BE1026317B1 - SET FOR WHITE MAKING TEETH AND USE THEREOF - Google Patents

Abstract

The invention relates to a set for teeth whitening comprising a melamine foam stain remover and an activation composition, the activation composition comprising the following: a bleaching enzymatic complex comprising a protease or a mixture of proteases; a glaze enhancing agent selected from the group consisting of a sugar alcohol and a biologically available mineral; and an aqueous carrier. The invention further relates to a method for activating a melamine foam stain remover and a method for bleaching the teeth.

Description

SET FOR WHITE MAKING TEETH AND USE THEREOF

FIELD OF THE INVENTION

The invention is generally in the field of cosmetics. In particular, the invention relates to a set for bleaching and cleaning the teeth.

BACKGROUND OF THE INVENTION

The usefulness of certain foods and beverages, such as coffee or tea, or smoking can cause teeth yellowing. It has been found that the perception of a smile is highly influenced by the color of the teeth. The whiter the teeth, the more beautiful a smile is experienced. Some people can be very self-conscious about the color of their teeth and in some extreme cases people deliberately try to avoid showing the teeth while laughing. Dentists offer teeth whitening, but these treatments are often expensive and invasive. This requires making an appointment and a visit to the dentist and therefore it takes time and effort. There is a need for methods and sets for teeth whitening which one can use at a chosen time and at any place whatsoever.

Teeth whitening sets are available, but these teeth whitening sets include various complex parts, such as trays or mouth guards, syringes filled with chemical compounds, exposure devices and so on. These complex parts make these teeth whitening sets difficult to use or they are time consuming to use. These trays and mouth guards often have a universal size, which in practice leads to poor fitting and poor results. There is therefore a need for teeth whitening sets that can be easily used by anyone. There is a further need for sets for whitening teeth that do not depend on the fit of a tray or mouth guard.

Tooth whitening sets often include chemicals, such as hydrogen peroxide, that are aggressive to soft tissue, such as gums. There is a need for whitening sets of teeth that do not include chemicals that are aggressive to soft tissues.

In some teeth whitening sets, soft abrasives are used to remove stains from teeth. However, these abrasives could leave scratches on the enamel of the teeth, increasing the tendency to create new stains on the tooth surface. There is therefore a need for whitening sets of teeth that do not leave any scratches on the enamel.

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Some tooth whitening sets only remove superficial stains, but not stains that are embedded in the pellicle and / or plaque. Therefore, there is a need for whitening sets for teeth that remove embedded stains in the pellicle and / or plaque.

Some teeth whitening sets bleach the teeth gradually after each application, so that multiple applications are required to achieve a clearly visible result. Therefore, there is a need for teeth whitening sets that provide a clearly visible result even after the first application.

In view of the above, there remains a need in the art for further and / or improved sets for whitening teeth.

SUMMARY OF THE INVENTION

The present inventors have found a teeth whitening set through experimental testing that addresses one or more of the aforementioned problems in the art.

Accordingly, a first aspect of the invention relates to a set for teeth whitening comprising a melamine foam stain remover and an activation composition, the activation composition comprising: a bleaching enzymatic complex comprising a protease or a mixture of proteases; a glaze enhancing agent selected from the group consisting of a sugar alcohol and a biologically available mineral; and an aqueous carrier.

The present set makes it possible to bleach and clean the teeth while it is safer than brushing teeth. The present set has a direct effect with immediate bleaching effect on the teeth after a single application. The combination of the melamine foam stain remover and the activation composition advantageously makes it possible to bleach the teeth by removing superficial stains, while at the same time reinforcing and protecting the enamel and neutralizing harmful mouth acids. The set is a self-contained system that can be used en route. In comparison with sets according to the prior art, no tap water with a variable and sometimes unknown composition is required.

A further aspect provides an activation composition for teeth whitening, the activation composition comprising:

- a bleaching enzymatic complex comprising a protease or a mixture of proteases;

- a glaze-enhancing agent selected from the group consisting of a sugar alcohol and a biologically available mineral; and

- an aqueous carrier.

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A further aspect relates to a method for activating a melamine foam stain remover for teeth whitening, comprising the following steps:

- providing a set for whitening teeth as defined herein; and

- applying the activation composition to the melamine foam stain remover, whereby the melamine foam stain remover is activated.

The present method advantageously makes it possible to activate the melamine foam just before the use of the melamine foam stain remover. The user can easily activate the melamine foam without the need to provide substances or compositions from outside, such as tap water, the composition of which may be variable and sometimes unknown.

A further aspect relates to a method for whitening the teeth, comprising the following steps:

- providing a set for whitening teeth as defined herein;

- applying the activation composition to the melamine foam stain remover, whereby the melamine foam stain remover is activated; and

- rubbing the activated melamine foam stain remover over the surface of the teeth.

The present method makes it possible to bleach and clean the teeth while it is safer than brushing teeth. The present method has a direct effect with immediate bleaching effect on the teeth after a single application. The combination of the melamine foam stain remover and the activation composition advantageously makes it possible to bleach the teeth by removing superficial stains, while at the same time reinforcing and protecting the enamel and neutralizing harmful mouth acids.

The above and further aspects and preferred embodiments of the invention are described in the following paragraphs and in the appended claims. The content of the appended claims is hereby specifically included in this description.

DESCRIPTION OF THE DRAWINGS

FIG. 1 represents a three-dimensional view of a tooth whitening set (1) according to an embodiment of the invention. A melamine foam stain remover (2) is not (yet) connected to the handle (3).

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FIG. 2 represents a three-dimensional view of a tooth whitening set (1) according to an embodiment of the invention. A melamine foam stain remover (2) is connected to the handle (3).

FIG. 3A represents a photograph showing the smile zone.

FIG. 3B represents a photograph showing the laughing zone with the dental arch half, which is assigned to a treatment group.

FIG. 4A represents a baseline photo before treatment with a set and method according to an embodiment of the invention of 6 blocks of highly discolored bovine enamel divided into 3 groups of two: R = Reference; F = Foam-treated, P = Pasta-treated.

FIG. 4B represents a photo after treatment with a set and method according to an embodiment of the invention of 6 blocks of highly discolored bovine enamel divided into 3 groups of two: R = Reference; F = Foam-treated, P = Pasta-treated.

The following reference numbers are used in the present description:

- teeth whitening set; 2 - melamine foam stain remover; 21 melamine foam section; 22 - cartridge; 23 - part to be connected; 3 - handle; 31 connecting means; 4 - activation composition; 5 - bottle; 6 - applicator; 7 - tray; 8 - base station; 10 - melamine foam stain removal device.

DETAILED DESCRIPTION OF THE INVENTION

As used herein, the singular forms include one, the, and both references to the singular and to the plural, unless the context clearly dictates otherwise.

The terms comprising, including and including as used herein are synonymous with included, including or including, contained and they are inclusive or with an open end and do not exclude further unnamed members, elements or steps of a method. The terms also include consisting of and consisting essentially of.

The indication of numerical areas by means of end points includes all numbers and fractions that lie in the respective areas, as well as the end points mentioned.

The term approximately as used herein when reference is made to a measurable value, such as a parameter, an amount, a duration and the like, is intended to mean variations with respect to the stated value, in particular variations of +/- 10% or less, preferably + / 5% or less, more preferably +/- 1% or less and even more preferably +/- 0.1% or less relative to the stated value, to the extent that such variations apply to the disclosed invention. It should be understood that the value to which the assay roughly refers refers to itself also specifically and preferably disclosed.

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Although the term one or more, such as one or more members of a group of members, is clear per se, the term includes, by way of further explanation, a reference to one of the members or to two or more of the members, such as for example> 3,> 4,> 5,> 6 or> 7 etc. of the members and up to all of these members.

All documents mentioned in the present description are hereby incorporated by reference in their entirety.

Unless otherwise stated, all terms used to disclose the invention, including technical and scientific terms, have the meaning as would generally be clear to a person skilled in the art to which this invention belongs. As further guidance, definitions of terms may be included to better understand the teaching of the present invention.

The present inventors have found a teeth whitening set comprising a melamine foam stain remover and an activation composition that can remove stains from the teeth and / or reduce yellowing of the teeth.

The invention relates to a set for whitening teeth comprising a melamine foam stain remover and an activation composition. More particularly, the invention relates to a tooth whitening set comprising a melamine foam stain remover and an activation composition, the activation composition comprising the following:

- a bleaching enzymatic complex comprising a protease or a mixture of proteases;

- a glaze-enhancing agent selected from the group consisting of a sugar alcohol and a biologically available mineral; and

- an aqueous carrier, such as water.

It has been found that rubbing melamine foam over the tooth surface is more effective at removing stains than brushing teeth. The present set is self-contained with the activation composition that allows the activation of the melamine foam without the need for other compounds, such as tap water. The present set is also less invasive than brushing teeth and can lead to a long-lasting beauty of the tooth surface. This can also make the present tooth whitening set suitable for maintaining oral hygiene after oral surgery or in the case of gum disease.

The terms and expressions set, set of parts, assembly, tooth whitening set, or set for whitening teeth may be used interchangeably herein.

Activation composition

In certain embodiments, the activation composition as disclosed herein comprises:

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- a bleaching enzymatic complex comprising a protease or a mixture of proteases;

- a glaze-enhancing agent selected from the group consisting of a sugar alcohol and a biologically available mineral; and

- an aqueous carrier, such as water.

