AU772682B2 - Highly-mineralized osteogenic sponge compositions, and uses thereof - Google Patents
Highly-mineralized osteogenic sponge compositions, and uses thereof Download PDFInfo
- Publication number
- AU772682B2 AU772682B2 AU27568/00A AU2756800A AU772682B2 AU 772682 B2 AU772682 B2 AU 772682B2 AU 27568/00 A AU27568/00 A AU 27568/00A AU 2756800 A AU2756800 A AU 2756800A AU 772682 B2 AU772682 B2 AU 772682B2
- Authority
- AU
- Australia
- Prior art keywords
- osteogenic
- sponge
- bone
- composition
- matrix material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000002188 osteogenic effect Effects 0.000 title claims abstract description 108
- 239000000203 mixture Substances 0.000 title claims abstract description 98
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 68
- 238000000034 method Methods 0.000 claims abstract description 68
- 239000011707 mineral Substances 0.000 claims abstract description 68
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 52
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims abstract description 23
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims abstract description 23
- 229940112869 bone morphogenetic protein Drugs 0.000 claims abstract description 23
- 239000007943 implant Substances 0.000 claims abstract description 21
- 230000002138 osteoinductive effect Effects 0.000 claims abstract description 6
- 239000011159 matrix material Substances 0.000 claims description 68
- 102000008186 Collagen Human genes 0.000 claims description 46
- 108010035532 Collagen Proteins 0.000 claims description 46
- 229920001436 collagen Polymers 0.000 claims description 46
- 230000004927 fusion Effects 0.000 claims description 36
- 241000288906 Primates Species 0.000 claims description 30
- 230000008468 bone growth Effects 0.000 claims description 26
- 239000002245 particle Substances 0.000 claims description 26
- 241000124008 Mammalia Species 0.000 claims description 21
- 239000001506 calcium phosphate Substances 0.000 claims description 14
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 14
- 230000006698 induction Effects 0.000 claims description 12
- 102100033337 PDZ and LIM domain protein 7 Human genes 0.000 claims description 11
- 101710121660 PDZ and LIM domain protein 7 Proteins 0.000 claims description 11
- 230000002051 biphasic effect Effects 0.000 claims description 11
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 11
- 235000011010 calcium phosphates Nutrition 0.000 claims description 11
- 210000002997 osteoclast Anatomy 0.000 claims description 10
- 210000000963 osteoblast Anatomy 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 9
- 239000000919 ceramic Substances 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 7
- 230000001054 cortical effect Effects 0.000 claims description 6
- 210000001185 bone marrow Anatomy 0.000 claims description 5
- 239000004068 calcium phosphate ceramic Substances 0.000 claims description 5
- 239000002773 nucleotide Substances 0.000 claims description 5
- 125000003729 nucleotide group Chemical group 0.000 claims description 5
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims description 4
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims description 4
- 238000003780 insertion Methods 0.000 claims description 4
- 230000037431 insertion Effects 0.000 claims description 4
- 230000000717 retained effect Effects 0.000 claims description 4
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims description 2
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims description 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims description 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims description 2
