AU750820B2 - Nucleic acid ligands of tissue target - Google Patents
Nucleic acid ligands of tissue target Download PDFInfo
- Publication number
- AU750820B2 AU750820B2 AU16004/99A AU1600499A AU750820B2 AU 750820 B2 AU750820 B2 AU 750820B2 AU 16004/99 A AU16004/99 A AU 16004/99A AU 1600499 A AU1600499 A AU 1600499A AU 750820 B2 AU750820 B2 AU 750820B2
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- Prior art keywords
- seq
- nucleic acid
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- feature
- selex
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
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- A—HUMAN NECESSITIES
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- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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- C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
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- G01N2333/96486—Metalloendopeptidases (3.4.24)
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- G01N2333/90—Enzymes; Proenzymes
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- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
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- G01N2333/972—Plasminogen activators
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- G—PHYSICS
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- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
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- G—PHYSICS
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- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/976—Trypsin; Chymotrypsin
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- Health & Medical Sciences (AREA)
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- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Crystallography & Structural Chemistry (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/976,413 US6127119A (en) | 1990-06-11 | 1997-11-21 | Nucleic acid ligands of tissue target |
| US08/976413 | 1997-11-21 | ||
| PCT/US1998/025006 WO1999027138A1 (en) | 1997-11-21 | 1998-11-19 | Nucleic acid ligands of tissue target |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU1600499A AU1600499A (en) | 1999-06-15 |
| AU750820B2 true AU750820B2 (en) | 2002-07-25 |
Family
ID=25524076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU16004/99A Expired AU750820B2 (en) | 1997-11-21 | 1998-11-19 | Nucleic acid ligands of tissue target |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6127119A (enExample) |
| EP (1) | EP1032708A4 (enExample) |
| JP (1) | JP2001524320A (enExample) |
| AU (1) | AU750820B2 (enExample) |
| CA (1) | CA2311164A1 (enExample) |
| WO (1) | WO1999027138A1 (enExample) |
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| US6232071B1 (en) * | 1990-06-11 | 2001-05-15 | Gilead Sciences, Inc. | Tenascin-C nucleic acid ligands |
| US7005260B1 (en) | 2000-01-28 | 2006-02-28 | Gilead Sciences, Inc. | Tenascin-C nucleic acid ligands |
| DE10019154A1 (de) * | 2000-04-18 | 2001-10-31 | Univ Eberhard Karls | Zellbindende Nukleinsäuremoleküle (Aptamere) |
| US8914114B2 (en) | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| EP2322648A1 (en) * | 2000-09-26 | 2011-05-18 | Duke University | RNA aptamers and methods for identifying the same |
| IL159053A0 (en) | 2001-05-25 | 2004-05-12 | Univ Duke | Modulators of pharmacological agents |
| US7206639B2 (en) * | 2002-03-15 | 2007-04-17 | Sarcos Investments Lc | Cochlear drug delivery system and method |
| US7727969B2 (en) | 2003-06-06 | 2010-06-01 | Massachusetts Institute Of Technology | Controlled release nanoparticle having bound oligonucleotide for targeted delivery |
| WO2005059509A2 (en) * | 2003-12-12 | 2005-06-30 | Saint Louis University | Biosensors for detecting macromolecules and other analytes |
| US8389710B2 (en) | 2004-02-27 | 2013-03-05 | Operational Technologies Corporation | Therapeutic nucleic acid-3′-conjugates |
| US8318920B2 (en) * | 2004-02-27 | 2012-11-27 | Operational Technologies Corporation | Therapeutic nucleic acid-3′-conjugates |
| US7910297B2 (en) * | 2004-02-27 | 2011-03-22 | Operational Technologies Corporation | Therapeutic nucleic acid-3' -conjugates |
| US10912712B2 (en) | 2004-03-25 | 2021-02-09 | The Feinstein Institutes For Medical Research | Treatment of bleeding by non-invasive stimulation |
| AU2005225458B2 (en) | 2004-03-25 | 2008-12-04 | The Feinstein Institutes For Medical Research | Neural tourniquet |
| PT1745062E (pt) * | 2004-04-22 | 2014-07-11 | Regado Biosciences Inc | Moduladores melhorados de fatores de coagulação |
| ATE489132T1 (de) | 2004-12-27 | 2010-12-15 | The Feinstein Inst Medical Res | Behandlung von entzündlichen erkrankungen durch elektrische stimulation des vagus-nervs |
| US11207518B2 (en) | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
| US8956857B2 (en) | 2005-06-06 | 2015-02-17 | Mediomics, Llc | Three-component biosensors for detecting macromolecules and other analytes |
| US7795009B2 (en) * | 2005-06-15 | 2010-09-14 | Saint Louis University | Three-component biosensors for detecting macromolecules and other analytes |
| CA2611198C (en) * | 2005-06-10 | 2015-04-28 | Saint Louis University | Methods for the selection of aptamers |
| US7811809B2 (en) * | 2005-06-15 | 2010-10-12 | Saint Louis University | Molecular biosensors for use in competition assays |
| US7964356B2 (en) * | 2007-01-16 | 2011-06-21 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US8975026B2 (en) | 2007-01-16 | 2015-03-10 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| WO2009029614A1 (en) | 2007-08-27 | 2009-03-05 | The Feinstein Institute For Medical Research | Devices and methods for inhibiting granulocyte activation by neural stimulation |
| WO2009052301A1 (en) * | 2007-10-16 | 2009-04-23 | Regado Biosciences, Inc. | Steady-state subcutaneous administration of aptamers |
| US9211409B2 (en) | 2008-03-31 | 2015-12-15 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation of T-cell activity |
| US9662490B2 (en) | 2008-03-31 | 2017-05-30 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug |
| US8703416B2 (en) | 2008-07-17 | 2014-04-22 | Somalogic, Inc. | Method for purification and identification of sperm cells |
| ES2452484T3 (es) | 2008-11-18 | 2014-04-01 | Setpoint Medical Corporation | Dispositivos para optimizar la colocación de electrodos para la estimulación antiinflamatoria |
| EP2350657A4 (en) | 2008-11-21 | 2013-06-12 | Univ Saint Louis | BIOSENSOR FOR DETECTING MULTIPLE EPITOPES ON ONE TARGET |
| US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| US8788034B2 (en) | 2011-05-09 | 2014-07-22 | Setpoint Medical Corporation | Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| US8996116B2 (en) | 2009-10-30 | 2015-03-31 | Setpoint Medical Corporation | Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction |
| WO2010141771A1 (en) | 2009-06-03 | 2010-12-09 | Regado Biosciences, Inc. | Nucleic acid modulators of glycoprotein vi |
| CN102573986B (zh) | 2009-06-09 | 2016-01-20 | 赛博恩特医疗器械公司 | 用于无导线刺激器的具有袋部的神经封套 |
| US8841429B2 (en) | 2009-11-03 | 2014-09-23 | Vivonics, Inc. | Nucleic acid ligands against infectious prions |
| US8236570B2 (en) | 2009-11-03 | 2012-08-07 | Infoscitex | Methods for identifying nucleic acid ligands |
| US9833621B2 (en) | 2011-09-23 | 2017-12-05 | Setpoint Medical Corporation | Modulation of sirtuins by vagus nerve stimulation |
| WO2014169145A1 (en) | 2013-04-10 | 2014-10-16 | Setpoint Medical Corporation | Closed-loop vagus nerve stimulation |
| EP2515996B1 (en) | 2009-12-23 | 2019-09-18 | Setpoint Medical Corporation | Neural stimulation devices and systems for treatment of chronic inflammation |
| US20110165037A1 (en) * | 2010-01-07 | 2011-07-07 | Ismagilov Rustem F | Interfaces that eliminate non-specific adsorption, and introduce specific interactions |
| US9040287B2 (en) | 2010-02-12 | 2015-05-26 | Mediomics, Llc | Molecular biosensors capable of signal amplification |
| US12172017B2 (en) | 2011-05-09 | 2024-12-24 | Setpoint Medical Corporation | Vagus nerve stimulation to treat neurodegenerative disorders |
| WO2013119602A1 (en) | 2012-02-06 | 2013-08-15 | President And Fellows Of Harvard College | Arrdc1-mediated microvesicles (armms) and uses thereof |
| US9572983B2 (en) | 2012-03-26 | 2017-02-21 | Setpoint Medical Corporation | Devices and methods for modulation of bone erosion |
| WO2015117201A1 (en) | 2014-02-05 | 2015-08-13 | Deakin University | Aptamer construct |
| US10274484B2 (en) | 2014-09-12 | 2019-04-30 | Mediomics Llc | Molecular biosensors with a modular design |
| US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
| US9816080B2 (en) | 2014-10-31 | 2017-11-14 | President And Fellows Of Harvard College | Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs) |
| WO2016126807A1 (en) | 2015-02-03 | 2016-08-11 | Setpoint Medical Corporation | Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator |
| US11634704B2 (en) | 2015-04-13 | 2023-04-25 | Research Foundation Of The City University Of New York | Ligand-guided-selection method for screening antigen-specific ligands |
| US10253314B2 (en) * | 2015-04-13 | 2019-04-09 | Research Foundation Of The City University Of New York | Ligand-guided-selection method for screening antigen-specific ligands |
| US10596367B2 (en) | 2016-01-13 | 2020-03-24 | Setpoint Medical Corporation | Systems and methods for establishing a nerve block |
| CN114904142A (zh) | 2016-01-20 | 2022-08-16 | 赛博恩特医疗器械公司 | 迷走神经刺激的控制 |
| US11471681B2 (en) | 2016-01-20 | 2022-10-18 | Setpoint Medical Corporation | Batteryless implantable microstimulators |
| WO2017127758A1 (en) | 2016-01-20 | 2017-07-27 | Setpoint Medical Corporation | Implantable microstimulators and inductive charging systems |
| US10583304B2 (en) | 2016-01-25 | 2020-03-10 | Setpoint Medical Corporation | Implantable neurostimulator having power control and thermal regulation and methods of use |
| US11730823B2 (en) | 2016-10-03 | 2023-08-22 | President And Fellows Of Harvard College | Delivery of therapeutic RNAs via ARRDC1-mediated microvesicles |
| EP3668402B1 (en) | 2017-08-14 | 2024-07-31 | Setpoint Medical Corporation | Vagus nerve stimulation pre-screening test |
| US11660443B2 (en) | 2018-04-20 | 2023-05-30 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via electrical trigeminal nerve stimulation |
| US11260229B2 (en) | 2018-09-25 | 2022-03-01 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation |
| AU2020272128B9 (en) | 2019-04-12 | 2025-11-20 | Setpoint Medical Corporation | Vagus nerve stimulation to treat neurodegenerative disorders |
| AU2020381646A1 (en) * | 2019-11-14 | 2022-04-07 | i-ZUM-X Pty Ltd | Method of detection of fibrin clots |
| JP2023526080A (ja) | 2020-05-21 | 2023-06-20 | ザ・フェインステイン・インスティチュート・フォー・メディカル・リサーチ | 迷走神経刺激のためのシステムおよび方法 |
| WO2022245878A1 (en) | 2021-05-17 | 2022-11-24 | Setpoint Medical Corporation | Neurostimulation parameter authentication and expiration system for neurostimulation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4434585A (en) * | 1985-03-30 | 1986-10-23 | Marc Ballivet | Method for obtaining dna, rna, peptides, polypeptides or proteins by means of a dna recombinant technique |
| WO1989006694A1 (en) * | 1988-01-15 | 1989-07-27 | Trustees Of The University Of Pennsylvania | Process for selection of proteinaceous substances which mimic growth-inducing molecules |
| US5270163A (en) * | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5750342A (en) * | 1990-06-11 | 1998-05-12 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands of tissue target |
| US5688935A (en) * | 1990-06-11 | 1997-11-18 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands of tissue target |
| AU1435492A (en) * | 1991-02-21 | 1992-09-15 | Gilead Sciences, Inc. | Aptamer specific for biomolecules and method of making |
| WO1994006934A1 (en) * | 1992-09-11 | 1994-03-31 | Duke University | Method for deriving epitopes |
| US5614503A (en) * | 1993-11-12 | 1997-03-25 | Aronex Pharmaceuticals, Inc. | Amphipathic nucleic acid transporter |
| EP1564290B1 (en) * | 1995-05-03 | 2008-07-16 | Gilead Sciences, Inc. | Method for identifying nucleic acid ligands of tissue targets |
-
1997
- 1997-11-21 US US08/976,413 patent/US6127119A/en not_active Expired - Fee Related
-
1998
- 1998-11-19 CA CA002311164A patent/CA2311164A1/en not_active Abandoned
- 1998-11-19 EP EP98960403A patent/EP1032708A4/en not_active Withdrawn
- 1998-11-19 JP JP2000522279A patent/JP2001524320A/ja not_active Withdrawn
- 1998-11-19 WO PCT/US1998/025006 patent/WO1999027138A1/en not_active Ceased
- 1998-11-19 AU AU16004/99A patent/AU750820B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP1032708A4 (en) | 2004-09-15 |
| US6127119A (en) | 2000-10-03 |
| EP1032708A1 (en) | 2000-09-06 |
| WO1999027138A1 (en) | 1999-06-03 |
| JP2001524320A (ja) | 2001-12-04 |
| CA2311164A1 (en) | 1999-06-03 |
| AU1600499A (en) | 1999-06-15 |
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