) SI2371392T1 (en)
TW (2) TWI438010B (en)
UA (1) UA88599C2 (en)
WO (1) WO2003092623A2 (en)
ZA (2) ZA200409752B (en)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6905669B2 (en) 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
US20110045005A1 (en) * 2001-10-19 2011-02-24 Craig Crowley Compositions and methods for the treatment of tumor of hematopoietic origin
GB0210121D0 (en) 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
WO2003092623A2 (en) * 2002-05-02 2003-11-13 Wyeth Holdings Corporation Calicheamicin derivative-carrier conjugates
TW200539855A (en) * 2004-03-15 2005-12-16 Wyeth Corp Calicheamicin conjugates
JP5470597B2 (en) * 2004-05-26 2014-04-16 国立大学法人 香川大学 Cell / tissue / organ preservation solution using rare sugar D-allose and preservation method using the solution
TW200621282A (en) * 2004-08-13 2006-07-01 Wyeth Corp Stabilizing formulations
TWI374935B (en) 2004-08-27 2012-10-21 Pfizer Ireland Pharmaceuticals Production of α-abeta
US7294484B2 (en) 2004-08-27 2007-11-13 Wyeth Research Ireland Limited Production of polypeptides
US7300773B2 (en) 2004-08-27 2007-11-27 Wyeth Research Ireland Limited Production of TNFR-Ig
CA2486285C (en) * 2004-08-30 2017-03-07 Viktor S. Goldmakher Immunoconjugates targeting syndecan-1 expressing cells and use thereof
JP2008512485A (en) * 2004-09-10 2008-04-24 ワイス Humanized anti-5T4 antibody and anti-5T4 antibody / calicheamicin conjugate
EP1661584A1 (en) * 2004-11-26 2006-05-31 Heinz Dr. Faulstich Use of conjugates of amatoxins and phallotoxins with macromolecules for cancer and inflammation therapy
US20110166319A1 (en) * 2005-02-11 2011-07-07 Immunogen, Inc. Process for preparing purified drug conjugates
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
US20070003559A1 (en) * 2005-07-01 2007-01-04 Wyeth Methods of determining pharmacokinetics of targeted therapies
CN101242820A (en) 2005-08-16 2008-08-13 辛塔制药公司 Bis(thio-hydrazide amide) formulation
EP2399609B1 (en) 2005-08-24 2015-03-18 ImmunoGen, Inc. Process for preparing maytansinoid antibody conjugates
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US9393215B2 (en) 2005-12-02 2016-07-19 Novartis Ag Nanoparticles for use in immunogenic compositions
BRPI0619476A2 (en) * 2005-12-05 2011-10-04 Wyeth Corp Interleukin-11 compositions and methods of use
JP5523824B2 (en) 2006-03-10 2014-06-18 ワイス・エルエルシー Anti-5T4 antibody and use thereof
ATE521366T1 (en) * 2006-05-27 2011-09-15 Faulstich Heinz Dr APPLICATION OF AMATOXIN CONJUGATES AND PHALLOTOXIN CONJUGATES WITH MACROMOLECLES FOR CANCER THERAPY AND THERAPY OF INFLAMMATION
MX2009000349A (en) 2006-07-13 2009-03-09 Wyeth Corp Production of glycoproteins.