- 102000013275 Somatomedins Human genes 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 229940126864 fibroblast growth factor Drugs 0.000 claims description 2
- 230000012010 growth Effects 0.000 claims description 2
- 150000003431 steroids Chemical class 0.000 claims description 2
- 230000001131 transforming effect Effects 0.000 claims description 2
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims 2
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims 2
- 102000003839 Human Proteins Human genes 0.000 claims 2
- 108090000144 Human Proteins Proteins 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 229910010293 ceramic material Inorganic materials 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 abstract description 5
- 230000008439 repair process Effects 0.000 abstract description 3
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000002131 composite material Substances 0.000 description 14
- 239000002002 slurry Substances 0.000 description 12
- 241001465754 Metazoa Species 0.000 description 9
- 239000000463 material Substances 0.000 description 8
- 230000011164 ossification Effects 0.000 description 7
- 241000282412 Homo Species 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 239000000515 collagen sponge Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 239000013598 vector Substances 0.000 description 4
- 239000011800 void material Substances 0.000 description 4
- 241000282560 Macaca mulatta Species 0.000 description 3
- 102100026632 Mimecan Human genes 0.000 description 3
- 101800002327 Osteoinductive factor Proteins 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003462 bioceramic Substances 0.000 description 3
- 230000010256 bone deposition Effects 0.000 description 3
- 238000002591 computed tomography Methods 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 3
- 235000019731 tricalcium phosphate Nutrition 0.000 description 3
- 229940078499 tricalcium phosphate Drugs 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 208000037873 arthrodesis Diseases 0.000 description 2
- 239000000316 bone substitute Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 102000045896 human BMP2 Human genes 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000001599 osteoclastic effect Effects 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- 241000112853 Arthrodes Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 102000012422 Collagen Type I Human genes 0.000 description 1
- 108010022452 Collagen Type I Proteins 0.000 description 1
- 102000001187 Collagen Type III Human genes 0.000 description 1
- 108010069502 Collagen Type III Proteins 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 description 1
- 101000899361 Homo sapiens Bone morphogenetic protein 7 Proteins 0.000 description 1
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
- 208000023178 Musculoskeletal disease Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 241001447056 Uristes Species 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 229940064804 betadine Drugs 0.000 description 1
- 230000010072 bone remodeling Effects 0.000 description 1
- 239000008366 buffered solution Substances 0.000 description 1
- SIEYLFHKZGLBNX-UHFFFAOYSA-N bupivacaine hydrochloride (anhydrous) Chemical compound [Cl-].CCCC[NH+]1CCCCC1C(=O)NC1=C(C)C=CC=C1C SIEYLFHKZGLBNX-UHFFFAOYSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 102000013373 fibrillar collagen Human genes 0.000 description 1
