AU8878491A - Implantable biodegradable material and method for producing same - Google Patents

Implantable biodegradable material and method for producing same

Info

Publication number
AU8878491A
AU8878491A AU88784/91A AU8878491A AU8878491A AU 8878491 A AU8878491 A AU 8878491A AU 88784/91 A AU88784/91 A AU 88784/91A AU 8878491 A AU8878491 A AU 8878491A AU 8878491 A AU8878491 A AU 8878491A
Authority
AU
Australia
Prior art keywords
tissue
biodegradable material
active substance
producing same
groupings
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU88784/91A
Other versions
AU635673B2 (en
Inventor
Paul Bonnevialle
Anne Julia
Albert Lebugle
Fernand Rodriguez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of AU8878491A publication Critical patent/AU8878491A/en
Application granted granted Critical
Publication of AU635673B2 publication Critical patent/AU635673B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A material is provided which can be implanted in living tissue, particularly bony tissue, and has a biodegradation rate matching the rate at which the tissue regenerates. The material may include an active substance providing an extended therapeutical effect. Said material includes (a) a calcium phosphate having an apatitic or triclinic structure and containing HPO4? and PO4? groupings; (b) a biodegradable oside or polyoside, particularly dextran; (c) as required, an active substance having amine groupings such as netilmicin and/or gentamicin in sulphate form. The implantable material can be produced without using heat by compacting the various components in powder form.
AU88784/91A 1990-10-26 1991-10-22 Implantable biodegradable material and method for producing same Expired AU635673B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9013424A FR2668367B1 (en) 1990-10-26 1990-10-26 IMPLANTABLE MEDICINE WITH PROLONGED EFFECT.
FR9013424 1990-10-26

Publications (2)

Publication Number Publication Date
AU8878491A true AU8878491A (en) 1992-05-26
AU635673B2 AU635673B2 (en) 1993-03-25

Family

ID=9401689

Family Applications (1)

Application Number Title Priority Date Filing Date
AU88784/91A Expired AU635673B2 (en) 1990-10-26 1991-10-22 Implantable biodegradable material and method for producing same

Country Status (11)

Country Link
EP (1) EP0507944B1 (en)
JP (1) JPH07102224B2 (en)
AT (1) ATE112162T1 (en)
AU (1) AU635673B2 (en)
CA (1) CA2070803C (en)
DE (1) DE69104345T2 (en)
DK (1) DK0507944T3 (en)
ES (1) ES2062896T3 (en)
FR (1) FR2668367B1 (en)
MX (1) MX9203526A (en)
WO (1) WO1992007554A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817327A (en) * 1994-07-27 1998-10-06 The Trustees Of The University Of Pennsylvania Incorporation of biologically active molecules into bioactive glasses
US5591453A (en) * 1994-07-27 1997-01-07 The Trustees Of The University Of Pennsylvania Incorporation of biologically active molecules into bioactive glasses
DE10114244A1 (en) 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Antibiotic / antibiotic preparation with active ingredient release
DE10114245A1 (en) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Production and use of an antibiotic / antibiotic preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3374659D1 (en) * 1983-02-03 1988-01-07 Ethicon Inc Paste for hemostasis and for temporary relief of defects in the traumatism of bones
GB8328074D0 (en) * 1983-10-20 1983-11-23 Geistlich Soehne Ag Chemical compositions
FR2570606A1 (en) * 1984-09-26 1986-03-28 Landanger Laboratoire Obturator in particular for the cavity of the femur or the bottom of the acetabulum (cotyl)
FI81010C (en) * 1986-09-05 1990-09-10 Biocon Oy Benomplaceringsimplants
JPH0223967A (en) * 1988-07-13 1990-01-26 Mamoru Nagase Artificial bone cured and formed by mixing tricalcium phosphate, acid, polysaccharides, water and hydroxyapatite
JPH02102165A (en) * 1988-10-12 1990-04-13 Asahi Optical Co Ltd Production of calcium phosphate-based ceramic

Also Published As

Publication number Publication date
FR2668367B1 (en) 1994-05-13
JPH07102224B2 (en) 1995-11-08
ES2062896T3 (en) 1994-12-16
CA2070803A1 (en) 1992-04-27
EP0507944A1 (en) 1992-10-14
AU635673B2 (en) 1993-03-25
CA2070803C (en) 1997-01-07
JPH04506471A (en) 1992-11-12
FR2668367A1 (en) 1992-04-30
EP0507944B1 (en) 1994-09-28
WO1992007554A1 (en) 1992-05-14
DE69104345T2 (en) 1995-05-04
MX9203526A (en) 1992-07-01
DK0507944T3 (en) 1995-04-10
DE69104345D1 (en) 1994-11-03
ATE112162T1 (en) 1994-10-15

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