The activation composition advantageously moistens the foam, making the foam more flexible during use, so that it can reach gaps between the teeth (which are harder to reach). Furthermore, the activation composition contributes to the whitening of the teeth and the strengthening of the enamel.

The terms composition, formulation, serum or emulsion can be used interchangeably herein and refer to a mixture of active ingredients.

The terms bleaching enzymatic complex, enamel enhancing agent, cooling agent include active ingredients of the activation composition.

The terms active ingredient or active ingredient can be used interchangeably and generally refer to a compound or substance that when provided in an effective amount leads to a desired outcome. The desired outcome can be cosmetic, therapeutic and / or prophylactic. Typically, an active ingredient can lead to such an outcome (or similar outcomes) by interacting with and / or modulating living cells or organisms.

The term active / active in the terms active ingredient or active component refers to pharmacologically active and / or physically active.

The reference to an active ingredient includes one or more of the active ingredients, such as two or more, three or more or four or more, such as five, six, seven, eight or more of the active ingredients. As an example, the reference to an enamel enhancing agent includes one or more enamel enhancing agents such as two or more, three or more or four or more, such as five, six, seven, eight or more enamel enhancing agents.

In certain embodiments, the activation composition comprises a bleaching enzymatic complex comprising a protease or a mixture of proteases. The bleaching enzymatic complex destroys and / or removes the protein portion of the pellicle and / or plaque. Stains can build up in the pellicle or plaque and in this way stains can sit there for years and can be very difficult to remove because they are embedded by the pellicle and / or plaque. As a result, the bleaching enzymatic complex makes it possible to remove stains bound to these proteins. The breakdown of these proteins has a particularly large one

BE2019 / 5066 stain remover after the first application. Therefore, the use of the present set leads to an immediate bleaching effect on the teeth even after the first application.

In certain embodiments, the bleaching enzymatic complex may comprise a cysteine protease, a sulfhydryl protease, or a mixture thereof.

In certain embodiments, the bleaching enzymatic complex may be present in a fruit extract.

In certain embodiments of the sets, methods, or uses as disclosed herein, the bleaching enzymatic complex may include papain, bromelain, or a combination thereof, or consist essentially of or consist of it.

In certain embodiments, the bleaching enzymatic complex may be papain and / or bromelain.

The terms papain or papaya proteinase I refer to a cysteine protease that may be present in or isolated from papaya (Carica papaya) or mountain papaya (Vasconcellea cundinamarcensis). Papain has 3.4.22.2 as EC number and 9001-73-4 as CAS number.

The term bromelain as used herein refers to an enzyme extract that may be present in or isolated from pineapple plants (Ananas comosus). Bromelain is mainly present in the stem of pineapples. Bromelain is often used to indicate an extract comprising the sulfhydryl proteases stem bromelain and fruit bromelain. The extract may comprise other compounds in addition to these enzymes.

Stem bromelain is a sulfhydryl protease. Stengel bromelain has 3.4.22.32 as EC number and 37189-34-7 as CAS number.

Fruit bromelain is a sulfhydryl protease. Fruit bromelain has 3.4.22.33 as EC number and 9001-00-7 as CAS number.

In certain embodiments, the activation composition may include papain and bromelain.

In certain embodiments, the composition as disclosed herein may comprise from about 0.1% by weight to about 10% by weight of the bleaching enzymatic complex, such as papain and / or bromelain. In certain embodiments, the composition as disclosed herein may be from about 0.5% to about 10%, about 1.0% to about 5.0%, or about 1.0% to about 3, 0% by weight of the bleaching enzymatic complex, such as papain and / or bromelain.

In certain embodiments, the activation composition comprises an enamel-enhancing agent selected from the group consisting of a sugar alcohol and a biologically available mineral. Weak or under-mineralized enamel is susceptible to wear and scratching

BE2019 / 5066 a frictional movement. The glaze enhancing agent reinforces the glaze and therefore prevents the glaze wear and scratching of the glaze.

In certain embodiments, the activation composition comprises a sugar alcohol. Bacteria on the surface of the teeth produce a biofilm that can completely cover the teeth and cause discoloration of the teeth. The enamel enhancing agent as disclosed herein, in particular a sugar alcohol, such as xylitol, can block communication between bacteria and blocks the production of compounds that hold the biofilm together. As a result, the biofilm can eventually break up and slide off the surface of the teeth. The enamel enhancing agent as disclosed herein, in particular a sugar alcohol such as xylitol, can also interfere with the ability of the bacteria to produce acid, thereby increasing the pH of the mouth. Cariogenic bacteria thrive at lower pH values and these bacteria produce even more acid that demineralises the enamel. It has been found that the enamel-enhancing agent as disclosed herein, in particular, lowers a sugar alcohol such as xylitol, Streptococcus mutans levels in saliva and plaque, thereby improving oral hygiene in general and in particular the healthy condition of the teeth maintains. It has been found that the enamel-enhancing agent as disclosed herein, especially a sugar alcohol such as xylitol, increases oral hygiene, reducing the risk of gum disease and caries. The reduction of bacteria also leads to a breath-refreshing effect.

The terms sugar alcohol, polyhydroxy alcohol, polyalcohol, alditol, or glycitol refer to an organic compound that contains multiple hydroxyl groups and is typically derived from sugars. Sugar alcohols, a class of polyols, are usually obtained by hydrogenation of sugars.

In certain embodiments, the glaze enhancing agent can be a sugar alcohol. In certain embodiments of the sets, methods, or use as disclosed herein, the enamel enhancing agent may be a sugar alcohol selected from the group consisting of xylitol, erythritol, sorbitol, mannitol, maltitol, isomalt, lactitol, arabitol, glycerol, and hydrogenated. starch hydrolyzate.

In certain embodiments, the glaze-enhancing agent may be a sugar alcohol selected from the group consisting of xylitol, erythritol, sorbitol, mannitol, maltitol, isomalt, lactitol, and hydrogenated starch hydrolyzate.

In certain embodiments of the sets, methods, or use as disclosed herein, the enamel enhancing agent may be xylitol.

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The terms xylitol, adonitol, ribitol or D-xylitol can be used interchangeably and refer to a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. Xylitol has (2S, 4R) -pentane-1,2,3,4,5-pentol as IUPAC name. Xylitol has 87-99-0 as the CAS number.

In certain embodiments, the composition as disclosed herein may comprise from about 0.1% to about 20% by weight of a sugar alcohol such as xylitol. In certain embodiments, the composition as disclosed herein may be from about 0.5% to about 10%, about 1.0% to about 10%, about 1.0% to about 5.0% % or about 1.0% to about 3.0% by weight of a sugar alcohol, such as xylitol.

In certain embodiments, the activation composition comprises a biologically available mineral.

The term bioavailable generally refers to the ability of a substance or composition, for example a mineral, to be absorbed and used by the body.

The term bioavailable mineral refers to a mineral that can be incorporated into the enamel and can form part of the structure of the enamel.

In certain embodiments, the glaze enhancing agent can be a biologically available mineral. In certain embodiments of the sets, methods, or use as disclosed herein, the enamel enhancing agent may be a biologically available mineral selected from the group consisting of a biologically available calcium, a biologically available magnesium, and a biologically available phosphate. In certain embodiments of the sets, methods, or use as disclosed herein, the enamel enhancing agent may be a bioavailable mineral selected from the group consisting of a bioavailable calcium and a bioavailable magnesium. Preferably, the glaze enhancing agent is a combination of a bioavailable calcium and a bioavailable magnesium. It has been found that biologically available minerals, in particular biologically available calcium and / or biologically available magnesium, remineralize the teeth and improve their appearance, so that this has a bleaching effect and enhances the glare of the teeth. In particular, biologically available calcium has a large glaze-enhancing effect. Biologically available magnesium reduces white points and helps neutralize harmful acids.

In certain embodiments, the biologically available calcium can be a calcium salt. The calcium salt can be calcium lactate, calcium gluconate, amorphous calcium phosphate (ACP),

BE2019 / 5066 octacalcium phosphate, calcium phosphate, tetracalcium phosphate (TTCP), anhydrous dicalcium phosphate, dicalcium phosphate dihydrate, tricalcium phosphate, calcium sodium phosphosilicate glass, calcium lactate gluconate, calcium calcium citrate, calcium calcium carbonate.

In certain embodiments, the biologically available calcium can be an apatite, such as hydroxyapatite.

The term apatite refers to a group of phosphate minerals with high concentrations of OH ^- - F ^- - or Cl ^- ions in the crystal.

The terms hydroxyapatite or hydroxylapatite (HA) refer to a naturally occurring mineral form of calcium apatite.

In certain embodiments, the biologically available calcium may be casein and / or casein phosphopeptide stabilized amorphous calcium phosphate complexes (CPP-ACP).

In certain embodiments, the biologically available calcium may include calcium phosphate, brushite (i.e., dicalcium phosphate dihydrate), β-tricalcium phosphate (β-TCP); octacalcium phosphate, hydroxyapatite, fluorapatite, nanohydroxyapatite, calcium sodium phosphosilicate, amorphous calcium phosphate (ACP), amorphous calcium fluoride phosphate (ACFP), casein phosphopeptides (CPP) -ACP, CPP-ACFP or a combination thereof.

In certain embodiments, the biologically available calcium may include calcium lactate, calcium gluconate, ACP, octacalcium phosphate, calcium phosphate, TTCP, anhydrous dicalcium phosphate, dicalcium phosphate dihydrate, tricalcium phosphate, calcium sodium phosphosilicate calcium, calcium lactate, calcium calcium, calcium nitrate, calcium calcium, calcium nitrate, calcium calcium, calcium citrate, calcium calcium, calcium citrate, calcium calcium, calcium, calcium, calcium, calcium, calcium, calcium, calcium, calcium. -ACP or a combination thereof.

In certain embodiments, the biologically available magnesium can be a magnesium salt. The magnesium salt can be magnesium sulfate, monomagnesium phosphate, dimagnesium phosphate, trimagnesium phosphate, amorphous magnesium phosphate, magnesium oxide, magnesium citrate, magnesium chloride, magnesium hydroxide, magnesium glycinate, magnesium orotate, magnesium threonate, magnesium aspartate, magnesium gluconate, magnesium malate or a combination thereof.

In certain embodiments, the biologically available magnesium can be magnesium sulfate, monomagnesium phosphate, dimagnesium phosphate, trimagnesium phosphate, amorphous magnesium phosphate, magnesium oxide, magnesium citrate, magnesium chloride, magnesium hydroxide,

BE2019 / 5066 magnesium glycinate, magnesium orotate, magnesium threonate, magnesium aspartate, magnesium gluconate, magnesium malate or a combination thereof.

In certain embodiments, the bio-available phosphate, amorphous calcium phosphate (ACP), octacalcium phosphate, calcium phosphate, tetracalcium phosphate (TTCP), anhydrous dicalcium phosphate, dicalcium phosphate dihydrate, tricalcium phosphate, calciumnatriumfosfosilicaatglas, hydroxyapatite, fluorapatite, nanohydroxyapatiet, amorphous calcium fluoride phosphate (ACFP), casein phosphopeptides (CPP) -ACP, CPP-ACFP, monomagnesium phosphate, dimagnesium phosphate, trimagnesium phosphate, amorphous magnesium phosphate or a combination thereof.

In certain embodiments, the glaze enhancing agent can be a calcium salt, a magnesium salt, or a combination thereof. Preferably, the glaze enhancing agent is a combination of a calcium salt and a magnesium salt. As an example, the glaze enhancing agent can be calcium lactate, calcium gluconate and magnesium sulfate.

In certain embodiments, the glaze enhancing agents may be xylitol, bioavailable calcium, and bioavailable magnesium. In certain embodiments, the glaze enhancing agents may be xylitol, calcium lactate, calcium gluconate, and magnesium sulfate.

In certain embodiments, the composition as disclosed herein may comprise from about 0.1% to about 20% by weight of a biologically available mineral, such as calcium lactate, calcium gluconate, and / or magnesium sulfate. In certain embodiments, the composition as disclosed herein may be from about 0.2% by weight to about 10% by weight, from about 0.5% by weight to about 5.0% by weight, or from about 0.5% by weight to about 3%, 0% by weight of a biologically available mineral, such as calcium lactate, calcium gluconate and / or magnesium sulfate.

In certain embodiments, the activation composition may comprise a sugar alcohol, a biologically available mineral, or a combination thereof. Preferably, the activation composition comprises a combination of a sugar alcohol and a biologically available mineral.

In certain embodiments, the activation composition may include xylitol, bioavailable calcium, and bioavailable magnesium. In certain embodiments, the activation composition may include xylitol, calcium lactate, calcium gluconate, and magnesium sulfate.

In certain embodiments of the sets, methods, or use as disclosed herein, the activation composition may include papain, bromelain, xylitol, bioavailable calcium, and bioavailable magnesium. In certain embodiments, the activation composition may include papain, bromelain, xylitol, calcium lactate, calcium gluconate, and magnesium sulfate.

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In certain embodiments, the composition as disclosed herein may comprise from about 0.1% by weight to about 20% by weight of the one or more enamel enhancing agents. In certain embodiments, the composition as disclosed herein may be from about 0.5% to about 10%, about 1.0% to about 10%, or about 1.0% to about 5.0% % of the one or more glaze enhancing agents.

The composition as disclosed herein may comprise an aqueous carrier.

The terms aqueous carrier or aqueous solution generally refer to a solution in which the solvent comprises water, consists essentially of water or consists of water. In certain embodiments, the aqueous carrier comprises at least 1 volume% of water. As an example, the aqueous carrier comprises at least 5% by volume, at least 10% by volume, at least 20% by volume, at least 30% by volume, at least 40% by volume, at least 50% by volume, at least 60 vol.%, At least 70 vol.%, At least 80 vol.%, At least 90 vol.%, At least 95 vol.% Or at least 99 vol.% Water. In certain embodiments, the aqueous carrier consists of water.

In certain embodiments of the sets, methods, or uses as disclosed herein, the aqueous carrier is water.

In certain embodiments, the composition as disclosed herein may comprise from about 50% to about 98% by weight of the aqueous carrier, such as water. In certain embodiments, the composition as disclosed herein may be from about 60% to about 98%, about 65% to about 97%, about 70% to about 96%, about 75% by weight up to about 95% by weight, about 80% by weight to about 95% by weight or about 80% by weight to about 90% by weight of the aqueous carrier, such as water. In certain embodiments, the composition as disclosed herein may comprise from about 50% to about 99% by weight of the aqueous carrier, such as water, such as from about 60% to about 95% or about 70% to about 90% by weight. % of the aqueous carrier, such as water.

In certain embodiments of the sets, methods, or uses as disclosed herein, the activation composition may include, consist of, or consist of, an aqueous carrier, papain, bromelain, xylitol, bioavailable calcium, and bioavailable magnesium. In certain embodiments, the activation composition may comprise, consist essentially of, or consist of, an aqueous carrier, papain, bromelain, xylitol, calcium lactate, calcium gluconate, and magnesium sulfate.

In certain embodiments of the sets, methods, or use as disclosed herein, the activation composition may further comprise a cooling agent, preferably a physically cooling agent. The cooling agent can provide a breath-refreshing effect.

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The term physiologically cooling agent refers to an agent that exerts a chemical action at or near nerve endings associated with the sensation of cold.

In certain embodiments of the sets, methods, or uses as disclosed herein, the activation composition may further be a physiologically cooling agent selected from the group consisting of N, 2,3-trimethyl-2- (1-methylethyl) butanamide; menthol;

menthylpyrrolidone carboxylate; menthyl lactate; isopulegol; menthone; N-ethyl pmentane carboxamide; ethyl 2- (2-isopropyl-5-methylcyclohexanecarboxamido) acetate; menthone glycerin acetal; monomenthyl succinate; monomenthyl glutarate; O-menthyl glycerin; 2-sec-butylcyclohexanone; menthan; camphor; pulegol; cineole; mint oil; peppermint oil; aarmunt oil; eucalyptus oil; 3-1-menthoxypropane-1,2-diol; 3-1-menthoxy-2-methylpropane-1,2-diol; pmentane-3,8-diol; 2-1-menthoxyethane-1-ol; 3-1-menthoxypropan-1-ol; 4-1-menthoxybutane-1ol; 2-isopropyl-5-methylcyclohexanecarboxylic acid (4-cyanomethylphenyl) amide; 2-isopropyl-5-methylcyclohexanecarboxylic acid (4-cyanophenyl) amide; 4 - [(2-isopropyl-5-methylcyclohexanecarbonyl) amino] benzamide; 3 - [(2-isopropyl-5-methylcyclohexanecarbonyl) amino] benzamide; 2 isopropyl-5-methyl-N- (4- (4-methylpiperazine-1-carbonyl) phenyl) cyclohexanecarboxamide; 2-isopropyl-5-methylcyclohexane carboxylic acid pyridine-2-ylamide; and 2-isopropyl-5-methylcyclohexanecarboxylic acid (2-pyridine-2-ylethyl) amide.

In certain embodiments of the sets, methods, or use as disclosed herein, the physiological cooling agent may be N, 2,3-trimethyl-2- (1-methylethyl) butanamide.

The term N, 2,3-trimethyl-2- (1-methylethyl) butanamide, also called N, 2,3-trimethyl-2- (propan-2-yl) butanamide or trimethylisopropylbutanamide methyl diisopropylpropionamide, can be represented by structure (I)

^Π (I)

N, 2,3-trimethyl-2- (1-methylethyl) butanamide has 51115-67-4 as CAS number.

This cooling agent according to structure (I) provides an odorless and tasteless cooling feeling, in particular on the tongue and in the mouth. The effect can be experienced the same as the effect of menthol, but without the mint flavor.

In certain embodiments, the composition as disclosed herein may comprise from about 0.001% to about 1.0% by weight of a cooling agent, preferably a physically cooling

BE2019 / 5066, such as methyl diisopropylpropionamide. In certain embodiments, the composition as disclosed herein may be from about 0.005% to about 1.0% or about 0.01% to about 0.9% by weight of a cooling agent, preferably a physically cooling agent, such as methyl diisopropylpropionamide.

In certain embodiments of the sets, methods, or use, as disclosed herein, the activation composition may include the following:

papain, bromelain or a combination thereof, preferably papain and bromelain;

xylitol, biologically available calcium, biologically available magnesium or a combination thereof, preferably xylitol, biologically available calcium and biologically available magnesium;

- optionally a cooling agent, preferably a physiologically cooling agent.

