FR2570606A1 - Obturator in particular for the cavity of the femur or the bottom of the acetabulum (cotyl) - Google Patents
Obturator in particular for the cavity of the femur or the bottom of the acetabulum (cotyl) Download PDFInfo
- Publication number
- FR2570606A1 FR2570606A1 FR8414790A FR8414790A FR2570606A1 FR 2570606 A1 FR2570606 A1 FR 2570606A1 FR 8414790 A FR8414790 A FR 8414790A FR 8414790 A FR8414790 A FR 8414790A FR 2570606 A1 FR2570606 A1 FR 2570606A1
- Authority
- FR
- France
- Prior art keywords
- obturator
- biodegradable
- shutter
- femur
- bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/104—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/222—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
- A61F2310/00383—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
Description
OBTURATEUR NOTAMMENT DE PUITS FEMORAL OU DE FOND DE COTYLE
La présente invention concerne un obturateur notamment d'un puits fémoral ou d'un fond de cotyle. L'obturateur est destiné a éviter qu'un ciment osseux utilisé pour fixer une queue ou autre partie d'une prothèse de hanche, ne pénètre plus profondément que nécessaire dans le canal médullaire du fémur ou dans le fond de la cavité cotyloide au-dessus de la tete du fémur.SHUTTER, ESPECIALLY A FEMORAL OR COTYL WELL
The present invention relates to a obturator in particular of a femoral well or of a cup bottom. The obturator is intended to prevent a bone cement used to fix a tail or other part of a hip prosthesis, penetrating more deeply than necessary in the medullary canal of the femur or in the bottom of the acetabulum cavity above of the head of the femur.
Les obturateurs actuellement utilisés ne donnent pas entièrement satisfaction. Les obturateurs ne sont pas biodégradables et sont généralement réalisés en polyéthylène, matériau bien toléré. L'obturateur reste ainsi à demeure dans l'os et peut former un bouchon intramédullaire dans l'os. La présence de l'obturateur est gênante lorsqu'Pst reprise une opération de prothèse totale de hanche, par exemple à cause d'une infection nécessitant une reprise précoce ou d'un descellement nécessitant une reprise tardive. L'obturateur est alors difficile à enlever. The shutters currently used are not entirely satisfactory. The shutters are not biodegradable and are generally made of polyethylene, a well tolerated material. The obturator thus remains permanently in the bone and can form an intramedullary plug in the bone. The presence of the obturator is troublesome when Pst resumes a total hip prosthesis operation, for example because of an infection requiring an early resumption or a loosening requiring a late resumption. The shutter is then difficult to remove.
L'invention vise à fournir un obturateur en un matériau ne présentant pas les inconvénients précédents. The invention aims to provide a shutter in a material which does not have the above drawbacks.
A cette fin, l'obturateur est en un matériau biodégradable. De préférence le matériau est biodégradable rapidement, sous environ 48 heures, ce qui constitue une caractéristique avantageuse, notamment pour une reprise précoce de prothèse. To this end, the shutter is made of a biodegradable material. Preferably, the material is rapidly biodegradable, within about 48 hours, which constitutes an advantageous characteristic, in particular for an early resumption of prosthesis.
Le matériau peut être biodégradable au sens strict du terme, tel que de la gélatine, ou au sens large du terme, c'est-à-dire susceptible d'être transporté par le sang et éliminé par voie urinaire, tel que du polyvinylalcool. Selon une caractéristique de l'invention, le matériau est à base de dextran, de caséine, de gélatine ou de polyvinylalcool, éventuellement modifié chimiquement, ou à base d'une combinaison de ces produits. Le matériau peut être chargé avec un ou plusieurs produits inertes tels que du phosphate de calcium, ou avec un ou plusieurs produits radio-opaques tels que du sulfate de baryum, ou encore avec un ou plusieurs antibiotiques. En outre, il est possible d'ajouter d'autres adjuvants nécessaires à la fabrication de l'obturateur. The material can be biodegradable in the strict sense of the term, such as gelatin, or in the broad sense of the term, that is to say capable of being transported by the blood and eliminated via the urine, such as polyvinyl alcohol. According to a characteristic of the invention, the material is based on dextran, casein, gelatin or polyvinyl alcohol, optionally chemically modified, or based on a combination of these products. The material can be loaded with one or more inert products such as calcium phosphate, or with one or more radio-opaque products such as barium sulfate, or with one or more antibiotics. In addition, it is possible to add other adjuvants necessary for the manufacture of the shutter.