- 108060002894 fibrillar collagen Proteins 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 102000046148 human BMP4 Human genes 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229960002725 isoflurane Drugs 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000004705 lumbosacral region Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940106885 marcaine Drugs 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000005541 medical transmission Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000921 morphogenic effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 238000007500 overflow downdraw method Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229940052907 telazol Drugs 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11861599P | 1999-02-04 | 1999-02-04 | |
| US60/118615 | 1999-02-04 | ||
| PCT/US2000/003043 WO2000045871A1 (en) | 1999-02-04 | 2000-02-04 | Highly-mineralized osteogenic sponge compositions, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2756800A AU2756800A (en) | 2000-08-25 |
| AU772682B2 true AU772682B2 (en) | 2004-05-06 |
Family
ID=22379695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU27568/00A Ceased AU772682B2 (en) | 1999-02-04 | 2000-02-04 | Highly-mineralized osteogenic sponge compositions, and uses thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7563455B2 (https=) |
| EP (1) | EP1150726B1 (https=) |
| JP (1) | JP2002536077A (https=) |
| AT (1) | ATE253385T1 (https=) |
| AU (1) | AU772682B2 (https=) |
| CA (1) | CA2362049A1 (https=) |
| DE (1) | DE60006356T2 (https=) |
| ES (1) | ES2209820T3 (https=) |
| WO (1) | WO2000045871A1 (https=) |
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040081704A1 (en) | 1998-02-13 | 2004-04-29 | Centerpulse Biologics Inc. | Implantable putty material |
| DE60006356T2 (de) * | 1999-02-04 | 2004-09-09 | SDGI Holding, Inc., Wilmington | Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung |
| AU770196B2 (en) * | 1999-02-04 | 2004-02-12 | Warsaw Orthopedic, Inc. | Osteogenic paste compositions and uses thereof |
| US8226729B2 (en) * | 2000-10-24 | 2012-07-24 | Warsaw Orthopedic, Inc. | Spinal fusion methods and devices |
| US7435260B2 (en) * | 1999-08-13 | 2008-10-14 | Ferree Bret A | Use of morphogenetic proteins to treat human disc disease |
| US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
| US6949251B2 (en) | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
| ATE303169T1 (de) | 2001-11-19 | 2005-09-15 | Scil Technology Gmbh | Homogen beschichtete vorrichtung mit osteoinduktiven und osteokonduktiven eigenschaften |
| JP2003169845A (ja) * | 2001-12-07 | 2003-06-17 | Japan Science & Technology Corp | スポンジ状多孔質アパタイト・コラーゲン複合体、スポンジ状超多孔質アパタイト・コラーゲン複合体及びそれらの製造方法 |
| TW200400062A (en) | 2002-04-03 | 2004-01-01 | Mathys Medizinaltechnik Ag | Kneadable, pliable bone replacement material |
| US7166133B2 (en) * | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
| AU2003253049A1 (en) | 2002-09-10 | 2004-04-30 | Scil Technology Gmbh | Metal implant coated under reduced oxygen concentration with osteoinductive protein |
| AU2003277593A1 (en) * | 2002-11-07 | 2004-06-07 | Ichiro Ono | Therapeutic device for osteogenesis |
| US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| US8734421B2 (en) | 2003-06-30 | 2014-05-27 | Johnson & Johnson Consumer Companies, Inc. | Methods of treating pores on the skin with electricity |
| US20070010892A1 (en) * | 2003-08-27 | 2007-01-11 | Makoto Ogiso | Structural body constituted of biocompatible material impregnated with fine bone dust and process for producing the same |
| US7666230B2 (en) | 2003-12-08 | 2010-02-23 | Depuy Products, Inc. | Implant device for cartilage regeneration in load bearing articulation regions |
| US7189263B2 (en) * | 2004-02-03 | 2007-03-13 | Vita Special Purpose Corporation | Biocompatible bone graft material |