In certain embodiments of the sets, methods, or uses as disclosed herein, the activation composition may include, consist of, or consist of, an aqueous carrier, papain, bromelain, xylitol, bioavailable calcium, bioavailable magnesium, and a physiologically cooling agent . In certain embodiments, the activation composition may comprise, consist essentially of, or consist of, an aqueous carrier, papain, bromelain, xylitol, calcium lactate, calcium gluconate, magnesium sulfate, and a physiologically cooling agent. In certain embodiments, the activation composition may comprise, consist of, or consist essentially of, an aqueous carrier, papain, bromelain, xylitol, calcium lactate, calcium gluconate, magnesium sulfate, and N, 2,3-trimethyl-2- (1-methylethyl) butanamide.

In certain embodiments, the composition as disclosed herein may comprise an abrasive. Any abrasive commonly used in cosmetic preparations can be used in the compositions disclosed herein.

The term abrasive refers to a substance that can polish a softer material, such as the enamel.

In certain embodiments, the abrasive can be hydrated silica.

The term hydrated silica refers to a form of silica. When dissolved in water, it is usually known as silica.

Examples of hydrated silica include Sident 9 (Evonik Industries AG, Essen, Germany), which is an abrasive silica with moderate hardness and moderate thickening behavior.

In certain embodiments, the composition as disclosed herein may comprise from about 1.0% to about 10% by weight of an abrasive, such as hydrated silica. In certain

BE2019 / 5066 embodiments, the composition as disclosed herein can be from about 2.0% to about 8.0% by weight, about 3.0% by weight to about 7.0% by weight or about 4.0% by weight to about 6.0% by weight of an abrasive, such as hydrated silica.

In certain embodiments, the composition as disclosed herein may also comprise a preservative. A variety of preservatives, in particular water-soluble preservatives, can be added to the composition to improve their shelf life.

The term preservative refers to a substance that can prevent decomposition of a product, such as the composition disclosed herein, by microbial growth or by undesired chemical change.

In certain embodiments, the composition as disclosed herein may further comprise a preservative selected from the group consisting of a phenol derivative, an alkyl glyceryl ether derivative, and a urea derivative.

In certain embodiments, the preservative may be a water-based preservative.

In certain embodiments, the phenol derivative can be phenoxyethanol or phenylethyl alcohol.

The terms phenoxyethanol or 2-phenoxyethanol refer to a compound with CAS number 122-99-6.

The terms phenylethyl alcohol, 2-phenylethan-1-ol or 2-phenylethanol refer to a compound with CAS number 60-12-8.

In certain embodiments, the alkyl glyceryl ether derivative can be ethyl hexyl glycerine.

The terms ethylhexylglycerin, 3 - [(2-ethylhexyl) oxy] -1,2-propanediol or octoxyglycerin refer to a compound of CAS number 70445-33-9.

In certain embodiments, the urea derivative can be imidazolidinyl urea or diazolidinyl urea.

The terms imidazolidinyl urea or 1,1'-methylenebis {3- [4- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] urea} refer to a compound of CAS number 39236-46-9.

The terms diazolidinyl urea or 1- [3,4-bis (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] -1,3 bis (hydroxymethyl) urea refer to a compound having CAS number 78491-02-8.

In certain embodiments of the sets, methods, or use as disclosed herein, the composition as disclosed herein may further comprise a preservative selected from phenoxyethanol, phenylethyl alcohol, ethylhexyl glycerin, imidazolidinyl urea, diazolidinyl urea, or a combination thereof.

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In certain embodiments, the composition as disclosed herein may comprise diazolidinyl urea.

In certain embodiments, the composition as disclosed herein may comprise from about 0.1% by weight to about 10% by weight of a preservative selected from the group consisting of a phenol derivative, an alkyl glyceryl ether derivative, and a urea derivative such as diazolidinyl urea. In certain embodiments, the composition as disclosed herein may comprise from about 0.1% by weight to about 5.0% by weight or from about 0.1% by weight to about 1.0% by weight of a preservative selected from the group consisting of a phenol derivative, an alkyl glyceryl ether derivative and a urea derivative such as diazolidinyl urea.

In certain embodiments, the composition as disclosed herein may comprise one or more excipients selected from the group consisting of a humectant, a gelling agent, an emulsifying agent, a buffering agent, and an aroma.

In certain embodiments, the composition as disclosed herein may comprise a humectant. The term humectans as used herein refers to a hydroscopic substance. Often it comprises humectant molecules with multiple hydrophilic groups. Examples of humectants are glycerin, glycerol triacetate, propylene glycol, sorbitol, urea and xylitol. Preferably, the composition as disclosed herein comprises glycerin.

In certain embodiments, the composition as disclosed herein may comprise from about 1.0% to about 25% by weight of a humectant such as glycerin. In certain embodiments, the composition as disclosed herein may be from about 1.0% to about 20.0% by weight, about 1.0% by weight to about 10.0% by weight, about 2.0% by weight to about 8.0% by weight or about 3.0% by weight to about 6.0% by weight of a humectant, such as glycerin.

The terms glycerin or glycerol can be used interchangeably herein and refer to a polyol compound. The IUPAC name is propane-1,2,3-triol. The CAS number is 56-81-5.

In certain embodiments, the composition as disclosed herein may comprise a gelling agent. The term gelling agent or gel former as used herein refers to a substance that gives a liquid composition the texture of a gel (i.e., a semi-solid state with some elasticity). Gelling agents form a specific group of thickeners. Examples of gelling agents are acacia gum, alginic acid, bentonite, carbomers, carboxymethylcellulose, ethylcellulose, gelatin, hydroxyethylcellulose, hydroxypropylcellulose, magnesium aluminum silicate, dicaprylyl carbonate, methylcellulose, poloxamers (Pluronics), polyvinyl alcohol, sodium alginate, tragacanthane gum. Preferably, the composition as disclosed herein comprises Senegal gum and xanthan gum.

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In certain embodiments, the composition as disclosed herein may comprise from about 0.1% to about 10% by weight of a gelling agent, such as Senegal gum and xanthan gum. In certain embodiments, the composition as disclosed herein may comprise from about 0.1% by weight to about 5.0% by weight or from about 0.1% by weight to about 1.0% by weight of a gelling agent such as Senegal gum and xanthan gum. .

In certain embodiments, the composition as disclosed herein may comprise an emulsifier. The term emulsifier or emulsifier as used herein refers to a substance that stabilizes an emulsion, or in other words helps to mix two or more components that are normally not or difficult to mix. Examples of emulsifiers include glyceryl monostearate, polysorbate 20, polysorbate 60, polysorbate 80, sorbitan mono- and diesters of saturated and unsaturated fatty acids, alkyl mono- and oligoglycosides, polyol esters and mixed esters thereof, partially saturated / saturated / branched / unbranched C ₆ -C ₂₂ fatty acids, ricinoleic acid, 12-hydroxystearic acid and polyglycerol, pentaerythritol, dipentaerythritol, sugar alcohols, alkyl glucosides, polyglycosides or mixed esters (for example, glyceryl stearate citrate and glyceryl stearate lactate), mixed esters of pentaerythritol, mixed esters of fatty acids C ₆ -C ₈ C ₂₂ fatty acids, methyl glucose and polyols, polysiloxane / polyalkyl / polyether copolymers and derivatives thereof.

In certain embodiments, the composition as disclosed herein may comprise from about 0.1% by weight to about 10.0% by weight of an emulsifier. In certain embodiments, the composition as disclosed herein may be from about 0.3% by weight to about 7.0% by weight, about 0.5% by weight to about 5.0% by weight, about 1.0% by weight to about 3.0 wt% or about 1.5 wt% to about 2.5 wt% of an emulsifier.

In certain embodiments, the composition as disclosed herein may comprise a buffering agent. The terms pH adjuster, buffering agent or pH modifying agent as used herein refer to a substance that controls the pH of a composition at a certain value or in a certain range. pH controllers are or form buffer systems. Examples of pH regulators include sodium citrate, citric acid, adipic acid, tartaric acid or (sodium) hydrogen carbonate.

In certain embodiments, the composition as disclosed herein may comprise from about 0.01% to about 5.0% by weight of a buffering agent, such as sodium citrate. In certain embodiments, the composition as disclosed herein may be from about 0.05% to about 2.0%, about 0.1% to about 1.0%, or about 0.1% to about 0.1% by weight. 0.5% by weight of a buffering agent, such as sodium citrate.

In certain embodiments, the composition as disclosed herein may comprise an aroma. The terms aroma or flavoring as used herein refer to a substance that is a

BE2019 / 5066 pleasant taste. The aroma itself can be a mixture of ingredients. Preferably, the composition as disclosed herein comprises ginger mint flavor liquid.

In certain embodiments, the composition as disclosed herein may comprise from about 0.01% to about 2.0% by weight of an aroma. In certain embodiments, the composition as disclosed herein may be from about 0.05% to about 1.0% by weight, about 0.1% by weight to about 1.0% by weight, or about 0.1% by weight to about 0.5% by weight of an aroma.

In certain embodiments, the composition as disclosed herein may be an emulsion, a solution, or a lotion. Preferably, the composition as disclosed herein is an emulsion. The emulsion can also be referred to herein as a tooth whitening serum.