Tous les matériaux d'obturateur selon l'invention offrent une certaine affinité pour l'eau de liquides physiologiques. Ils présentent des propriétés adhésives importantes qui maintiennent l'obturateur à sa place. De plus, la solubilité des matériaux dans l'eau confère une désagrégation rapide de l'obturateur. All the shutter materials according to the invention offer a certain affinity for water of physiological liquids. They have significant adhesive properties that keep the shutter in place. In addition, the solubility of the materials in water confers rapid disintegration of the shutter.
L'obturateur selon l'invention est obtenu au moyen de l'un des matériaux biodégradables précédents selon l'un des procédés suivants, savoir
- par compression d'une poudre fine du matériau biodégradable dans un moule ;
- ou par évaporation de solvant d'une solution aqueuse du matériau biodégradable.The shutter according to the invention is obtained by means of one of the preceding biodegradable materials according to one of the following processes, namely
- by compression of a fine powder of the biodegradable material in a mold;
- Or by evaporation of solvent from an aqueous solution of the biodegradable material.
Par exemple, un obturateur pour puits fémoral ayant de bonnes propriétés mécaniques est obtenu en comprimant une poudre fine de dextran (Sigma Clinical Grade) dans un moule de 13 mm de diamètre sous une pression de 7500 kgf/cm2. Selon un autre exemple, un fond de cotyle est obtenu à partir d'une solution à 15 % de gélatine dans l'eau. For example, a shutter for a femoral well having good mechanical properties is obtained by compressing a fine powder of dextran (Sigma Clinical Grade) in a mold 13 mm in diameter under a pressure of 7500 kgf / cm2. According to another example, a cup base is obtained from a 15% solution of gelatin in water.
Des essais ont été réalisés pour vérifier si les matériaux selon l'invention conservaient leurs bonnes propriétés de biocompatibilité et de biodégradabilité lorsqu'ils sont placés dans un tissu osseux. Des cylindres ayant 3 mm de diamètre et 4 mm de hauteur, obtenus par compression d'une poudre fine de matériau, ont été implantés dans des fémurs de lapins. Après sacrifice des lapins, des études anatomo-pathologiques ont été faites sur le tissu osseux et sur les reins des lapins. Les études ont montré que les matériaux sont très bien tolérés. Lorsque le matériau est à base de polyvinylalcool, une élimination du polyvinylalcool ntentraîne aucune lésion des reins. Tests have been carried out to check whether the materials according to the invention retain their good biocompatibility and biodegradability properties when they are placed in bone tissue. Cylinders 3 mm in diameter and 4 mm in height, obtained by compression of a fine powder of material, were implanted in femurs of rabbits. After sacrificing the rabbits, pathological studies were carried out on the bone tissue and on the kidneys of the rabbits. Studies have shown that materials are very well tolerated. When the material is based on polyvinyl alcohol, elimination of the polyvinyl alcohol does not cause any damage to the kidneys.
Des cinétiques de dégradation ont également été réalisées sur des lapins. Dans ce cas, les obturateurs contiennent 10 % en poids de sulfate de baryum afin d'observer leur disparition au cours du temps, par radiologie. Les études ont montré que la vitesse de disparition de l'obturateur dépend de la nature du polymère, et de sa masse moléculaire. Par exemple, chez les lapins, un obturateur ayant 3 mm de diamètre et 4 mm de hauteur, realisé avec un dextran ayant une faible masse moléculaire a pratiquement disparu totalement après un quart d'heure. Degradation kinetics have also been carried out on rabbits. In this case, the shutters contain 10% by weight of barium sulfate in order to observe their disappearance over time, by radiology. Studies have shown that the speed of disappearance of the shutter depends on the nature of the polymer, and on its molecular weight. For example, in rabbits, a shutter having a diameter of 3 mm and a height of 4 mm, produced with a dextran having a low molecular mass has practically disappeared completely after a quarter of an hour.
Des essais pratiques ont été réalisés sur l'homme pour juger de l'efficacité des obturateurs selon l'invention dans des conditions opératoires analogues à celles utilisées pour la pose d'une prothèse totale de la hanche. Ces essais ont été effectués sur des hommes dont une jambe devait être amputée pour des problèmes circulatoires. Les essais ont eu lieu au cours d'une intervention chirurgicale, avant amputation, sur le tibia de la jambe, au lieu du fémur, afin de traumatiser le moins possible le patient. Practical tests have been carried out on humans to judge the effectiveness of the obturators according to the invention under operating conditions similar to those used for the fitting of a total hip prosthesis. These tests were carried out on men whose leg had to be amputated for circulatory problems. The tests took place during a surgical intervention, before amputation, on the tibia of the leg, instead of the femur, in order to traumatize the patient as little as possible.