| US20050192675A1 (en) * | 2004-03-01 | 2005-09-01 | Robinson Dane Q. | Device for use in stimulating bone growth |
| US9220595B2 (en) | 2004-06-23 | 2015-12-29 | Orthovita, Inc. | Shapeable bone graft substitute and instruments for delivery thereof |
| EP1799277B1 (en) * | 2004-09-14 | 2012-11-07 | Agency for Science, Technology and Research | Porous biomaterial-filler composite and a method for making the same |
| US7722895B1 (en) | 2004-09-20 | 2010-05-25 | Warsaw Orthopedic, Inc. | Osteogenic implants with combined implant materials, and materials and methods for same |
| US20090319045A1 (en) | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US8114841B2 (en) | 2004-10-14 | 2012-02-14 | Biomimetic Therapeutics, Inc. | Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix |
| US7473678B2 (en) * | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| US7670384B2 (en) * | 2004-10-14 | 2010-03-02 | Biomet Manufacturing Corp. | Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone |
| US20060083769A1 (en) * | 2004-10-14 | 2006-04-20 | Mukesh Kumar | Method and apparatus for preparing bone |
| DE102005016443A1 (de) * | 2004-11-23 | 2006-05-24 | Ossacur Ag | Bioresorbierbares und mineralisiertes Material zur Füllung von Knochendefekten |
| WO2006089359A1 (en) * | 2005-02-25 | 2006-08-31 | Eugene Sherry | Replacement bone tissue |
| EP1868539A2 (en) | 2005-04-15 | 2007-12-26 | Musculoskeletal Transplant Foundation | Vertebral disc repair |
| US8506646B2 (en) * | 2005-04-29 | 2013-08-13 | Warsaw Orthopedic, Inc. | Multi-purpose medical implant devices |
| US7857853B2 (en) * | 2005-04-29 | 2010-12-28 | Sdgi Holdings, Inc | Synthetic loadbearing collagen-mineral composites useful for spinal implants, and methods of manufacture |
| US8092548B2 (en) * | 2005-06-22 | 2012-01-10 | Warsaw Orthopedic, Inc. | Osteograft treatment to promote osteoinduction and osteograft incorporation |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| CA2623106C (en) | 2005-09-19 | 2013-12-24 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
| US20070077267A1 (en) * | 2005-10-03 | 2007-04-05 | Sdgi Holdings, Inc. | Bioactive composite implants |
| US9132208B2 (en) * | 2008-08-07 | 2015-09-15 | Lifenet Health | Composition for a tissue repair implant and methods of making the same |
| US9005646B2 (en) | 2005-10-12 | 2015-04-14 | Lifenet Health | Compositions for repair of defects in tissues, and methods of making the same |
| US7939092B2 (en) * | 2006-02-01 | 2011-05-10 | Warsaw Orthopedic, Inc. | Cohesive osteogenic putty and materials therefor |
| US7824703B2 (en) | 2006-02-01 | 2010-11-02 | Warsaw Orthopedics, Inc. | Medical implants with reservoir(s), and materials preparable from same |
| ES2427993T3 (es) * | 2006-02-09 | 2013-11-05 | Biomimetic Therapeutics, Llc | Composiciones y métodos para el tratamiento de hueso |
| US7833270B2 (en) * | 2006-05-05 | 2010-11-16 | Warsaw Orthopedic, Inc | Implant depots to deliver growth factors to treat osteoporotic bone |
| US9161967B2 (en) * | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| CA2656278C (en) | 2006-06-30 | 2016-02-09 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating rotator cuff injuries |
| WO2008013763A2 (en) | 2006-07-25 | 2008-01-31 | Musculoskeletal Transplant Foundation | Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation |
| US8524265B2 (en) * | 2006-08-17 | 2013-09-03 | Warsaw Orthopedic, Inc. | Medical implant sheets useful for tissue regeneration |
| US8106008B2 (en) | 2006-11-03 | 2012-01-31 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
| US20080147197A1 (en) * | 2006-12-14 | 2008-06-19 | Mckay William F | Biodegradable osteogenic porous biomedical implant with impermeable membrane |
