AU772960C - 3-bicycloindole compounds as 5-HT1D ligands - Google Patents

3-bicycloindole compounds as 5-HT1D ligands

Info

Publication number
AU772960C
AU772960C AU56135/99A AU5613599A AU772960C AU 772960 C AU772960 C AU 772960C AU 56135/99 A AU56135/99 A AU 56135/99A AU 5613599 A AU5613599 A AU 5613599A AU 772960 C AU772960 C AU 772960C
Authority
AU
Australia
Prior art keywords
indolizinyl
indole
hexahydro
group
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU56135/99A
Other languages
English (en)
Other versions
AU5613599A (en
AU772960B2 (en
Inventor
Louise Edwards
Abdelmalik Slassi
Ashok Tehim
Tao Xin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NPS Allelix Corp Canada
Original Assignee
NPS Allelix Corp Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NPS Allelix Corp Canada filed Critical NPS Allelix Corp Canada
Publication of AU5613599A publication Critical patent/AU5613599A/en
Assigned to NPS ALLELIX CORP. reassignment NPS ALLELIX CORP. Amend patent request/document other than specification (104) Assignors: ALLELIX BIOPHARMACEUTICALS INC.
Application granted granted Critical
Publication of AU772960B2 publication Critical patent/AU772960B2/en
Publication of AU772960C publication Critical patent/AU772960C/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Conductive Materials (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
AU56135/99A 1998-09-18 1999-09-13 3-bicycloindole compounds as 5-HT1D ligands Ceased AU772960C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/156,496 US6562809B1 (en) 1998-09-18 1998-09-18 3-bicycloindole compounds
US09/156496 1998-09-18
PCT/CA1999/000833 WO2000017198A1 (fr) 1998-09-18 1999-09-13 Composes de 3-bicycloindole comme ligands de 5-ht¿1d?

Publications (3)

Publication Number Publication Date
AU5613599A AU5613599A (en) 2000-04-10
AU772960B2 AU772960B2 (en) 2004-05-13
AU772960C true AU772960C (en) 2005-04-07

Family

ID=22559821

Family Applications (1)

Application Number Title Priority Date Filing Date
AU56135/99A Ceased AU772960C (en) 1998-09-18 1999-09-13 3-bicycloindole compounds as 5-HT1D ligands

Country Status (8)

Country Link
US (1) US6562809B1 (fr)
EP (1) EP1114049B1 (fr)
JP (1) JP2002526497A (fr)
AT (1) ATE234837T1 (fr)
AU (1) AU772960C (fr)
CA (1) CA2343391A1 (fr)
DE (1) DE69906101D1 (fr)
WO (1) WO2000017198A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1204662T3 (da) * 1999-08-12 2004-10-04 Nps Allelix Corp Azaindoler med serotoninreceptoraffinitet
US6686374B1 (en) 1999-08-12 2004-02-03 Nps Allelix Corp. Azaindoles having serotonin receptor affinity
GB9926303D0 (en) * 1999-11-05 2000-01-12 Smithkline Beecham Plc Novel compounds
US7375219B2 (en) 2005-04-13 2008-05-20 Neuraxon, Inc. Substituted indole compounds having NOS inhibitory activity
US7696229B2 (en) 2006-02-17 2010-04-13 Memory Pharmaceuticals Corporation Compounds having 5-HT6 receptor affinity
TW200808780A (en) 2006-04-13 2008-02-16 Neuraxon Inc 1,5 and 3,6- substituted indole compounds having NOS inhibitory activity
BRPI0820632A2 (pt) 2007-11-16 2015-06-16 Neuraxon Inc Compostos de indol e métodos para tratamento de dor visceral

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0875513A1 (fr) * 1997-04-14 1998-11-04 Eli Lilly And Company Composés hétéroaromatiques substitués agonistes du récepteur 5-HT1F

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9519558D0 (en) * 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
GB9601786D0 (en) * 1996-01-30 1996-04-03 Merck Sharp & Dohme Therapeutic agents
AU2759597A (en) * 1996-05-16 1997-12-05 Allelix Biopharmaceuticals Inc. Thiophene- and furan-tryptamine derivatives
ATE251136T1 (de) * 1996-11-26 2003-10-15 Nps Allelix Corp 5-cyclo-indolverbindungen als 5-ht1d rezeptor liganden
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0875513A1 (fr) * 1997-04-14 1998-11-04 Eli Lilly And Company Composés hétéroaromatiques substitués agonistes du récepteur 5-HT1F

Also Published As

Publication number Publication date
CA2343391A1 (fr) 2000-03-30
DE69906101D1 (de) 2003-04-24
JP2002526497A (ja) 2002-08-20
ATE234837T1 (de) 2003-04-15
EP1114049A1 (fr) 2001-07-11
AU5613599A (en) 2000-04-10
WO2000017198A1 (fr) 2000-03-30
EP1114049B1 (fr) 2003-03-19
US6562809B1 (en) 2003-05-13
AU772960B2 (en) 2004-05-13

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Legal Events

Date Code Title Description
TC Change of applicant's name (sec. 104)

Owner name: NPS ALLELIX CORP.

Free format text: FORMER NAME: ALLELIX BIOPHARMACEUTICALS INC.

FGA Letters patent sealed or granted (standard patent)
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE PROPOSED AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20040721

DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE PROPOSED AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20040813