In certain embodiments, the composition as disclosed herein may be packaged in a volume of 5 ml to 50 ml. In certain embodiments, the composition as disclosed herein may be packaged in a volume of 5 ml to 25 ml or 5 ml to 20 ml. As an example, the composition as disclosed herein may be packaged in a volume of 5 ml to 10 ml, such as in a volume of 8 ml.

In certain embodiments, the composition as disclosed herein may be packaged in a bottle. In certain embodiments, the bottle may contain a volume of 5 ml to 50 ml of the composition as disclosed herein. In certain embodiments, the bottle may contain a volume of 5 ml to 25 ml or 5 ml to 20 ml of the composition as disclosed herein. As an example, the bottle may contain a volume of 5 ml to 10 ml, such as a volume of 8 ml, of the composition as disclosed herein.

A further aspect provides an activation composition as defined herein for teeth whitening. Thus, one aspect provides an activation composition for teeth whitening, the activation composition comprising the following:

- a bleaching enzymatic complex comprising a protease or a mixture of proteases;

- a glaze-enhancing agent selected from the group consisting of a sugar alcohol and a biologically available mineral; and

- an aqueous carrier, such as water.

Melamine foam stain remover

The term melamine foam stain remover as used herein refers to a stain remover comprising a melamine foam or the melamine foam portion.

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The terms stain remover or stain wiper can be used interchangeably and refer to a product used to remove stains or spots from a surface.

The terms melamine foam, melamine resin or the melamine foam portion can be used interchangeably and refer to a foam-like material consisting of a formaldehyde-melamine-sodium bisulfite copolymer. For example, a melamine foam can be defined as an open-cell cross-linked foam; a microporous open-cell foam; or a kind of open-cell (for example more than 99% open) thermosetting and environmentally friendly foam.

The term microporous as used herein has the meaning as intended by the IUPAC definition for micropore in catalysis, that is, a material with pore diameters of less than 2.0 nm.

The term foam or resin as used herein refers to a form-retaining foam, such as a sponge.

In certain embodiments of the sets, methods, or uses as disclosed herein, the melamine foam portion may consist of a copolymer made from a monomer blend comprising melamine, formaldehyde, and sodium bisulfite. Such a copolymer is hard so that the melamine foam can very effectively create dirt and stains on the surface of the teeth.

In certain embodiments of the sets, methods, or uses as disclosed herein, the porosity of the melamine foam is at least 85.0%, such as at least 90.0%, at least 93.0%, at least 95.0% , at least 98.0% or at least 99.0%.

In certain embodiments, the apparent density of the melamine foam, determined according to ISO 845: 2006, is at most 30 kg / m ³ , preferably at most 25 kg / m ³ , more preferably at most 20 kg / m ³ , with even more preferably at most 15 kg / m ³ and most preferably at most 10 kg / m ³ . In certain embodiments, the apparent density of the melamine foam, determined according to ISO 845: 2006, is 1 kg / m ³ to 30 kg / m ³ , preferably 2 kg / m ³ to 25 kg / m ³ , more preferably 3 kg / m ³ . m ³ to 20 kg / m ³ , even more preferably 4 kg / m ³ to 15 kg / m ³ and most preferably 4 kg / m ³ to 10 kg / m ³ . As an example, the apparent density of the melamine foam, determined according to ISO 845: 2006, is 4 kg / m ³ to 14 kg / m ³ , 4 kg / m ³ to 13 kg / m ³ , 4 kg / m ³ to 12 kg / m m ³ or 4 kg / m ³ to 11 kg / m ³ .

In certain embodiments, the melamine foam comprises a plurality of open cells in the vicinity of the surface. These open cells can create the stain (s) of the tooth surface.

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In certain embodiments, the average diameter of the melamine foam cells is at most 10.0 nm, preferably at most 7.0 nm, more preferably at most 5.0 nm, even more preferably at most 4.0 nm, even more preferably at most 3.0 nm and most preferably at most 2.0 nm. The diameter of the cells can be determined by microscopy as is known in the art and the average diameter can be calculated. Such cell diameters make it possible for the melamine foam material to enter the surface of the teeth in very small pits and grooves, so that dirt and stains can be removed from these pits and grooves. The melamine foam can act as a kind of extremely fine sandpaper that removes stains and dirt from the surface of the teeth.

In certain embodiments, the melamine foam has a foam structure with cells having a wall thickness of at most 0.5 µm, such as at most 0.4 µm, at most 0.3 µm or at most 0.2 µm. Such thin foam structures can reach stains in hard-to-reach surface areas.

In certain embodiments, the melamine foam stain remover can be a disposable product. In certain embodiments, the melamine foam stain remover may be intended for single use.

In certain embodiments of the sets, methods, or use as disclosed herein, the melamine foam stain remover may comprise a melamine foam portion and a handle. The handle facilitates holding the melamine foam stain remover when it is rubbed over the tooth surface.

In certain embodiments of the sets, methods, or use as disclosed herein, the melamine foam stain remover may include a melamine foam portion and a cartridge. The cartridge advantageously contains the melamine foam section and makes it possible to connect the melamine foam section with a handle.

In certain embodiments, the melamine foam stain remover or melamine foam portion may have the following dimensions:

a length of about 30 mm to about 50 mm, for example a length of about 35 mm to about 45 mm or a length of about 40 mm to about 45 mm;

a width of about 5 mm to about 20 mm, for example a width of about 7 mm to about 15 mm or a width of about 8 mm to about 12 mm; and

a thickness of about 1 mm to about 8 mm, for example a thickness of about 2 mm to about 6 mm or a thickness of about 3 mm to about 4 mm.

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In certain embodiments, the melamine foam stain remover or the melamine foam portion may have a length of about 43 mm; a width of approximately 10 mm; and have a thickness of about 3.25 mm.

In certain embodiments, the melamine foam portion may comprise or consist of an elongate body defining a longitudinal axis A-A '.

In certain embodiments, the melamine foam portion may be folded. As an example, the melamine foam section can be folded in the middle of the elongated body along an axis perpendicular to the longitudinal axis A-A '.

In certain embodiments, the melamine foam portion may be patterned. In certain embodiments, the melamine foam portion may be folded and patterned. In certain embodiments, the melamine foam portion may be folded at the center of the elongate body along an axis perpendicular to the longitudinal axis AA 'and patterned.

The term cartridge as used herein refers to a container to contain the melamine foam portion.

In certain embodiments, the cartridge may include an inner portion to contain the melamine foam portion and an outer portion (i.e., portion to be joined) to connect the melamine foam portion to the handle.

In certain embodiments, the cartridge may contain the melamine foam portion. In certain embodiments, the interior portion of the cartridge may contain the melamine foam portion. The cartridge can be dimensioned such that the melamine foam portion is retained in the cartridge when it is inserted into the interior portion.

In certain embodiments, the cartridge comprises a part to be connected to connect to the handle. In certain embodiments, the cartridge comprises a part to be connected for releasably connecting to the handle. As an example, the cartridge may comprise a part to be connected, preferably a part that can be detachably connected. The part to be connected can be adapted to be clicked on the connecting means of a handle. After use, the part to be connected can easily be detached again from the connecting means of a handle.

Further components

In certain embodiments, the set as disclosed herein may comprise further elements, such as a handle, a tray, a bottle, etc.

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In certain embodiments of the sets, methods, or use as disclosed herein, the teeth whitening set may further comprise a handle. The handle is preferably equipped for releasable connection with the melamine foam stain remover.

The handle may comprise a connecting means, preferably a releasable connecting means. The handle may comprise a connecting means which is equipped for connection to the part of the melamine foam stain remover to be connected and is preferably equipped for releasable connection to the part of the melamine foam stain remover to be connected. The handle may comprise a connecting means, which is equipped for receiving the melamine foam stain remover, preferably a connecting means, which is equipped for receiving the part to be joined from the melamine foam stain remover.

In certain embodiments, the melamine foam stain remover may be connected to the handle, preferably by the detachable connecting means, which forms a melamine foam stain remover device. This allows the user to precisely rub the melamine foam stain remover over the surface of the teeth.

In certain embodiments, the melamine foam stain remover can be releasably connected to the handle. This makes it possible to dispose of the melamine foam stain remover after each use. The handle, which stays clean during use, can be stored and later reused.

In certain embodiments of the sets, methods, or use as disclosed herein, the teeth whitening set may include multiple melamine foam stain removers. In certain embodiments of the sets, methods, or use as disclosed herein, the teeth whitening set may include one or more melamine foam stain removers. As an example, the teeth whitening set may comprise two or more, three or more, four or more, five or more, six or more, seven or more, eight or more, nine or more or ten or more melamine foam stain removers.

In certain embodiments, the teeth whitening set may comprise a plurality of foam stain removers which can be releasably connected to the handle in succession, thereby forming the melamine foam stain removal device. Preferably, the teeth whitening set includes a single handle suitable for reuse with the plurality of foam stain removers.

In certain embodiments of the sets, methods, or use as disclosed herein, the teeth whitening kit may include a tray to contain the melamine foam stain removers and optionally a lid to close the tray. The tray can include a base station to hold the handle.

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The terms tray or dispenser can be used interchangeably herein and refer to a device for containing the melamine foam stain removers.