| US8048857B2 (en) * | 2006-12-19 | 2011-11-01 | Warsaw Orthopedic, Inc. | Flowable carrier compositions and methods of use |
| US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
| US20080195476A1 (en) * | 2007-02-09 | 2008-08-14 | Marchese Michael A | Abandonment remarketing system |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| CA2720269A1 (en) * | 2007-04-18 | 2008-10-30 | Mcgill University | Composition for enhancing bone formation |
| EP2014256A1 (en) | 2007-07-12 | 2009-01-14 | Straumann Holding AG | Composite bone repair material |
| CA2699868A1 (en) | 2007-09-19 | 2009-03-26 | Surmodics, Inc. | Biocompatible foams, systems, and methods |
| US20090110637A1 (en) * | 2007-10-26 | 2009-04-30 | Warsaw Orthopedic, Inc. | LMP and Regulation of Tissue Growth |
| US9056150B2 (en) | 2007-12-04 | 2015-06-16 | Warsaw Orthopedic, Inc. | Compositions for treating bone defects |
| EP2259807B1 (en) * | 2008-02-07 | 2013-04-24 | Biomimetic Therapeutics, Inc. | Compositions for distraction osteogenesis |
| US8840913B2 (en) * | 2008-03-27 | 2014-09-23 | Warsaw Orthopedic, Inc. | Malleable multi-component implants and materials therefor |
| US9095569B2 (en) | 2008-04-18 | 2015-08-04 | Collplant Ltd. | Methods of generating and using procollagen |
| US9492375B2 (en) | 2008-07-23 | 2016-11-15 | Warsaw Orthopedic, Inc. | Foam carrier for bone grafting |
| US8039433B2 (en) * | 2008-08-19 | 2011-10-18 | Warsaw Orthopedic, Inc. | Osteogenic compositions containing a coloring agent |
| KR20110067035A (ko) * | 2008-09-09 | 2011-06-20 | 바이오미메틱 세라퓨틱스, 인크. | 건 및 인대 손상의 치료를 위한 혈소판-유래 성장 인자 조성물 및 방법 |
| US9192695B2 (en) | 2008-11-20 | 2015-11-24 | Allosource | Allografts combined with tissue derived stem cells for bone healing |
| WO2010102266A1 (en) * | 2009-03-05 | 2010-09-10 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects |
| US20120089232A1 (en) | 2009-03-27 | 2012-04-12 | Jennifer Hagyoung Kang Choi | Medical devices with galvanic particulates |
| US20110060419A1 (en) * | 2009-03-27 | 2011-03-10 | Jennifer Hagyoung Kang Choi | Medical devices with galvanic particulates |
| WO2011063152A1 (en) * | 2009-11-18 | 2011-05-26 | Affinergy, Inc. | Methods and compositions for soft tissue repair |
| US20140286911A1 (en) | 2013-03-15 | 2014-09-25 | Allosource | Cell repopulated collagen matrix for soft tissue repair and regeneration |
| US8475824B2 (en) | 2010-01-26 | 2013-07-02 | Warsaw Orthopedic, Inc. | Resorbable matrix having elongated particles |
| US8758791B2 (en) | 2010-01-26 | 2014-06-24 | Warsaw Orthopedic, Inc. | Highly compression resistant matrix with porous skeleton |
| CN102811622A (zh) | 2010-02-22 | 2012-12-05 | 生物模拟治疗公司 | 用于治疗腱病的血小板衍生生长因子组合物和方法 |
| US8501690B2 (en) | 2010-04-30 | 2013-08-06 | John G. Stark | Use of selective estrogen receptor modulator for joint fusion and other repair or healing of connective tissue |
| CA3048850A1 (en) | 2010-05-11 | 2011-11-17 | Howmedica Osteonics Corp. | Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods |
| PH12013500294A1 (en) | 2010-08-20 | 2017-08-23 | Wyeth Llc | Designer osteogenic proteins |
| AU2011329054B2 (en) | 2010-11-15 | 2015-05-28 | Zimmer Orthobiologics, Inc. | Bone void fillers |
| US8551525B2 (en) | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
| US9358122B2 (en) | 2011-01-07 | 2016-06-07 | K2M, Inc. | Interbody spacer |
| US9717779B2 (en) | 2011-01-31 | 2017-08-01 | Warsaw Orthopedic, Inc. | Implantable matrix having optimum ligand concentrations |
| CN103476440B (zh) * | 2011-02-25 | 2016-10-19 | 新特斯有限责任公司 | 促进成骨的植入物以及诱导骨生长的方法 |
