AU8941491A - Retarded-action urapidil formulation - Google Patents

Retarded-action urapidil formulation

Info

Publication number
AU8941491A
AU8941491A AU89414/91A AU8941491A AU8941491A AU 8941491 A AU8941491 A AU 8941491A AU 89414/91 A AU89414/91 A AU 89414/91A AU 8941491 A AU8941491 A AU 8941491A AU 8941491 A AU8941491 A AU 8941491A
Authority
AU
Australia
Prior art keywords
urapidil
formulation
action
retarded
adjuvants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU89414/91A
Inventor
Gerald Dr. Benedikt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of AU8941491A publication Critical patent/AU8941491A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Described is a retarded-action formulation for urapidil, based on the principle of osmotic action, in which the active substance, together with adjuvants, is enclosed in a semi-permeable envelope with an outlet hole. The formulation is characterized in that it contains a readily soluble salt of urapidil as the active substance, plus sugars and/or sugar alcohols with a solubility of less than 30 % by wt. in water at 37 DEG C as adjuvants. Formulations of readily soluble urapidil salts can be prepared for once-daily or twice-daily administration, these formulations being characterized above all by a high bioavailability which is unaffected by the intake of food.
AU89414/91A 1990-11-27 1991-11-26 Retarded-action urapidil formulation Abandoned AU8941491A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH3763/90 1990-11-27
CH376390 1990-11-27
CN92103927A CN1079147A (en) 1990-11-27 1992-05-23 Urapidil slow-release preparation

Publications (1)

Publication Number Publication Date
AU8941491A true AU8941491A (en) 1992-06-25

Family

ID=25693784

Family Applications (1)

Application Number Title Priority Date Filing Date
AU89414/91A Abandoned AU8941491A (en) 1990-11-27 1991-11-26 Retarded-action urapidil formulation

Country Status (10)

Country Link
EP (1) EP0559702B1 (en)
CN (1) CN1079147A (en)
AT (1) ATE116133T1 (en)
AU (1) AU8941491A (en)
DE (2) DE4193036D2 (en)
DK (1) DK0559702T3 (en)
ES (1) ES2069317T3 (en)
GR (1) GR3015176T3 (en)
WO (1) WO1992009273A1 (en)
ZA (1) ZA923492B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA95828C2 (en) 2007-02-01 2011-09-12 Такеда Фармасьютикал Компани Лимитед Solid preparation comprising alogliptin and pioglitazone

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2336218C3 (en) * 1973-07-17 1985-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Oral dosage form

Also Published As

Publication number Publication date
CN1079147A (en) 1993-12-08
DK0559702T3 (en) 1995-05-15
ES2069317T3 (en) 1995-05-01
DE59104100D1 (en) 1995-02-09
ZA923492B (en) 1992-12-30
EP0559702A1 (en) 1993-09-15
GR3015176T3 (en) 1995-05-31
ATE116133T1 (en) 1995-01-15
DE4193036D2 (en) 1996-06-27
WO1992009273A1 (en) 1992-06-11
EP0559702B1 (en) 1994-12-28

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