In certain embodiments, the tray may further comprise a base station for the handle. The base station may include the handle or melamine foam stain remover device (i.e., after connection of the melamine foam stain remover with the handle) so that the user can easily apply the activation composition to the melamine foam portion without having to hold the handle.

In certain embodiments, the tray and the base station are made as a whole.

In certain embodiments of the sets, methods, or use as disclosed herein, the teeth whitening set may include a bottle to contain the activation composition.

In certain embodiments of the sets, methods, or use as disclosed herein, the bottle may include an applicator that is adapted to apply the activation composition (e.g., an amount of one or more drops thereof) to the melamine foam stain remover.

In certain embodiments, the teeth whitening set may include one or more melamine foam stain removers, a tray to contain the one or more melamine foam stain removers, a handle, and an activation composition; wherein each melamine foam stain remover comprises a melamine foam portion and a cartridge, the cartridge comprising a portion to be connected for connection to the handle; wherein the activation composition is a bleaching enzymatic complex comprising a protease or a mixture of proteases; a glaze enhancing agent selected from the group consisting of a sugar alcohol and a biologically available mineral; and an aqueous carrier; and wherein the activation composition is present in a bottle comprising an applicator. Such a teeth whitening set provides everything needed for simple application of the activation composition and for trouble-free use, wherein no access to water is required, thereby facilitating whitening on the go.

Methods and use

A further aspect relates to a method for activating a melamine foam stain remover for teeth whitening, the method comprising the following steps:

- providing a set for whitening teeth as defined herein; and

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- applying the activation composition to the melamine foam stain remover, whereby the melamine foam stain remover is activated.

In certain embodiments, the method may include the following:

- providing a set for whitening teeth as defined herein; and

- applying the activation composition to a melamine foam portion of the melamine foam stain remover, whereby the melamine foam stain remover is activated.

Such a method advantageously makes it possible to activate the melamine foam just before the use of the melamine foam stain remover. The user can easily activate the melamine foam without the need to provide substances or compositions from outside, such as tap water, the composition of which may be variable and sometimes unknown. No incubation period is required for activation, which is an advantage.

In certain embodiments of the methods as disclosed herein, the step of providing a whitening set as defined herein includes:

- providing a melamine foam stain remover as defined herein and

- providing an activation composition as defined herein.

In certain embodiments of the methods disclosed herein, the step of providing a melamine foam stain remover may include the step of attaching a melamine foam stain remover to a handle, e.g., by connecting the handle connecting means to the melamine foam stain remover pattern, thereby a melamine foam stain removal device is formed.

In certain embodiments, the method may include the following:

- providing a set for whitening teeth as defined herein;

- connecting the melamine foam stain remover to the handle, for example by connecting the connecting means of the handle to the part of the cartridge to be connected; and

- applying the activation composition to a melamine foam section, whereby the melamine foam stain remover is activated.

In certain embodiments, the activation composition may be applied to the melamine foam stain remover, in particular to the melamine foam portion of the melamine foam stain remover, in an amount of one or more drops, such as at least one drop. As an example, the activation composition may be on the

BE2019 / 5066 melamine foam stain remover, in particular on the melamine foam stain of the melamine foam stain remover, are applied in an amount of at least two drops, at least three drops, at least four drops or at least five drops.

In certain embodiments, the activation composition may be applied to the melamine foam stain remover, in particular to the melamine foam portion of the melamine foam stain remover, in an amount of up to ten drops. As an example, the activation composition can be applied to the melamine foam stain remover, in particular to the melamine foam stain of the melamine foam stain remover, in an amount of at most nine drops, at most eight drops, at most seven drops or at most six drops.

In certain embodiments, the activation composition may be applied to the melamine foam stain remover, particularly to the melamine foam stain of the melamine foam stain remover, in an amount of one to six drops, for example in an amount of two to five drops or in an amount of two or three drops.

In certain embodiments, the bottle containing the activation composition may be (gently) shaken prior to application to the melamine foam stain remover.

A related aspect provides the use of the activation composition as defined herein for activating a melamine foam stain remover as defined herein. In certain embodiments, the invention provides the use of the activation composition as defined herein to activate a melamine foam portion of a melamine foam stain remover as defined herein.

A further aspect provides a method for teeth whitening, the method comprising the steps of the method for activating a melamine foam stain remover for the teeth whitening and the step of rubbing the activated melamine foam stain remover over the surface of the teeth .

The terms whitening or bleaching can be used interchangeably herein.

The terms teeth whitening or whitening of the teeth as used herein refer to lightening the teeth to obtain a whiter color. Tooth whitening makes it possible to remove stains or other discoloration from the tooth surface.

Accordingly, one aspect provides a method for teeth whitening, the method comprising the following steps:

- providing a set for whitening teeth as defined herein;

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- applying the activation composition to the melamine foam stain remover, whereby the melamine foam stain remover is activated; and

- rubbing the activated melamine foam stain remover over the surface of the teeth.

In certain embodiments, the method may include the following:

- providing a set for whitening teeth as defined herein;

- connecting the melamine foam stain remover to the handle, for example connecting the cartridge to the handle, for example connecting the part of the cartridge to be connected to the connecting means of the handle; and

- applying the activation composition to a melamine foam section, whereby the melamine foam stain remover is activated; and

- rubbing the activated melamine foam stain remover over the surface of the teeth.

The term rubbing as used herein refers to applying pressure to the surface of something (here the surface of the teeth), usually using a repeated movement.

In certain embodiments, the rubbing of the activated melamine foam stain remover can be performed on the surface of the teeth by rubbing the activated melamine foam stain remover one or more times, such as two, three or more times, over the same surface of the teeth.

In certain embodiments, the rubbing of the activated melamine foam stain remover can be performed on the surface of the teeth by lightly rubbing (e.g. without exerting excessive pressure) the activated melamine foam stain remover on the surface of the teeth.

In certain embodiments, the rubbing can be performed in vertical up and down movements.

In certain embodiments, the rubbing may take at least 10 seconds, for example, at least 15 seconds, at least 20 seconds, at least 25 seconds, at least 30 seconds, at least 60 seconds (1 minute) or at least 120 seconds (2 minutes) .

In certain embodiments, the rubbing may take at least 10 seconds to at most 300 seconds, e.g. at least 15 seconds to at most 240 seconds (4 minutes),

BE2019 / 5066 last at least 20 seconds to at most 180 seconds (3 minutes), at least 25 seconds to at most 120 seconds, at least 30 seconds to at most 60 seconds.

In certain embodiments, the method may further include rinsing the mouth with water, e.g. tap water, or with a mouthwash, after rubbing. This step advantageously removes residues of melanin foam or stains from the mouth.

In certain embodiments, the method may further comprise removing the melamine foam stain remover from the handle, for example by snap-off. In certain embodiments, the method may further include disposing of the melamine foam stain remover.

In certain embodiments, the method may further comprise cleaning the handle with water, for example tap water, and optionally drying the handle, for example with a towel. This step makes it possible to keep the teeth whitening set in a hygienic condition.

A further aspect provides the use of the teeth whitening set as defined herein for teeth whitening.

The present application also provides aspects and embodiments as defined in the following statements:

Statement 1. A set for whitening teeth comprising a melamine foam stain remover and an activation composition, the activation composition comprising the following:

- a bleaching enzymatic complex comprising a protease or a mixture of proteases;

- a glaze-enhancing agent selected from the group consisting of a sugar alcohol and a biologically available mineral; and

- an aqueous carrier.

Statement 2. The teeth whitening set according to statement 1, wherein the bleaching enzymatic complex comprises papain, bromelain or a combination thereof.

Statement 3. The teeth whitening set according to statement 1 or 2, wherein the enamel-enhancing agent is a sugar alcohol selected from the group consisting of xylitol, erythritol, sorbitol, mannitol, maltitol, isomalt, lactitol, arabitol, glycerol and hydrogenated starch hydrolyzate.

Statement 4. The set for whitening teeth according to any of the statements 1 to 3, wherein the enamel-enhancing agent is xylitol.

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Statement 5. The teeth whitening set according to any of claims 1 to 4, wherein the enamel-enhancing agent is a biologically available mineral selected from the group consisting of a biologically available calcium, a biologically available magnesium and a biologically available phosphate.

Statement 6. The set for whitening teeth according to any of the statements 1 to 5, wherein the activation composition further comprises a cooling agent.

Statement 7. The teeth whitening set according to any of claims 1 to 6, wherein the activation composition further comprises a physiologically cooling agent selected from the group consisting of N, 2,3-trimethyl-2- (1-methylethyl) butanamide; menthol;

menthylpyrrolidone carboxylate; menthyl lactate; isopulegol; menthone; N-ethyl pmentane carboxamide; ethyl 2- (2-isopropyl-5-methylcyclohexanecarboxamido) acetate;

menthone glycerin acetal; monomenthyl succinate; monomenthyl glutarate; O-menthyl glycerin; 2sec butylcyclohexanone; menthan; camphor; pulegol; cineole; mint oil; peppermint oil; aarmunt oil; eucalyptus oil; 3-1-menthoxypropane-1,2-diol; 3-1-menthoxy-2-methylpropane-1,2-diol; p-menthan-3,8-diol; 2-1-menthoxyethane-1-ol; 3-1-menthoxypropan-1-ol; 4-1 menthoxybutane-1-ol; 2-isopropyl-5-methylcyclohexanecarboxylic acid (4-cyanomethylphenyl) amide; 2-isopropyl-5-methylcyclohexanecarboxylic acid (4-cyanophenyl) amide; 4 - [(2-isopropyl-5-methylcyclohexanecarbonyl) amino] benzamide; 3 - [(2-isopropyl-5-methylcyclohexanecarbonyl) amino] benzamide; 2-isopropyl-5-methyl-N- (4- (4-methylpiperazine-1-carbonyl) phenyl) cyclohexanecarboxamide; 2-isopropyl-5-methylcyclohexanecarboxylic acid pyridine-2-ylamide; and 2 isopropyl 5-methylcyclohexanecarboxylic acid (2-pyridine-2-ylethyl) amide.

