AU779880B2 - Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones - Google Patents
Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones Download PDFInfo
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- AU779880B2 AU779880B2 AU72484/01A AU7248401A AU779880B2 AU 779880 B2 AU779880 B2 AU 779880B2 AU 72484/01 A AU72484/01 A AU 72484/01A AU 7248401 A AU7248401 A AU 7248401A AU 779880 B2 AU779880 B2 AU 779880B2
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0015205.8A GB0015205D0 (en) | 2000-06-21 | 2000-06-21 | Bioisosteric thyroid receptor ligands and method |
| GB0015205 | 2000-06-21 | ||
| PCT/EP2001/006815 WO2001098256A1 (en) | 2000-06-21 | 2001-06-15 | Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU7248401A AU7248401A (en) | 2002-01-02 |
| AU779880B2 true AU779880B2 (en) | 2005-02-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| AU72484/01A Ceased AU779880B2 (en) | 2000-06-21 | 2001-06-15 | Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones |
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| EP (1) | EP1296936A1 (enExample) |
| JP (1) | JP2004501132A (enExample) |
| KR (1) | KR20030058952A (enExample) |
| AU (1) | AU779880B2 (enExample) |
| CA (1) | CA2412161C (enExample) |
| GB (1) | GB0015205D0 (enExample) |
| WO (1) | WO2001098256A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7163918B2 (en) * | 2000-08-22 | 2007-01-16 | New River Pharmaceuticals Inc. | Iodothyronine compositions |
| US20040242594A1 (en) * | 2001-11-17 | 2004-12-02 | Dan Peters | Prodrugs of antidepressants and their use for treating depressions |
| GB0208384D0 (en) * | 2002-04-11 | 2002-05-22 | Karobio Ab | Novel compounds |
| WO2004013299A2 (en) * | 2002-08-02 | 2004-02-12 | The General Hospital Corporation | Methods for the production of cells and mammals with desired genetic modifications |
| FR2858232B1 (fr) * | 2003-07-29 | 2006-03-03 | Pierre Potier | Utilisation d'un derive de biguanide pour proteger la peau des radiations uvb |
| JP2007512359A (ja) | 2003-11-19 | 2007-05-17 | メタバシス・セラピューティクス・インコーポレイテッド | 新規なリン含有甲状腺ホルモン様物質 |
| AU2006249350B2 (en) | 2003-11-19 | 2012-02-16 | Metabasis Therapeutics, Inc. | Thyromimetics for the treatment of fatty liver diseases |
| WO2005054176A1 (en) * | 2003-11-25 | 2005-06-16 | Eli Lilly And Company | Peroxisome proliferator activated receptor modulators |
| WO2005090297A1 (en) * | 2004-03-19 | 2005-09-29 | Biotie Therapies Corporation | Sulphonamide derivatives |
| GB0406378D0 (en) * | 2004-03-22 | 2004-04-21 | Karobio Ab | Novel pharmaceutical compositions |
| GB0406380D0 (en) * | 2004-03-22 | 2004-04-21 | Karobio Ab | Novel pharmaceutical compositions |
| KR100927563B1 (ko) | 2004-08-06 | 2009-11-23 | 오쓰까 세이야꾸 가부시키가이샤 | 방향족 화합물 |
| US20060039890A1 (en) * | 2004-08-20 | 2006-02-23 | Renshaw Perry F | Treatment of psychological and cognitive disorders using a cholesterol -lowering agent in combination with an antidepressant |
| WO2006028835A2 (en) * | 2004-09-01 | 2006-03-16 | Trustees Of Boston University | Use of thyroid hormone conversion inhibitors |
| US20090028925A1 (en) * | 2005-05-26 | 2009-01-29 | Erion Mark D | Novel Phosphinic Acid-Containing Thyromimetics |
| GB0513692D0 (en) * | 2005-07-04 | 2005-08-10 | Karobio Ab | Novel pharmaceutical compositions |
| WO2007066784A2 (en) | 2005-12-05 | 2007-06-14 | Otsuka Pharmaceutical Co., Ltd. | Diarylether derivatives as antitumor agents |
| GB0608724D0 (en) | 2006-05-03 | 2006-06-14 | Karobio Ab | Novel Pharmaceutical Compositions |
| NZ575507A (en) | 2006-08-21 | 2011-10-28 | Array Biopharma Inc | 4-substituted phenoxyphenylacetic acid derivatives |
| UA95978C2 (ru) | 2006-10-02 | 2011-09-26 | Оцука Фармас'Ютікел Ко., Лтд. | Ингибитор активации stat3/5 |
| GB0725214D0 (en) * | 2007-12-24 | 2008-02-06 | Karobio Ab | Pharmaceutical compounds |
| JP2011088826A (ja) * | 2008-01-31 | 2011-05-06 | Astellas Pharma Inc | 芳香族カルボン酸化合物 |
| JP5487202B2 (ja) | 2009-04-20 | 2014-05-07 | 田辺三菱製薬株式会社 | 新規甲状腺ホルモンβ受容体作動薬 |
| CA2777234C (en) | 2009-10-11 | 2019-02-26 | Rutgers, The State University Of New Jersey | Biocompatible polymers for medical devices |
| AU2013214799B2 (en) | 2012-02-03 | 2016-05-12 | Rutgers, The State Of University Of New Jersey | Polymeric biomaterials derived from phenolic monomers and their medical uses |
| US11472918B2 (en) | 2012-02-03 | 2022-10-18 | Rutgers, The State University Of New Jersey | Polymeric biomaterials derived from phenolic monomers and their medical uses |
| US10774030B2 (en) | 2014-12-23 | 2020-09-15 | Rutgers, The State University Of New Jersey | Polymeric biomaterials derived from phenolic monomers and their medical uses |