L'obturateur stérile est placé dans le canal médullaire du tibia, après alésage sur une hauteur convenable, au diamètre de 13 mm. On constate que l'obturateur au contact des liquides physiologiques devient extrêmement collant et est ainsi bien fermement tenu dans le canal médullaire du tibia. On introduit ensuite le ciment osseux (CMW) dans des conditions identiques à celles utilisées dans l'intervention d'une prothèse totale, notamment en exerçant des pression et compactage analogues. Après amputation, le tibia est coupé au-dessous de l'obturateur. L'examen de la coupe montre que l'obturateur a pleinement joué son rôle : on ne décèle pas la présence du ciment. De plus, on constate qu'après un quart d'heure, l'obturateur n"a pas subi de modification importante : il présente donc une tenue dans le temps, tout à fait compatible avec la durée de l'intervention chirurgicale. The sterile obturator is placed in the medullary canal of the tibia, after reaming to a suitable height, with a diameter of 13 mm. It can be seen that the obturator in contact with physiological fluids becomes extremely sticky and is thus firmly held in the medullary canal of the tibia. Bone cement (CMW) is then introduced under conditions identical to those used in the intervention of a total prosthesis, in particular by exerting similar pressure and compaction. After amputation, the tibia is cut below the obturator. Examination of the cut shows that the shutter has fully played its role: we do not detect the presence of cement. In addition, it can be seen that after a quarter of an hour, the obturator has not undergone any significant modification: it therefore exhibits resistance over time, entirely compatible with the duration of the surgical intervention.
Bien que l'invention ait été décrite à titre d'exemple pour des obturateurs de canal médullaire de fémur ou de tibia ou de fond de cotyle, les obturateurs selon l'invention peuvent être utilisés également chaque fois qu'il est nécessaire d'obturer un passage, orifice, canal, cavité ou analogue dans un os pour la pose d'une prothèse. Although the invention has been described by way of example for obturators of the medullary canal of the femur or tibia or of the acetabulum, the obturators according to the invention can also be used whenever it is necessary to obturate a passage, orifice, channel, cavity or the like in a bone for fitting a prosthesis.
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8414790A FR2570606A1 (en) | 1984-09-26 | 1984-09-26 | Obturator in particular for the cavity of the femur or the bottom of the acetabulum (cotyl) |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8414790A FR2570606A1 (en) | 1984-09-26 | 1984-09-26 | Obturator in particular for the cavity of the femur or the bottom of the acetabulum (cotyl) |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2570606A1 true FR2570606A1 (en) | 1986-03-28 |
Family
ID=9308101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8414790A Withdrawn FR2570606A1 (en) | 1984-09-26 | 1984-09-26 | Obturator in particular for the cavity of the femur or the bottom of the acetabulum (cotyl) |
Country Status (1)
Country | Link |
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FR (1) | FR2570606A1 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0338981A1 (en) * | 1988-04-22 | 1989-10-25 | Mathys AG Bettlach | Plug for the medullary canal |
WO1992007554A1 (en) * | 1990-10-26 | 1992-05-14 | Centre National De La Recherche Scientifique (Cnrs) | Implantable biodegradable material and method for producing same |
WO1993007910A1 (en) * | 1991-10-22 | 1993-04-29 | Isis Innovation Limited | Bioactive material |
FR2687577A1 (en) * | 1992-02-26 | 1993-08-27 | Icp Sa | Biomaterial for the production of products applicable in human medicine, particularly in orthopaedics and process for manufacturing it |
FR2692485A1 (en) * | 1992-06-17 | 1993-12-24 | Patrinove | Biodegradable, radiation-sterilisable plug for blocking bone cavity - consists of desoxy-ribonucleic acid which is combined with mineral or organic element |