Statement 8. The teeth whitening set according to statement 7, wherein the physiological cooling agent is N, 2,3-trimethyl-2- (1-methylethyl) butanamide.

Statement 9. The teeth whitening set according to any of claims 1 to 8, wherein the activation composition comprises an aqueous carrier, papain, bromelain, xylitol, bioavailable calcium, bioavailable magnesium and a physiologically cooling agent.

Statement 10. The set for whitening teeth according to any of the statements 1 to 9, wherein the melamine foam stain remover comprises a melamine foam section and a pattern.

Statement 11. The teeth whitening set according to any of claims 1 to 10, wherein the teeth whitening set further comprises a handle, the handle preferably being equipped for releasable connection to the melamine foam stain remover.

Statement 12. The set for whitening teeth according to one of the statements 1 to 11, wherein the set for whitening teeth comprises several melamine foam stain removers.

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Statement 13. The teeth whitening set according to any of the statements 1 to 12, wherein the teeth whitening set comprises a tray for containing the melamine foam stain remover and optionally a lid for closing the tray.

Statement 14. The teeth whitening set according to any of the statements 1 to 13, wherein the teeth whitening set comprises a bottle to contain the activation composition.

Statement 15. The teeth whitening set according to statement 14, wherein the bottle comprises an applicator, which is equipped for applying the activation composition to the melamine foam stain remover.

Statement 16. An activation composition for teeth whitening, the activation composition comprising the following:

- a bleaching enzymatic complex comprising a protease or a mixture of proteases;

- a glaze-enhancing agent selected from the group consisting of a sugar alcohol and a biologically available mineral; and

- an aqueous carrier.

Statement 17. A method for activating a melamine foam stain remover for teeth whitening, comprising the following steps:

- providing a set for whitening teeth as defined in one of the statements 1 to 15; and

- applying the activation composition to the melamine foam stain remover, whereby the melamine foam stain remover is activated.

Statement 18. A method for whitening the teeth, comprising the following steps:

- providing a set for whitening teeth as defined in one of the statements 1 to 15;

- applying the activation composition to the melamine foam stain remover, whereby the melamine foam stain remover is activated; and

- rubbing the activated melamine foam stain remover over the surface of the teeth.

The above aspects and embodiments are further supported by the following non-limiting examples.

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EXAMPLES

Example 1: Tooth whitening set according to an embodiment of the invention

FIG. 1 and FIG. 2 show an embodiment of a tooth whitening set (1) according to an embodiment of the invention. The set (1) comprises a set of five melamine foam stain removers (2). The set (1) further comprises a bottle (5) which contains the activation composition (4). The bottle (5) comprises an applicator (6). The set further comprises a handle (3), which is equipped for releasable connection to a melamine foam stain remover (2). The melamine foam stain remover comprises a melamine foam section (21) and a cartridge (22). Each melamine foam section has a length of 43 mm ± 0.5 mm; a width of 10 mm ± 0.3 mm; and a thickness of 3.25 mm ± 0.3 mm. The melamine foam section is folded and patterned. The cartridge (22) comprises a part (23) to be connected for releasably connecting it to the handle. The handle (3) has a connecting means (31) which can be releasably connected to the melamine foam stain remover (2).

The melamine foam stain removers (2) are provided in a tray (7). The tray (7) comprises a base station (8) which contains the handle (3). In FIG. 1, the handle (3) is not yet connected to a melamine foam stain remover (2). In FIG. 2, the handle (3) is connected to a melamine foam stain remover (2). The connecting means (31) is snapped into the cartridge (22) of the melamine foam stain remover (2), whereby a melamine foam stain remover device (10) is obtained. The melamine foam stain removal device (10) is placed in the base station (8), ready to apply the activation composition (4) to the melamine foam section (21).

Example 2: Activation composition according to an embodiment of the invention

A typical activation composition according to an embodiment of the present invention is provided in Table 1, wherein the components and the amount of each component in the composition are listed. The composition is useful for activating the melamine foam stain remover before it is rubbed over the surface of the teeth. The activation composition was formulated as an emulsion (also referred to as tooth whitening serum).

Table 1: Activation composition according to an embodiment of the invention

Components (INCI) Trade name Supplier Quantity (%) Aqua Aqua Brenntag 70-90

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Components (INCI) Trade name Supplier Quantity (%) Glycerin Glycerin Brenntag 3.0-6.0 Hydrated silica Sident 9 Evonik 4.0-6.0 Xylitol Xylitol Triconor 1.0-3.0 Bromelain and maltodextrin Bromelain Inside EX 3.6 Activ'inside 1.0-3.0 Magnesium sulfate Magnesium sulfate Caldic 0.5-3.0 Calcium Lactate and Calcium gluconate Calcium Lactate Gluconate Jungbunzlauer 0.5-3.0 Acacia Senegal eraser and xanthan eraser Solagum AX Seppic 0.1-1.0 Papain and maltodextrin Papain Inside EX 1.6 SF Activ'inside 0.1-2.0 Diazolidinyl Urea Germal II Ashland 0.1-1.0 Aroma Ginger Mint Flavoring Liquid IFF 0.1-1.0 Sodium Citrate Sodium Citrate Caldic 0.1-1.0 Methyl Diisopropyl Propionamide WS-23 SAS DIFFUSIONS AROMATIQUES 0.01-0.9

Example 3: Clinical field study with the teeth whitening set according to an embodiment of the invention

The purpose of the clinical practice study was to determine whether a teeth whitening set illustrating the invention provided immediate efficacy. This was objectively assessed by an expert using a grading system and a timeline. The teeth whitening set illustrating the invention was the set as described in Examples 1 and 2.

Methodological approach

This monocentric, evaluator-blind clinical study based on dental arch halves was conducted with a panel of healthy human individuals. This study was defined as a non-intervening clinical trial in accordance with ethical principles for medical scientific research (Ethical Principles for Medical Research Involving Human Subjects, adopted by the 18th WMA General Assembly Helsinki, Finland, June 1964 and subsequent changes) and with all relevant changes national guidelines.

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The study was conducted based on the following protocol. The protocol defined an approach to the study based on dental arch halves, which means that one side of the upper and lower dental arch (Left or Right) was treated, treatment, and the other side left untreated, control. Only the smile zone was considered the target area. The laughing zone varies from patient to patient, but usually extends from the first prefix to its contralateral counterpart. Based on this, the smile zone was defined as the teeth between the first preselections (FIG. 3A).

Therefore, the target zone of the dental arc halves extends from the first preselections to their respective incisor both of the upper and lower dental arcs (FIG. 3B).

Both dental arch sides were assessed and compared with each other in order to avoid differences between individuals. The assignment of the respective dental arch side to be treated was done randomly and was blind to the assessor. The assessor is a trained health care expert with many years of clinical trial experience. The randomization schedule is shown in Table 2.

Table 2: Randomization scheme for the treated dental arch side

Individual reference Randomized dental arch side IWX1 R IWX2 R IWX3 L. IWX4 R IWX5 R IWX6 R IWX7 R IWX8 R IWX9 L. IWX10 L. IWX11 R IWX12 L. IWX13 L. IWX14 R IWX15 L. IWX16 L. IWX17 L. IWX18 R

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Individual reference Randomized dental arch side IWX19 R IWX20 L. IWX21 L. IWX22 L.

At the start of the study and after one treatment, the assessor assessed both dental arch sides separately using a numerical evaluation scale. The numerical evaluation scale runs from 0 Absent, which means no discoloration on the teeth / very clean teeth, to 4 Very clear, which means strongly discolored teeth / dirty teeth.

The results were expressed by their variations (Δ%) of the different parameters examined. These were calculated with the following formula:

(VDti-VDtO)

Δ% = -------- X100

VDtO where: VD: acquired value; tO: before product application; ti: after application of product.

The expression (Δ%) gave the variation, in percent, on the zone of the measurement compared to the initial conditions.

A timeline was kept to record the time required to perform the treatment. This was done through a clock. At the end of the study, an average of the timelines was taken to validate the treatment time. Based on the fact that an approach based on dental arch halves has been defined, the treatment time should be multiplied by two so that it corresponds to a full smile zone.

A group of 22 volunteers was considered sufficient to show statistical significance of the proposed endpoints. Individuals were recruited prior to the study based on well-defined inclusion / exclusion criteria. The following admission criteria were defined: Individuals admitted to this study had to be Caucasian and had to be 18 years or older. Individuals must demonstrate that they understand the purpose of the study. They must demonstrate their willingness to participate by voluntarily signing the consent on paper with information in advance and as such respecting all study procedures and limitations. They should also, in the opinion of the investigator, be in good general health and have no clinically significant and relevant abnormalities in their medical history or dental check-up. They should clearly discolor / not clean teeth in the

BE2019 / 5066 defined smile zone. Finally, the volunteers must not have had bleaching treatment during the year.