| WO2012158527A2 (en) | 2011-05-13 | 2012-11-22 | Howmedica Osteonics | Organophosphorous & multivalent metal compound compositions & methods |
| EP2529764A1 (de) | 2011-05-31 | 2012-12-05 | Curasan AG | Biologisch degradierbares kompositmaterial |
| US8998925B2 (en) | 2011-06-20 | 2015-04-07 | Rdc Holdings, Llc | Fixation system for orthopedic devices |
| WO2012177759A1 (en) | 2011-06-20 | 2012-12-27 | Rdc Holdings, Llc | System and method for repairing joints |
| US8920511B2 (en) | 2011-11-17 | 2014-12-30 | Allosource | Multi-piece machine graft systems and methods |
| US9162011B2 (en) | 2011-12-19 | 2015-10-20 | Allosource | Flowable matrix compositions and methods |
| US9642933B2 (en) | 2012-01-30 | 2017-05-09 | Board Of Regents, The University Of Texas System | Compositions comprising bioadhesives and methods of making the same |
| US20150031772A1 (en) * | 2012-02-17 | 2015-01-29 | Bacterin International, Inc. | Adjustable bioactive agent dispersion within a polymeric coating |
| US8697107B2 (en) | 2012-04-27 | 2014-04-15 | Warsaw Orthopedic, Inc. | Flowable implant with crosslinkable surface membrane |
| US10207027B2 (en) | 2012-06-11 | 2019-02-19 | Globus Medical, Inc. | Bioactive bone graft substitutes |
| US9585764B2 (en) * | 2012-07-26 | 2017-03-07 | Warsaw Orthopedic, Inc. | Bone implant device |
| CN110755447A (zh) * | 2013-01-04 | 2020-02-07 | 德克萨斯系统大学董事会 | 包含柠檬酸的组合物及其应用 |
| AU2014218734B2 (en) | 2013-02-22 | 2018-03-15 | Allosource | Cartilage mosaic compositions and methods |
| CA2897855A1 (en) | 2013-03-07 | 2014-09-12 | Allosource | Consistent calcium content bone allograft systems and methods |
| MX2015011820A (es) * | 2013-03-14 | 2016-01-25 | Genzyme Corp | Composiciones termosensibles para crecimiento oseo. |
| WO2014151939A1 (en) | 2013-03-15 | 2014-09-25 | Allosource | Perforated osteochondral allograft compositions |
| US9486483B2 (en) | 2013-10-18 | 2016-11-08 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
| US9539286B2 (en) | 2013-10-18 | 2017-01-10 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
| US9579421B2 (en) | 2014-02-07 | 2017-02-28 | Globus Medical Inc. | Bone grafts and methods of making and using bone grafts |
| US9463264B2 (en) | 2014-02-11 | 2016-10-11 | Globus Medical, Inc. | Bone grafts and methods of making and using bone grafts |
| WO2015175983A1 (en) | 2014-05-16 | 2015-11-19 | Allosource | Composite bone constructs and methods |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| US10130678B2 (en) | 2014-12-29 | 2018-11-20 | Bioventus, LLC. | Systems and methods for improved delivery of osteoinductive molecules in bone repair |
| CA3177726A1 (en) | 2015-05-21 | 2016-11-24 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| US10016529B2 (en) | 2015-06-10 | 2018-07-10 | Globus Medical, Inc. | Biomaterial compositions, implants, and methods of making the same |
| US11426489B2 (en) | 2015-06-10 | 2022-08-30 | Globus Medical, Inc. | Biomaterial compositions, implants, and methods of making the same |
| WO2017100339A1 (en) * | 2015-12-07 | 2017-06-15 | Nuvasive, Inc. | Immunomodulation with implantation of cellular allograft bone into a non-bony site |
| US20170319750A1 (en) * | 2016-05-09 | 2017-11-09 | Bioventus, Llc | Composite matrices designed for enhanced bone repair |
| MX384888B (es) | 2017-04-13 | 2025-03-14 | Septodont Ou Septodont Sas Ou Specialites Septodont | Material regenerativo de tejidos conectivos, tal como hueso, dentina o pulpa, que comprende silicato de calcio |
| EP3388092A1 (en) | 2017-04-13 | 2018-10-17 | Septodont ou Septodont SAS ou Specialites Septodont | Connective tissues, such as bone, dentin or pulp, regenerative material comprising calcium silicate |