EP0652016A1 (en) * | 1993-11-10 | 1995-05-10 | Patrinove | Resorbable and radiosterilisable intramedullary or diaphysary or blocking plugs |
WO1995034331A1 (en) * | 1994-06-10 | 1995-12-21 | Ao-Forschungsinstitut Davos | Self-expanding, adaptable cavity plug for use in implantation of endo-joint prosthesis |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1108900B (en) * | 1955-02-24 | 1961-06-15 | Helopharm Petrik Co Kg | Process for the production of shaped, resorbable bodies from hardened proteins for purposes of alloplastic surgery |
CH593676A5 (en) * | 1975-12-16 | 1977-12-15 | Intermedicat Gmbh | Sealing of blood vessel implants of velour-coated fabric - by impregnating with organic colloidal solns. and drying |
GB2032777A (en) * | 1978-10-09 | 1980-05-14 | Merck Patent Gmbh | Bioresorbable masses containing collagen |
EP0011523A1 (en) * | 1978-10-18 | 1980-05-28 | ESSILOR INTERNATIONAL Compagnie Générale d'Optique | Hydrogels from natural protein polymers, their production and soft contact lenses made from them |
EP0023787A2 (en) * | 1979-07-25 | 1981-02-11 | University Of Exeter | Plugs for the medullary canal of a bone |
DE2947985A1 (en) * | 1979-11-28 | 1981-09-17 | Vsesojuznyj naučno-issledovatel'skij i ispytatel'nyj institut medicinskoj techniki, Moskva | Matrix material for fixing bone fractures - consisting of a copolymer of hydrophilic and hydrophobic monomers reinforced with resorbable non-non-toxic fibres |
EP0089782A1 (en) * | 1982-03-12 | 1983-09-28 | United States Surgical Corporation | Polymeric acrylic prosthesis |
-
1984
- 1984-09-26 FR FR8414790A patent/FR2570606A1/en not_active Withdrawn
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1108900B (en) * | 1955-02-24 | 1961-06-15 | Helopharm Petrik Co Kg | Process for the production of shaped, resorbable bodies from hardened proteins for purposes of alloplastic surgery |
CH593676A5 (en) * | 1975-12-16 | 1977-12-15 | Intermedicat Gmbh | Sealing of blood vessel implants of velour-coated fabric - by impregnating with organic colloidal solns. and drying |
GB2032777A (en) * | 1978-10-09 | 1980-05-14 | Merck Patent Gmbh | Bioresorbable masses containing collagen |
EP0011523A1 (en) * | 1978-10-18 | 1980-05-28 | ESSILOR INTERNATIONAL Compagnie Générale d'Optique | Hydrogels from natural protein polymers, their production and soft contact lenses made from them |
EP0023787A2 (en) * | 1979-07-25 | 1981-02-11 | University Of Exeter | Plugs for the medullary canal of a bone |
DE2947985A1 (en) * | 1979-11-28 | 1981-09-17 | Vsesojuznyj naučno-issledovatel'skij i ispytatel'nyj institut medicinskoj techniki, Moskva | Matrix material for fixing bone fractures - consisting of a copolymer of hydrophilic and hydrophobic monomers reinforced with resorbable non-non-toxic fibres |
EP0089782A1 (en) * | 1982-03-12 | 1983-09-28 | United States Surgical Corporation | Polymeric acrylic prosthesis |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0338981A1 (en) * | 1988-04-22 | 1989-10-25 | Mathys AG Bettlach | Plug for the medullary canal |
WO1992007554A1 (en) * | 1990-10-26 | 1992-05-14 | Centre National De La Recherche Scientifique (Cnrs) | Implantable biodegradable material and method for producing same |
WO1993007910A1 (en) * | 1991-10-22 | 1993-04-29 | Isis Innovation Limited | Bioactive material |
US5508267A (en) * | 1991-10-22 | 1996-04-16 | Isis Innovation Limited | Bioactive material |
FR2687577A1 (en) * | 1992-02-26 | 1993-08-27 | Icp Sa | Biomaterial for the production of products applicable in human medicine, particularly in orthopaedics and process for manufacturing it |
FR2692485A1 (en) * | 1992-06-17 | 1993-12-24 | Patrinove | Biodegradable, radiation-sterilisable plug for blocking bone cavity - consists of desoxy-ribonucleic acid which is combined with mineral or organic element |
EP0652016A1 (en) * | 1993-11-10 | 1995-05-10 | Patrinove | Resorbable and radiosterilisable intramedullary or diaphysary or blocking plugs |
WO1995034331A1 (en) * | 1994-06-10 | 1995-12-21 | Ao-Forschungsinstitut Davos | Self-expanding, adaptable cavity plug for use in implantation of endo-joint prosthesis |
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