AU7566987A - Process for the recovery of daunorubicin hydrochloride - Google Patents
Process for the recovery of daunorubicin hydrochlorideInfo
- Publication number
- AU7566987A AU7566987A AU75669/87A AU7566987A AU7566987A AU 7566987 A AU7566987 A AU 7566987A AU 75669/87 A AU75669/87 A AU 75669/87A AU 7566987 A AU7566987 A AU 7566987A AU 7566987 A AU7566987 A AU 7566987A
- Authority
- AU
- Australia
- Prior art keywords
- daunorubicin hydrochloride
- recovery
- chromatography
- eluent
- adsorbent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- NAALWFYYHHJEFQ-ZASNTINBSA-N (2s,5r,6r)-6-[[(2r)-2-[[6-[4-[bis(2-hydroxyethyl)sulfamoyl]phenyl]-2-oxo-1h-pyridine-3-carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound N([C@@H](C(=O)N[C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C=1C=CC(O)=CC=1)C(=O)C(C(N1)=O)=CC=C1C1=CC=C(S(=O)(=O)N(CCO)CCO)C=C1 NAALWFYYHHJEFQ-ZASNTINBSA-N 0.000 title abstract 2
- 229960003109 daunorubicin hydrochloride Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 238000011084 recovery Methods 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 235000010633 broth Nutrition 0.000 abstract 1
- 239000012043 crude product Substances 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Abstract
Daunorubicin hydrochloride is obtained from fermentation broths by extraction, evaporation of the extract and purification of the crude product by chromatography. The chromatography is carried out on a column containing silica gel as adsorbent and with a mixture of chloroform and methanol containing formic acid as eluent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP87110159A EP0306541B1 (en) | 1987-07-14 | 1987-07-14 | Process for obtaining daunorubicin-hydrochloride from fermentation broths |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU7566987A true AU7566987A (en) | 1989-01-19 |
Family
ID=8197127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU75669/87A Abandoned AU7566987A (en) | 1987-07-14 | 1987-07-15 | Process for the recovery of daunorubicin hydrochloride |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0306541B1 (en) |
| AT (1) | ATE71386T1 (en) |
| AU (1) | AU7566987A (en) |
| DE (1) | DE3775928D1 (en) |
| DK (1) | DK356087A (en) |
| ES (1) | ES2027662T3 (en) |
| GR (1) | GR3003833T3 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103641868A (en) * | 2013-11-18 | 2014-03-19 | 宁夏泰瑞制药股份有限公司 | Method for producing daunorubicin hydrochloride by utilizing daunorubicin fermentation broth |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1036797B1 (en) * | 1997-12-05 | 2010-11-17 | Mercian Corporation | Crystalline anthracycline antibiotic and process for producing the same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52148064A (en) * | 1976-05-31 | 1977-12-08 | Microbial Chem Res Found | Antitumors |
| JPS5921394A (en) * | 1982-07-24 | 1984-02-03 | Sanraku Inc | Preparation of daunomycin |
| IT1155446B (en) * | 1982-12-23 | 1987-01-28 | Erba Farmitalia | PROCEDURE FOR THE PURIFICATION OF ANTHRACYCLINONIC GLUCOSIDES BY SELECTIVE ADSOBMENT ON RESINS |
-
1987
- 1987-07-09 DK DK356087A patent/DK356087A/en not_active Application Discontinuation
- 1987-07-14 DE DE8787110159T patent/DE3775928D1/en not_active Expired - Lifetime
- 1987-07-14 AT AT87110159T patent/ATE71386T1/en not_active IP Right Cessation
- 1987-07-14 EP EP87110159A patent/EP0306541B1/en not_active Expired - Lifetime
- 1987-07-14 ES ES198787110159T patent/ES2027662T3/en not_active Expired - Lifetime
- 1987-07-15 AU AU75669/87A patent/AU7566987A/en not_active Abandoned
-
1992
- 1992-02-18 GR GR920400255T patent/GR3003833T3/el unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103641868A (en) * | 2013-11-18 | 2014-03-19 | 宁夏泰瑞制药股份有限公司 | Method for producing daunorubicin hydrochloride by utilizing daunorubicin fermentation broth |
| CN103641868B (en) * | 2013-11-18 | 2015-12-09 | 宁夏泰瑞制药股份有限公司 | A kind of method utilizing daunorubicin fermentation liquor to produce daunorubicin hydrochloride |
Also Published As
| Publication number | Publication date |
|---|---|
| GR3003833T3 (en) | 1993-03-16 |
| EP0306541A1 (en) | 1989-03-15 |
| ATE71386T1 (en) | 1992-01-15 |
| DK356087A (en) | 1989-01-10 |
| EP0306541B1 (en) | 1992-01-08 |
| DK356087D0 (en) | 1987-07-09 |
| ES2027662T3 (en) | 1992-06-16 |
| DE3775928D1 (en) | 1992-02-20 |
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