| WO2019006328A1 (en) | 2017-06-30 | 2019-01-03 | Allosource | CELL BONE GRAFTS, AND METHODS OF MAKING AND USING |
| US11896736B2 (en) | 2020-07-13 | 2024-02-13 | Globus Medical, Inc | Biomaterial implants and methods of making the same |
| US11883302B2 (en) | 2021-11-22 | 2024-01-30 | Warsaw Orthopedic, Inc. | Spinal implant having a compressible insert |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997040137A1 (en) * | 1996-04-19 | 1997-10-30 | Osiris Therapeutics, Inc. | Regeneration and augmentation of bone using mesenchymal stem cells |
| WO1998017330A1 (en) * | 1996-10-24 | 1998-04-30 | Sdgi Holdings, Inc. | Ceramic fusion implants and compositions containing osteoinductive factors |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0030583B1 (de) | 1979-12-18 | 1984-06-13 | Oscobal Ag | Knochenersatzmaterial und Verfahren zur Herstellung eines Knochenersatzmaterials |
| US4394370A (en) | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
| US4795804A (en) * | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
| US4888366A (en) * | 1984-10-24 | 1989-12-19 | Collagen Corporation | Inductive collagen-based bone repair preparations |
| US5001169A (en) * | 1984-10-24 | 1991-03-19 | Collagen Corporation | Inductive collagen-based bone repair preparations |
| US5273964A (en) | 1985-03-20 | 1993-12-28 | Lemons J E | Inorganic and organic composition for treatment of bone lesions |
| US5246457A (en) | 1985-03-28 | 1993-09-21 | Collagen Corporation | Xenogeneic collagen/mineral preparations in bone repair |
| US4992226A (en) | 1985-03-28 | 1991-02-12 | Collagen Corporation | Method of making molds with xenogeneic collagen/mineral preparations for bone repair |
| US4776890A (en) | 1985-12-18 | 1988-10-11 | Collagen Corporation | Preparation of collagen hydroxyapatite matrix for bone repair |
| US4780450A (en) | 1985-12-20 | 1988-10-25 | The University Of Maryland At Baltimore | Physically stable composition and method of use thereof for osseous repair |
| US4743229A (en) | 1986-09-29 | 1988-05-10 | Collagen Corporation | Collagen/mineral mixing device and method |
| US4865602A (en) | 1986-11-06 | 1989-09-12 | Collagen Corporation | Gamma irradiation of collagen/mineral mixtures |
| US4861733A (en) * | 1987-02-13 | 1989-08-29 | Interpore International | Calcium phosphate bone substitute materials |
| CA1339083C (en) * | 1987-11-13 | 1997-07-29 | Steven R. Jefferies | Bone repair material and delayed drug delivery system |
| US5573771A (en) * | 1988-08-19 | 1996-11-12 | Osteomedical Limited | Medicinal bone mineral products |
| US5106626A (en) * | 1988-10-11 | 1992-04-21 | International Genetic Engineering, Inc. | Osteogenic factors |
| US5231169A (en) * | 1990-10-17 | 1993-07-27 | Norian Corporation | Mineralized collagen |
| US5270300A (en) * | 1991-09-06 | 1993-12-14 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone |
| US5626861A (en) * | 1994-04-01 | 1997-05-06 | Massachusetts Institute Of Technology | Polymeric-hydroxyapatite bone composite |
| US5817327A (en) * | 1994-07-27 | 1998-10-06 | The Trustees Of The University Of Pennsylvania | Incorporation of biologically active molecules into bioactive glasses |
| CN1134810A (zh) * | 1995-02-17 | 1996-11-06 | 索发默达纳集团股份有限公司 | 改进的体内脊骨融合植入件 |
| CA2222626A1 (en) * | 1995-06-06 | 1996-12-12 | Biocoll Laboratories, Inc. | Modified osteogenic materials |
| US5702449A (en) * | 1995-06-07 | 1997-12-30 | Danek Medical, Inc. | Reinforced porous spinal implants |
| CA2172917A1 (en) | 1995-06-07 | 1996-12-08 | Hugh R. Mcmullin | Moldable collagen compositions for hard tissue repair and augmentation |
| US5776193A (en) | 1995-10-16 | 1998-07-07 | Orquest, Inc. | Bone grafting matrix |