US8609720B2 (en) 2006-08-21 2013-12-17 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
KR20090069330A (en) * 2006-10-12 2009-06-30 와이어쓰 Changes in ionic strength in antibody solutions to reduce opalescent / aggregates
CA2666317C (en) 2006-11-03 2013-08-06 Wyeth Glycolysis-inhibiting substances in cell culture
TWI447124B (en) * 2006-12-01 2014-08-01 Medarex Llc Human antibodies that bind cd22 and uses thereof
WO2008079897A2 (en) * 2006-12-22 2008-07-03 The Regents Of The University Of California Macromolecular conjugates of cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof
WO2008088849A2 (en) * 2007-01-16 2008-07-24 Wyeth Inflammation treatment, detection and monitoring via trem-1
US9012180B2 (en) 2007-03-02 2015-04-21 Wyeth Llc Use of copper and glutamate in cell culture for production of polypeptides
US8110705B2 (en) * 2007-05-22 2012-02-07 Wyeth Llc Processes for making hydrazides
PE20090309A1 (en) * 2007-06-04 2009-04-18 Wyeth Corp CARRIER-KALICHEAMICIN CONJUGATE AND A METHOD OF DETECTION OF KALIQUEAMICIN
WO2009052431A2 (en) * 2007-10-19 2009-04-23 Seattle Genetics, Inc. Cd19 binding agents and uses thereof
WO2009086072A2 (en) * 2007-12-21 2009-07-09 Genentech, Inc. Therapy of rituximab-refractory rheumatoid arthritis patients
CA2710483C (en) * 2007-12-26 2018-05-08 Biotest Ag Methods and agents for improving targeting of cd138 expressing tumor cells
WO2009080831A1 (en) * 2007-12-26 2009-07-02 Biotest Ag Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
RU2547939C2 (en) * 2007-12-26 2015-04-10 Биотест Аг Anti-cd138 immunoconjugates and using them
JP5990365B2 (en) 2007-12-26 2016-09-14 バイオテスト・アクチエンゲゼルシヤフト Agents targeting CD138 and uses thereof
US20090186026A1 (en) * 2008-01-18 2009-07-23 Wyeth Ephrin and eph receptor agonists for modulation of bone formation and resorption
WO2009124109A1 (en) 2008-04-04 2009-10-08 The Government Of The U.S. A. As Represented By The Secretary Of The Dept. Of Health &Human Services Human monoclonal antibodies specific for cd22
FR2930443B1 (en) 2008-04-29 2010-06-25 Oreal EXTEMPORANE CARE PRODUCT BASED ON MICROORGANISM LYOPHILISATE AND SURFACTANT (S) HLB UP TO 12
JP5769616B2 (en) 2008-04-30 2015-08-26 イミュノジェン・インコーポレーテッド Crosslinkers and their use
AU2010256659B2 (en) * 2009-06-03 2015-01-29 Immunogen, Inc. Conjugation methods
EP2533814A2 (en) * 2010-02-11 2012-12-19 Ablynx N.V. Delivery of immunoglobulin variable domains and constructs thereof
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US20130150554A1 (en) 2010-08-20 2013-06-13 Wyeth Llc Cell culture of growth factor-free adapted cells
CA2821992A1 (en) 2010-10-01 2012-04-05 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2637692A4 (en) 2010-11-12 2014-09-10 Scott & White Healthcare ANTIBODIES AGAINST THE MARKER 8 TUMOR ENDOTHELIAL
US20120222979A1 (en) * 2011-03-04 2012-09-06 Elwha LLC, a limited liability company of the State of Delaware Glassy compositions
CN107537040A (en) 2011-03-29 2018-01-05 伊缪诺金公司 Class maytansine antibody conjugates are prepared by one-step method
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
AU2012302051B2 (en) 2011-08-30 2017-04-27 Astex Pharmaceuticals, Inc. Decitabine derivative formulations
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
DK3682905T3 (en) 2011-10-03 2022-02-28 Modernatx Inc MODIFIED NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS AND USES THEREOF
KR20140077977A (en) 2011-10-21 2014-06-24 화이자 인코포레이티드 Addition of iron to improve cell culture
BR112014013694A2 (en) 2011-12-08 2017-06-13 Biotest Ag method to treat a disease and kit
KR20140102759A (en) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 Modified nucleoside, nucleotide, and nucleic acid compositions
WO2013151672A2 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of oncology-related proteins and peptides
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
WO2014008404A1 (en) 2012-07-03 2014-01-09 Washington University Antibodies to tau
US8883979B2 (en) 2012-08-31 2014-11-11 Bayer Healthcare Llc Anti-prolactin receptor antibody formulations
CN105209592A (en) 2012-10-04 2015-12-30 伊缪诺金公司 Purification of cell-binding agent cytotoxic agent conjugates using PVDF membranes
CN105849086B (en) 2012-11-24 2018-07-31 杭州多禧生物科技有限公司 Hydrophily chain junctor and its application on drug molecule and cell-binding molecules conjugation reaction
LT2922554T (en) 2012-11-26 2022-06-27 Modernatx, Inc. Terminally modified rna
BR112015014712A2 (en) 2012-12-21 2017-07-11 Abgenomics Int Inc hydrophilic autoimolation linkers and their conjugates
WO2014113203A1 (en) 2013-01-17 2014-07-24 Case Western Reserve University Viral nanoparticle multimers
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
MY192404A (en) * 2013-05-02 2022-08-19 Hoffmann La Roche Combination therapy of an afucosylated cd20 antibody with a cd22 antibody-drug conjugate
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
SG11201602503TA (en) 2013-10-03 2016-04-28 Moderna Therapeutics Inc Polynucleotides encoding low density lipoprotein receptor
BR112016010051A2 (en) 2013-11-04 2017-12-05 Pfizer "anti-efna4 antibody-drug conjugates"
WO2015063680A1 (en) * 2013-11-04 2015-05-07 Pfizer Inc. Intermediates and methods for synthesizing calicheamicin derivatives
CN114262344A (en) 2014-02-28 2022-04-01 杭州多禧生物科技有限公司 Charged linkers and their use in conjugation reactions
WO2015140708A1 (en) 2014-03-19 2015-09-24 Pfizer Inc. Method of cell culture
US11998594B2 (en) 2014-04-02 2024-06-04 Case Western Reserve University Anti-cancer plant virus particles linked to HER2 antigens
CN106661124A (en) 2014-06-20 2017-05-10 荷商台医(有限合伙)公司 Anti-folate receptor alpha (FRA) antibody-drug conjugates and methods of use thereof
TWI734975B (en) 2014-06-27 2021-08-01 美商Ｃ２Ｎ醫療診斷有限責任公司 Humanized anti-tau antibodies
GB201412658D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
US9925281B2 (en) 2014-08-05 2018-03-27 Case Western Reserve University Coated plant virus imaging agents
WO2016073972A1 (en) 2014-11-07 2016-05-12 Case Western Reserve University Cancer immunotherapy using virus particles
BR112017020689A2 (en) 2015-04-07 2018-06-26 Univ Cornell nanoparticulate immunoconjugates
CA2983158A1 (en) * 2015-04-21 2016-10-27 Abbvie Stemcentrx Llc Calicheamicin constructs and methods of use
GB201506870D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method
CA2986575A1 (en) 2015-05-21 2016-11-24 Harpoon Therapeutics, Inc. Trispecific binding proteins and methods of use
EP3313527B1 (en) 2015-06-29 2021-02-24 Case Western Reserve University Anticancer drug-containing plant virus particles
BR112018000054A2 (en) 2015-07-02 2018-09-04 Otsuka Pharmaceutical Co., Ltd. lyophilized pharmaceutical compositions
CN108449940B (en) 2015-07-12 2021-06-08 杭州多禧生物科技有限公司 Conjugated bridging linkers to cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
EP3725332B1 (en) 2015-07-16 2023-10-04 Case Western Reserve University Plant virus particles for delivery of antimitotic agents
GB201601073D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies
GB201601075D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies molecules
GB201601077D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibody molecule
EP3353313B1 (en) 2015-09-23 2024-08-07 Pfizer Inc. Cells and method of cell culture
KR20180073693A (en) 2015-11-09 2018-07-02 브리스톨-마이어스 스큅 컴퍼니 How to manipulate the quality attributes of polypeptides produced in CHO cells
ES2880731T3 (en) 2016-01-08 2021-11-25 Altrubio Inc Quadrivalent anti-PSGL-1 antibodies and uses thereof
US20170281758A1 (en) * 2016-03-29 2017-10-05 Sorrento Therapeutics, Inc. Calicheamicin antibody drug conjugates linking an amidoacetyl group to a sugar moiety on calicheamicin
MX394238B (en) 2016-04-05 2025-03-19 Pfizer CELL CULTURE PROCESS
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
GB201610512D0 (en) 2016-06-16 2016-08-03 Autolus Ltd Chimeric antigen receptor
WO2018017985A1 (en) 2016-07-21 2018-01-25 Case Western Reserve University Plant virus or virus-like particle constructs
EP3535283A4 (en) 2016-11-03 2020-08-12 Case Western Reserve University MELT-PROCESSED VIRAL NANOPARTICLE CONSTRUCTS
KR20220147720A (en) 2016-11-14 2022-11-03 항저우 디에이씨 바이오테크 씨오, 엘티디 Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
US11590183B2 (en) 2017-03-10 2023-02-28 Case Western Reserve University Cancer immunotherapy using virus particles
EP3596206A1 (en) 2017-03-16 2020-01-22 Pfizer Inc Tyrosine prototrophy
JP7090347B2 (en) 2017-05-12 2022-06-24 ハープーン セラピューティクス，インク． Mesothelin-binding protein
WO2018213587A1 (en) 2017-05-17 2018-11-22 Case Western Reserve University Anticancer trail-targeted plant virus particles
JP2020529409A (en) 2017-08-03 2020-10-08 大塚製薬株式会社 Drug compounds and their purification methods
JP2020533983A (en) 2017-09-15 2020-11-26 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Online biomass capacitance monitoring during large-scale production of the polypeptide of interest
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B cell maturation antigen binding proteins
CN118978600A (en) 2017-10-13 2024-11-19 哈普恩治疗公司 Trispecific proteins and methods of use
US11739301B2 (en) 2017-10-27 2023-08-29 Case Western Reserve University Tymovirus virus and virus-like particles as nanocarriers for imaging and therapeutic agents
CN111902160B (en) 2018-03-16 2025-05-09 百时美施贵宝公司 Metabolic enzyme activity and disulfide bond reduction during protein production
CN110507824A (en) * 2018-05-21 2019-11-29 荣昌生物制药（烟台）有限公司 A kind of Anti-mesothelin antibodies and its antibody drug conjugate
CN112135843A (en) * 2018-05-30 2020-12-25 艾伯维施特姆森特克斯有限责任公司 anti-SEZ 6 antibody drug conjugates and methods of use
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
US10815311B2 (en) 2018-09-25 2020-10-27 Harpoon Therapeutics, Inc. DLL3 binding proteins and methods of use
CN113056288A (en) 2018-11-20 2021-06-29 康奈尔大学 Macrocyclic complexes of radionuclides and their use in radiotherapy of cancer
US20220073942A1 (en) 2018-12-06 2022-03-10 Pfizer Inc. Cells with reduced inhibitor production and methods of use thereof
CA3127142A1 (en) * 2019-02-13 2020-08-20 Coimmune, Inc. Cancer immunotherapy using combinations of cells expressing chimeric antigen receptors and monoclonal antibodies
JP7684947B2 (en) 2019-03-19 2025-05-28 フンダシオ プリバダ インスティトゥト ディンベスティガシオ オンコロジカ デ バル エブロン Combination Therapies for the Treatment of Cancer
US11390853B2 (en) 2019-04-26 2022-07-19 Case Western Reserve University Freeze dried viral nanoparticle constructs
US20220288219A1 (en) * 2019-07-08 2022-09-15 Mythic Therapeutics, Inc. Antigen-binding protein constructs and uses thereof
WO2021024020A1 (en) 2019-08-06 2021-02-11 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
US11896676B2 (en) 2019-08-07 2024-02-13 Case Western Reserve University Targeting cancer cells and tissue using filamentous plant virus particles
WO2021113740A1 (en) * 2019-12-04 2021-06-10 The Research Foundation For The State University Of New York Compositions and methods for reducing off-target toxicity of antibody drug conjugates
US12203073B2 (en) 2019-12-20 2025-01-21 Case Western Reserve University Plant viral RNA delivery nanoparticles and uses thereof
US11529430B2 (en) 2019-12-20 2022-12-20 Case Western Reserve University Polydopamine decorated tobacco mosaic theranostic virus nanoparticles
KR20230035576A (en) 2020-07-07 2023-03-14 비온테크 에스이 RNA for the treatment of HPV-positive cancer
WO2022135667A1 (en) 2020-12-21 2022-06-30 BioNTech SE Therapeutic rna for treating cancer
WO2022135666A1 (en) 2020-12-21 2022-06-30 BioNTech SE Treatment schedule for cytokine proteins
TW202245808A (en) 2020-12-21 2022-12-01 德商拜恩迪克公司 Therapeutic rna for treating cancer
CN112724263B (en) * 2021-04-02 2021-08-03 上海偌妥生物科技有限公司 Method for improving drug efficacy of anti-CD 20 monoclonal antibody by modifying anti-CD 20 monoclonal antibody and application thereof
CA3225254A1 (en) 2021-07-13 2023-01-19 BioNTech SE Multispecific binding agents against cd40 and cd137 in combination therapy for cancer
TW202333802A (en) 2021-10-11 2023-09-01 德商拜恩迪克公司 Therapeutic rna for lung cancer
WO2022078524A2 (en) 2021-11-03 2022-04-21 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody
WO2023148598A1 (en) 2022-02-02 2023-08-10 Pfizer Inc. Cysteine prototrophy
CN119855620A (en) * 2022-09-16 2025-04-18 国立研究开发法人量子科学技术研究开发机构 Method for producing intermediate of radiopharmaceutical composition, and kit for purifying intermediate of radiopharmaceutical composition
AU2023370106A1 (en) 2022-10-25 2025-05-08 Fundació Privada Institut D'investigació Oncològica De Vall Hebron Combination therapy for the treatment of cancer
KR20250120305A (en) 2022-12-14 2025-08-08 아스텔라스 파마 유럽 비.브이. Combination therapy involving a dual-specificity binding agent that binds to CLDN18.2 and CD3 and an immune checkpoint inhibitor
WO2024218706A1 (en) 2023-04-21 2024-10-24 Pfizer Inc. Improved cells and cell cultures
WO2024251846A1 (en) 2023-06-07 2024-12-12 Fundació Privada Institut D'investigació Oncològica De Vall Hebron Combination therapy with mek inhibitors for the treatment of cancer
WO2024251854A1 (en) 2023-06-07 2024-12-12 Fundació Privada Institut D'investigació Oncològica De Vall Hebron Combination therapy with braf inhibitors for the treatment of cancer
EP4473974A1 (en) 2023-06-07 2024-12-11 Peptomyc, S.L. Omomyc and kras inhibitors combination therapy for the treatment of cancer
WO2025063789A1 (en) * 2023-09-21 2025-03-27 주식회사 피노바이오 Carrier-drug conjugate and combination therapy with dnmt-1 inhibitor
WO2025120866A1 (en) 2023-12-08 2025-06-12 Astellas Pharma Inc. Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2
WO2025120867A1 (en) 2023-12-08 2025-06-12 Astellas Pharma Inc. Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies
WO2025121445A1 (en) 2023-12-08 2025-06-12 Astellas Pharma Inc. Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4671958A (en) 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4970198A (en) 1985-10-17 1990-11-13 American Cyanamid Company Antitumor antibiotics (LL-E33288 complex)
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4771128A (en) * 1986-10-10 1988-09-13 Cetus Corporation Method of purifying toxin conjugates using hydrophobic interaction chromatography
US5079233A (en) 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5037651A (en) 1987-01-30 1991-08-06 American Cyanamid Company Dihydro derivatives of LL-E33288 antibiotics
US5053394A (en) 1988-09-21 1991-10-01 American Cyanamid Company Targeted forms of methyltrithio antitumor agents
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5134075A (en) * 1989-02-17 1992-07-28 Oncogen Limited Partnership Monoclonal antibody to novel antigen associated with human tumors
GB8928874D0 (en) * 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
DE69132771T2 (en) * 1990-06-27 2002-08-01 Princeton University, Princeton PROBE FOR DETECTING THE P53 MUTANT
DE69233153T2 (en) * 1991-03-06 2004-05-27 Merck Patent Gmbh HUMANIZED MONOCLONAL ANTIBODIES
US5714350A (en) * 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US5686072A (en) * 1992-06-17 1997-11-11 Board Of Regents, The University Of Texas Epitope-specific monoclonal antibodies and immunotoxins and uses thereof
US5484892A (en) * 1993-05-21 1996-01-16 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells
US6180377B1 (en) * 1993-06-16 2001-01-30 Celltech Therapeutics Limited Humanized antibodies
US5436265A (en) * 1993-11-12 1995-07-25 Merck Frosst Canada, Inc. 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
US5712474A (en) * 1993-09-29 1998-01-27 Canon Kabushiki Kaisha Image processing apparatus for correcting blurring of an image photographed by a video camera
US6310185B1 (en) 1994-03-08 2001-10-30 Memorial Sloan Kettering Cancer Center Recombinant human anti-Lewis Y antibodies
US5773001A (en) 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
EP0705903B2 (en) 1994-08-12 2009-08-12 The University of Utah Research Foundation Mutations in the 17q-linked breast and ovarian cancer susceptibility gene
DE69534530T2 (en) 1994-08-12 2006-07-06 Immunomedics, Inc. FOR B-CELL LYMPHOMA AND LEUKEMIA SPECIMEN IMMUNOCONJUGATES AND HUMAN ANTIBODIES
US5714586A (en) 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US6267958B1 (en) * 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US7147851B1 (en) * 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
US20020141990A1 (en) * 1996-11-01 2002-10-03 Smithkline Beecham Corporation Anti-RSV human monoclonal antibodies
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
WO1998041641A1 (en) 1997-03-20 1998-09-24 The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services Recombinant antibodies and immunoconjugates targeted to cd-22 bearing cells and tumors
US6306393B1 (en) 1997-03-24 2001-10-23 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
US6183744B1 (en) * 1997-03-24 2001-02-06 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
DE69810481T2 (en) 1997-06-13 2003-09-25 Genentech Inc., San Francisco STABILIZED ANTIBODY FORMULATION
AT408613B (en) * 1998-06-17 2002-01-25 Immuno Ag PHARMACEUTICAL FACTOR VII PREPARATION
US6183477B1 (en) * 1998-09-04 2001-02-06 Smith & Nephew, Inc. Attachment tool for drill guide
KR100345463B1 (en) * 1998-11-19 2003-01-08 주)녹십자 Humanized Antibodies to Surface Antigen Free-S1 of Hepatitis B Virus and Methods for Making the Same
JP2000226336A (en) * 1998-11-30 2000-08-15 Sankyo Co Ltd Immunoglobulin preparation
EP2154535A1 (en) 1998-12-10 2010-02-17 Bristol-Myers Squibb Company Protein scaffolds for antibody mimics and other binding proteins
HK1046635B (en) * 1999-06-09 2009-10-09 Immunomedics, Inc. Immunotherapy of autoimmune disorders using antibodies which target b-cells
ATE264340T1 (en) * 1999-08-17 2004-04-15 Novo Nordisk Healthcare Ag STABILIZATION OF FREEZE-DRIED CAKE
ATE236398T1 (en) * 1999-10-12 2003-04-15 Connex Ges Zur Optimierung Von IMPROVED METHOD FOR DETECTING ACID-RESISTANT BACTERIA OF THE GENUS HELICOBACTER IN CHEESE
US20010046496A1 (en) * 2000-04-14 2001-11-29 Brettman Lee R. Method of administering an antibody
GB0013810D0 (en) * 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
WO2003092623A2 (en) * 2002-05-02 2003-11-13 Wyeth Holdings Corporation Calicheamicin derivative-carrier conjugates
GB0210121D0 (en) * 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products

Also Published As

Publication number Publication date
CY1116634T1 (en) 2017-03-15
NO2017061I1 (en) 2017-11-21
NO339730B1 (en) 2017-01-23
IL230659A0 (en) 2014-03-31
CA2871117A1 (en) 2003-11-13
LUC00044I2 (en) 2018-02-26
PH12013501159B1 (en) 2015-12-02
AU2003231293A1 (en) 2003-11-17
TW200404005A (en) 2004-03-16
LUC00044I1 (en) 2017-11-03
LTC2371392I2 (en) 2019-03-25
EP3127553A1 (en) 2017-02-08
SG165158A1 (en) 2010-10-28
WO2003092623A2 (en) 2003-11-13
PL228741B1 (en) 2018-05-30
JP2017105801A (en) 2017-06-15
KR101062628B1 (en) 2011-09-07
HUE027590T2 (en) 2016-11-28
EP1507556A2 (en) 2005-02-23
US9351986B2 (en) 2016-05-31
TWI379693B (en) 2012-12-21
EP1507556B1 (en) 2016-07-27
JP5153057B2 (en) 2013-02-27
DK1507556T3 (en) 2016-09-12
ECSP045445A (en) 2005-01-28
LTPA2017036I1 (en) 2017-11-27
US20040082764A1 (en) 2004-04-29
EP3127553B1 (en) 2021-12-01
SI3127553T1 (en) 2022-02-28
CR20130390A (en) 2013-11-08
NO20044663L (en) 2005-01-25
JP5756489B2 (en) 2015-07-29
PH12013501158B1 (en) 2015-11-09
CY2017035I2 (en) 2018-04-04
US20180339058A1 (en) 2018-11-29
HUE057124T2 (en) 2022-04-28
RU2602878C2 (en) 2016-11-20
PL224001B1 (en) 2016-11-30
JP2005524700A (en) 2005-08-18
CR20120364A (en) 2012-10-05
CR7557A (en) 2008-10-03
JP2012051900A (en) 2012-03-15
BR122019027966B1 (en) 2020-11-17
EP1507556A4 (en) 2009-01-07
TW201231089A (en) 2012-08-01
BR122019027974B1 (en) 2022-06-14
JP2013163678A (en) 2013-08-22
NO20161431A1 (en) 2005-01-25
DK2371392T3 (en) 2015-08-31
PH12013501159A1 (en) 2015-12-02
HK1070825A1 (en) 2005-06-30
PL224150B1 (en) 2016-11-30
BR0309868A (en) 2005-10-18
WO2003092623A3 (en) 2004-03-18
FR17C1054I1 (en) 2018-01-12
CY1124900T1 (en) 2023-01-05
BRPI0309868B1 (en) 2020-04-28
PT1507556T (en) 2016-09-28
ES2916174T3 (en) 2022-06-28
PL413302A1 (en) 2016-05-23
JP2015061875A (en) 2015-04-02
KR20110050753A (en) 2011-05-16
TWI438010B (en) 2014-05-21
BR122019027966B8 (en) 2021-07-27
RU2422157C3 (en) 2021-04-23
HUE057124T4 (en) 2022-02-28
UA88599C2 (en) 2009-11-10
FR17C1054I2 (en) 2019-01-11
SI1507556T1 (en) 2016-10-28
US8835611B2 (en) 2014-09-16
AU2009202609B2 (en) 2012-07-26
IL230659A (en) 2016-02-29
RU2678818C2 (en) 2019-02-04
CY1117973T1 (en) 2017-05-17
EP2371392B1 (en) 2015-07-08
IL164946A0 (en) 2005-12-18
RU2016141576A3 (en) 2018-05-03
NZ573563A (en) 2010-10-29
PL410219A1 (en) 2015-03-30
PL411824A1 (en) 2015-08-17
PH12013501158A1 (en) 2015-11-09
RU2422157C2 (en) 2011-06-27
PL374523A1 (en) 2005-10-31
KR20050006220A (en) 2005-01-15
IL164946A (en) 2015-06-30
RU2011108928A (en) 2012-09-20
NZ586071A (en) 2012-02-24
JP6872376B2 (en) 2021-05-19
PT3127553T (en) 2022-01-24
US8153768B2 (en) 2012-04-10
RU2016141576A (en) 2018-05-03
PL410218A1 (en) 2015-03-30
BRPI0309868B8 (en) 2021-05-25
DK3127553T3 (en) 2022-01-31
HUS1700038I1 (en) 2017-11-28
PT2371392E (en) 2015-10-07
NL300903I2 (en) 2018-02-08
LT1507556T (en) 2016-10-10
US20120213804A1 (en) 2012-08-23
AU2009202609A1 (en) 2009-07-16
EP2371392A1 (en) 2011-10-05
KR101125524B1 (en) 2012-03-22
CA2483552A1 (en) 2003-11-13
PL222725B1 (en) 2016-08-31
PL224844B1 (en) 2017-02-28
HUE030806T2 (en) 2017-05-29
US20040192900A1 (en) 2004-09-30
US20160303252A1 (en) 2016-10-20
HK1162926A1 (en) 2012-09-07
RU2004135101A (en) 2005-06-27
CN100482277C (en) 2009-04-29
ES2545745T3 (en) 2015-09-15
JP5441971B2 (en) 2014-03-12
SI2371392T1 (en) 2015-10-30
SG187991A1 (en) 2013-03-28
ZA200409752B (en) 2010-08-25
SG10201700289RA (en) 2017-02-27
US8747857B2 (en) 2014-06-10
RU2602878C3 (en) 2021-11-24
LT3127553T (en) 2022-04-11
MXPA04010792A (en) 2005-03-07
CN1665532A (en) 2005-09-07
CY2017035I1 (en) 2018-04-04
US20140235835A1 (en) 2014-08-21
ZA201003874B (en) 2019-12-18
NO344509B1 (en) 2020-01-20
ES2593304T3 (en) 2016-12-07

Similar Documents

Publication Publication Date Title
BE2019C547I2 (en)
BE2019C510I2 (en)
BE2018C021I2 (en)
FR17C1054I1 (en)
BE2017C005I2 (en)
BE2016C069I2 (en)
BE2016C040I2 (en)
BE2016C013I2 (en)
BE2015C078I2 (en)
BE2016C002I2 (en)
BE2018C018I2 (en)
BE2015C017I2 (en)
BE2014C053I2 (en)
BE2014C051I2 (en)
BE2011C038I2 (en)
JP2003198604A5 (en)
BE2015C068I2 (en)
IN192749B (en)
DE60330807D1 (en)
JP2003056473A5 (en)
DE60333727D1 (en)
HU0202032D0 (en)
JP2003232859A5 (en)
JP2002224360A5 (en)
JP2003208898A5 (en)