The following patients were excluded: allergy / intolerance: known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds); medication: use of any systemic medication that could have an effect on the study outcome within 30 days of the screening visit; clinical study / experimental medication: participation in another clinical study or receiving a research drug within 30 days of the test visit; substance abuse: recent history (in the last year) of abuse of alcohol or another substance; or persons with tetracycline stains on their teeth.

Results

A total of 22 volunteers were included in this trial. One of the dental arch sides of each volunteer was randomly assigned to the treatment group. The assessor had to perform a blinded assessment of both dental arch sides, ie the treatment and the check.

Table 3: Summary of statistics for baseline characteristics

Variable Average baseline score given by the assessor (T0) 2.77 Median given by the assessor baseline score (T0) 3.00 Number of female individuals 12 Number of male individuals 10

None of the volunteers withdrew from the study, so the total number of individuals to be used remained 22.

There was a significant difference between the assessment scores of the treatment group and the control group. The average relative improvement (%) of the treatment group was 60.61% compared to the control group. This shows that the product had a clear and powerful effect on tooth discoloration.

The average recorded time needed to perform the treatment was 22.17 seconds (half of the arch).

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Conclusion

The purpose of this clinical study was to determine whether a teeth whitening set illustrating the invention immediately cleaned the teeth and eliminated tooth discoloration. The results of this study showed that the treated laughing zone was significantly cleaned and bleached relative to the control. This result was obtained on average after 22.17 seconds on a dental arch half, which means that it would take 44.34 seconds for an entire smile zone.

The clinical practice study thus yielded important improvements with regard to tooth cleaning / bleaching after one treatment using the grading system. These results were obtained within one minute.

The teeth whitening set illustrating the invention gave an immediate cleaning / bleaching effect after one application.

Example 4: Preliminary testing of the teeth whitening set and method according to an embodiment of the invention

The purpose of this preliminary experiment was to measure the effect of a teeth whitening set and method according to an embodiment of the invention with respect to teeth whitening compared to standard toothbrushing and toothpaste. The teeth whitening set illustrating the invention was the set as described in Examples 1 and 2.

The testing was performed as follows:

- 6 blocks of highly stained (tea and coffee) beef glaze were taken and divided into 3 groups of two. FIG. 4A shows a baseline photo with R = Reference, F = Foam (i.e., melamine foam stain remover and activation composition), P = Paste (i.e., toothbrush and toothpaste);

- For the foam-treated blocks: 1 drop of activation composition was applied to the melamine foam section of the melamine foam stain remover and the melamine foam stain remover was rubbed over the teeth by hand for 30 s. This was repeated twice;

- For the toothpaste blocks: a spread of Sensodyne Pronamel toothpaste was applied to a toothbrush and the teeth were brushed with a wet toothbrush for 30 s. This was repeated twice;

- Photos were taken after each time interval. FIG. 4B provides a photo after treatment for 90 seconds.

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As shown in FIG. 4B, the beneficial effect on bleaching after a total of 90 s rub with the melamine foam stain remover (FIG. 4B, F) was very clearly and visibly superior to the toothpaste (FIG. 4B, P).

Example 5: Method for bleaching teeth according to an embodiment of the invention

A typical method for teeth whitening illustrating the invention comprises the following steps:

Step 1: Make sure your hands are clean and dry.

Step 2: Prepare for use by providing a tooth whitening set according to an embodiment of the invention, for example the tooth whitening set as described in Example 1, and connecting a melamine foam stain remover to the handle.

Step 3: Gently shake the activation composition according to an embodiment of the invention, for example the dental bleaching serum as described in Example 2.

Step 4: Activate the melamine foam part with a few drops of the activation composition and gently rub the teeth with the flat side of the melamine foam part with vertical up and down movements. Use a new melamine foam stain remover if the melamine foam section becomes damaged.

Step 5: Ensure that the melamine foam section remains moist during use and, if necessary, reapply a few drops of the activation composition.

Step 6: Rinse your mouth with water or a mouthwash.

Step 7: Disconnect the melamine foam stain remover from the handle and discard it. Use a new melamine foam stain remover for each new treatment.

Step 8: Clean the handle with water after each use.

Claims (17)

A teeth whitening set (1) comprising a melamine foam stain remover (2) and an activation composition (4), the activation composition (4) comprising: - a bleaching enzymatic complex comprising a protease or a mixture of proteases; - a glaze-enhancing agent selected from the group consisting of a sugar alcohol and a biologically available mineral; and - an aqueous carrier. The teeth whitening kit (1) according to claim 1, wherein the bleaching enzymatic complex comprises papain, bromelain or a combination thereof. A teeth whitening kit (1) according to claim 1 or 2, wherein the enamel-enhancing agent is a sugar alcohol selected from the group consisting of xylitol, erythritol, sorbitol, mannitol, maltitol, isomalt, lactitol, arabitol, glycerol and hydrogenated starch hydrolyzate. The teeth whitening kit (1) according to any of claims 1 to 3, wherein the enamel enhancing agent is xylitol. The teeth whitening kit (1) according to any of claims 1 to 4, wherein the enamel enhancing agent is a biologically available mineral selected from the group consisting of a biologically available calcium, a biologically available magnesium and a biologically available phosphate , is. The teeth whitening kit (1) according to any of claims 1 to 5, wherein the activation composition further comprises a cooling agent. The teeth whitening kit (1) according to any of claims 1 to 6, wherein the activation composition further comprises a physiologically cooling agent selected from the group consisting of N, 2,3-trimethyl-2- (1-methylethyl) butanamide; menthol; menthylpyrrolidone carboxylate; menthyl lactate; isopulegol; menthon; N-ethyl pmentane carboxamide; ethyl 2- (2-isopropyl-5-methylcyclohexanecarboxamido) acetate; menthonglycerin acetal; monomenthyl succinate; monomenthyl glutarate; O-menthyl glycerin; 2-sec-butylcyclohexanone; menthan; camphor; pulegol; cineole; mint oil; peppermint oil; aarmunt oil; eucalyptus oil; 3-1-menthoxypropane-1,2-diol; 3-1-menthoxy-2-methylpropane-1,2-diol; p-menthan-3,8-diol; 2-1-menthoxyethane-1-ol; 3-1-menthoxypropan-1-ol; 4-1 menthoxybutane-1-ol; 2-isopropyl-5-methylcyclohexanecarboxylic acid (4-cyanomethyl-phenyl) amide; 2-isopropyl-5-methylcyclohexanecarboxylic acid (4-cyanophenyl) amide; 4 - [(2-isopropyl-5-methylcyclohexanecarbonyl) amino] benzamide; 3 - [(2-isopropyl-5-methylcyclohexanecarbonyl) amino] benzamide; 2-isopropyl-5-methyl-N- (4- (4-methylpiperazine-1-carbonyl) phenyl) cyclohexanecarboxamide; 2-isopropyl-538 methylcyclohexanecarboxylic acid pyridine-2-ylamide; and 2-isopropyl-5-methylcyclopethyl 2019/5066 hexane carboxylic acid (2-pyridin-2-yl-ethyl) amide. The teeth whitening kit (1) according to claim 7, wherein the physiological cooling agent is N, 2,3-trimethyl-2- (1-methylethyl) butanamide. The teeth whitening kit (1) according to any of claims 1 to 8, wherein the activating composition (4) comprises an aqueous carrier, papain, bromelain, xylitol, bioavailable calcium, bioavailable magnesium and a physiologically cooling agent . The teeth whitening set (1) according to any of claims 1 to 9, wherein the melamine foam stain remover comprises a melamine foam section (21) and a cartridge (22). The teeth whitening set (1) according to any of claims 1 to 10, wherein the teeth whitening set (1) further comprises a handle (3), the handle (3) preferably being equipped for releasable connection with the melamine foam stain remover (2). The teeth whitening set (1) according to any of claims 1 to 11, wherein the teeth whitening set (1) comprises a plurality of melamine foam stain removers (2). The teeth whitening set according to any of claims 1 to 12, wherein the teeth whitening set (1) includes a tray (7) for containing the melamine foam stain remover (2) and optionally a lid for the tray (7). The teeth whitening set according to any of claims 1 to 13, wherein the teeth whitening set (1) comprises a bottle (5) to contain the activation composition (4). The teeth whitening set according to claim 14, wherein the bottle (5) comprises an applicator (6), which is equipped for applying the activation composition (4) to the melamine foam stain remover (2). A method for activating a melamine foam stain remover (2) for teeth whitening, comprising the following steps: - providing a set for whitening teeth (1) as defined in any one of claims 1 to 15; and - applying the activation composition (4) to the melamine foam stain remover (2), whereby the melamine foam stain remover is activated (2). A method of bleaching the teeth, comprising the following steps: - providing a set for whitening teeth (1) as defined in any one of claims 1 to 15; - applying the activation composition (4) to the melamine foam stain remover BE2019 / 5066 (2), whereby the melamine foam stain remover (2) is activated; and - rubbing the activated melamine foam stain remover (2) over the surface of the teeth.