| EP0883410B1 (en) * | 1996-02-29 | 2004-08-18 | Bioactive Bone Substitute OY, AB | An osteogenic device and a method for preparing the device |
| US5741261A (en) * | 1996-06-25 | 1998-04-21 | Sdgi Holdings, Inc. | Minimally invasive spinal surgical methods and instruments |
| US5972368A (en) * | 1997-06-11 | 1999-10-26 | Sdgi Holdings, Inc. | Bone graft composites and spacers |
| DE60006356T2 (de) * | 1999-02-04 | 2004-09-09 | SDGI Holding, Inc., Wilmington | Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung |
-
2000
- 2000-02-04 DE DE60006356T patent/DE60006356T2/de not_active Expired - Fee Related
- 2000-02-04 AT AT00905989T patent/ATE253385T1/de not_active IP Right Cessation
- 2000-02-04 AU AU27568/00A patent/AU772682B2/en not_active Ceased
- 2000-02-04 ES ES00905989T patent/ES2209820T3/es not_active Expired - Lifetime
- 2000-02-04 EP EP00905989A patent/EP1150726B1/en not_active Expired - Lifetime
- 2000-02-04 JP JP2000596990A patent/JP2002536077A/ja active Pending
- 2000-02-04 CA CA002362049A patent/CA2362049A1/en not_active Abandoned
- 2000-02-04 WO PCT/US2000/003043 patent/WO2000045871A1/en not_active Ceased
-
2001
- 2001-08-06 US US09/923,116 patent/US7563455B2/en not_active Expired - Fee Related
-
2009
- 2009-01-16 US US12/355,569 patent/US8147862B2/en not_active Expired - Fee Related
-
2012
- 2012-02-09 US US13/369,929 patent/US8399010B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997040137A1 (en) * | 1996-04-19 | 1997-10-30 | Osiris Therapeutics, Inc. | Regeneration and augmentation of bone using mesenchymal stem cells |
| WO1998017330A1 (en) * | 1996-10-24 | 1998-04-30 | Sdgi Holdings, Inc. | Ceramic fusion implants and compositions containing osteoinductive factors |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60006356T2 (de) | 2004-09-09 |
| US8147862B2 (en) | 2012-04-03 |
| EP1150726B1 (en) | 2003-11-05 |
| ES2209820T3 (es) | 2004-07-01 |
| US8399010B2 (en) | 2013-03-19 |
| US7563455B2 (en) | 2009-07-21 |
| US20020082694A1 (en) | 2002-06-27 |
| AU2756800A (en) | 2000-08-25 |
| WO2000045871A1 (en) | 2000-08-10 |
| CA2362049A1 (en) | 2000-08-10 |
| EP1150726A1 (en) | 2001-11-07 |
| DE60006356D1 (de) | 2003-12-11 |
| JP2002536077A (ja) | 2002-10-29 |
| ATE253385T1 (de) | 2003-11-15 |
| US20120141557A1 (en) | 2012-06-07 |
| US20090196904A1 (en) | 2009-08-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU772682B2 (en) | Highly-mineralized osteogenic sponge compositions, and uses thereof | |
| AU770196B2 (en) | Osteogenic paste compositions and uses thereof | |
| US8690874B2 (en) | Composition and process for bone growth and repair | |
| Alam et al. | Evaluation of ceramics composed of different hydroxyapatite to tricalcium phosphate ratios as carriers for rhBMP-2 | |
| AU2011329054B2 (en) | Bone void fillers | |
| Breitbart et al. | Tricalcium phosphate and osteogenin: a bioactive onlay bone graft substitute | |
| EP0616814A1 (en) | Compositions for controlled release of biologically active TGF - beta | |
| JP2004262758A (ja) | 多孔性β−リン酸三カルシウム顆粒および同一のものを生成する方法 | |
| US20190117734A1 (en) | System and Method for Multiphasic Release of Growth Factors | |
| US20210213165A1 (en) | Autologous Bone Graft Substitute Composition | |
| CA2868992C (en) | System and method for multiphasic release of growth factors | |
| US20090061002A1 (en) | Calcium phospate based delivery of growth and differentiation factors to compromised bone | |
| Lee | A Pilot Study to Compare the Activity of Different Bone Morphogenetic Protein Bioimplants In Vivo | |
| Li | Biodegradable polyurethane scaffolds and delivery systems for regeneration of bone tissue |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |