AU8133294A - 7beta -substituted-4-aza-5alpha-cholestan-3-ones as selective 5alpha-reductase 1 inhibitors - Google Patents

7beta -substituted-4-aza-5alpha-cholestan-3-ones as selective 5alpha-reductase 1 inhibitors

Info

Publication number
AU8133294A
AU8133294A AU81332/94A AU8133294A AU8133294A AU 8133294 A AU8133294 A AU 8133294A AU 81332/94 A AU81332/94 A AU 81332/94A AU 8133294 A AU8133294 A AU 8133294A AU 8133294 A AU8133294 A AU 8133294A
Authority
AU
Australia
Prior art keywords
5alpha
7beta
cholestan
aza
reductase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU81332/94A
Inventor
Raman K. Bakshi
Georgianna Harris
Gool F. Patel
Gary H. Rasmusson
Richard L. Tolman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU8133294A publication Critical patent/AU8133294A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
AU81332/94A 1993-11-12 1994-11-07 7beta -substituted-4-aza-5alpha-cholestan-3-ones as selective 5alpha-reductase 1 inhibitors Abandoned AU8133294A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15300693A 1993-11-12 1993-11-12
US153006 1993-11-12
PCT/US1994/012817 WO1995013077A1 (en) 1993-11-12 1994-11-07 7β-SUBSTITUTED-4-AZA-5α-CHOLESTAN-3-ONES AS SELECTIVE 5α-REDUCTASE 1 INHIBITORS

Publications (1)

Publication Number Publication Date
AU8133294A true AU8133294A (en) 1995-05-29

Family

ID=22545401

Family Applications (1)

Application Number Title Priority Date Filing Date
AU81332/94A Abandoned AU8133294A (en) 1993-11-12 1994-11-07 7beta -substituted-4-aza-5alpha-cholestan-3-ones as selective 5alpha-reductase 1 inhibitors

Country Status (4)

Country Link
AU (1) AU8133294A (en)
IL (1) IL111467A0 (en)
WO (1) WO1995013077A1 (en)
ZA (1) ZA948909B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2190500A1 (en) 1994-05-19 1995-11-30 Ross A. Miller Oxidation of steroids having allylic groups
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
JPH10508586A (en) * 1994-10-21 1998-08-25 メルク エンド カンパニー インコーポレーテッド Combination type acne treatment method
JP2001523259A (en) * 1997-05-07 2001-11-20 ノヴォファーム リミテッド 4-aza-steroids
US20080125403A1 (en) * 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9006023D0 (en) * 1990-03-16 1990-05-09 Smithkline Beecham Corp Synergistic compositions
EP0555309A1 (en) * 1990-10-31 1993-08-18 BEECHAM GROUP plc Topical composition with retinoid penetration enhancer
IL101245A0 (en) * 1991-03-20 1992-11-15 Merck & Co Inc Pharmaceutical compositions for the treatment of prostatic cancer
RU94046044A (en) * 1992-05-20 1996-10-10 Мерк Энд Ко. NEW 7β-SUBSTITUTED 4-AZA-5a-CHOLESTAN-ONES AS INHIBITORS OF 5a-REDUCTASE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHOD OF ITS PREPARING
US5237064A (en) * 1992-05-20 1993-08-17 Merck & Co., Inc. Process for producing 7β-substituted-aza-5αandrostan-3-ones

Also Published As

Publication number Publication date
IL111467A0 (en) 1994-12-29
WO1995013077A1 (en) 1995-05-18
ZA948909B (en) 1995-10-10

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