| EP3237487B1 (en) | 2014-12-23 | 2021-02-17 | Rutgers, the State University of New Jersey | Biocompatible iodinated diphenol monomers and polymers |
| KR20190104524A (ko) | 2016-11-21 | 2019-09-10 | 바이킹 테라퓨틱스 인코포레이티드 | 당원축적질환의 치료 방법 |
| EA201992703A1 (ru) | 2017-06-05 | 2020-04-15 | Вайкинг Терапьютикс, Инк. | Композиции для лечения фиброза |
| US12090252B2 (en) | 2017-09-14 | 2024-09-17 | Riken | Method for producing retinal tissues |
| KR20200138283A (ko) | 2018-03-22 | 2020-12-09 | 바이킹 테라퓨틱스 인코포레이티드 | 결정질 형태, 및 결정질 형태의 화합물을 제조하는 방법 |
| US12102646B2 (en) | 2018-12-05 | 2024-10-01 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
| CN111320609A (zh) | 2018-12-13 | 2020-06-23 | 拓臻股份有限公司 | 一种THRβ受体激动剂化合物及其制备方法和用途 |
| US20220170098A1 (en) | 2019-03-13 | 2022-06-02 | Sumitomo Dainippon Pharma Co., Ltd. | Method for Evaluating Quality of Transplant Neural Retina, and Transplant Neural Retina Sheet |
| KR20220017917A (ko) | 2019-05-08 | 2022-02-14 | 알리고스 테라퓨틱스 인코포레이티드 | Thr-베타의 조절제 및 이의 사용 방법 |
| CA3154488A1 (en) * | 2019-08-23 | 2021-03-04 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
| WO2021050945A1 (en) | 2019-09-12 | 2021-03-18 | Terns, Inc. | Thyroid hormone receptor beta agonist compounds |
| CA3194226A1 (en) | 2020-09-11 | 2022-03-17 | Riken | Complex containing neural retina-containing cell aggregates and matrix, and method for manufacturing same |
| EP4201428A4 (en) | 2020-09-11 | 2024-09-11 | Sumitomo Pharma Co., Ltd. | MEDIUM FOR TISSUE INTENDED FOR TRANSPLANTATION |
| EP4240722A1 (en) * | 2020-11-06 | 2023-09-13 | Aligos Therapeutics, Inc. | Oxindoles and methods of use thereof |
| JPWO2023090427A1 (enExample) | 2021-11-19 | 2023-05-25 | ||
| EP4568664A1 (en) | 2023-04-07 | 2025-06-18 | Terns Pharmaceuticals, Inc. | Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating a liver disorder or a cardiometabolic disease |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0580550A1 (en) * | 1992-07-21 | 1994-01-26 | Ciba-Geigy Ag | Oxamic acid derivatives as hypocholesteremic agents |
| WO1996005190A1 (en) * | 1994-08-11 | 1996-02-22 | Karo Bio Ab | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists |
| US5883294A (en) * | 1997-06-18 | 1999-03-16 | The Regeants Of The University Of California | Selective thyroid hormone analogs |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB642159A (en) * | 1947-10-23 | 1950-08-30 | Glaxo Lab Ltd | Improvements in or relating to the preparation of diphenyl ethers |
| GB643089A (en) * | 1947-10-23 | 1950-09-15 | Glaxo Lab Ltd | Improvements in or relating to the preparation of 2:6-dihalogeno diphenyl ethers |
| US3652665A (en) * | 1970-04-20 | 1972-03-28 | Merck & Co Inc | Halo-phenoxy salicylic acids |
| US4465508A (en) * | 1979-07-18 | 1984-08-14 | Imperial Chemical Industries Plc | Diphenyl ether herbicides |
| DE19527305A1 (de) * | 1995-07-26 | 1997-01-30 | Hoechst Ag | Substituierte Zimtsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| OA11839A (en) * | 1999-03-01 | 2005-08-23 | Pfizer Prod Inc | Oxamic acids and derivatives as thyroid receptor ligands. |
-
2000
- 2000-06-21 GB GBGB0015205.8A patent/GB0015205D0/en not_active Ceased
-
2001
- 2001-06-15 CA CA002412161A patent/CA2412161C/en not_active Expired - Fee Related
- 2001-06-15 AU AU72484/01A patent/AU779880B2/en not_active Ceased
- 2001-06-15 US US10/311,524 patent/US7199265B2/en not_active Expired - Fee Related
- 2001-06-15 EP EP01951600A patent/EP1296936A1/en not_active Withdrawn
- 2001-06-15 KR KR1020027017478A patent/KR20030058952A/ko not_active Withdrawn
- 2001-06-15 WO PCT/EP2001/006815 patent/WO2001098256A1/en not_active Ceased
- 2001-06-15 JP JP2002504212A patent/JP2004501132A/ja not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0580550A1 (en) * | 1992-07-21 | 1994-01-26 | Ciba-Geigy Ag | Oxamic acid derivatives as hypocholesteremic agents |
| WO1996005190A1 (en) * | 1994-08-11 | 1996-02-22 | Karo Bio Ab | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists |
| US5883294A (en) * | 1997-06-18 | 1999-03-16 | The Regeants Of The University Of California | Selective thyroid hormone analogs |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2412161C (en) | 2009-03-17 |
| EP1296936A1 (en) | 2003-04-02 |
| US20040097589A1 (en) | 2004-05-20 |
| JP2004501132A (ja) | 2004-01-15 |
| GB0015205D0 (en) | 2000-08-09 |
| WO2001098256A1 (en) | 2001-12-27 |
| AU7248401A (en) | 2002-01-02 |
| KR20030058952A (ko) | 2003-07-07 |
| CA2412161A1 (en) | 2001-12-27 |
| US7199265B2 (en) | 2007-04-03 |
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| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |